Project 1: Inhibition of Indole-amine 2, 3 Dioxygenase to Enhance Ovarian Tumor Immunity
This project tests a novel, therapeutic strategy to break indoleamine 2, 3-dioxygenase (IDO)-mediated immune tolerance in ovarian cancer, while inducing anti-tumor-specific immunity in patients in second remission.
Project 2: Rapamycin and IL-21 Conditioned CD8+ T cells for Adoptive Cellular Therapy of Ovarian Cancer
This project tests a combinatorial strategy of mTOR inhibition and IL-21 for ex vivo conditioning of antigen stimulated CD8+ T cells for effector and memory functional attributes, and also whether the ex vivo generated cells produce durable immunity against ovarian tumor in a clinical trial.
Project 3: MHC-Restricted and MHC-Non-Restricted Targeting of Ovarian Cancer by Alpha DC1-induced CTLs
This project tests whether autologous tumor-loaded type-1-polarized dendritic cells (αDC1s) will generate CTLs capable of recognizing ovarian cancer in either MHC class I-restricted-or MHC class I-unrestricted fashion, when used both as a vaccine and for adoptive T cell therapy.
Co-Leaders: Robert P. Edwards, MD; Pawel Kalinski, MD, PhD
Project 4: Myeloid Derived Suppressor Cells in Ovarian Carcinogenesis
Project 4 will determine the predictive significance of myeloid derived suppressor cells (MDSCs), which have strong immunosuppressive properties, in the long-term survival of ovarian cancer patients.