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Cancer Epidemiology investigators

Randall Brand, MD
Contact:
Shadyside Medical Building
5200 Centre Avenue, Suite 409
Pittsburgh PA
Research Interests and Keywords:
  • Hereditary pancreatic cancer
  • early detection of pancreatic cancer
  • pancreatitis
  • colon cancer
Jane Cauley, DrPH
Contact:
130 De Soto Street, A533 Crabtree Hall
Pittsburgh PA
Research Interests and Keywords:
  • Breast cancer
  • epidemiology
  • sex hormones
  • osteoporosis
Summary
Dr. Cauley's primary research interest is the epidemiology of osteoporosis, osteoporosis treatment and the consequences of osteoporosis in both men and women. She also has a major interest in breast cancer and served on the American Society of Clinical Oncology Writing Group about the use of bisphosphonates in women with breast cancer. Her other research has focused on women's health and aging, falls, the interaction between endogenous and exogenous hormones, risk factors, inflammation, and disease outcomes. She examines the physical and psychological changes that occur in postmenopausal women.
Mary Ganguli, MD, MPH
Contact:
3811 O'Hara St.
Pittsburgh PA
Research Interests and Keywords:
  • Aging
  • epidemiology
Robert Schoen, MD, MPH
Contact:
PUH - Mezz. 2 - C Wing
200 Lothrop Street
Pittsburgh PA
Research Interests and Keywords:
  • Early detection and prevention of colorectal cancer (CRC)
  • flexible sigmoidoscopy
  • acceptability and implementation of CRC screening
  • surveillance colonoscopy
  • relationship of insulin/insulin-like growth factors to adenomatous polyps and CRC
David Wilson, MD, MPH
Contact:
5150 Centre Ave. Ste. 4c
Pittsburgh PA
Phone: 412-687-3355
Research Interests and Keywords:
  • Lung cancer screening, chemoprevention, diagnosis, staging and treatment
  • COPD
  • pulmonary medicine
Summary
Dr. Wilson's research interests include: lung cancer screening and chemoprevention, diagnosis, staging and treatment; COPD, especially as it relates to lung cancer; occupational lung diseases; and general pulmonary medicine.
Joseph Zmuda, PhD
Contact:
A544 Crabtree Hall
Pittsburgh PA
Phone: 412-624-2970
Research Interests and Keywords:
  • Genetic and molecular epidemiology
  • osteoporosis
  • aging
Summary
My research primarily focuses on the epidemiology and genetics of osteoporosis. A long-term goal is to identify and characterize the genetic factors underlying osteoporosis susceptibility in different ethnic/racial groups. To achieve these goals, we have used several strategies including: population-based candidate gene methods; genome-wide admixture, linkage and association mapping; and most recently, an in vitro cellular model. This later approach is enabling us to translate discoveries made at the cellular level to the 'population' and vice versa to gain insight into the molecular genetic mechanisms underlying osteoporosis susceptibility.
Clareann Bunker, PhD
Contact:
A542 Crabtree
130 DeSoto Street
Pittsburgh PA
Phone: 412-624-3467
Research Interests and Keywords:
  • Prostate cancer
  • ovarian cancer
  • molecular epidemiology
Summary
Dr. Bunker has been an active researcher and mentor in cancer research since 1996. Her major research project, 1997 to present, has been a longitudinal study of prostate cancer screening outcome and prostate cancer etiology among African descent men on the Caribbean Island of Tobago. Dr. Bunker has also been the PI of a large ovarian cancer case-control study, the HOPE Study. Dr. Bunker is particularly interested in factors which may contribute to the wide differences in prostate cancer risk between Caucasians and populations of African descent, and among populations of African descent.
Brenda Diergaarde, PhD
Contact:
UPMC Cancer Pavilion
5150 Centre Ave, Suite 4C
Pittsburgh PA
Phone: 412-623-5891
Research Interests and Keywords:
  • Molecular epidemiology
  • cancer epidemiology
  • genetic variation
  • diet
  • lifestyle
  • cancer prevention
  • biomarkers
  • lung cancer
  • head and neck cancer
Summary
Dr. Diergaarde's research examines the role of diet, lifestyle and genetic variation in the development, progression and treatment of cancer, including cancers of the lung, head and neck, colon, ovaries and breast, and aims to identify markers for risk stratification, early detection and response to treatment. She is currently Co-Leader of Project 2 of the UPCI Specialized Program of Research Excellence (SPORE) in Lung Cancer. This project seeks to establish the relationship between vitamin D exposure, pulmonary inflammation and lung cancer risk and so provide strong rationale for a vitamin D-based approach to lung cancer prevention. She is also Leader of Project 1 of the UPCI SPORE in Head and Neck Cancer. Using data and samples from a large, clinic-based case-control study, this project investigates the role of genetic variation and gene-environment interactions in the development, progression and treatment of head and neck squamous cell carcinoma.
James Herman, MD
Contact:
Hillman Cancer Center, 2.18d
Pittsburgh PA
Research Interests and Keywords:
  • Lung cancer
  • DNA methylation
  • tumor suppressor genes
  • epigenetics
  • biomarkers
  • transcription factors
  • early detection
  • cancer prognosis
Evelyn Talbott, DrPH, MPH
Contact:
A526 Crabtree Hall
Pittsburgh PA
Phone: 412-624-3074
Research Interests and Keywords:
  • Environmental epidemiology
Summary
Dr. Talbott's areas of expertise are in environmental and cardiovascular epidemiology. Dr. Talbott has worked closely with both state and local health departments to conduct health studies investigating potential linkage of environmental exposures and health effects.
Jian-Min Yuan, MD, PhD
Contact:
UPMC Cancer Pavilion
5150 Centre Avenue - Suite 4C Office 470
Pittsburgh PA
Phone: 412-864-7889
Research Interests and Keywords:
  • Gene-environment interaction in cancer etiology
  • cancer biomarkers
  • cancer risk prediction
  • dietary chemopreventive agents
  • cancer epidemiology
  • cancer prevention
  • clinical trials
Summary
Dr. Yuan is a cancer epidemiologist with extensive experience in research on cancer etiology and prevention. Dr. Yuan is Principal Investigator of the Shanghai Cohort Study and the Singapore Chinese Health Study, two population-based prospective cohorts of more than 80,000 Chinese men and women with available baseline blood and urine samples with more than 25 years of active follow-up for cancer and other major health outcomes.

Utilizing these two large cohort resources coupled with a biomarker approach, Dr. Yuan and his research team have made several noteworthy contributions to the field of cancer epidemiology including (1) dietary aflatoxins as human hepatocarcinogens, (2) dietary isothiocyanates, a group of phytochemicals found in cruciferous vegetables, as potential chemopreventive agents against lung cancer development, and (3) urinary biomarkers of nicotine, tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons as risk predictors for lung cancer in smokers.

Dr. Yuan also has extensive experience in designing and conducting randomized, double-blind intervention studies on cancer prevention. Dr. Yuan is leading the effort to conduct a randomized, double-blind phase II clinical trial to evaluate the effectiveness of dietary 2-phenethyl isothiocyanates (PEITC) supplementation on reduction of risk markers for lung cancer in smokers. In addition, Dr. Yuan, collaborating with Dr. Mindy Kurzer, his former colleague at the University of Minnesota, is conducting a randomized, double-blind phase II clinical trial to evaluate the efficacy of oral supplementation of green tea extracts (Polyphenon E) on reduction of risk markers for breast cancer in women.

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