Publications

Mechanisms of Genome Stability

Dralle H, Machens A, Basa J, Fatourechi V, Franceschi S, Hay ID, Nikiforov YE, Pacini F, Pasieka JL, Sherman SI. Follicular cell-derived thyroid cancer. Nat Rev Dis Primers. 2015 Dec 10;115077. doi: 10.1038/nrdp.2015.77. PubMed PMID: 27188261.
Teng PN, Bateman NW, Darcy KM, Hamilton CA, Maxwell GL, Bakkenist CJ, Conrads TP. Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells. Gynecol Oncol. 2015 Mar;136(3):554-61. doi: 10.1016/j.ygyno.2014.12.035. PubMed PMID: 25560806; PMCID: PMC4382918.
Chen X, Velmurugu Y, Zheng G, Park B, Shim Y, Kim Y, Liu L, Van Houten B, He C, Ansari A, Min JH. Kinetic gating mechanism of DNA damage recognition by Rad4/XPC. Nat Commun. 2015 Jan 6;65849. doi: 10.1038/ncomms6849. PubMed PMID: 25562780; PMCID: PMC4354021.
Qian W, Salamoun J, Wang J, Roginskaya V, Van Houten B, Wipf P. The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak. Bioorg Med Chem Lett. 2015 Feb 15;25(4):856-63. doi: 10.1016/j.bmcl.2014.12.072. PubMed PMID: 25582599; PMCID: PMC4318771.
Böhm S, Mihalevic MJ, Casal MA, Bernstein KA. Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells. DNA Repair (Amst). 2015 Feb;261-14. doi: 10.1016/j.dnarep.2014.12.004. PubMed PMID: 25588990; PMCID: PMC4308569.
Godin SK, Meslin C, Kabbinavar F, Bratton-Palmer DS, Hornack C, Mihalevic MJ, Yoshida K, Sullivan M, Clark NL, Bernstein KA. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. Genetics. 2015 Apr;199(4):1023-33. doi: 10.1534/genetics.114.173518. PubMed PMID: 25659377; PMCID: PMC4391554.
Argani P, Lewin JR, Edmonds P, Netto GJ, Prieto-Granada C, Zhang L, Jungbluth AA, Antonescu CR. Primary renal sclerosing epithelioid fibrosarcoma: report of 2 cases with EWSR1-CREB3L1 gene fusion. Am J Surg Pathol. 2015 Mar;39(3):365-73. doi: 10.1097/PAS.0000000000000338. PubMed PMID: 25353281; PMCID: PMC4326586.
Buryk MA, Picarsic JL, Creary SE, Shaw PH, Simons JP, Deutsch M, Monaco SE, Nikiforov YE, Witchel SF. Identification of Unique, Heterozygous Germline Mutation, STK11 (p.F354L), in a Child with an Encapsulated Follicular Variant of Papillary Thyroid Carcinoma within Six Months of Completing Treatment for Neuroblastoma. Pediatr Dev Pathol. 2015 Jul-Aug;18(4):318-23. doi: 10.2350/15-01-1597-CR.1. PubMed PMID: 25751324.
Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, Koehn BH, Pfeifer D, Taylor PA, Prinz G, Dierbach H, Stickel N, Beck Y, Warncke M, Junt T, Schmitt-Graeff A, Nakae S, Follo M, Wertheimer T, Schwab L, Devlin J, Watkins SC, Duyster J, Ferrara JL, Turnquist HR, Zeiser R, Blazar BR. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood. 2015 May 14;125(20):3183-92. doi: 10.1182/blood-2014-10-606830. PubMed PMID: 25814531; PMCID: PMC4432012.
Knickelbein K, Zhang L. Mutant KRAS as a critical determinant of the therapeutic response of colorectal cancer. Genes Dis. 2015 Mar;2(1):4-12. doi: 10.1016/j.gendis.2014.10.002. PubMed PMID: 25815366; PMCID: PMC4372129.
Wang X, Wei L, Cramer JM, Leibowitz BJ, Judge C, Epperly M, Greenberger J, Wang F, Li L, Stelzner MG, Dunn JCY, Martin MG, Lagasse E, Zhang L, Yu J. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10;58566. doi: 10.1038/srep08566. PubMed PMID: 25858503; PMCID: PMC4392360.
Tsai FL, Vijayraghavan S, Prinz J, MacAlpine HK, MacAlpine DM, Schwacha A. Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate. Mol Cell Biol. 2015 Jun;35(12):2131-43. doi: 10.1128/MCB.01357-14. PubMed PMID: 25870112; PMCID: PMC4438241.
Chen X, Song X, Yue W, Chen D, Yu J, Yao Z, Zhang L. Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer. Oncotarget. 2015 Jun 20;6(17):15022-34. doi: 10.18632/oncotarget.3609. PubMed PMID: 25909283; PMCID: PMC4558133.
Gomez-Casal R, Bhattacharya C, Epperly MW, Basse PH, Wang H, Wang X, Proia DA, Greenberger JS, Socinski MA, Levina V. The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells. Cancers (Basel). 2015 May 22;7(2):876-907. doi: 10.3390/cancers7020814. PubMed PMID: 26010604; PMCID: PMC4491689.
Wang T, Guan W, Lin J, Boutaoui N, Canino G, Luo J, Celedón JC, Chen W. A systematic study of normalization methods for Infinium 450K methylation data using whole-genome bisulfite sequencing data. Epigenetics. 2015;10(7):662-9. doi: 10.1080/15592294.2015.1057384. PubMed PMID: 26036609; PMCID: PMC4623491.
Sun L, Tan R, Xu J, LaFace J, Gao Y, Xiao Y, Attar M, Neumann C, Li GM, Su B, Liu Y, Nakajima S, Levine AS, Lan L. Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death. Nucleic Acids Res. 2015 Jul 27;43(13):6334-47. doi: 10.1093/nar/gkv598. PubMed PMID: 26082495; PMCID: PMC4513870.
Bakkenist CJ, Czambel RK, Hershberger PA, Tawbi H, Beumer JH, Schmitz JC. A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells. Oncoscience. 2015;2(5):542-54. doi: 10.18632/oncoscience.162. PubMed PMID: 26097887; PMCID: PMC4468340.
Wei L, Nakajima S, Böhm S, Bernstein KA, Shen Z, Tsang M, Levine AS, Lan L. DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3495-504. doi: 10.1073/pnas.1507105112. PubMed PMID: 26100862; PMCID: PMC4500203.
Wu C, Jiao H, Lai Y, Zheng W, Chen K, Qu H, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, Chen J, Chen D, Xiao G. Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015 Jul 7;67531. doi: 10.1038/ncomms8531. PubMed PMID: 26151572; PMCID: PMC4498276.
Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P. Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4828-4833. doi: 10.1016/j.bmcl.2015.06.073. PubMed PMID: 26159482; PMCID: PMC4607627.
Pardee AD, Yano H, Weinstein AM, Ponce AA, Ethridge AD, Normolle DP, Vujanovic L, Mizejewski GJ, Watkins SC, Butterfield LH. Route of antigen delivery impacts the immunostimulatory activity of dendritic cell-based vaccines for hepatocellular carcinoma. J Immunother Cancer. 2015;332. doi: 10.1186/s40425-015-0077-x. PubMed PMID: 26199728; PMCID: PMC4509479.
Gaines WA, Godin SK, Kabbinavar FF, Rao T, VanDemark AP, Sung P, Bernstein KA. Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52. Nat Commun. 2015 Jul 28;67834. doi: 10.1038/ncomms8834. PubMed PMID: 26215801; PMCID: PMC4525180.
Fortian A, Dionne LK, Hong SH, Kim W, Gygi SP, Watkins SC, Sorkin A. Endocytosis of Ubiquitylation-Deficient EGFR Mutants via Clathrin-Coated Pits is Mediated by Ubiquitylation. Traffic. 2015 Nov;16(11):1137-54. doi: 10.1111/tra.12314. PubMed PMID: 26251007; PMCID: PMC4607634.
Yip L, Nikiforova MN, Yoo JY, McCoy KL, Stang MT, Armstrong MJ, Nicholson KJ, Ohori NP, Coyne C, Hodak SP, Ferris RL, LeBeau SO, Nikiforov YE, Carty SE. Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer: a study of 1510 patients. Ann Surg. 2015 Sep;262(3):519-25; discussion 524-5. doi: 10.1097/SLA.0000000000001420. PubMed PMID: 26258321; PMCID: PMC5264519.
Tong GX, Mody K, Wang Z, Hamele-Bena D, Nikiforova MN, Nikiforov YE. Mutations of TSHR and TP53 Genes in an Aggressive Clear Cell Follicular Carcinoma of the Thyroid. Endocr Pathol. 2015 Dec;26(4):315-9. doi: 10.1007/s12022-015-9388-1. PubMed PMID: 26260781.
Wallace CT, St Croix CM, Watkins SC. Data management and archiving in a large microscopy-and-imaging, multi-user facility: Problems and solutions. Mol Reprod Dev. 2015 Sep;82(9):630-4. doi: 10.1002/mrd.22538. PubMed PMID: 26284826; PMCID: PMC4878693.
Nikiforov YE, Carty SE, Chiosea SI, Coyne C, Duvvuri U, Ferris RL, Gooding WE, LeBeau SO, Ohori NP, Seethala RR, Tublin ME, Yip L, Nikiforova MN. Impact of the Multi-Gene ThyroSeq Next-Generation Sequencing Assay on Cancer Diagnosis in Thyroid Nodules with Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Cytology. Thyroid. 2015 Nov;25(11):1217-23. doi: 10.1089/thy.2015.0305. PubMed PMID: 26356635; PMCID: PMC4652198.
Dickson R, Kim JO, Huq MS, Bednarz G, Suyama J, Yealy DM, Wang H, Greenberger JS. A Mobile Alert System for Preparing the Delivery of Radiation Mitigators. In Vivo. 2015 Sep-Oct;29(5):505-13. PubMed PMID: 26359406.
Shrestha RT, Karunamurthy A, Amin K, Nikiforov YE, Caramori ML. Multiple Mutations Detected Preoperatively May Predict Aggressive Behavior of Papillary Thyroid Cancer and Guide Management--A Case Report. Thyroid. 2015 Dec;25(12):1375-8. doi: 10.1089/thy.2015.0278. PubMed PMID: 26355276.
Picarsic JL, Buryk MA, Ozolek J, Ranganathan S, Monaco SE, Simons JP, Witchel SF, Gurtunca N, Joyce J, Zhong S, Nikiforova MN, Nikiforov YE. Molecular Characterization of Sporadic Pediatric Thyroid Carcinoma with the DNA/RNA ThyroSeq v2 Next-Generation Sequencing Assay. Pediatr Dev Pathol. 2016 Mar-Apr;19(2):115-22. doi: 10.2350/15-07-1667-OA.1. PubMed PMID: 26367451; PMCID: PMC5894824.
Uttam S, Pham HV, LaFace J, Leibowitz B, Yu J, Brand RE, Hartman DJ, Liu Y. Early Prediction of Cancer Progression by Depth-Resolved Nanoscale Mapping of Nuclear Architecture from Unstained Tissue Specimens. Cancer Res. 2015 Nov 15;75(22):4718-27. doi: 10.1158/0008-5472.CAN-15-1274. PubMed PMID: 26383164; PMCID: PMC4651746.
Balasubramanian K, Maeda A, Lee JS, Mohammadyani D, Dar HH, Jiang JF, St Croix CM, Watkins S, Tyurin VA, Tyurina YY, Klöditz K, Polimova A, Kapralova VI, Xiong Z, Ray P, Klein-Seetharaman J, Mallampalli RK, Bayir H, Fadeel B, Kagan VE. Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity. Sci Signal. 2015 Sep 22;8(395):ra95. doi: 10.1126/scisignal.aaa6179. PubMed PMID: 26396268; PMCID: PMC4760701.
Misale S, Bozic I, Tong J, Peraza-Penton A, Lallo A, Baldi F, Lin KH, Truini M, Trusolino L, Bertotti A, Di Nicolantonio F, Nowak MA, Zhang L, Wood KC, Bardelli A. Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers. Nat Commun. 2015 Sep 22;68305. doi: 10.1038/ncomms9305. PubMed PMID: 26392303; PMCID: PMC4595628.
Afkhami M, Karunamurthy A, Chiosea S, Nikiforova MN, Seethala R, Nikiforov YE, Coyne C. Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAF(K601E) Mutation. Thyroid. 2016 Feb;26(2):242-7. doi: 10.1089/thy.2015.0227. PubMed PMID: 26422023.
Beumer JH, Fu KY, Anyang BN, Siegfried JM, Bakkenist CJ. Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma. BMC Cancer. 2015 Oct 5;15649. doi: 10.1186/s12885-015-1649-3. PubMed PMID: 26438152; PMCID: PMC4595318.
Phinney DG, Di Giuseppe M, Njah J, Sala E, Shiva S, St Croix CM, Stolz DB, Watkins SC, Di YP, Leikauf GD, Kolls J, Riches DW, Deiuliis G, Kaminski N, Boregowda SV, McKenna DH, Ortiz LA. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nat Commun. 2015 Oct 7;68472. doi: 10.1038/ncomms9472. PubMed PMID: 26442449; PMCID: PMC4598952.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PubMed PMID: 26462967; PMCID: PMC4739132.
Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, Krämer A, Roncaioli JL, Sand F, Heuckmann JM, Ikram F, Schmidt R, Ackermann S, Engesser A, Kahlert Y, Vogel W, Altmüller J, Nürnberg P, Thierry-Mieg J, Thierry-Mieg D, Mariappan A, Heynck S, Mariotti E, Henrich KO, Gloeckner C, Bosco G, Leuschner I, Schweiger MR, Savelyeva L, Watkins SC, Shao C, Bell E, Höfer T, Achter V, Lang U, Theissen J, Volland R, Saadati M, Eggert A, de Wilde B, Berthold F, Peng Z, Zhao C, Shi L, Ortmann M, Büttner R, Perner S, Hero B, Schramm A, Schulte JH, Herrmann C, O'Sullivan RJ, Westermann F, Thomas RK, Fischer M. Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature. 2015 Oct 29;526(7575):700-4. doi: 10.1038/nature14980. PubMed PMID: 26466568; PMCID: PMC4881306.
Vendetti FP, Lau A, Schamus S, Conrads TP, O'Connor MJ, Bakkenist CJ. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo. Oncotarget. 2015 Dec 29;6(42):44289-305. doi: 10.18632/oncotarget.6247. PubMed PMID: 26517239; PMCID: PMC4792557.
Gomez-Casal R, Epperly MW, Wang H, Proia DA, Greenberger JS, Levina V. Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition. Oncotarget. 2015 Dec 29;6(42):44306-22. doi: 10.18632/oncotarget.6248. PubMed PMID: 26517240; PMCID: PMC4792558.
Liu S, Tsai WH, Ding Y, Chen R, Fang Z, Huo Z, Kim S, Ma T, Chang TY, Priedigkeit NM, Lee AV, Luo J, Wang HW, Chung IF, Tseng GC. Comprehensive evaluation of fusion transcript detection algorithms and a meta-caller to combine top performing methods in paired-end RNA-seq data. Nucleic Acids Res. 2016 Mar 18;44(5):e47. doi: 10.1093/nar/gkv1234. PubMed PMID: 26582927; PMCID: PMC4797269.
Phong BL, Avery L, Sumpter TL, Gorman JV, Watkins SC, Colgan JD, Kane LP. Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation. J Exp Med. 2015 Dec 14;212(13):2289-304. doi: 10.1084/jem.20150388. PubMed PMID: 26598760; PMCID: PMC4689164.
Bogdanova TI, Zurnadzhy LY, Nikiforov YE, Leeman-Neill RJ, Tronko MD, Chanock S, Mabuchi K, Likhtarov IA, Kovgan LM, Drozdovitch V, Little MP, Hatch M, Zablotska LB, Shpak VM, McConnell RJ, Brenner AV. Histopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort. Br J Cancer. 2015 Dec 1;113(11):1556-64. doi: 10.1038/bjc.2015.372. PubMed PMID: 26625214; PMCID: PMC4705885.
Pasta S, Phillippi JA, Tsamis A, D'Amore A, Raffa GM, Pilato M, Scardulla C, Watkins SC, Wagner WR, Gleason TG, Vorp DA. Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parameters. Med Eng Phys. 2016 Feb;38(2):121-30. doi: 10.1016/j.medengphy.2015.11.001. PubMed PMID: 26669606; PMCID: PMC4755864.
Nikiforova MN, Wald AI, Melan MA, Roy S, Zhong S, Hamilton RL, Lieberman FS, Drappatz J, Amankulor NM, Pollack IF, Nikiforov YE, Horbinski C. Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central nervous system tumors. Neuro Oncol. 2016 Mar;18(3):379-87. doi: 10.1093/neuonc/nov289. PubMed PMID: 26681766; PMCID: PMC4767245.
Simons M, Pollard MR, Hughes CD, Ward AD, Van Houten B, Towrie M, Botchway SW, Parker AW, Kad NM. Directly interrogating single quantum dot labelled UvrA2 molecules on DNA tightropes using an optically trapped nanoprobe. Sci Rep. 2015 Dec 22;518486. doi: 10.1038/srep18486. PubMed PMID: 26691010; PMCID: PMC4686980.
Bostanci Z, Mack RP Jr, Enomoto LM, Alam S, Brown A, Neumann C, Soybel DI, Kelleher SL. Marginal zinc intake reduces the protective effect of lactation on mammary gland carcinogenesis in a DMBA-induced tumor model in mice. Oncol Rep. 2016 Mar;35(3):1409-16. doi: 10.3892/or.2015.4508. PubMed PMID: 26707944.
Van Houten B, Hunter SE, Meyer JN. Mitochondrial DNA damage induced autophagy, cell death, and disease. Front Biosci (Landmark Ed). 2016 Jan 1;2142-54. PubMed PMID: 26709760; PMCID: PMC4750375.
Böhm S, Szakal B, Herken BW, Sullivan MR, Mihalevic MJ, Kabbinavar FF, Branzei D, Clark NL, Bernstein KA. The Budding Yeast Ubiquitin Protease Ubp7 Is a Novel Component Involved in S Phase Progression. J Biol Chem. 2016 Feb 26;291(9):4442-52. doi: 10.1074/jbc.M115.671057. PubMed PMID: 26740628; PMCID: PMC4813472.
Tong GX, Chang Q, Hamele-Bena D, Carew J, Hoffman RS, Nikiforova MN, Nikiforov YE. Targeted Next-Generation Sequencing Analysis of a Pendred Syndrome-Associated Thyroid Carcinoma. Endocr Pathol. 2016 Mar;27(1):70-5. doi: 10.1007/s12022-015-9413-4. PubMed PMID: 26744121.
Beadling C, Wald AI, Warrick A, Neff TL, Zhong S, Nikiforov YE, Corless CL, Nikiforova MN. A Multiplexed Amplicon Approach for Detecting Gene Fusions by Next-Generation Sequencing. J Mol Diagn. 2016 Mar;18(2):165-75. doi: 10.1016/j.jmoldx.2015.10.002. PubMed PMID: 26747586.
Greenberger J, Kagan V, Bayir H, Wipf P, Epperly M. Antioxidant Approaches to Management of Ionizing Irradiation Injury. Antioxidants (Basel). 2015 Jan 23;4(1):82-101. doi: 10.3390/antiox4010082. PubMed PMID: 26785339; PMCID: PMC4665573.
Prasad ML, Vyas M, Horne MJ, Virk RK, Morotti R, Liu Z, Tallini G, Nikiforova MN, Christison-Lagay ER, Udelsman R, Dinauer CA, Nikiforov YE. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Cancer. 2016 Apr 1;122(7):1097-107. doi: 10.1002/cncr.29887. PubMed PMID: 26784937.
Shinde A, Berhane H, Rhieu BH, Kalash R, Xu K, Goff J, Epperly MW, Franicola D, Zhang X, Dixon T, Shields D, Wang H, Wipf P, Parmar K, Guinan E, Kagan V, Tyurin V, Ferris RL, Zhang X, Li S, Greenberger JS. Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice. Radiat Res. 2016 Feb;185(2):134-50. doi: 10.1667/RR14035.1. PubMed PMID: 26789701; PMCID: PMC4773657.
Huang Z, Epperly M, Watkins SC, Greenberger JS, Kagan VE, Bayır H. Necrostatin-1 rescues mice from lethal irradiation. Biochim Biophys Acta. 2016 Apr;1862(4):850-856. doi: 10.1016/j.bbadis.2016.01.014. PubMed PMID: 26802452; PMCID: PMC4788560.
Godin SK, Lee AG, Baird JM, Herken BW, Bernstein KA. Tryptophan biosynthesis is important for resistance to replicative stress in Saccharomyces cerevisiae. Yeast. 2016 May;33(5):183-9. doi: 10.1002/yea.3150. PubMed PMID: 26804060; PMCID: PMC4856547.
He J, Wang Y, Missinato MA, Onuoha E, Perkins LA, Watkins SC, St Croix CM, Tsang M, Bruchez MP. A genetically targetable near-infrared photosensitizer. Nat Methods. 2016 Mar;13(3):263-8. doi: 10.1038/nmeth.3735. PubMed PMID: 26808669; PMCID: PMC4916159.
Pinilla-Macua I, Watkins SC, Sorkin A. Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomes. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2122-7. doi: 10.1073/pnas.1520301113. PubMed PMID: 26858456; PMCID: PMC4776482.
Gurda GT, Ambros T, Nikiforova MN, Nikiforov YE, Lucas PC, Dabbs DJ, Lee AV, Brufsky AM, Puhalla SL, Bhargava R. Characterizing Molecular Variants and Clinical Utilization of Next-generation Sequencing in Advanced Breast Cancer. Appl Immunohistochem Mol Morphol. 2017 Jul;25(6):392-398. doi: 10.1097/PAI.0000000000000322. PubMed PMID: 26862949.
Roy S, LaFramboise WA, Nikiforov YE, Nikiforova MN, Routbort MJ, Pfeifer J, Nagarajan R, Carter AB, Pantanowitz L. Next-Generation Sequencing Informatics: Challenges and Strategies for Implementation in a Clinical Environment. Arch Pathol Lab Med. 2016 Sep;140(9):958-75. doi: 10.5858/arpa.2015-0507-RA. PubMed PMID: 26901284.
Gertz RJ, Nikiforov Y, Rehrauer W, McDaniel L, Lloyd RV. Mutation in BRAF and Other Members of the MAPK Pathway in Papillary Thyroid Carcinoma in the Pediatric Population. Arch Pathol Lab Med. 2016 Feb;140(2):134-9. doi: 10.5858/arpa.2014-0612-OA. PubMed PMID: 26910217.
Sharlow ER, Leimgruber S, Lira A, McConnell MJ, Norambuena A, Bloom GS, Epperly MW, Greenberger JS, Lazo JS. A Small Molecule Screen Exposes mTOR Signaling Pathway Involvement in Radiation-Induced Apoptosis. ACS Chem Biol. 2016 May 20;11(5):1428-37. doi: 10.1021/acschembio.5b00909. PubMed PMID: 26938669; PMCID: PMC5488269.
Chen D, Yu J, Zhang L. Necroptosis: an alternative cell death program defending against cancer. Biochim Biophys Acta. 2016 Apr;1865(2):228-36. doi: 10.1016/j.bbcan.2016.03.003. PubMed PMID: 26968619; PMCID: PMC4860077.
Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA. Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors. JAMA Oncol. 2016 Aug 1;2(8):1023-9. doi: 10.1001/jamaoncol.2016.0386. PubMed PMID: 27078145; PMCID: PMC5539411.
Maletta F, Massa F, Torregrossa L, Duregon E, Casadei GP, Basolo F, Tallini G, Volante M, Nikiforov YE, Papotti M. Cytological features of "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" and their correlation with tumor histology. Hum Pathol. 2016 Aug;54134-42. doi: 10.1016/j.humpath.2016.03.014. PubMed PMID: 27085556.
Wang Y, Wang X, Flores ER, Yu J, Chang S. Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. Aging Cell. 2016 Aug;15(4):646-60. doi: 10.1111/acel.12476. PubMed PMID: 27113195; PMCID: PMC4933665.
Kaseb HO, Lewis DW, Saunders WS, Gollin SM. Cell division patterns and chromosomal segregation defects in oral cancer stem cells. Genes Chromosomes Cancer. 2016 Sep;55(9):694-709. doi: 10.1002/gcc.22371. PubMed PMID: 27123539.
Khare A, Raundhal M, Chakraborty K, Das S, Corey C, Kamga CK, Quesnelle K, St Croix C, Watkins SC, Morse C, Oriss TB, Huff R, Hannum R, Ray P, Shiva S, Ray A. Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation. Cell Rep. 2016 May 24;15(8):1700-14. doi: 10.1016/j.celrep.2016.04.060. PubMed PMID: 27184852; PMCID: PMC4880515.
Yu C, Yan S, Khambu B, Chen X, Dong Z, Luo J, Michalopoulos GK, Wu S, Yin XM. Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers. PLoS One. 2016;11(5):e0155211. doi: 10.1371/journal.pone.0155211. PubMed PMID: 27196317; PMCID: PMC4873180.
Godin SK, Sullivan MR, Bernstein KA. Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication. Biochem Cell Biol. 2016 Oct;94(5):407-418. doi: 10.1139/bcb-2016-0012. PubMed PMID: 27224545; PMCID: PMC5045787.
Keskinov AA, Tapias V, Watkins SC, Ma Y, Shurin MR, Shurin GV. Impact of the Sensory Neurons on Melanoma Growth In Vivo. PLoS One. 2016;11(5):e0156095. doi: 10.1371/journal.pone.0156095. PubMed PMID: 27227315; PMCID: PMC4882065.
Moiseeva TN, Gamper AM, Hood BL, Conrads TP, Bakkenist CJ. Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. DNA Repair (Amst). 2016 Jul;439-17. doi: 10.1016/j.dnarep.2016.04.007. PubMed PMID: 27235625; PMCID: PMC4917431.
Villaruz LC, Jones H, Dacic S, Abberbock S, Kurland BF, Stabile LP, Siegfried JM, Conrads TP, Smith NR, O'Connor MJ, Pierce AJ, Bakkenist CJ. ATM protein is deficient in over 40% of lung adenocarcinomas. Oncotarget. 2016 Sep 6;7(36):57714-57725. doi: 10.18632/oncotarget.9757. PubMed PMID: 27259260; PMCID: PMC5295384.
Houten BV, Kuper J, Kisker C. Role of XPD in cellular functions: To TFIIH and beyond. DNA Repair (Amst). 2016 Aug;44136-142. doi: 10.1016/j.dnarep.2016.05.019. PubMed PMID: 27262611.
Godin SK, Zhang Z, Herken BW, Westmoreland JW, Lee AG, Mihalevic MJ, Yu Z, Sobol RW, Resnick MA, Bernstein KA. The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products. Nucleic Acids Res. 2016 Sep 30;44(17):8199-215. doi: 10.1093/nar/gkw535. PubMed PMID: 27298254; PMCID: PMC5041462.
He K, Chen D, Ruan H, Li X, Tong J, Xu X, Zhang L, Yu J. BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. Oncotarget. 2016 Jul 26;7(30):47699-47710. doi: 10.18632/oncotarget.10277. PubMed PMID: 27351224; PMCID: PMC5216972.
Zerbato JM, Serrao E, Lenzi G, Kim B, Ambrose Z, Watkins SC, Engelman AN, Sluis-Cremer N. Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro. J Virol. 2016 Sep 15;90(18):8059-73. doi: 10.1128/JVI.00553-16. PubMed PMID: 27356901; PMCID: PMC5008097.
Sehrawat A, Croix CS, Baty CJ, Watkins S, Tailor D, Singh RP, Singh SV. Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate. Mitochondrion. 2016 Sep;3067-77. doi: 10.1016/j.mito.2016.06.006. PubMed PMID: 27374852; PMCID: PMC5023488.
Kao YC, Sung YS, Zhang L, Huang SC, Argani P, Chung CT, Graf NS, Wright DC, Kellie SJ, Agaram NP, Ludwig K, Zin A, Alaggio R, Antonescu CR. Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney. Am J Surg Pathol. 2016 Aug;40(8):1009-20. doi: 10.1097/PAS.0000000000000629. PubMed PMID: 26945340; PMCID: PMC4942366.
Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. Immunity. 2016 Aug 16;45(2):374-88. doi: 10.1016/j.immuni.2016.07.009. PubMed PMID: 27496732; PMCID: PMC5207350.
Sallmyr A, Matsumoto Y, Roginskaya V, Van Houten B, Tomkinson AE. Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1-Dependent Apoptosis in Cancer Cells. Cancer Res. 2016 Sep 15;76(18):5431-41. doi: 10.1158/0008-5472.CAN-15-3243. PubMed PMID: 27503931; PMCID: PMC5036517.
Helfield B, Chen X, Watkins SC, Villanueva FS. Biophysical insight into mechanisms of sonoporation. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9983-8. doi: 10.1073/pnas.1606915113. PubMed PMID: 27551081; PMCID: PMC5018802.
Vijayraghavan S, Tsai FL, Schwacha A. A Checkpoint-Related Function of the MCM Replicative Helicase Is Required to Avert Accumulation of RNA:DNA Hybrids during S-phase and Ensuing DSBs during G2/M. PLoS Genet. 2016 Aug;12(8):e1006277. doi: 10.1371/journal.pgen.1006277. PubMed PMID: 27556397; PMCID: PMC4996524.
Martino J, Bernstein KA. The Shu complex is a conserved regulator of homologous recombination. FEMS Yeast Res. 2016 Sep;16(6): doi: 10.1093/femsyr/fow073. PubMed PMID: 27589940; PMCID: PMC5976032.
Zhang X, Hou W, Epperly MW, Rigatti L, Wang H, Franicola D, Sivanathan A, Greenberger JS. Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2-/- mouse long-term bone marrow cultures. Oncotarget. 2016 Oct 18;7(42):68449-68472. doi: 10.18632/oncotarget.12036. PubMed PMID: 27637088; PMCID: PMC5356567.
Klei LR, Hu D, Panek R, Alfano DN, Bridwell RE, Bailey KM, Oravecz-Wilson KI, Concel VJ, Hess EM, Van Beek M, Delekta PC, Gu S, Watkins SC, Ting AT, Gough PJ, Foley KP, Bertin J, McAllister-Lucas LM, Lucas PC. MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage. Cell Rep. 2016 Sep 27;17(1):221-232. doi: 10.1016/j.celrep.2016.08.080. PubMed PMID: 27681433; PMCID: PMC5087334.
Kong M, Liu L, Chen X, Driscoll KI, Mao P, Böhm S, Kad NM, Watkins SC, Bernstein KA, Wyrick JJ, Min JH, Van Houten B. Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process. Mol Cell. 2016 Oct 20;64(2):376-387. doi: 10.1016/j.molcel.2016.09.005. PubMed PMID: 27720644; PMCID: PMC5123691.
Song X, Xie Y, Kang R, Hou W, Sun X, Epperly MW, Greenberger JS, Tang D. FANCD2 protects against bone marrow injury from ferroptosis. Biochem Biophys Res Commun. 2016 Nov 18;480(3):443-449. doi: 10.1016/j.bbrc.2016.10.068. PubMed PMID: 27773819.
Van Der Kraak L, Goel G, Ramanan K, Kaltenmeier C, Zhang L, Normolle DP, Freeman GJ, Tang D, Nason KS, Davison JM, Luketich JD, Dhupar R, Lotze MT. 5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers. J Immunother Cancer. 2016;465. doi: 10.1186/s40425-016-0163-8. PubMed PMID: 27777774; PMCID: PMC5067917.
Brand RM, Epperly MW, Stottlemyer JM, Skoda EM, Gao X, Li S, Huq S, Wipf P, Kagan VE, Greenberger JS, Falo LD Jr. A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage. J Invest Dermatol. 2017 Mar;137(3):576-586. doi: 10.1016/j.jid.2016.09.033. PubMed PMID: 27794421; PMCID: PMC5466072.
Garcia-Exposito L, Bournique E, Bergoglio V, Bose A, Barroso-Gonzalez J, Zhang S, Roncaioli JL, Lee M, Wallace CT, Watkins SC, Opresko PL, Hoffmann JS, O'Sullivan RJ. Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres. Cell Rep. 2016 Nov 8;17(7):1858-1871. doi: 10.1016/j.celrep.2016.10.048. PubMed PMID: 27829156; PMCID: PMC5406014.
Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayır H. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017 Jan;13(1):81-90. doi: 10.1038/nchembio.2238. PubMed PMID: 27842066; PMCID: PMC5506843.
Patel SG, Carty SE, McCoy KL, Ohori NP, LeBeau SO, Seethala RR, Nikiforova MN, Nikiforov YE, Yip L. Preoperative detection of RAS mutation may guide extent of thyroidectomy. Surgery. 2017 Jan;161(1):168-175. doi: 10.1016/j.surg.2016.04.054. PubMed PMID: 27863786; PMCID: PMC5497309.
Kao YC, Sung YS, Zhang L, Jungbluth AA, Huang SC, Argani P, Agaram NP, Zin A, Alaggio R, Antonescu CR. BCOR Overexpression Is a Highly Sensitive Marker in Round Cell Sarcomas With BCOR Genetic Abnormalities. Am J Surg Pathol. 2016 Dec;40(12):1670-1678. doi: 10.1097/PAS.0000000000000697. PubMed PMID: 27428733; PMCID: PMC5106294.
Shah AA, La Fortune K, Miller C, Mills SE, Baloch Z, LiVolsi V, Dacic S, Mahaffey AL, Nikiforova M, Nikiforov YE, Seethala RR. Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: a clinicopathologic and molecular analysis of a distinct entity. Mod Pathol. 2017 Mar;30(3):329-339. doi: 10.1038/modpathol.2016.180. PubMed PMID: 27910944; PMCID: PMC5497311.
Kong M, Van Houten B. Rad4 recognition-at-a-distance: Physical basis of conformation-specific anomalous diffusion of DNA repair proteins. Prog Biophys Mol Biol. 2017 Aug;12793-104. doi: 10.1016/j.pbiomolbio.2016.12.004. PubMed PMID: 27939760; PMCID: PMC5462892.
Li X, Li M, Ruan H, Qiu W, Xu X, Zhang L, Yu J. Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. Oncotarget. 2017 Feb 7;8(6):9280-9292. doi: 10.18632/oncotarget.14063. PubMed PMID: 28030835; PMCID: PMC5354731.
Zhao J, Fuhrmann-Stroissnigg H, Gurkar AU, Flores RR, Dorronsoro A, Stolz DB, St Croix CM, Niedernhofer LJ, Robbins PD. Quantitative Analysis of Cellular Senescence in Culture and In Vivo. Curr Protoc Cytom. 2017 Jan 5;799.51.1-9.51.25. doi: 10.1002/cpcy.16. PubMed PMID: 28055114.
Epperly MW, Sacher JR, Krainz T, Zhang X, Wipf P, Liang M, Fisher R, Li S, Wang H, Greenberger JS. Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators. In Vivo. 2017 Jan 2;31(1):39-43. doi: 10.21873/invivo.11022. PubMed PMID: 28064218; PMCID: PMC5267945.
Lehman CE, Dillon LW, Nikiforov YE, Wang YH. DNA fragile site breakage as a measure of chemical exposure and predictor of individual susceptibility to form oncogenic rearrangements. Carcinogenesis. 2017 Mar 1;38(3):293-301. doi: 10.1093/carcin/bgw210. PubMed PMID: 28069693; PMCID: PMC5862292.
Yilmaz E, Watkins SC, Gold MS. Paclitaxel-induced increase in mitochondrial volume mediates dysregulation of intracellular Ca2+ in putative nociceptive glabrous skin neurons from the rat. Cell Calcium. 2017 Mar;6216-28. doi: 10.1016/j.ceca.2017.01.005. PubMed PMID: 28109678; PMCID: PMC5365154.
Wang Y, Ballou B, Schmidt BF, Andreko S, St Croix CM, Watkins SC, Bruchez MP. Affibody-targeted fluorogen activating protein for in vivo tumor imaging. Chem Commun (Camb). 2017 Feb 7;53(12):2001-2004. doi: 10.1039/c6cc09137g. PubMed PMID: 28120951; PMCID: PMC5340305.
Luo J, Kong M, Liu L, Samanta S, Van Houten B, Deiters A. Optical Control of DNA Helicase Function through Genetic Code Expansion. Chembiochem. 2017 Mar 2;18(5):466-469. doi: 10.1002/cbic.201600624. PubMed PMID: 28120472; PMCID: PMC5516474.
Adamik J, Jin S, Sun Q, Zhang P, Weiss KR, Anderson JL, Silbermann R, Roodman GD, Galson DL. EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma-Induced Epigenetic Suppression of Osteoblast Differentiation. Mol Cancer Res. 2017 Apr;15(4):405-417. doi: 10.1158/1541-7786.MCR-16-0242-T. PubMed PMID: 28119431; PMCID: PMC5524543.
Seethala RR, Chiosea SI, Liu CZ, Nikiforova M, Nikiforov YE. Clinical and Morphologic Features of ETV6-NTRK3 Translocated Papillary Thyroid Carcinoma in an Adult Population Without Radiation Exposure. Am J Surg Pathol. 2017 Apr;41(4):446-457. doi: 10.1097/PAS.0000000000000814. PubMed PMID: 28125451; PMCID: PMC5384267.
Vendetti FP, Leibowitz BJ, Barnes J, Schamus S, Kiesel BF, Abberbock S, Conrads T, Clump DA, Cadogan E, O'Connor MJ, Yu J, Beumer JH, Bakkenist CJ. Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation. Sci Rep. 2017 Feb 1;741892. doi: 10.1038/srep41892. PubMed PMID: 28145510; PMCID: PMC5286430.
Bernard ME, Glaser SM, Gill BS, Beriwal S, Heron DE, Luketich JD, Friedland DM, Socinski MA, Greenberger JS. Results of a Single Institution Experience with Dose-Escalated Chemoradiation for Locally Advanced Unresectable Non-Small Cell Lung Cancer. Front Oncol. 2017;71. doi: 10.3389/fonc.2017.00001. PubMed PMID: 28168163; PMCID: PMC5253386.
Montecalvo A, Watkins SC, Orange J, Kane LP. Inducible turnover of optineurin regulates T cell activation. Mol Immunol. 2017 May;859-17. doi: 10.1016/j.molimm.2017.01.027. PubMed PMID: 28192730; PMCID: PMC5385146.
Panebianco F, Kelly LM, Liu P, Zhong S, Dacic S, Wang X, Singhi AD, Dhir R, Chiosea SI, Kuan SF, Bhargava R, Dabbs D, Trivedi S, Gandhi M, Diaz R, Wald AI, Carty SE, Ferris RL, Lee AV, Nikiforova MN, Nikiforov YE. THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2307-2312. doi: 10.1073/pnas.1614265114. PubMed PMID: 28193878; PMCID: PMC5338560.
Tong J, Wang P, Tan S, Chen D, Nikolovska-Coleska Z, Zou F, Yu J, Zhang L. Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017 May 1;77(9):2512-2521. doi: 10.1158/0008-5472.CAN-16-3242. PubMed PMID: 28202514; PMCID: PMC5626525.
Kiesel BF, Shogan JC, Rachid M, Parise RA, Vendetti FP, Bakkenist CJ, Beumer JH. LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma. J Pharm Biomed Anal. 2017 May 10;138158-165. doi: 10.1016/j.jpba.2017.01.055. PubMed PMID: 28213176; PMCID: PMC5357441.
Muthuswamy R, Okada NJ, Jenkins FJ, McGuire K, McAuliffe PF, Zeh HJ, Bartlett DL, Wallace C, Watkins S, Henning JD, Bovbjerg DH, Kalinski P. Epinephrine promotes COX-2-dependent immune suppression in myeloid cells and cancer tissues. Brain Behav Immun. 2017 May;6278-86. doi: 10.1016/j.bbi.2017.02.008. PubMed PMID: 28212885.
Zhang Y, Hu K, Beumer JH, Bakkenist CJ, D'Argenio DZ. RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology. DNA Repair (Amst). 2017 Apr;5224-30. doi: 10.1016/j.dnarep.2017.02.004. PubMed PMID: 28254357; PMCID: PMC5396547.
Epperly MW, Rhieu BH, Franicola D, Dixon T, Cao S, Zhang X, Shields D, Wang H, Wipf P, Greenberger JS. Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350. In Vivo. 2017 Mar-Apr;31(2):159-168. doi: 10.21873/invivo.11040. PubMed PMID: 28358695; PMCID: PMC5411740.
Franks J, Wallace CT, Shibata M, Suga M, Erdman N, Stolz DB, Watkins SC. Correlative Fluorescence and Electron Microscopy in 3D-Scanning Electron Microscope Perspective. Curr Protoc Cytom. 2017 Apr 3;8012.45.1-12.45.15. doi: 10.1002/cpcy.18. PubMed PMID: 28369763.
Hopkins BL, Nadler M, Skoko JJ, Bertomeu T, Pelosi A, Shafaei PM, Levine K, Schempf A, Pennarun B, Yang B, Datta D, Bucur O, Ndebele K, Oesterreich S, Yang D, Giulia Rizzo M, Khosravi-Far R, Neumann CA. A Peroxidase Peroxiredoxin 1-Specific Redox Regulation of the Novel FOXO3 microRNA Target let-7. Antioxid Redox Signal. 2018 Jan 1;28(1):62-77. doi: 10.1089/ars.2016.6871. PubMed PMID: 28398822; PMCID: PMC5695745.
Epperly MW, Zhang X, Fisher R, Hou W, Franicola D, Shields D, Quickel M, Hankey-Giblin P, Wang H, Greenberger JS. Reduced Competitive Repopulation Capacity of Multipotential Hematopoietic Stem Cells in the Bone Marrow of Friend Virus-infected Fv2-resistant Mice. In Vivo. 2017 May-Jun;31(3):313-320. doi: 10.21873/invivo.11061. PubMed PMID: 28438857; PMCID: PMC5461439.
Vujanovic L, Stahl EC, Pardee AD, Geller DA, Tsung A, Watkins SC, Gibson GA, Storkus WJ, Butterfield LH. Tumor-Derived α-Fetoprotein Directly Drives Human Natural Killer-Cell Activation and Subsequent Cell Death. Cancer Immunol Res. 2017 Jun;5(6):493-502. doi: 10.1158/2326-6066.CIR-16-0216. PubMed PMID: 28468916.
Malapelle U, Mayo-de-Las-Casas C, Molina-Vila MA, Rosell R, Savic S, Bihl M, Bubendorf L, Salto-Tellez M, de Biase D, Tallini G, Hwang DH, Sholl LM, Luthra R, Weynand B, Vander Borght S, Missiaglia E, Bongiovanni M, Stieber D, Vielh P, Schmitt F, Rappa A, Barberis M, Pepe F, Pisapia P, Serra N, Vigliar E, Bellevicine C, Fassan M, Rugge M, de Andrea CE, Lozano MD, Basolo F, Fontanini G, Nikiforov YE, Kamel-Reid S, da Cunha Santos G, Nikiforova MN, Roy-Chowdhuri S, Troncone G, Molecular Cytopathology Meeting Group.. Consistency and reproducibility of next-generation sequencing and other multigene mutational assays: A worldwide ring trial study on quantitative cytological molecular reference specimens. Cancer Cytopathol. 2017 Aug;125(8):615-626. doi: 10.1002/cncy.21868. PubMed PMID: 28475299.
Kinner-Bibeau LB, Sedlacek AL, Messmer MN, Watkins SC, Binder RJ. HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells. Nat Commun. 2017 May 31;815648. doi: 10.1038/ncomms15648. PubMed PMID: 28561043; PMCID: PMC5460028.
Kondrashova O, Nguyen M, Shield-Artin K, Tinker AV, Teng NNH, Harrell MI, Kuiper MJ, Ho GY, Barker H, Jasin M, Prakash R, Kass EM, Sullivan MR, Brunette GJ, Bernstein KA, Coleman RL, Floquet A, Friedlander M, Kichenadasse G, O'Malley DM, Oza A, Sun J, Robillard L, Maloney L, Bowtell D, Giordano H, Wakefield MJ, Kaufmann SH, Simmons AD, Harding TC, Raponi M, McNeish IA, Swisher EM, Lin KK, Scott CL, AOCS Study Group.. Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma. Cancer Discov. 2017 Sep;7(9):984-998. doi: 10.1158/2159-8290.CD-17-0419. PubMed PMID: 28588062; PMCID: PMC5612362.
Tong J, Tan S, Nikolovska-Coleska Z, Yu J, Zou F, Zhang L. FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors. Mol Cancer Ther. 2017 Sep;16(9):1979-1988. doi: 10.1158/1535-7163.MCT-17-0032. PubMed PMID: 28619760; PMCID: PMC5587378.
Yang S, Zhang L, Thomas S, Hu Y, Li S, Cipollo J, Zhang H. Modification of Sialic Acids on Solid Phase: Accurate Characterization of Protein Sialylation. Anal Chem. 2017 Jun 20;89(12):6330-6335. doi: 10.1021/acs.analchem.7b01048. PubMed PMID: 28505427; PMCID: PMC5583724.
Kong M, Beckwitt EC, Springall L, Kad NM, Van Houten B. Single-Molecule Methods for Nucleotide Excision Repair: Building a System to Watch Repair in Real Time. Methods Enzymol. 2017;592213-257. doi: 10.1016/bs.mie.2017.03.027. PubMed PMID: 28668122; PMCID: PMC5656006.
Beckwitt EC, Kong M, Van Houten B. Studying protein-DNA interactions using atomic force microscopy. Semin Cell Dev Biol. 2018 Jan;73220-230. doi: 10.1016/j.semcdb.2017.06.028. PubMed PMID: 28673677; PMCID: PMC5762137.
Ohori NP, Wolfe J, Carty SE, Yip L, LeBeau SO, Berg AN, Schoedel KE, Nikiforov YE, Seethala RR. The influence of the noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) resection diagnosis on the false-positive thyroid cytology rate relates to quality assurance thresholds and the application of NIFTP criteria. Cancer Cytopathol. 2017 Sep;125(9):692-700. doi: 10.1002/cncy.21892. PubMed PMID: 28678437.
Weinstein AM, Chen L, Brzana EA, Patil PR, Taylor JL, Fabian KL, Wallace CT, Jones SD, Watkins SC, Lu B, Stroncek DF, Denning TL, Fu YX, Cohen PA, Storkus WJ. Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment. Oncoimmunology. 2017;6(6):e1322238. doi: 10.1080/2162402X.2017.1322238. PubMed PMID: 28680760; PMCID: PMC5486180.
Watson AM, Rose AH, Gibson GA, Gardner CL, Sun C, Reed DS, Lam LKM, St Croix CM, Strick PL, Klimstra WB, Watkins SC. Ribbon scanning confocal for high-speed high-resolution volume imaging of brain. PLoS One. 2017;12(7):e0180486. doi: 10.1371/journal.pone.0180486. PubMed PMID: 28686653; PMCID: PMC5501561.
Suntharalingam M, Winter K, Ilson D, Dicker AP, Kachnic L, Konski A, Chakravarthy AB, Anker CJ, Thakrar H, Horiba N, Dubey A, Greenberger JS, Raben A, Giguere J, Roof K, Videtic G, Pollock J, Safran H, Crane CH. Effect of the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation Therapy for Patients With Esophageal Cancer: The NRG Oncology RTOG 0436 Phase 3 Randomized Clinical Trial. JAMA Oncol. 2017 Nov 1;3(11):1520-1528. doi: 10.1001/jamaoncol.2017.1598. PubMed PMID: 28687830; PMCID: PMC5710193.
Tourkova IL, Liu L, Sutjarit N, Larrouture QC, Luo J, Robinson LJ, Blair HC. Adrenocorticotropic hormone and 1,25-dihydroxyvitamin D3 enhance human osteogenesis in vitro by synergistically accelerating the expression of bone-specific genes. Lab Invest. 2017 Sep;97(9):1072-1083. doi: 10.1038/labinvest.2017.62. PubMed PMID: 28737765; PMCID: PMC5844701.
Zacchi LF, Dittmar JC, Mihalevic MJ, Shewan AM, Schulz BL, Brodsky JL, Bernstein KA. Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE. Dis Model Mech. 2017 Sep 1;10(9):1129-1140. doi: 10.1242/dmm.029926. PubMed PMID: 28768697; PMCID: PMC5611967.
Akiyama H, Ramirez NP, Gibson G, Kline C, Watkins S, Ambrose Z, Gummuluru S. Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon. J Virol. 2017 Nov 1;91(21): doi: 10.1128/JVI.00972-17. PubMed PMID: 28794041; PMCID: PMC5640826.
Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, Zhong M, Yuan H, Zhang L, Billiar TR, Lotze MT, Zeh HJ 3rd, Kang R, Kroemer G, Tang D. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep. 2017 Aug 15;20(7):1692-1704. doi: 10.1016/j.celrep.2017.07.055. PubMed PMID: 28813679.
Tyurina YY, Shrivastava I, Tyurin VA, Mao G, Dar HH, Watkins S, Epperly M, Bahar I, Shvedova AA, Pitt B, Wenzel SE, Mallampalli RK, Sadovsky Y, Gabrilovich D, Greenberger JS, Bayır H, Kagan VE. "Only a Life Lived for Others Is Worth Living": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions. Antioxid Redox Signal. 2018 Nov 1;29(13):1333-1358. doi: 10.1089/ars.2017.7124. PubMed PMID: 28835115; PMCID: PMC6157439.
Helfield BL, Chen X, Qin B, Watkins SC, Villanueva FS. Mechanistic Insight into Sonoporation with Ultrasound-Stimulated Polymer Microbubbles. Ultrasound Med Biol. 2017 Nov;43(11):2678-2689. doi: 10.1016/j.ultrasmedbio.2017.07.017. PubMed PMID: 28847500; PMCID: PMC5644032.
Kiesel BF, Scemama J, Parise RA, Villaruz L, Iffland A, Doyle A, Ivy P, Chu E, Bakkenist CJ, Beumer JH. LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma. J Pharm Biomed Anal. 2017 Nov 30;146244-250. doi: 10.1016/j.jpba.2017.08.037. PubMed PMID: 28888173; PMCID: PMC5632222.
Muller L, Simms P, Hong CS, Nishimura MI, Jackson EK, Watkins SC, Whiteside TL. Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms. Oncoimmunology. 2017;6(8):e1261243. doi: 10.1080/2162402X.2016.1261243. PubMed PMID: 28919985; PMCID: PMC5593709.
Tian L, Eldridge L, Chaudhari P, Zhang L, Anders RA, Schwarz KB, Ye Z, Jang YY. Derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient. Stem Cell Res. 2017 Oct;2425-28. doi: 10.1016/j.scr.2017.08.001. PubMed PMID: 29034890; PMCID: PMC5881114.
Varlakhanova NV, Mihalevic MJ, Bernstein KA, Ford MGJ. Pib2 and the EGO complex are both required for activation of TORC1. J Cell Sci. 2017 Nov 15;130(22):3878-3890. doi: 10.1242/jcs.207910. PubMed PMID: 28993463; PMCID: PMC5702048.
Pradhan-Sundd T, Zhou L, Vats R, Jiang A, Molina L, Singh S, Poddar M, Russell J, Stolz DB, Oertel M, Apte U, Watkins S, Ranganathan S, Nejak-Bowen KN, Sundd P, Monga SP. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology. 2018 Jun;67(6):2320-2337. doi: 10.1002/hep.29585. PubMed PMID: 29023813; PMCID: PMC5893443.
Hernandez-Prera JC, Machado RA, Asa SL, Baloch Z, Faquin WC, Ghossein R, LiVolsi VA, Lloyd RV, Mete O, Nikiforov YE, Seethala RR, Suster S, Thompson LD, Turk AT, Sadow PM, Urken ML, Wenig BM. Pathologic Reporting of Tall-Cell Variant of Papillary Thyroid Cancer: Have We Reached a Consensus? Thyroid. 2017 Dec;27(12):1498-1504. doi: 10.1089/thy.2017.0280. PubMed PMID: 29020884.
Rudich P, Snoznik C, Watkins SC, Monaghan J, Pandey UB, Lamitina ST. Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans. Hum Mol Genet. 2017 Dec 15;26(24):4916-4928. doi: 10.1093/hmg/ddx372. PubMed PMID: 29036691; PMCID: PMC5886095.
Seethala RR, Baloch ZW, Barletta JA, Khanafshar E, Mete O, Sadow PM, LiVolsi VA, Nikiforov YE, Tallini G, Thompson LD. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: a review for pathologists. Mod Pathol. 2018 Jan;31(1):39-55. doi: 10.1038/modpathol.2017.130. PubMed PMID: 29052599.
Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell. 2017 Oct 19;171(3):628-641.e26. doi: 10.1016/j.cell.2017.09.044. PubMed PMID: 29053969; PMCID: PMC5683852.
Washington MA, Balmert SC, Fedorchak MV, Little SR, Watkins SC, Meyer TY. Monomer sequence in PLGA microparticles: Effects on acidic microclimates and in vivo inflammatory response. Acta Biomater. 2018 Jan;65259-271. doi: 10.1016/j.actbio.2017.10.043. PubMed PMID: 29101019.
Duangkhae P, Erdos G, Ryman KD, Watkins SC, Falo LD Jr, Marques ETA Jr, Barratt-Boyes SM. Interplay between Keratinocytes and Myeloid Cells Drives Dengue Virus Spread in Human Skin. J Invest Dermatol. 2018 Mar;138(3):618-626. doi: 10.1016/j.jid.2017.10.018. PubMed PMID: 29106931.
Liu L, Kong M, Gassman NR, Freudenthal BD, Prasad R, Zhen S, Watkins SC, Wilson SH, Van Houten B. PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1. Nucleic Acids Res. 2017 Dec 15;45(22):12834-12847. doi: 10.1093/nar/gkx1047. PubMed PMID: 29121337; PMCID: PMC5728402.
Moiseeva T, Hood B, Schamus S, O'Connor MJ, Conrads TP, Bakkenist CJ. ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1. Nat Commun. 2017 Nov 9;8(1):1392. doi: 10.1038/s41467-017-01401-x. PubMed PMID: 29123096; PMCID: PMC5680267.
Kaufman BA, Van Houten B. POLB: A new role of DNA polymerase beta in mitochondrial base excision repair. DNA Repair (Amst). 2017 Dec;60A1-A5. doi: 10.1016/j.dnarep.2017.11.002. PubMed PMID: 29129598; PMCID: PMC5713914.
Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, Greenberger JS. Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways. Radiat Res. 2018 Jan;189(1):68-83. doi: 10.1667/RR14787.1. PubMed PMID: 29140165; PMCID: PMC5808408.
Woodcock CC, Huang Y, Woodcock SR, Salvatore SR, Singh B, Golin-Bisello F, Davidson NE, Neumann CA, Freeman BA, Wendell SG. Nitro-fatty acid inhibition of triple-negative breast cancer cell viability, migration, invasion, and tumor growth. J Biol Chem. 2018 Jan 26;293(4):1120-1137. doi: 10.1074/jbc.M117.814368. PubMed PMID: 29158255; PMCID: PMC5787792.
Van Houten B, Santa-Gonzalez GA, Camargo M. DNA repair after oxidative stress: current challenges. Curr Opin Toxicol. 2018 Feb;79-16. doi: 10.1016/j.cotox.2017.10.009. PubMed PMID: 29159324; PMCID: PMC5693256.
Efanov AA, Brenner AV, Bogdanova TI, Kelly LM, Liu P, Little MP, Wald AI, Hatch M, Zurnadzy LY, Nikiforova MN, Drozdovitch V, Leeman-Neill R, Mabuchi K, Tronko MD, Chanock SJ, Nikiforov YE. Investigation of the Relationship Between Radiation Dose and Gene Mutations and Fusions in Post-Chernobyl Thyroid Cancer. J Natl Cancer Inst. 2018 Apr 1;110(4):371-378. doi: 10.1093/jnci/djx209. PubMed PMID: 29165687; PMCID: PMC6059206.
Argani P, Kao YC, Zhang L, Bacchi C, Matoso A, Alaggio R, Epstein JI, Antonescu CR. Primary Renal Sarcomas With BCOR-CCNB3 Gene Fusion: A Report of 2 Cases Showing Histologic Overlap With Clear Cell Sarcoma of Kidney, Suggesting Further Link Between BCOR-related Sarcomas of the Kidney and Soft Tissues. Am J Surg Pathol. 2017 Dec;41(12):1702-1712. doi: 10.1097/PAS.0000000000000926. PubMed PMID: 28817404; PMCID: PMC5680139.
Schultz MA, Diaz AM, Smite S, Lay AR, DeCant B, McKinney R, Mascarinas WE, Xia Y, Neumann C, Bentrem D, Dawson DW, Grippo PJ. Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer. Oncotarget. 2017 Nov 3;8(54):92667-92681. doi: 10.18632/oncotarget.21539. PubMed PMID: 29190947; PMCID: PMC5696213.
Geskin LJ, Akilov OE, Kwon S, Schowalter M, Watkins S, Whiteside TL, Butterfield LH, Falo LD Jr. Therapeutic reduction of cell-mediated immunosuppression in mycosis fungoides and Sézary syndrome. Cancer Immunol Immunother. 2018 Mar;67(3):423-434. doi: 10.1007/s00262-017-2090-z. PubMed PMID: 29204699.
Orenstein A, Berlyoung AS, Rastede EE, Pham HH, Fouquerel E, Murphy CT, Leibowitz BJ, Yu J, Srivastava T, Armitage BA, Opresko PL. γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue. Molecules. 2017 Dec 2;22(12): doi: 10.3390/molecules22122117. PubMed PMID: 29207465; PMCID: PMC5895088.
Hampton MB, Vick KA, Skoko JJ, Neumann CA. Peroxiredoxin Involvement in the Initiation and Progression of Human Cancer. Antioxid Redox Signal. 2018 Mar 1;28(7):591-608. doi: 10.1089/ars.2017.7422. PubMed PMID: 29237274.
Springall L, Hughes CD, Simons M, Azinas S, Van Houten B, Kad NM. Recruitment of UvrBC complexes to UV-induced damage in the absence of UvrA increases cell survival. Nucleic Acids Res. 2018 Feb 16;46(3):1256-1265. doi: 10.1093/nar/gkx1244. PubMed PMID: 29240933; PMCID: PMC5814901.
Christner S, Guo J, Parise RA, Ringeval M, Hoye AT, Wipf P, Epperly MW, Greenberger JS, Beumer JH, Eiseman JL. Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma. J Pharm Biomed Anal. 2018 Feb 20;150169-175. doi: 10.1016/j.jpba.2017.12.023. PubMed PMID: 29245086; PMCID: PMC5767136.
Westmoreland JW, Mihalevic MJ, Bernstein KA, Resnick MA. The global role for Cdc13 and Yku70 in preventing telomere resection across the genome. DNA Repair (Amst). 2018 Feb;628-17. doi: 10.1016/j.dnarep.2017.11.010. PubMed PMID: 29247743; PMCID: PMC5989325.
Pinilla-Macua I, Grassart A, Duvvuri U, Watkins SC, Sorkin A. EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo. Elife. 2017 Dec 21;6 doi: 10.7554/eLife.31993. PubMed PMID: 29268862; PMCID: PMC5741375.
Glaser SM, Kalash R, Bongiorni DR, Roberts MS, Balasubramani GK, Jacobs BL, Beriwal S, Heron DE, Greenberger JS. Challenges in the Analysis of Outcomes for Surgical Compared to Radiotherapy Treatment of Prostate Cancer. In Vivo. 2018 Jan-Feb;32(1):113-120. doi: 10.21873/invivo.11212. PubMed PMID: 29275307; PMCID: PMC5892645.
Perkins LA, Yan Q, Schmidt BF, Kolodieznyi D, Saurabh S, Larsen MB, Watkins SC, Kremer L, Bruchez MP. Genetically Targeted Ratiometric and Activated pH Indicator Complexes (TRApHIC) for Receptor Trafficking. Biochemistry. 2018 Feb 6;57(5):861-871. doi: 10.1021/acs.biochem.7b01135. PubMed PMID: 29283245.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE. Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules. Cancer. 2018 Apr 15;124(8):1682-1690. doi: 10.1002/cncr.31245. PubMed PMID: 29345728; PMCID: PMC5891361.
Leipnitz G, Mohsen AW, Karunanidhi A, Seminotti B, Roginskaya VY, Markantone DM, Grings M, Mihalik SJ, Wipf P, Van Houten B, Vockley J. Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency. Sci Rep. 2018 Jan 18;8(1):1165. doi: 10.1038/s41598-018-19543-3. PubMed PMID: 29348607; PMCID: PMC5773529.
Wei L, Leibowitz BJ, Epperly M, Bi C, Li A, Steinman J, Wipf P, Li S, Zhang L, Greenberger J, Yu J. The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice. Sci Rep. 2018 Feb 1;8(1):2072. doi: 10.1038/s41598-018-20370-9. PubMed PMID: 29391546; PMCID: PMC5794877.
Fletcher R, Wang YJ, Schoen RE, Finn OJ, Yu J, Zhang L. Colorectal cancer prevention: Immune modulation taking the stage. Biochim Biophys Acta Rev Cancer. 2018 Apr;1869(2):138-148. doi: 10.1016/j.bbcan.2017.12.002. PubMed PMID: 29391185; PMCID: PMC5955808.
Leibowitz BJ, Yang L, Wei L, Buchanan ME, Rachid M, Parise RA, Beumer JH, Eiseman JL, Schoen RE, Zhang L, Yu J. Targeting p53-dependent stem cell loss for intestinal chemoprotection. Sci Transl Med. 2018 Feb 7;10(427): doi: 10.1126/scitranslmed.aam7610. PubMed PMID: 29437148; PMCID: PMC5827930.
Ma J, Salamoun J, Wipf P, Edwards R, Van Houten B, Qian W. Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential. Oncotarget. 2018 Jan 19;9(5):6042-6054. doi: 10.18632/oncotarget.23679. PubMed PMID: 29464053; PMCID: PMC5814193.
Bo W, Schoedel KE, Carty SE, Radkay LA, Ohori NP, Nikiforov YE, Nikiforova MN, Yip L. Incidental Diagnosis of Parathyroid Lesions by Preoperative Use of Next-Generation Molecular Testing. World J Surg. 2018 Sep;42(9):2840-2845. doi: 10.1007/s00268-018-4548-3. PubMed PMID: 29470700.
Li X, Li M, Ruan H, Qiu W, Xu X, Lin Z, Yu J. Correction: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. Oncotarget. 2018 Jan 23;9(6):7271. doi: 10.18632/oncotarget.24288. PubMed PMID: 29467964; PMCID: PMC5805550.
Thompson LDR, Poller DN, Kakudo K, Burchette R, Nikiforov YE, Seethala RR. An International Interobserver Variability Reporting of the Nuclear Scoring Criteria to Diagnose Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: a Validation Study. Endocr Pathol. 2018 Sep;29(3):242-249. doi: 10.1007/s12022-018-9520-0. PubMed PMID: 29508145.
Menk AV, Scharping NE, Rivadeneira DB, Calderon MJ, Watson MJ, Dunstane D, Watkins SC, Delgoffe GM. 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses. J Exp Med. 2018 Apr 2;215(4):1091-1100. doi: 10.1084/jem.20171068. PubMed PMID: 29511066; PMCID: PMC5881463.
Mon SY, Riedlinger G, Abbott CE, Seethala R, Ohori NP, Nikiforova MN, Nikiforov YE, Hodak SP. Cancer risk and clinicopathological characteristics of thyroid nodules harboring thyroid-stimulating hormone receptor gene mutations. Diagn Cytopathol. 2018 May;46(5):369-377. doi: 10.1002/dc.23915. PubMed PMID: 29516685.
Luthra S, Chandran U, Diergaarde B, Becich M, Lee AV, Neumann CA. Expression of reactive species related genes is associated with patient survival in luminal B breast cancer. Free Radic Biol Med. 2018 May 20;120170-180. doi: 10.1016/j.freeradbiomed.2018.03.011. PubMed PMID: 29545070; PMCID: PMC5940524.
Evdokimova VN, Gandhi M, Nikitski AV, Bakkenist CJ, Nikiforov YE. Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements. Oncotarget. 2018 Mar 2;9(17):13612-13622. doi: 10.18632/oncotarget.24434. PubMed PMID: 29568381; PMCID: PMC5862602.
Willis J, Epperly MW, Fisher R, Zhang X, Shields D, Hou W, Wang H, Li S, Wipf P, Parmar K, Guinan E, Steinman J, Greenberger JS. Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca-/- and Fancg-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039). Radiat Res. 2018 Jun;189(6):560-578. doi: 10.1667/RR14878.1. PubMed PMID: 29584588; PMCID: PMC5973476.
Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J, Zhang L. PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3930-3935. doi: 10.1073/pnas.1717190115. PubMed PMID: 29581256; PMCID: PMC5899441.
Ning J, Zhong Z, Fischer DK, Harris G, Watkins SC, Ambrose Z, Zhang P. Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid. J Virol. 2018 Jul 1;92(13): doi: 10.1128/JVI.00368-18. PubMed PMID: 29643241; PMCID: PMC6002704.
Watkins SC, St Croix CM. Light sheet imaging comes of age. J Cell Biol. 2018 May 7;217(5):1567-1569. doi: 10.1083/jcb.201804016. PubMed PMID: 29653995; PMCID: PMC5940317.
Choy CH, Saffi G, Gray MA, Wallace C, Dayam RM, Ou ZA, Lenk G, Puertollano R, Watkins SC, Botelho RJ. Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence. J Cell Sci. 2018 May 21;131(10): doi: 10.1242/jcs.213587. PubMed PMID: 29661845; PMCID: PMC6031331.
Kao YC, Owosho AA, Sung YS, Zhang L, Fujisawa Y, Lee JC, Wexler L, Argani P, Swanson D, Dickson BC, Fletcher CDM, Antonescu CR. BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas. Am J Surg Pathol. 2018 May;42(5):604-615. doi: 10.1097/PAS.0000000000000965. PubMed PMID: 29300189; PMCID: PMC5893395.
Du T, Zhu L, Levine KM, Tasdemir N, Lee AV, Vignali DAA, Houten BV, Tseng GC, Oesterreich S. Invasive lobular and ductal breast carcinoma differ in immune response, protein translation efficiency and metabolism. Sci Rep. 2018 May 8;8(1):7205. doi: 10.1038/s41598-018-25357-0. PubMed PMID: 29739984; PMCID: PMC5940770.
Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol. 2018 Jul;17259-273. doi: 10.1016/j.redox.2018.04.007. PubMed PMID: 29747066; PMCID: PMC6006678.
Knickelbein K, Tong J, Chen D, Wang YJ, Misale S, Bardelli A, Yu J, Zhang L. Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. Oncogene. 2018 Aug;37(33):4599-4610. doi: 10.1038/s41388-018-0289-x. PubMed PMID: 29755130; PMCID: PMC6195818.
Kumar D, New J, Vishwakarma V, Joshi R, Enders J, Lin F, Dasari S, Gutierrez WR, Leef G, Ponnurangam S, Chavan H, Ganaden L, Thornton MM, Dai H, Tawfik O, Straub J, Shnayder Y, Kakarala K, Tsue TT, Girod DA, Van Houten B, Anant S, Krishnamurthy P, Thomas SM. Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression. Cancer Res. 2018 Jul 15;78(14):3769-3782. doi: 10.1158/0008-5472.CAN-17-1076. PubMed PMID: 29769197; PMCID: PMC6050074.
Hager NA, Krasowski CJ, Mackie TD, Kolb AR, Needham PG, Augustine AA, Dempsey A, Szent-Gyorgyi C, Bruchez MP, Bain DJ, Kwiatkowski AV, O'Donnell AF, Brodsky JL. Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model. J Biol Chem. 2018 Jul 13;293(28):11006-11021. doi: 10.1074/jbc.RA117.001293. PubMed PMID: 29784874; PMCID: PMC6052216.
Czerwińska J, Nowak M, Wojtczak P, Dziuban-Lech D, Cieśla JM, Kołata D, Gajewska B, Barańczyk-Kuźma A, Robinson AR, Shane HL, Gregg SQ, Rigatti LH, Yousefzadeh MJ, Gurkar AU, McGowan SJ, Kosicki K, Bednarek M, Zarakowska E, Gackowski D, Oliński R, Speina E, Niedernhofer LJ, Tudek B. ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. Free Radic Biol Med. 2018 Aug 20;12479-96. doi: 10.1016/j.freeradbiomed.2018.05.088. PubMed PMID: 29860127; PMCID: PMC6098728.
Zhang J, Tian XJ, Chen YJ, Wang W, Watkins S, Xing J. Pathway crosstalk enables cells to interpret TGF-β duration. NPJ Syst Biol Appl. 2018;418. doi: 10.1038/s41540-018-0060-5. PubMed PMID: 29872541; PMCID: PMC5972147.
Zhao J, Zhang L, Mu X, Doebelin C, Nguyen W, Wallace C, Reay DP, McGowan SJ, Corbo L, Clemens PR, Wilson GM, Watkins SC, Solt LA, Cameron MD, Huard J, Niedernhofer LJ, Kamenecka TM, Robbins PD. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun;16(6):e2004663. doi: 10.1371/journal.pbio.2004663. PubMed PMID: 29889904; PMCID: PMC6013238.
Tong J, Zheng X, Tan X, Fletcher R, Nikolovska-Coleska Z, Yu J, Zhang L. Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins. Cancer Res. 2018 Aug 15;78(16):4704-4715. doi: 10.1158/0008-5472.CAN-18-0399. PubMed PMID: 29895675; PMCID: PMC6298746.
Molina L, Bell D, Tao J, Preziosi M, Pradhan-Sundd T, Singh S, Poddar M, Luo J, Ranganathan S, Chikina M, Monga SP. Hepatocyte-Derived Lipocalin 2 Is a Potential Serum Biomarker Reflecting Tumor Burden in Hepatoblastoma. Am J Pathol. 2018 Aug;188(8):1895-1909. doi: 10.1016/j.ajpath.2018.05.006. PubMed PMID: 29920228; PMCID: PMC6099390.
Niedernhofer LJ, Gurkar AU, Wang Y, Vijg J, Hoeijmakers JHJ, Robbins PD. Nuclear Genomic Instability and Aging. Annu Rev Biochem. 2018 Jun 20;87295-322. doi: 10.1146/annurev-biochem-062917-012239. PubMed PMID: 29925262.
Lou W, Ting HC, Reynolds CA, Tyurina YY, Tyurin VA, Li Y, Ji J, Yu W, Liang Z, Stoyanovsky DA, Anthonymuthu TS, Frasso MA, Wipf P, Greenberger JS, Bayır H, Kagan VE, Greenberg ML. Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1354-1368. doi: 10.1016/j.bbalip.2018.06.016. PubMed PMID: 29935382.
Callenberg KM, Santana-Santos L, Chen L, Ernst WL, De Moura MB, Nikiforov YE, Nikiforova MN, Roy S. Clinical Implementation and Validation of Automated Human Genome Variation Society (HGVS) Nomenclature System for Next-Generation Sequencing-Based Assays for Cancer. J Mol Diagn. 2018 Sep;20(5):628-634. doi: 10.1016/j.jmoldx.2018.05.006. PubMed PMID: 29936258.
Ferris RL, Nikiforov Y, Terris D, Seethala RR, Ridge JA, Angelos P, Duh QY, Wong R, Sabra MM, Fagin JA, McIver B, Bernet VJ, Harrell RM, Busaidy N, Cibas ES, Faquin WC, Sadow P, Baloch Z, Shindo M, Orloff L, Davies L, Randolph GW. AHNS Series: Do you know your guidelines? AHNS Endocrine Section Consensus Statement: State-of-the-art thyroid surgical recommendations in the era of noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Head Neck. 2018 Sep;40(9):1881-1888. doi: 10.1002/hed.25141. PubMed PMID: 29947030; PMCID: PMC6175359.
Vendetti FP, Karukonda P, Clump DA, Teo T, Lalonde R, Nugent K, Ballew M, Kiesel BF, Beumer JH, Sarkar SN, Conrads TP, O'Connor MJ, Ferris RL, Tran PT, Delgoffe GM, Bakkenist CJ. ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation. J Clin Invest. 2018 Aug 31;128(9):3926-3940. doi: 10.1172/JCI96519. PubMed PMID: 29952768; PMCID: PMC6118586.
Pradhan-Sundd T, Vats R, Russell JO, Singh S, Michael AA, Molina L, Kakar S, Cornuet P, Poddar M, Watkins SC, Nejak-Bowen KN, Monga SP, Sundd P. Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice. Gastroenterology. 2018 Oct;155(4):1218-1232.e24. doi: 10.1053/j.gastro.2018.06.048. PubMed PMID: 29964040; PMCID: PMC6174089.
Lontos K, Adamik J, Tsagianni A, Galson DL, Chirgwin JM, Suvannasankha A. The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis. Front Endocrinol (Lausanne). 2018;9322. doi: 10.3389/fendo.2018.00322. PubMed PMID: 29971044; PMCID: PMC6018527.
Adamik J, Silbermann R, Marino S, Sun Q, Anderson JL, Zhou D, Xie XQ, Roodman GD, Galson DL. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression. Front Endocrinol (Lausanne). 2018;9344. doi: 10.3389/fendo.2018.00344. PubMed PMID: 30008697; PMCID: PMC6033965.
Caves EA, Cook SA, Lee N, Stoltz D, Watkins S, Shair KHY. Air-Liquid Interface Method To Study Epstein-Barr Virus Pathogenesis in Nasopharyngeal Epithelial Cells. mSphere. 2018 Jul 18;3(4): doi: 10.1128/mSphere.00152-18. PubMed PMID: 30021875; PMCID: PMC6052337.
Gurkar AU, Robinson AR, Cui Y, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Wang Y, Kelley EE, Croix CMS, Niedernhofer LJ, Gill MS. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biol. 2018 Sep;18191-199. doi: 10.1016/j.redox.2018.06.005. PubMed PMID: 30031267; PMCID: PMC6076207.
Bellare A, Epperly MW, Greenberger JS, Fisher R, Glowacki J. Development of tensile strength methodology for murine skin wound healing. MethodsX. 2018;5337-344. doi: 10.1016/j.mex.2018.04.002. PubMed PMID: 30050753; PMCID: PMC6058076.
Gomes-Lima CJ, Nikiforov YE, Lee W, Burman KD. Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations. J Endocr Soc. 2018 Aug 1;2(8):944-948. doi: 10.1210/js.2018-00132. PubMed PMID: 30087949; PMCID: PMC6065485.
Ganly I, Makarov V, Deraje S, Dong Y, Reznik E, Seshan V, Nanjangud G, Eng S, Bose P, Kuo F, Morris LGT, Landa I, Carrillo Albornoz PB, Riaz N, Nikiforov YE, Patel K, Umbricht C, Zeiger M, Kebebew E, Sherman E, Ghossein R, Fagin JA, Chan TA. Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes. Cancer Cell. 2018 Aug 13;34(2):256-270.e5. doi: 10.1016/j.ccell.2018.07.002. PubMed PMID: 30107176; PMCID: PMC6247912.
Pearlstein S, Lahouti AH, Opher E, Nikiforov YE, Kuriloff DB. Thyroseq V3 Molecular Profiling for Tailoring the Surgical Management of Hürthle Cell Neoplasms. Case Rep Endocrinol. 2018;20189329035. doi: 10.1155/2018/9329035. PubMed PMID: 30105107; PMCID: PMC6076910.
Nikitski AV, Rominski SL, Wankhede M, Kelly LM, Panebianco F, Barila G, Altschuler DL, Nikiforov YE. Mouse Model of Poorly Differentiated Thyroid Carcinoma Driven by STRN-ALK Fusion. Am J Pathol. 2018 Nov;188(11):2653-2661. doi: 10.1016/j.ajpath.2018.07.012. PubMed PMID: 30125543; PMCID: PMC6222272.
Tantikanlayaporn D, Tourkova IL, Larrouture Q, Luo J, Piyachaturawat P, Witt MR, Blair HC, Robinson LJ. Sphingosine-1-Phosphate Modulates the Effect of Estrogen in Human Osteoblasts. JBMR Plus. 2018 Jul;2(4):217-226. doi: 10.1002/jbm4.10037. PubMed PMID: 30123862; PMCID: PMC6095197.
Sannino S, Guerriero CJ, Sabnis AJ, Stolz DB, Wallace CT, Wipf P, Watkins SC, Bivona TG, Brodsky JL. Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells. J Cell Sci. 2018 Sep 5;131(17): doi: 10.1242/jcs.217760. PubMed PMID: 30131440; PMCID: PMC6140321.
Saydmohammed M, Yagi H, Calderon M, Clark MJ, Feinstein T, Sun M, Stolz DB, Watkins SC, Amack JD, Lo CW, Tsang M. Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality. Nat Commun. 2018 Aug 23;9(1):3381. doi: 10.1038/s41467-018-05866-2. PubMed PMID: 30139971; PMCID: PMC6107537.
Epperly MW, Wipf P, Fisher R, Franicola D, Beumer J, Li S, Brand RM, Falo LD Jr, Erdos G, Greenberger JS. Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039). In Vivo. 2018 Sep-Oct;32(5):1009-1023. doi: 10.21873/invivo.11341. PubMed PMID: 30150422; PMCID: PMC6199586.
Lee YS, Lee DH, Jeong SY, Park SH, Oh SC, Park YS, Yu J, Choudry HA, Bartlett DL, Lee YJ. Ferroptosis-inducing agents enhance TRAIL-induced apoptosis through upregulation of death receptor 5. J Cell Biochem. 2019 Jan;120(1):928-939. doi: 10.1002/jcb.27456. PubMed PMID: 30160785; PMCID: PMC6249082.
Brand RM, Wipf P, Durham A, Epperly MW, Greenberger JS, Falo LD Jr. Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage. Front Pharmacol. 2018;9920. doi: 10.3389/fphar.2018.00920. PubMed PMID: 30177881; PMCID: PMC6110189.
Krainz T, Lamade AM, Du L, Maskrey TS, Calderon MJ, Watkins SC, Epperly MW, Greenberger JS, Bayır H, Wipf P, Clark RSB. Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor. ACS Chem Biol. 2018 Oct 19;13(10):2868-2879. doi: 10.1021/acschembio.8b00423. PubMed PMID: 30184433; PMCID: PMC6402482.
Du T, Sikora MJ, Levine KM, Tasdemir N, Riggins RB, Wendell SG, Van Houten B, Oesterreich S. Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer. Breast Cancer Res. 2018 Sep 4;20(1):106. doi: 10.1186/s13058-018-1041-8. PubMed PMID: 30180878; PMCID: PMC6124012.
Moiseeva TN, Bakkenist CJ. Regulation of the initiation of DNA replication in human cells. DNA Repair (Amst). 2018 Dec;7299-106. doi: 10.1016/j.dnarep.2018.09.003. PubMed PMID: 30266203; PMCID: PMC6261693.
Petrusca DN, Toscani D, Wang FM, Park C, Crean CD, Anderson JL, Marino S, Mohammad KS, Zhou D, Silbermann R, Sun Q, Kurihara N, Galson DL, Giuliani N, Roodman GD. Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis. J Hematol Oncol. 2018 Oct 4;11(1):123. doi: 10.1186/s13045-018-0666-5. PubMed PMID: 30286780; PMCID: PMC6172782.
Pulugulla SH, Packard TA, Galloway NLK, Grimmett ZW, Doitsh G, Adamik J, Galson DL, Greene WC, Auron PE. Distinct mechanisms regulate IL1B gene transcription in lymphoid CD4 T cells and monocytes. Cytokine. 2018 Nov;111373-381. doi: 10.1016/j.cyto.2018.10.001. PubMed PMID: 30300855; PMCID: PMC6364691.
Deng M, Tang Y, Li W, Wang X, Zhang R, Zhang X, Zhao X, Liu J, Tang C, Liu Z, Huang Y, Peng H, Xiao L, Tang D, Scott MJ, Wang Q, Liu J, Xiao X, Watkins S, Li J, Yang H, Wang H, Chen F, Tracey KJ, Billiar TR, Lu B. The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis. Immunity. 2018 Oct 16;49(4):740-753.e7. doi: 10.1016/j.immuni.2018.08.016. PubMed PMID: 30314759; PMCID: PMC6300139.
Wang YJ, Fletcher R, Yu J, Zhang L. Immunogenic effects of chemotherapy-induced tumor cell death. Genes Dis. 2018 Sep;5(3):194-203. doi: 10.1016/j.gendis.2018.05.003. PubMed PMID: 30320184; PMCID: PMC6176216.
Pulugulla SH, Workman R, Rutter NW, Yang Z, Adamik J, Lupish B, Macar DA, El Abdouni S, Esposito EX, Galson DL, Camacho CJ, Madura JD, Auron PE. A combined computational and experimental approach reveals the structure of a C/EBPβ-Spi1 interaction required for IL1B gene transcription. J Biol Chem. 2018 Dec 28;293(52):19942-19956. doi: 10.1074/jbc.RA118.005627. PubMed PMID: 30355733; PMCID: PMC6311527.
D'Aiuto L, McNulty J, Hartline C, Demers M, Kalkeri R, Wood J, McClain L, Chattopadhyay A, Zhi Y, Naciri J, Smith A, Yolken R, Chowdari K, Zepeda-Velazquez C, Dokuburra CB, Marques E, Ptak R, Kinchington P, Watkins S, Prichard M, Bloom D, Nimgaonkar V. R430: A potent inhibitor of DNA and RNA viruses. Sci Rep. 2018 Nov 9;8(1):16662. doi: 10.1038/s41598-018-33904-y. PubMed PMID: 30413769; PMCID: PMC6226428.
Steward DL, Carty SE, Sippel RS, Yang SP, Sosa JA, Sipos JA, Figge JJ, Mandel S, Haugen BR, Burman KD, Baloch ZW, Lloyd RV, Seethala RR, Gooding WE, Chiosea SI, Gomes-Lima C, Ferris RL, Folek JM, Khawaja RA, Kundra P, Loh KS, Marshall CB, Mayson S, McCoy KL, Nga ME, Ngiam KY, Nikiforova MN, Poehls JL, Ringel MD, Yang H, Yip L, Nikiforov YE. Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study. JAMA Oncol. 2018 Nov 8; doi: 10.1001/jamaoncol.2018.4616. PubMed PMID: 30419129; PMCID: PMC6439562.
Seminotti B, Leipnitz G, Karunanidhi A, Kochersperger C, Roginskaya VY, Basu S, Wang Y, Wipf P, Van Houten B, Mohsen AW, Vockley J. Mitochondrial energetics is impaired in very long-chain acyl-CoA dehydrogenase deficiency and can be rescued by treatment with mitochondria-targeted electron scavengers. Hum Mol Genet. 2018 Nov 16; doi: 10.1093/hmg/ddy403. PubMed PMID: 30445591; PMCID: PMC6400046.
Zhang L, Zhao J, Gurkar A, Niedernhofer LJ, Robbins PD. Methods to Quantify the NF-κB Pathway During Senescence. Methods Mol Biol. 2019;1896231-250. doi: 10.1007/978-1-4939-8931-7_18. PubMed PMID: 30474851.
Asan A, Skoko JJ, Woodcock CC, Wingert BM, Woodcock SR, Normolle D, Huang Y, Stark JM, Camacho CJ, Freeman BA, Neumann CA. Electrophilic fatty acids impair RAD51 function and potentiate the effects of DNA-damaging agents on growth of triple-negative breast cells. J Biol Chem. 2019 Jan 11;294(2):397-404. doi: 10.1074/jbc.AC118.005899. PubMed PMID: 30478172; PMCID: PMC6333886.
Sivananthan A, Shields D, Fisher R, Hou W, Zhang X, Franicola D, Epperly MW, Wipf P, Greenberger JS. Continuous One Year Oral Administration of the Radiation Mitigator, MMS350, after Total-Body Irradiation, Restores Bone Marrow Stromal Cell Proliferative Capacity and Reduces Senescence in Fanconi Anemia (Fanca-/-) Mice. Radiat Res. 2019 Feb;191(2):139-153. doi: 10.1667/RR15199.1. PubMed PMID: 30499383; PMCID: PMC6388094.
Sullivan MR, Bernstein KA. RAD-ical New Insights into RAD51 Regulation. Genes (Basel). 2018 Dec 13;9(12): doi: 10.3390/genes9120629. PubMed PMID: 30551670; PMCID: PMC6316741.
Chen D, Ni HM, Wang L, Ma X, Yu J, Ding WX, Zhang L. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology. 2019 May;69(5):2164-2179. doi: 10.1002/hep.30422. PubMed PMID: 30552702; PMCID: PMC6461480.
Menolfi D, Jiang W, Lee BJ, Moiseeva T, Shao Z, Estes V, Frattini MG, Bakkenist CJ, Zha S. Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA. Nat Commun. 2018 Dec 17;9(1):5351. doi: 10.1038/s41467-018-07798-3. PubMed PMID: 30559436; PMCID: PMC6297235.
Ohori NP, Landau MS, Carty SE, Yip L, LeBeau SO, Manroa P, Seethala RR, Schoedel KE, Nikiforova MN, Nikiforov YE. Benign call rate and molecular test result distribution of ThyroSeq v3. Cancer Cytopathol. 2019 Mar;127(3):161-168. doi: 10.1002/cncy.22088. PubMed PMID: 30561907.
Surve SV, Myers PJ, Clayton SA, Watkins SC, Lazzara MJ, Sorkin A. Localization dynamics of endogenous fluorescently labeled RAF1 in EGF-stimulated cells. Mol Biol Cell. 2019 Feb 15;30(4):506-523. doi: 10.1091/mbc.E18-08-0512. PubMed PMID: 30586319.
Adamik J, Galson DL, Roodman GD. Osteoblast suppression in multiple myeloma bone disease. J Bone Oncol. 2018 Nov;1362-70. doi: 10.1016/j.jbo.2018.09.001. PubMed PMID: 30591859; PMCID: PMC6303385.
Barra V, Logsdon GA, Scelfo A, Hoffmann S, Hervé S, Aslanian A, Nechemia-Arbely Y, Cleveland DW, Black BE, Fachinetti D. Phosphorylation of CENP-A on serine 7 does not control centromere function. Nat Commun. 2019 Jan 11;10(1):175. doi: 10.1038/s41467-018-08073-1. PubMed PMID: 30635586; PMCID: PMC6329807.
Nikiforova MN, Nikitski AV, Panebianco F, Kaya C, Yip L, Williams M, Chiosea SI, Seethala RR, Roy S, Condello V, Santana-Santos L, Wald AI, Carty SE, Ferris RL, El-Naggar AK, Nikiforov YE. GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland. Thyroid. 2019 Feb;29(2):161-173. doi: 10.1089/thy.2018.0791. PubMed PMID: 30648929; PMCID: PMC6389773.
Klein HL, Ang KKH, Arkin MR, Beckwitt EC, Chang YH, Fan J, Kwon Y, Morten MJ, Mukherjee S, Pambos OJ, El Sayyed H, Thrall ES, Vieira-da-Rocha JP, Wang Q, Wang S, Yeh HY, Biteen JS, Chi P, Heyer WD, Kapanidis AN, Loparo JJ, Strick TR, Sung P, Van Houten B, Niu H, Rothenberg E. Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes. Microb Cell. 2019 Jan 7;6(1):65-101. doi: 10.15698/mic2019.01.665. PubMed PMID: 30652106; PMCID: PMC6334232.
Tan X, Tong J, Wang YJ, Fletcher R, Schoen RE, Yu J, Shen L, Zhang L. BET Inhibitors Potentiate Chemotherapy and Killing of SPOP-Mutant Colon Cancer Cells via Induction of DR5. Cancer Res. 2019 Mar 15;79(6):1191-1203. doi: 10.1158/0008-5472.CAN-18-3223. PubMed PMID: 30674532; PMCID: PMC6420862.
Tian H, Sparvero LJ, Blenkinsopp P, Amoscato AA, Watkins SC, Bayır H, Kagan VE, Winograd N. Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular Level. Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3156-3161. doi: 10.1002/anie.201814256. PubMed PMID: 30680861.
Skoko JJ, Attaran S, Neumann CA. Signals Getting Crossed in the Entanglement of Redox and Phosphorylation Pathways: Phosphorylation of Peroxiredoxin Proteins Sparks Cell Signaling. Antioxidants (Basel). 2019 Jan 23;8(2): doi: 10.3390/antiox8020029. PubMed PMID: 30678096; PMCID: PMC6406269.
Sehrawat A, Samanta SK, Hahm ER, St Croix C, Watkins S, Singh SV. Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics. Mitochondrion. 2019 Jan 24; doi: 10.1016/j.mito.2019.01.003. PubMed PMID: 30685490.
Hopkins BL, Neumann CA. Redoxins as gatekeepers of the transcriptional oxidative stress response. Redox Biol. 2019 Feb;21101104. doi: 10.1016/j.redox.2019.101104. PubMed PMID: 30690320; PMCID: PMC6351230.
Smith NG, Gyanchandani R, Shah OS, Gurda GT, Lucas PC, Hartmaier RJ, Brufsky AM, Puhalla S, Bahreini A, Kota K, Wald AI, Nikiforov YE, Nikiforova MN, Oesterreich S, Lee AV. Targeted mutation detection in breast cancer using MammaSeq™. Breast Cancer Res. 2019 Feb 8;21(1):22. doi: 10.1186/s13058-019-1102-7. PubMed PMID: 30736836; PMCID: PMC6368740.
Raza Q, Choi JY, Li Y, O'Dowd RM, Watkins SC, Chikina M, Hong Y, Clark NL, Kwiatkowski AV. Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila. PLoS Genet. 2019 Feb;15(2):e1007720. doi: 10.1371/journal.pgen.1007720. PubMed PMID: 30763317; PMCID: PMC6375579.
D'Aiuto L, Bloom DC, Naciri JN, Smith A, Edwards TG, McClain L, Callio JA, Jessup M, Wood J, Chowdari K, Demers M, Abrahamson EE, Ikonomovic MD, Viggiano L, De Zio R, Watkins S, Kinchington PR, Nimgaonkar VL. Modeling Herpes Simplex Virus 1 Infections in Human Central Nervous System Neuronal Cells Using Two- and Three-Dimensional Cultures Derived from Induced Pluripotent Stem Cells. J Virol. 2019 May 1;93(9): doi: 10.1128/JVI.00111-19. PubMed PMID: 30787148; PMCID: PMC6475775.
Zhang X, Fisher R, Shields D, Hou W, Franicola D, Wang H, Epperly MW, Rigatti L, Greenberger JS. Malignant Transformation of Fanconi Anemia Complementation Group D2-deficient (Fancd2 -/-) Hematopoietic Progenitor Cells by a Single HPV16 Oncogene. In Vivo. 2019 Mar-Apr;33(2):303-311. doi: 10.21873/invivo.11476. PubMed PMID: 30804107; PMCID: PMC6506306.
Ngo M, Wechter N, Tsai E, Shun TY, Gough A, Schurdak ME, Schwacha A, Vogt A. A High-Throughput Assay for DNA Replication Inhibitors Based upon Multivariate Analysis of Yeast Growth Kinetics. SLAS Discov. 2019 Feb 25;2472555219829740. doi: 10.1177/2472555219829740. PubMed PMID: 30802412.
Morosky S, Wells AI, Lemon K, Evans AS, Schamus S, Bakkenist CJ, Coyne CB. The neonatal Fc receptor is a pan-echovirus receptor. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3758-3763. doi: 10.1073/pnas.1817341116. PubMed PMID: 30808762; PMCID: PMC6397586.
Fischer DK, Saito A, Kline C, Cohen R, Watkins SC, Yamashita M, Ambrose Z. CA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity Phenotypes. J Virol. 2019 May 1;93(9): doi: 10.1128/JVI.00214-19. PubMed PMID: 30814280; PMCID: PMC6475785.
Baldock RA, Pressimone CA, Baird JM, Khodakov A, Luong TT, Grundy MK, Smith CM, Karpenshif Y, Bratton-Palmer DS, Prakash R, Jasin M, Garcin EB, Gon S, Modesti M, Bernstein KA. RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination. DNA Repair (Amst). 2019 Apr;7699-107. doi: 10.1016/j.dnarep.2019.02.008. PubMed PMID: 30836272; PMCID: PMC6508892.
Ejaz A, Epperly MW, Hou W, Greenberger JS, Rubin JP. Adipose-Derived Stem Cell Therapy Ameliorates Ionizing Irradiation Fibrosis via Hepatocyte Growth Factor-Mediated Transforming Growth Factor-β Downregulation and Recruitment of Bone Marrow Cells. Stem Cells. 2019 Jun;37(6):791-802. doi: 10.1002/stem.3000. PubMed PMID: 30861238.
Chefetz I, Grimley E, Yang K, Hong L, Vinogradova EV, Suciu R, Kovalenko I, Karnak D, Morgan CA, Chtcherbinine M, Buchman C, Huddle B, Barraza S, Morgan M, Bernstein KA, Yoon E, Lombard DB, Bild A, Mehta G, Romero I, Chiang CY, Landen C, Cravatt B, Hurley TD, Larsen SD, Buckanovich RJ. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. doi: 10.1016/j.celrep.2019.02.032. PubMed PMID: 30865894.
Adamik J, Roodman GD, Galson DL. Epigenetic-Based Mechanisms of Osteoblast Suppression in Multiple Myeloma Bone Disease. JBMR Plus. 2019 Mar;3(3):e10183. doi: 10.1002/jbm4.10183. PubMed PMID: 30918921; PMCID: PMC6419609.
Top