The centromere is a central genetic element responsible for accurate chromosome segregation during cell division. Functional centromeres are specified epigenetically through the stable acquisition of CENP-A, a histone H3 variant found exclusively in nucleosomes at all active centromeres. Using genome-wide approaches, we recently discovered that DNA replication serves as an error correction mechanism that restricts CENP-A to centromeres by removing it from the ectopic sites of deposition at the chromosome arms, while maintaining the positions of centromere-bound CENP-A with high precision throughout DNA replication. This error correction mechanism explains how centromere identity is epigenetically maintained and restricted to one position on the chromosome, thereby suppressing genome instability and ensuring long-term faithful chromosome inheritance.
Course director is Mark Goodman, MD
Every Friday from 9:15-10 am
The Bridgeside Research Forum is a seminar given by postdocs and graduate students every Friday from 12-1 pm during the academic year. Most weeks consist of two 30-minute talks, but there will be an occasional hour-long special seminar from an invited guest too.
The goal of this forum is to provide an opportunity for trainees to gain valuable experience presenting their research to a broad scientific community. The topics are diverse each week, so there is sure to be something for everyone. All are welcome to attend and enjoy a free lunch while you are there!
There is a free shuttle to transport people directly from the Hillman Cancer Center to Bridgeside Point II and back. The shuttle will depart Hillman at 11:30 am and then depart Bridgside at 1:15 pm
Please visit the Tumor Boards section under Healthcare Professionals for more information.
These meetings are for health care professionals and researchers and are not open to the public.
Course director is Mark Goodman, MD
The Provost’s Inaugural Lecture series invites University of Pittsburgh faculty members to give a lecture marking their recent appointments to endowed chairs. Dr. Aizenstein’s research focuses on cognitive and affective neuroscience of aging, late-life depression, and multimodal neuroimaging methods.
A reception with light refreshments will follow the talk.
Every Friday from 9:15-10 am
The Bridgeside Research Forum is a seminar given by postdocs and graduate students every Friday from 12-1 pm during the academic year. Most weeks consist of two 30-minute talks, but there will be an occasional hour-long special seminar from an invited guest too.
The goal of this forum is to provide an opportunity for trainees to gain valuable experience presenting their research to a broad scientific community. The topics are diverse each week, so there is sure to be something for everyone. All are welcome to attend and enjoy a free lunch while you are there!
There is a free shuttle to transport people directly from the Hillman Cancer Center to Bridgeside Point II and back. The shuttle will depart Hillman at 11:30 am and then depart Bridgside at 1:15 pm
Please feel free to attend the women faculty/trainee lunch on the first Friday of the month at the UPMC Hillman Cancer Center to informally chat and discuss issues pertaining to female scientists.
Please visit the Tumor Boards section under Healthcare Professionals for more information.
These meetings are for health care professionals and researchers and are not open to the public.
Course director is Mark Goodman, MD
Every Friday from 9:15-10 am
The Bridgeside Research Forum is a seminar given by postdocs and graduate students every Friday from 12-1 pm during the academic year. Most weeks consist of two 30-minute talks, but there will be an occasional hour-long special seminar from an invited guest too.
The goal of this forum is to provide an opportunity for trainees to gain valuable experience presenting their research to a broad scientific community. The topics are diverse each week, so there is sure to be something for everyone. All are welcome to attend and enjoy a free lunch while you are there!
There is a free shuttle to transport people directly from the Hillman Cancer Center to Bridgeside Point II and back. The shuttle will depart Hillman at 11:30 am and then depart Bridgside at 1:15 pm
Please visit the Tumor Boards section under Healthcare Professionals for more information.
These meetings are for health care professionals and researchers and are not open to the public.
THURSDAY, 17 OCTOBER
9:00 a.m. SPOTLIGHT SESSION 1: Inflammation, Immunology, and Disease
Moderator: Mark Shlomchik, MD
PhD Mark Shlomchik, MD, PhD Greg Delgoffe, PhD, Mandy McGeachy, PhD, Fadi Lakkis, MD
FRIDAY, 18 OCTOBER
2:00 p.m. SPOTLIGHT SESSION 11: Oxidative Stress
Moderator: Bruce Freeman, PhD
Patricia Opresko, PhD, Toren Finkel, MD, PhD, Patrick Pagano, PhD, Sruti Shiva, PhD
2:00 p.m. SPOTLIGHT SESSION 12: Tumorigenesis—Speeding It Up and Putting on the Brakes
Moderator: Steffi Oesterreich, PhD
Alan Wells, MD, DMSc, Ferruccio Galbiati, PhD, Yi-Nan Gong, PhD, Yael Nechemia-Arbely, PhD
Course director is Mark Goodman, MD
Rusland Medzhitov, PhD, Sterling Professor of Immunobiology at Yale University and a Howard Hughes Medical Institute investigator, will present the 2019 Dickson Prize in Medicine Lecture, “Host Defense Strategies,” as part of Science 2019, the University of Pittsburgh’s annual celebration of science and technology. The Dickson Prize in Medicine is the highest honor awarded by Pitt’s School of Medicine.
Medzhitov is credited with many fundamental discoveries concerning the importance of Toll-like receptors in controlling adaptive immunity, infections, chronic inflammation, and tumor growth. Many drug companies are actively targeting these receptors in hopes of treating cancer, sepsis, and inflammatory disease.
Every Friday from 9:15-10 am
The Bridgeside Research Forum is a seminar given by postdocs and graduate students every Friday from 12-1 pm during the academic year. Most weeks consist of two 30-minute talks, but there will be an occasional hour-long special seminar from an invited guest too.
The goal of this forum is to provide an opportunity for trainees to gain valuable experience presenting their research to a broad scientific community. The topics are diverse each week, so there is sure to be something for everyone. All are welcome to attend and enjoy a free lunch while you are there!
There is a free shuttle to transport people directly from the Hillman Cancer Center to Bridgeside Point II and back. The shuttle will depart Hillman at 11:30 am and then depart Bridgside at 1:15 pm
Please visit the Tumor Boards section under Healthcare Professionals for more information.
These meetings are for health care professionals and researchers and are not open to the public.
Course director is Mark Goodman, MD
Every Friday from 9:15-10 am
The Bridgeside Research Forum is a seminar given by postdocs and graduate students every Friday from 12-1 pm during the academic year. Most weeks consist of two 30-minute talks, but there will be an occasional hour-long special seminar from an invited guest too.
The goal of this forum is to provide an opportunity for trainees to gain valuable experience presenting their research to a broad scientific community. The topics are diverse each week, so there is sure to be something for everyone. All are welcome to attend and enjoy a free lunch while you are there!
There is a free shuttle to transport people directly from the Hillman Cancer Center to Bridgeside Point II and back. The shuttle will depart Hillman at 11:30 am and then depart Bridgside at 1:15 pm
Please visit the Tumor Boards section under Healthcare Professionals for more information.
These meetings are for health care professionals and researchers and are not open to the public.
Event Speaker: Rui Sun, PhD, Postdoctoral Associate, Chang Moore Lab, School of Medicine, University of Pittsburgh
Lecture Title: “Mitosis-related 4E-BP1 phosphorylation and its interaction with eIF4E—Peer into the complexity of protein multisite phosphorylation”
This meeting has been canceled.
Speaker: Ulrich Keilholz, MD
Speaker Title: Professor of Medical Oncology and Director, Charité Comprehensive Cancer Center, Berlin, Germany
Lecture Title: “The Charité Precision Oncology Program”
RSVP to Lola Thompson at thompsonla3@upmc.edu.
Event Speaker: Avi Maganty, MD, Department of Urology, UPMC
Lecture Title: “Undertreatment of Prostate Cancer in Rural Residents”
It is well established that species differences exist in susceptibility to infectious diseases. Additionally, significant species-specific differences exist in the immune response to infectious agents and neoplasia. To overcome the species-specific difference between rodents and humans, we have reconstituted immunodeficient rodents with requisite human organ systems for investigating sexually transmitted diseases (i.e. HIV) and immuno-oncology (i.e. ovarian cancer).
Course director is Mark Goodman, MD
Every Friday from 9:15-10 am
The Bridgeside Research Forum is a seminar given by postdocs and graduate students every Friday from 12-1 pm during the academic year. Most weeks consist of two 30-minute talks, but there will be an occasional hour-long special seminar from an invited guest too.
The goal of this forum is to provide an opportunity for trainees to gain valuable experience presenting their research to a broad scientific community. The topics are diverse each week, so there is sure to be something for everyone. All are welcome to attend and enjoy a free lunch while you are there!
There is a free shuttle to transport people directly from the Hillman Cancer Center to Bridgeside Point II and back. The shuttle will depart Hillman at 11:30 am and then depart Bridgside at 1:15 pm
Please feel free to attend the women faculty/trainee lunch on the first Friday of the month at the UPMC Hillman Cancer Center to informally chat and discuss issues pertaining to female scientists.
Please visit the Tumor Boards section under Healthcare Professionals for more information.
These meetings are for health care professionals and researchers and are not open to the public.
Event Speaker: David Lewis, MD, Distinguished Professor of Psychiatry and Neuroscience, University of Pittsburgh School of Medicine
Lecture Title: “A Neural Circuitry Substrate for Cognitive Dysfunction in Schizophrenia”
Course director is Mark Goodman, MD
Event Speaker: Xiaosong Wang, MD, PhD, Associate Professor of Pathology, UPMC Hillman Cancer Center
Lecture Title: “Integral Genomic Signature Analysis to Predict Cancer Targeted Therapy Response from Multi-OMIC Big Data”
Every Friday from 9:15-10 am
The Bridgeside Research Forum is a seminar given by postdocs and graduate students every Friday from 12-1 pm during the academic year. Most weeks consist of two 30-minute talks, but there will be an occasional hour-long special seminar from an invited guest too.
The goal of this forum is to provide an opportunity for trainees to gain valuable experience presenting their research to a broad scientific community. The topics are diverse each week, so there is sure to be something for everyone. All are welcome to attend and enjoy a free lunch while you are there!
There is a free shuttle to transport people directly from the Hillman Cancer Center to Bridgeside Point II and back. The shuttle will depart Hillman at 11:30 am and then depart Bridgside at 1:15 pm
The Provost’s Inaugural Lecture series invites University of Pittsburgh faculty members to give a lecture marking their recent appointments to endowed chairs. Dr. Musahl’s research focuses on the biomechanics of the knee and shoulder.
Please visit the Tumor Boards section under Healthcare Professionals for more information.
These meetings are for health care professionals and researchers and are not open to the public.
Course director is Mark Goodman, MD
Every Friday from 9:15-10 am
The Bridgeside Research Forum is a seminar given by postdocs and graduate students every Friday from 12-1 pm during the academic year. Most weeks consist of two 30-minute talks, but there will be an occasional hour-long special seminar from an invited guest too.
The goal of this forum is to provide an opportunity for trainees to gain valuable experience presenting their research to a broad scientific community. The topics are diverse each week, so there is sure to be something for everyone. All are welcome to attend and enjoy a free lunch while you are there!
There is a free shuttle to transport people directly from the Hillman Cancer Center to Bridgeside Point II and back. The shuttle will depart Hillman at 11:30 am and then depart Bridgside at 1:15 pm
Please visit the Tumor Boards section under Healthcare Professionals for more information.
These meetings are for health care professionals and researchers and are not open to the public.
The Provost’s Inaugural Lecture series invites University of Pittsburgh faculty members to give a lecture marking their recent appointments to endowed chairs. Dr. Finkel’s research focuses on mitochondrial function, cellular metabolism, oxidative stress, and aging.
A reception with light refreshments will follow the talk.
