Publications

Stimulatory Mechanisms in the TME

Anani WQ, Ojerholm E, Shurin MR. Resolving Transferrin Isoforms via Agarose Gel Electrophoresis. Lab Med. 2015 Winter;46(1):26-33. doi: 10.1309/LMVS2JB8JZN8MDVM. PubMed PMID: 25617389.
Mandal R, Muthukrishnan A, Ferris RL, de Almeida JR, Duvvuri U. Accuracy of early-phase versus dual-phase single-photon emission computed tomography/computed tomography in the localization of parathyroid disease. Laryngoscope. 2015 Jun;125(6):1496-501. doi: 10.1002/lary.25020. PubMed PMID: 25645695.
Delgoffe GM, Powell JD. Sugar, fat, and protein: new insights into what T cells crave. Curr Opin Immunol. 2015 Apr;3349-54. doi: 10.1016/j.coi.2015.01.015. PubMed PMID: 25665466; PMCID: PMC4397153.
Cascio S, Finn OJ. Complex of MUC1, CIN85 and Cbl in Colon Cancer Progression and Metastasis. Cancers (Basel). 2015 Feb 10;7(1):342-52. doi: 10.3390/cancers7010342. PubMed PMID: 25675408; PMCID: PMC4381262.
Zhu J, Ghosh A, Sarkar SN. OASL-a new player in controlling antiviral innate immunity. Curr Opin Virol. 2015 Jun;1215-9. doi: 10.1016/j.coviro.2015.01.010. PubMed PMID: 25676874; PMCID: PMC4470762.
Vargo JA, Ferris RL, Ohr J, Clump DA, Davis KS, Duvvuri U, Kim S, Johnson JT, Bauman JE, Gibson MK, Branstetter BF, Heron DE. A prospective phase 2 trial of reirradiation with stereotactic body radiation therapy plus cetuximab in patients with previously irradiated recurrent squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 2015 Mar 1;91(3):480-8. doi: 10.1016/j.ijrobp.2014.11.023. PubMed PMID: 25680594.
Wieland A, Shashidharamurthy R, Kamphorst AO, Han JH, Aubert RD, Choudhury BP, Stowell SR, Lee J, Punkosdy GA, Shlomchik MJ, Selvaraj P, Ahmed R. Antibody effector functions mediated by Fcγ-receptors are compromised during persistent viral infection. Immunity. 2015 Feb 17;42(2):367-378. doi: 10.1016/j.immuni.2015.01.009. PubMed PMID: 25680276; PMCID: PMC4339104.
Boyiadzis M, Whiteside TL. Information transfer by exosomes: A new frontier in hematologic malignancies. Blood Rev. 2015 Sep;29(5):281-90. doi: 10.1016/j.blre.2015.01.004. PubMed PMID: 25686749.
Fenton M, Whiteside TL, Ferrone S, Boyiadzis M. Chondroitin sulfate proteoglycan-4 (CSPG4)-specific monoclonal antibody 225.28 in detection of acute myeloid leukemia blasts. Oncol Res. 2015;22(2):117-21. doi: 10.3727/096504014X14174484758503. PubMed PMID: 25706398.
Madera D, Vitale-Cross L, Martin D, Schneider A, Molinolo AA, Gangane N, Carey TE, McHugh JB, Komarck CM, Walline HM, William WN Jr, Seethala RR, Ferris RL, Gutkind JS. Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3. Cancer Prev Res (Phila). 2015 Mar;8(3):197-207. doi: 10.1158/1940-6207.CAPR-14-0348. PubMed PMID: 25681087; PMCID: PMC4355306.
Whiteside TL, Ferris RL, Szczepanski M, Tublin M, Kiss J, Johnson R, Johnson JT. Dendritic cell-based autologous tumor vaccines for head and neck squamous cell carcinoma. Head Neck. 2016 Apr;38 Suppl 1E494-501. doi: 10.1002/hed.24025. PubMed PMID: 25735641; PMCID: PMC5542585.
Shvedova AA, Kisin ER, Yanamala N, Tkach AV, Gutkin DW, Star A, Shurin GV, Kagan VE, Shurin MR. MDSC and TGFβ Are Required for Facilitation of Tumor Growth in the Lungs of Mice Exposed to Carbon Nanotubes. Cancer Res. 2015 Apr 15;75(8):1615-23. doi: 10.1158/0008-5472.CAN-14-2376. PubMed PMID: 25744719; PMCID: PMC4401633.
Dixon KO, van der Kooij SW, Vignali DA, van Kooten C. Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members. Eur J Immunol. 2015 Jun;45(6):1736-47. doi: 10.1002/eji.201445217. PubMed PMID: 25820702; PMCID: PMC4617619.
Jie HB, Schuler PJ, Lee SC, Srivastava RM, Argiris A, Ferrone S, Whiteside TL, Ferris RL. CTLA-4⁺ Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis. Cancer Res. 2015 Jun 1;75(11):2200-10. doi: 10.1158/0008-5472.CAN-14-2788. PubMed PMID: 25832655; PMCID: PMC4452385.
Choby GW, Kim J, Ling DC, Abberbock S, Mandal R, Kim S, Ferris RL, Duvvuri U. Transoral robotic surgery alone for oropharyngeal cancer: quality-of-life outcomes. JAMA Otolaryngol Head Neck Surg. 2015 Jun;141(6):499-504. doi: 10.1001/jamaoto.2015.0347. PubMed PMID: 25834991.
Xu KM, Quan K, Clump DA, Ferris RL, Heron DE. Stereotactic ablative radiosurgery for locally advanced or recurrent skull base malignancies with prior external beam radiation therapy. Front Oncol. 2015;565. doi: 10.3389/fonc.2015.00065. PubMed PMID: 25853093; PMCID: PMC4362305.
Seo W, Kapralov AA, Shurin GV, Shurin MR, Kagan VE, Star A. Payload drug vs. nanocarrier biodegradation by myeloperoxidase- and peroxynitrite-mediated oxidations: pharmacokinetic implications. Nanoscale. 2015 May 21;7(19):8689-94. doi: 10.1039/c5nr00251f. PubMed PMID: 25902750; PMCID: PMC4582775.
Mandal R, Duvvuri U, Ferris RL, Kaffenberger TM, Choby GW, Kim S. Analysis of post-transoral robotic-assisted surgery hemorrhage: Frequency, outcomes, and prevention. Head Neck. 2016 Apr;38 Suppl 1E776-82. doi: 10.1002/hed.24101. PubMed PMID: 25916790.
Sawant DV, Hamilton K, Vignali DA. Interleukin-35: Expanding Its Job Profile. J Interferon Cytokine Res. 2015 Jul;35(7):499-512. doi: 10.1089/jir.2015.0015. PubMed PMID: 25919641; PMCID: PMC4507123.
Chen HM, Ma G, Gildener-Leapman N, Eisenstein S, Coakley BA, Ozao J, Mandeli J, Divino C, Schwartz M, Sung M, Ferris R, Kao J, Wang LH, Pan PY, Ko EC, Chen SH. Myeloid-Derived Suppressor Cells as an Immune Parameter in Patients with Concurrent Sunitinib and Stereotactic Body Radiotherapy. Clin Cancer Res. 2015 Sep 15;21(18):4073-4085. doi: 10.1158/1078-0432.CCR-14-2742. PubMed PMID: 25922428; PMCID: PMC4720266.
Ibsen MS, Gad HH, Andersen LL, Hornung V, Julkunen I, Sarkar SN, Hartmann R. Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling. Nucleic Acids Res. 2015 May 26;43(10):5236-48. doi: 10.1093/nar/gkv389. PubMed PMID: 25925578; PMCID: PMC4446440.
Maxwell JH, Rath TJ, Byrd JK, Albergotti WG, Wang H, Duvvuri U, Kim S, Johnson JT, Branstetter BF 4th, Ferris RL. Accuracy of computed tomography to predict extracapsular spread in p16-positive squamous cell carcinoma. Laryngoscope. 2015 Jul;125(7):1613-8. doi: 10.1002/lary.25140. PubMed PMID: 25946149.
Srivastava RM, Trivedi S, Concha-Benavente F, Hyun-Bae J, Wang L, Seethala RR, Branstetter BF 4th, Ferrone S, Ferris RL. STAT1-Induced HLA Class I Upregulation Enhances Immunogenicity and Clinical Response to Anti-EGFR mAb Cetuximab Therapy in HNC Patients. Cancer Immunol Res. 2015 Aug;3(8):936-45. doi: 10.1158/2326-6066.CIR-15-0053. PubMed PMID: 25972070; PMCID: PMC4526378.
Zhang Y, Chen G, Liu Z, Tian S, Zhang J, Carey CD, Murphy KM, Storkus WJ, Falo LD Jr, You Z. Genetic vaccines to potentiate the effective CD103+ dendritic cell-mediated cross-priming of antitumor immunity. J Immunol. 2015 Jun 15;194(12):5937-47. doi: 10.4049/jimmunol.1500089. PubMed PMID: 25972487; PMCID: PMC4458448.
Griffith CC, Pai RK, Schneider F, Duvvuri U, Ferris RL, Johnson JT, Seethala RR. Salivary gland tumor fine-needle aspiration cytology: a proposal for a risk stratification classification. Am J Clin Pathol. 2015 Jun;143(6):839-53. doi: 10.1309/AJCPMII6OSD2HSJA. PubMed PMID: 25972326; PMCID: PMC5257286.
Clump DA, Bauman JE, Ferris RL. Cancer of the oropharynx. Surg Oncol Clin N Am. 2015 Jul;24(3):509-20. doi: 10.1016/j.soc.2015.03.014. PubMed PMID: 25979397.
Mony JT, Zhang L, Ma T, Grabosch S, Tirodkar TS, Brozick J, Tseng G, Elishaev E, Edwards RP, Huang X, Vlad AM. Anti-PD-L1 prolongs survival and triggers T cell but not humoral anti-tumor immune responses in a human MUC1-expressing preclinical ovarian cancer model. Cancer Immunol Immunother. 2015 Sep;64(9):1095-108. doi: 10.1007/s00262-015-1712-6. PubMed PMID: 25998800; PMCID: PMC4545381.
Turnis ME, Andrews LP, Vignali DA. Inhibitory receptors as targets for cancer immunotherapy. Eur J Immunol. 2015 Jul;45(7):1892-905. doi: 10.1002/eji.201344413. PubMed PMID: 26018646; PMCID: PMC4549156.
Sehgal A, Whiteside TL, Boyiadzis M. Programmed death-1 checkpoint blockade in acute myeloid leukemia. Expert Opin Biol Ther. 2015;15(8):1191-203. doi: 10.1517/14712598.2015.1051028. PubMed PMID: 26036819; PMCID: PMC4778424.
Ferris RL, Baloch Z, Bernet V, Chen A, Fahey TJ 3rd, Ganly I, Hodak SP, Kebebew E, Patel KN, Shaha A, Steward DL, Tufano RP, Wiseman SM, Carty SE, American Thyroid Association Surgical Affairs Committee.. American Thyroid Association Statement on Surgical Application of Molecular Profiling for Thyroid Nodules: Current Impact on Perioperative Decision Making. Thyroid. 2015 Jul;25(7):760-8. doi: 10.1089/thy.2014.0502. PubMed PMID: 26058403; PMCID: PMC4519104.
Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M, Blay JY, Bonneville M, Butterfield LH, Caignard A, Castelli C, Cavallo F, Celis E, Chen L, Colombo MP, Comin-Anduix B, Coukos G, Dhodapkar MV, Dranoff G, Frazer IH, Fridman WH, Gabrilovich DI, Gilboa E, Gnjatic S, Jäger D, Kalinski P, Kaufman HL, Kiessling R, Kirkwood J, Knuth A, Liblau R, Lotze MT, Lugli E, Marincola F, Melero I, Melief CJ, Mempel TR, Mittendorf EA, Odun K, Overwijk WW, Palucka AK, Parmiani G, Ribas A, Romero P, Schreiber RD, Schuler G, Srivastava PK, Tartour E, Valmori D, van der Burg SH, van der Bruggen P, van den Eynde BJ, Wang E, Zou W, Whiteside TL, Speiser DE, Pardoll DM, Restifo NP, Anderson AC. Consensus nomenclature for CD8+ T cell phenotypes in cancer. Oncoimmunology. 2015 Apr;4(4):e998538. doi: 10.1080/2162402X.2014.998538. PubMed PMID: 26137416; PMCID: PMC4485711.
Ohkuri T, Ghosh A, Kosaka A, Sarkar SN, Okada H. Protective role of STING against gliomagenesis: Rational use of STING agonist in anti-glioma immunotherapy. Oncoimmunology. 2015 Apr;4(4):e999523. doi: 10.1080/2162402X.2014.999523. PubMed PMID: 26137417; PMCID: PMC4485761.
Edwards RP, Huang X, Vlad AM. Chronic inflammation in endometriosis and endometriosis-associated ovarian cancer: New roles for the "old" complement pathway. Oncoimmunology. 2015 May;4(5):e1002732. doi: 10.1080/2162402X.2014.1002732. PubMed PMID: 26155393; PMCID: PMC4485759.
Muller L, Muller-Haegele S, Mitsuhashi M, Gooding W, Okada H, Whiteside TL. Exosomes isolated from plasma of glioma patients enrolled in a vaccination trial reflect antitumor immune activity and might predict survival. Oncoimmunology. 2015 Jun;4(6):e1008347. doi: 10.1080/2162402X.2015.1008347. PubMed PMID: 26155415; PMCID: PMC4485717.
Dhar J, Cuevas RA, Goswami R, Zhu J, Sarkar SN, Barik S. 2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1. J Virol. 2015 Oct;89(19):10115-9. doi: 10.1128/JVI.01076-15. PubMed PMID: 26178980; PMCID: PMC4577923.
Graw S, Meier R, Minn K, Bloomer C, Godwin AK, Fridley B, Vlad A, Beyerlein P, Chien J. Robust gene expression and mutation analyses of RNA-sequencing of formalin-fixed diagnostic tumor samples. Sci Rep. 2015 Jul 23;512335. doi: 10.1038/srep12335. PubMed PMID: 26202458; PMCID: PMC4511951.
Maxwell JH, Thompson LD, Brandwein-Gensler MS, Weiss BG, Canis M, Purgina B, Prabhu AV, Lai C, Shuai Y, Carroll WR, Morlandt A, Duvvuri U, Kim S, Johnson JT, Ferris RL, Seethala R, Chiosea SI. Early Oral Tongue Squamous Cell Carcinoma: Sampling of Margins From Tumor Bed and Worse Local Control. JAMA Otolaryngol Head Neck Surg. 2015 Dec;141(12):1104-10. doi: 10.1001/jamaoto.2015.1351. PubMed PMID: 26225798; PMCID: PMC5242089.
Delgoffe GM, Powell JD. Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion. Mol Immunol. 2015 Dec;68(2 Pt C):492-6. doi: 10.1016/j.molimm.2015.07.026. PubMed PMID: 26256793; PMCID: PMC4837657.
Yip L, Nikiforova MN, Yoo JY, McCoy KL, Stang MT, Armstrong MJ, Nicholson KJ, Ohori NP, Coyne C, Hodak SP, Ferris RL, LeBeau SO, Nikiforov YE, Carty SE. Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer: a study of 1510 patients. Ann Surg. 2015 Sep;262(3):519-25; discussion 524-5. doi: 10.1097/SLA.0000000000001420. PubMed PMID: 26258321; PMCID: PMC5264519.
Whiteside TL. The potential of tumor-derived exosomes for noninvasive cancer monitoring. Expert Rev Mol Diagn. 2015;15(10):1293-310. doi: 10.1586/14737159.2015.1071666. PubMed PMID: 26289602; PMCID: PMC4813325.
Wang X, Zhao X, Feng C, Weinstein A, Xia R, Wen W, Lv Q, Zuo S, Tang P, Yang X, Chen X, Wang H, Zang S, Stollings L, Denning TL, Jiang J, Fan J, Zhang G, Zhang X, Zhu Y, Storkus W, Lu B. IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses. Cancer Cell. 2015 Sep 14;28(3):296-306. doi: 10.1016/j.ccell.2015.07.014. PubMed PMID: 26321222; PMCID: PMC4573903.
Maxwell JH, Grandis JR, Ferris RL. HPV-Associated Head and Neck Cancer: Unique Features of Epidemiology and Clinical Management. Annu Rev Med. 2016;6791-101. doi: 10.1146/annurev-med-051914-021907. PubMed PMID: 26332002; PMCID: PMC5242186.
Holsinger FC, Ferris RL. Transoral Endoscopic Head and Neck Surgery and Its Role Within the Multidisciplinary Treatment Paradigm of Oropharynx Cancer: Robotics, Lasers, and Clinical Trials. J Clin Oncol. 2015 Oct 10;33(29):3285-92. doi: 10.1200/JCO.2015.62.3157. PubMed PMID: 26351337; PMCID: PMC4586168.
Ferris RL. Immunology and Immunotherapy of Head and Neck Cancer. J Clin Oncol. 2015 Oct 10;33(29):3293-304. doi: 10.1200/JCO.2015.61.1509. PubMed PMID: 26351330; PMCID: PMC4586169.
Nikiforov YE, Carty SE, Chiosea SI, Coyne C, Duvvuri U, Ferris RL, Gooding WE, LeBeau SO, Ohori NP, Seethala RR, Tublin ME, Yip L, Nikiforova MN. Impact of the Multi-Gene ThyroSeq Next-Generation Sequencing Assay on Cancer Diagnosis in Thyroid Nodules with Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Cytology. Thyroid. 2015 Nov;25(11):1217-23. doi: 10.1089/thy.2015.0305. PubMed PMID: 26356635; PMCID: PMC4652198.
Finn OJ, Khleif SN, Herberman RB. The FDA guidance on therapeutic cancer vaccines: the need for revision to include preventive cancer vaccines or for a new guidance dedicated to them. Cancer Prev Res (Phila). 2015 Nov;8(11):1011-6. doi: 10.1158/1940-6207.CAPR-15-0234. PubMed PMID: 26353948; PMCID: PMC4633304.
Russell L, John S, Cullen J, Luo W, Shlomchik MJ, Garrett-Sinha LA. Requirement for Transcription Factor Ets1 in B Cell Tolerance to Self-Antigens. J Immunol. 2015 Oct 15;195(8):3574-83. doi: 10.4049/jimmunol.1500776. PubMed PMID: 26355157; PMCID: PMC4568556.
Shu Q, Lennemann NJ, Sarkar SN, Sadovsky Y, Coyne CB. ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry. PLoS Pathog. 2015 Sep;11(9):e1005150. doi: 10.1371/journal.ppat.1005150. PubMed PMID: 26372645; PMCID: PMC4570769.
de Almeida JR, Li R, Magnuson JS, Smith RV, Moore E, Lawson G, Remacle M, Ganly I, Kraus DH, Teng MS, Miles BA, White H, Duvvuri U, Ferris RL, Mehta V, Kiyosaki K, Damrose EJ, Wang SJ, Kupferman ME, Koh YW, Genden EM, Holsinger FC. Oncologic Outcomes After Transoral Robotic Surgery: A Multi-institutional Study. JAMA Otolaryngol Head Neck Surg. 2015 Dec;141(12):1043-1051. doi: 10.1001/jamaoto.2015.1508. PubMed PMID: 26402479; PMCID: PMC5019351.
Chapman BV, Wald AI, Akhtar P, Munko AC, Xu J, Gibson SP, Grandis JR, Ferris RL, Khan SA. MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer. BMC Cancer. 2015 Nov 6;15861. doi: 10.1186/s12885-015-1888-3. PubMed PMID: 26545583; PMCID: PMC4635687.
Li J, Srivastava RM, Ettyreddy A, Ferris RL. Cetuximab ameliorates suppressive phenotypes of myeloid antigen presenting cells in head and neck cancer patients. J Immunother Cancer. 2015;354. doi: 10.1186/s40425-015-0097-6. PubMed PMID: 26579227; PMCID: PMC4647471.
Macatangay BJ, Riddler SA, Wheeler ND, Spindler J, Lawani M, Hong F, Buffo MJ, Whiteside TL, Kearney MF, Mellors JW, Rinaldo CR. Therapeutic Vaccination With Dendritic Cells Loaded With Autologous HIV Type 1-Infected Apoptotic Cells. J Infect Dis. 2016 May 1;213(9):1400-9. doi: 10.1093/infdis/jiv582. PubMed PMID: 26647281; PMCID: PMC4813736.
Concha-Benavente F, Srivastava RM, Trivedi S, Lei Y, Chandran U, Seethala RR, Freeman GJ, Ferris RL. Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFNγ That Induce PD-L1 Expression in Head and Neck Cancer. Cancer Res. 2016 Mar 1;76(5):1031-43. doi: 10.1158/0008-5472.CAN-15-2001. PubMed PMID: 26676749; PMCID: PMC4775348.
Davis KS, Lim CM, Clump DA, Heron DE, Ohr JP, Kim S, Duvvuri U, Johnson JT, Ferris RL. Tumor volume as a predictor of survival in human papillomavirus-positive oropharyngeal cancer. Head Neck. 2016 Apr;38 Suppl 1E1613-7. doi: 10.1002/hed.24287. PubMed PMID: 26681273; PMCID: PMC4844840.
Xu RH, Wong EB, Rubio D, Roscoe F, Ma X, Nair S, Remakus S, Schwendener R, John S, Shlomchik M, Sigal LJ. Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection. Immunity. 2015 Dec 15;43(6):1148-59. doi: 10.1016/j.immuni.2015.11.015. PubMed PMID: 26682986; PMCID: PMC4684903.
Menekse E, McKolanis J, Finn OJ, McAuliffe PF, Johnson R, Soran A. Anti-MUC1 Antibody in Nipple Aspirate Fluids Correlates with Tumor Aggressiveness in Breast Cancer: A Feasibility Study. Dis Markers. 2015;2015179689. doi: 10.1155/2015/179689. PubMed PMID: 26693201; PMCID: PMC4676998.
Kiess AP, Agrawal N, Brierley JD, Duvvuri U, Ferris RL, Genden E, Wong RJ, Tuttle RM, Lee NY, Randolph GW. External-beam radiotherapy for differentiated thyroid cancer locoregional control: A statement of the American Head and Neck Society. Head Neck. 2016 Apr;38(4):493-8. doi: 10.1002/hed.24357. PubMed PMID: 26716601; PMCID: PMC4975923.
Dobrovolskaia MA, Shurin M, Shvedova AA. Current understanding of interactions between nanoparticles and the immune system. Toxicol Appl Pharmacol. 2016 May 15;29978-89. doi: 10.1016/j.taap.2015.12.022. PubMed PMID: 26739622; PMCID: PMC4811709.
Vlasova II, Kapralov AA, Michael ZP, Burkert SC, Shurin MR, Star A, Shvedova AA, Kagan VE. Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications. Toxicol Appl Pharmacol. 2016 May 15;29958-69. doi: 10.1016/j.taap.2016.01.002. PubMed PMID: 26768553; PMCID: PMC4811710.
Overacre AE, Vignali DA. T(reg) stability: to be or not to be. Curr Opin Immunol. 2016 Apr;3939-43. doi: 10.1016/j.coi.2015.12.009. PubMed PMID: 26774863; PMCID: PMC4801724.
Shinde A, Berhane H, Rhieu BH, Kalash R, Xu K, Goff J, Epperly MW, Franicola D, Zhang X, Dixon T, Shields D, Wang H, Wipf P, Parmar K, Guinan E, Kagan V, Tyurin V, Ferris RL, Zhang X, Li S, Greenberger JS. Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice. Radiat Res. 2016 Feb;185(2):134-50. doi: 10.1667/RR14035.1. PubMed PMID: 26789701; PMCID: PMC4773657.
Liu C, Workman CJ, Vignali DA. Targeting regulatory T cells in tumors. FEBS J. 2016 Jul;283(14):2731-48. doi: 10.1111/febs.13656. PubMed PMID: 26787424.
Yuan J, Hegde PS, Clynes R, Foukas PG, Harari A, Kleen TO, Kvistborg P, Maccalli C, Maecker HT, Page DB, Robins H, Song W, Stack EC, Wang E, Whiteside TL, Zhao Y, Zwierzina H, Butterfield LH, Fox BA. Novel technologies and emerging biomarkers for personalized cancer immunotherapy. J Immunother Cancer. 2016;43. doi: 10.1186/s40425-016-0107-3. PubMed PMID: 26788324; PMCID: PMC4717548.
Finn OJ, Beatty PL. Cancer immunoprevention. Curr Opin Immunol. 2016 Apr;3952-8. doi: 10.1016/j.coi.2016.01.002. PubMed PMID: 26799207; PMCID: PMC4805487.
Weisel FJ, Zuccarino-Catania GV, Chikina M, Shlomchik MJ. A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells. Immunity. 2016 Jan 19;44(1):116-130. doi: 10.1016/j.immuni.2015.12.004. PubMed PMID: 26795247; PMCID: PMC4724390.
Rowan NR, Johnson JT, Fratangelo CE, Smith BK, Kemerer PA, Ferris RL. Utility of a perioperative nutritional intervention on postoperative outcomes in high-risk head & neck cancer patients. Oral Oncol. 2016 Mar;5442-6. doi: 10.1016/j.oraloncology.2016.01.006. PubMed PMID: 26803343.
Muller L, Mitsuhashi M, Simms P, Gooding WE, Whiteside TL. Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets. Sci Rep. 2016 Feb 4;620254. doi: 10.1038/srep20254. PubMed PMID: 26842680; PMCID: PMC4740743.
Garcia-Bates TM, Kim E, Concha-Benavente F, Trivedi S, Mailliard RB, Gambotto A, Ferris RL. Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1. J Immunol. 2016 Mar 15;196(6):2870-8. doi: 10.4049/jimmunol.1502027. PubMed PMID: 26851223; PMCID: PMC4779745.
Thierauf J, Veit JA, Grünow J, Döscher J, Weißinger S, Whiteside T, Beutner D, Quaas A, Plinkert P, Hoffmann TK, Hess J. Expression of Submaxillary Gland Androgen-regulated Protein 3A (SMR3A) in Adenoid Cystic Carcinoma of the Head and Neck. Anticancer Res. 2016 Feb;36(2):611-5. PubMed PMID: 26851015.
Turnis ME, Sawant DV, Szymczak-Workman AL, Andrews LP, Delgoffe GM, Yano H, Beres AJ, Vogel P, Workman CJ, Vignali DA. Interleukin-35 Limits Anti-Tumor Immunity. Immunity. 2016 Feb 16;44(2):316-29. doi: 10.1016/j.immuni.2016.01.013. PubMed PMID: 26872697; PMCID: PMC4758699.
Veit JA, Heine D, Thierauf J, Lennerz J, Shetty S, Schuler PJ, Whiteside T, Beutner D, Meyer M, Grünewald I, Ritter G, Gnjatic S, Sikora AG, Hoffmann TK, Laban S. Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck. Head Neck. 2016 Jul;38(7):1008-16. doi: 10.1002/hed.24403. PubMed PMID: 26874246; PMCID: PMC5557286.
Zdanov S, Mandapathil M, Abu Eid R, Adamson-Fadeyi S, Wilson W, Qian J, Carnie A, Tarasova N, Mkrtichyan M, Berzofsky JA, Whiteside TL, Khleif SN. Mutant KRAS Conversion of Conventional T Cells into Regulatory T Cells. Cancer Immunol Res. 2016 Apr;4(4):354-65. doi: 10.1158/2326-6066.CIR-15-0241. PubMed PMID: 26880715; PMCID: PMC4884020.
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McCormick KD, Ghosh A, Trivedi S, Wang L, Coyne CB, Ferris RL, Sarkar SN. Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma. Carcinogenesis. 2016 May;37(5):522-9. doi: 10.1093/carcin/bgw032. PubMed PMID: 26992898; PMCID: PMC6086476.
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Horne ZD, Glaser SM, Vargo JA, Ferris RL, Balasubramani GK, Clump DA, Heron DE, Beriwal S. Confirmation of proposed human papillomavirus risk-adapted staging according to AJCC/UICC TNM criteria for positive oropharyngeal carcinomas. Cancer. 2016 Jul 1;122(13):2021-30. doi: 10.1002/cncr.30021. PubMed PMID: 27111669.
Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC. Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med. 2016 May 2;213(5):751-69. doi: 10.1084/jem.20150537. PubMed PMID: 27114609; PMCID: PMC4854724.
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Gildener-Leapman N, Kim J, Abberbock S, Choby GW, Mandal R, Duvvuri U, Ferris RL, Kim S. Utility of up-front transoral robotic surgery in tailoring adjuvant therapy. Head Neck. 2016 Aug;38(8):1201-7. doi: 10.1002/hed.24390. PubMed PMID: 27225507; PMCID: PMC5436619.
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Concha-Benavente F, Srivastava R, Ferrone S, Ferris RL. Immunological and clinical significance of HLA class I antigen processing machinery component defects in malignant cells. Oral Oncol. 2016 Jul;5852-8. doi: 10.1016/j.oraloncology.2016.05.008. PubMed PMID: 27264839; PMCID: PMC5264518.
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Ling DC, Vargo JA, Ferris RL, Ohr J, Clump DA, Yau WW, Duvvuri U, Kim S, Johnson JT, Bauman JE, Branstetter BF, Heron DE. Risk of Severe Toxicity According to Site of Recurrence in Patients Treated With Stereotactic Body Radiation Therapy for Recurrent Head and Neck Cancer. Int J Radiat Oncol Biol Phys. 2016 Jul 1;95(3):973-980. doi: 10.1016/j.ijrobp.2016.02.049. PubMed PMID: 27302512.
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Dobbins J, Gagnon E, Godec J, Pyrdol J, Vignali DA, Sharpe AH, Wucherpfennig KW. Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling. Sci Signal. 2016 Jul 26;9(438):ra75. doi: 10.1126/scisignal.aaf0626. PubMed PMID: 27460989; PMCID: PMC5929992.
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Lohmueller JJ, Sato S, Popova L, Chu IM, Tucker MA, Barberena R, Innocenti GM, Cudic M, Ham JD, Cheung WC, Polakiewicz RD, Finn OJ. Antibodies elicited by the first non-viral prophylactic cancer vaccine show tumor-specificity and immunotherapeutic potential. Sci Rep. 2016 Aug 22;631740. doi: 10.1038/srep31740. PubMed PMID: 27545199; PMCID: PMC4992835.
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Fecek RJ, Storkus WJ. Combination strategies to enhance the potency of monocyte-derived dendritic cell-based cancer vaccines. Immunotherapy. 2016 Oct;8(10):1205-18. doi: 10.2217/imt-2016-0071. PubMed PMID: 27605069; PMCID: PMC5619021.
Pollack IF, Jakacki RI, Butterfield LH, Hamilton RL, Panigrahy A, Normolle DP, Connelly AK, Dibridge S, Mason G, Whiteside TL, Okada H. Antigen-specific immunoreactivity and clinical outcome following vaccination with glioma-associated antigen peptides in children with recurrent high-grade gliomas: results of a pilot study. J Neurooncol. 2016 Dec;130(3):517-527. doi: 10.1007/s11060-016-2245-3. PubMed PMID: 27624914; PMCID: PMC5363717.
Cui A, Di Niro R, Vander Heiden JA, Briggs AW, Adams K, Gilbert T, O'Connor KC, Vigneault F, Shlomchik MJ, Kleinstein SH. A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data. J Immunol. 2016 Nov 1;197(9):3566-3574. doi: 10.4049/jimmunol.1502263. PubMed PMID: 27707999; PMCID: PMC5161250.
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Cascio S, Finn OJ. Intra- and Extra-Cellular Events Related to Altered Glycosylation of MUC1 Promote Chronic Inflammation, Tumor Progression, Invasion, and Metastasis. Biomolecules. 2016 Oct 13;6(4): doi: 10.3390/biom6040039. PubMed PMID: 27754373; PMCID: PMC5197949.
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Ols ML, Cullen JL, Turqueti-Neves A, Giles J, Shlomchik MJ. Dendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand. Immunity. 2016 Nov 15;45(5):1052-1065. doi: 10.1016/j.immuni.2016.10.005. PubMed PMID: 27793595; PMCID: PMC5112117.
Trivedi S, Srivastava RM, Concha-Benavente F, Ferrone S, Garcia-Bates TM, Li J, Ferris RL. Anti-EGFR Targeted Monoclonal Antibody Isotype Influences Antitumor Cellular Immunity in Head and Neck Cancer Patients. Clin Cancer Res. 2016 Nov 1;22(21):5229-5237. doi: 10.1158/1078-0432.CCR-15-2971. PubMed PMID: 27217441; PMCID: PMC5093040.
Visperas A, Vignali DA. Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them? J Immunol. 2016 Nov 15;197(10):3762-3770. doi: 10.4049/jimmunol.1601118. PubMed PMID: 27815439; PMCID: PMC5119643.
Chen Y, Xia R, Huang Y, Zhao W, Li J, Zhang X, Wang P, Venkataramanan R, Fan J, Xie W, Ma X, Lu B, Li S. An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy. Nat Commun. 2016 Nov 7;713443. doi: 10.1038/ncomms13443. PubMed PMID: 27819653; PMCID: PMC5103075.
Delgoffe GM. VHL Brings Warburg into the Memory Spotlight. Immunity. 2016 Nov 15;45(5):953-955. doi: 10.1016/j.immuni.2016.11.001. PubMed PMID: 27851921.
Li J, Shayan G, Avery L, Jie HB, Gildener-Leapman N, Schmitt N, Lu BF, Kane LP, Ferris RL. Tumor-infiltrating Tim-3+ T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk. Oncoimmunology. 2016;5(10):e1200778. doi: 10.1080/2162402X.2016.1200778. PubMed PMID: 27853635; PMCID: PMC5087305.
Turner MT, Byrd JK, Ferris RL. Current Role of Surgery in the Management of Oropharyngeal Cancer. J Oncol Pract. 2016 Nov;12(11):1176-1183. doi: 10.1200/JOP.2016.015263. PubMed PMID: 27858544; PMCID: PMC5423357.
Eskiizmir G, Baskın Y, Yalçın F, Ellidokuz H, Ferris RL. Risk factors for radiation failure in early-stage glottic carcinoma: A systematic review and meta-analysis. Oral Oncol. 2016 Nov;6290-100. doi: 10.1016/j.oraloncology.2016.10.013. PubMed PMID: 27865377.
Bunimovich YL, Keskinov AA, Shurin GV, Shurin MR. Schwann cells: a new player in the tumor microenvironment. Cancer Immunol Immunother. 2017 Aug;66(8):959-968. doi: 10.1007/s00262-016-1929-z. PubMed PMID: 27885383; PMCID: PMC5509513.
Delgoffe GM. Filling the Tank: Keeping Antitumor T Cells Metabolically Fit for the Long Haul. Cancer Immunol Res. 2016 Dec;4(12):1001-1006. doi: 10.1158/2326-6066.CIR-16-0244. PubMed PMID: 27908931; PMCID: PMC5408882.
Walline HM, Carey TE, Goudsmit CM, Bellile EL, D'Souza G, Peterson LA, McHugh JB, Pai SI, Lee JJ, Shin DM, Ferris RL, HNC SPORE HIV supplement consortium.. High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV. Mol Cancer Res. 2017 Feb;15(2):179-188. doi: 10.1158/1541-7786.MCR-16-0255. PubMed PMID: 27899422; PMCID: PMC5290187.
Scharping NE, Delgoffe GM. Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity. Vaccines (Basel). 2016 Dec 6;4(4): doi: 10.3390/vaccines4040046. PubMed PMID: 27929420; PMCID: PMC5192366.
Scharping NE, Menk AV, Whetstone RD, Zeng X, Delgoffe GM. Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia. Cancer Immunol Res. 2017 Jan;5(1):9-16. doi: 10.1158/2326-6066.CIR-16-0103. PubMed PMID: 27941003; PMCID: PMC5340074.
Phong B, Avery L, Menk AV, Delgoffe GM, Kane LP. Cutting Edge: Murine Mast Cells Rapidly Modulate Metabolic Pathways Essential for Distinct Effector Functions. J Immunol. 2017 Jan 15;198(2):640-644. doi: 10.4049/jimmunol.1601150. PubMed PMID: 27974455; PMCID: PMC5225044.
Hu W, Li X, Li Q, Tan Y, Xu B, Xie Q, Deng X, Lu B, Jiang J, Wu C. Interleukin-33 Expression does not Correlate with Survival of Gastric Cancer Patients. Pathol Oncol Res. 2017 Jul;23(3):615-619. doi: 10.1007/s12253-016-0167-1. PubMed PMID: 28000059.
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Panebianco F, Kelly LM, Liu P, Zhong S, Dacic S, Wang X, Singhi AD, Dhir R, Chiosea SI, Kuan SF, Bhargava R, Dabbs D, Trivedi S, Gandhi M, Diaz R, Wald AI, Carty SE, Ferris RL, Lee AV, Nikiforova MN, Nikiforov YE. THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2307-2312. doi: 10.1073/pnas.1614265114. PubMed PMID: 28193878; PMCID: PMC5338560.
Albergotti WG, Gooding WE, Kubik MW, Geltzeiler M, Kim S, Duvvuri U, Ferris RL. Assessment of Surgical Learning Curves in Transoral Robotic Surgery for Squamous Cell Carcinoma of the Oropharynx. JAMA Otolaryngol Head Neck Surg. 2017 Jun 1;143(6):542-548. doi: 10.1001/jamaoto.2016.4132. PubMed PMID: 28196200; PMCID: PMC5614443.
Shayan G, Srivastava R, Li J, Schmitt N, Kane LP, Ferris RL. Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer. Oncoimmunology. 2017;6(1):e1261779. doi: 10.1080/2162402X.2016.1261779. PubMed PMID: 28197389; PMCID: PMC5283618.
Concha-Benavente F, Ferris RL. Oncogenic growth factor signaling mediating tumor escape from cellular immunity. Curr Opin Immunol. 2017 Apr;4552-59. doi: 10.1016/j.coi.2017.01.004. PubMed PMID: 28208102; PMCID: PMC5449256.
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Giles JR, Neves AT, Marshak-Rothstein A, Shlomchik MJ. Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation. JCI Insight. 2017 Feb 23;2(4):e90870. doi: 10.1172/jci.insight.90870. PubMed PMID: 28239656; PMCID: PMC5313065.
Geltzeiler M, Doerfler S, Turner M, Albergotti WG, Kubik M, Kim S, Ferris R, Duvvuri U. Transoral robotic surgery for management of cervical unknown primary squamous cell carcinoma: Updates on efficacy, surgical technique and margin status. Oral Oncol. 2017 Mar;669-13. doi: 10.1016/j.oraloncology.2016.12.033. PubMed PMID: 28249654.
Andrews LP, Marciscano AE, Drake CG, Vignali DA. LAG3 (CD223) as a cancer immunotherapy target. Immunol Rev. 2017 Mar;276(1):80-96. doi: 10.1111/imr.12519. PubMed PMID: 28258692; PMCID: PMC5338468.
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Du W, Yang M, Turner A, Xu C, Ferris RL, Huang J, Kane LP, Lu B. TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action. Int J Mol Sci. 2017 Mar 16;18(3): doi: 10.3390/ijms18030645. PubMed PMID: 28300768; PMCID: PMC5372657.
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Teng B, Jiang J, Zhao L, Gao J, Chen J, Liu Z, Wang H, Lu B. Ginsenoside PPD's Antitumor Effect via Down-Regulation of mTOR Revealed by Super-Resolution Imaging. Molecules. 2017 Mar 19;22(3): doi: 10.3390/molecules22030486. PubMed PMID: 28335497; PMCID: PMC6155369.
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Gebhardt BJ, Ohr JP, Ferris RL, Duvvuri U, Kim S, Johnson JT, Heron DE, Clump DA 2nd. Concurrent Chemoradiotherapy in the Adjuvant Treatment of High-risk Primary Salivary Gland Malignancies. Am J Clin Oncol. 2018 Sep;41(9):888-893. doi: 10.1097/COC.0000000000000386. PubMed PMID: 28394767.
Ludwig S, Floros T, Theodoraki MN, Hong CS, Jackson EK, Lang S, Whiteside TL. Suppression of Lymphocyte Functions by Plasma Exosomes Correlates with Disease Activity in Patients with Head and Neck Cancer. Clin Cancer Res. 2017 Aug 15;23(16):4843-4854. doi: 10.1158/1078-0432.CCR-16-2819. PubMed PMID: 28400428; PMCID: PMC5559308.
Whiteside TL. Targeting adenosine in cancer immunotherapy: a review of recent progress. Expert Rev Anticancer Ther. 2017 Jun;17(6):527-535. doi: 10.1080/14737140.2017.1316197. PubMed PMID: 28399672.
Fabian KP, Chi-Sabins N, Taylor JL, Fecek R, Weinstein A, Storkus WJ. Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice. Oncoimmunology. 2017;6(3):e1290035. doi: 10.1080/2162402X.2017.1290035. PubMed PMID: 28405524; PMCID: PMC5384378.
Jie HB, Srivastava RM, Argiris A, Bauman JE, Kane LP, Ferris RL. Increased PD-1+ and TIM-3+ TILs during Cetuximab Therapy Inversely Correlate with Response in Head and Neck Cancer Patients. Cancer Immunol Res. 2017 May;5(5):408-416. doi: 10.1158/2326-6066.CIR-16-0333. PubMed PMID: 28408386; PMCID: PMC5497750.
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Vujanovic L, Stahl EC, Pardee AD, Geller DA, Tsung A, Watkins SC, Gibson GA, Storkus WJ, Butterfield LH. Tumor-Derived α-Fetoprotein Directly Drives Human Natural Killer-Cell Activation and Subsequent Cell Death. Cancer Immunol Res. 2017 Jun;5(6):493-502. doi: 10.1158/2326-6066.CIR-16-0216. PubMed PMID: 28468916.
Grabosch S, Tseng G, Edwards RP, Lankes HA, Moore K, Odunsi K, Vlad A, Ma T, Strange M, Brozick J, Lugade A, Omilian A, Bshara W, Stuckey AR, Walker JL, Birrer M. Multiplex profiling identifies distinct local and systemic alterations during intraperitoneal chemotherapy for ovarian cancer: An NRG Oncology/Gynecologic Oncology Group Study. Gynecol Oncol. 2017 Jul;146(1):137-145. doi: 10.1016/j.ygyno.2017.04.008. PubMed PMID: 28483269; PMCID: PMC5705948.
Vogel P, Janke L, Gravano DM, Lu M, Sawant DV, Bush D, Shuyu E, Vignali DAA, Pillai A, Rehg JE. Globule Leukocytes and Other Mast Cells in the Mouse Intestine. Vet Pathol. 2018 Jan;55(1):76-97. doi: 10.1177/0300985817705174. PubMed PMID: 28494703.
Butterfield LH, Zhao F, Lee S, Tarhini AA, Margolin KA, White RL, Atkins MB, Cohen GI, Whiteside TL, Kirkwood JM, Lawson DH. Immune Correlates of GM-CSF and Melanoma Peptide Vaccination in a Randomized Trial for the Adjuvant Therapy of Resected High-Risk Melanoma (E4697). Clin Cancer Res. 2017 Sep 1;23(17):5034-5043. doi: 10.1158/1078-0432.CCR-16-3016. PubMed PMID: 28536308; PMCID: PMC5581724.
Overacre-Delgoffe AE, Chikina M, Dadey RE, Yano H, Brunazzi EA, Shayan G, Horne W, Moskovitz JM, Kolls JK, Sander C, Shuai Y, Normolle DP, Kirkwood JM, Ferris RL, Delgoffe GM, Bruno TC, Workman CJ, Vignali DAA. Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity. Cell. 2017 Jun 1;169(6):1130-1141.e11. doi: 10.1016/j.cell.2017.05.005. PubMed PMID: 28552348; PMCID: PMC5509332.
Guo ZS, Liu Z, Kowalsky S, Feist M, Kalinski P, Lu B, Storkus WJ, Bartlett DL. Oncolytic Immunotherapy: Conceptual Evolution, Current Strategies, and Future Perspectives. Front Immunol. 2017;8555. doi: 10.3389/fimmu.2017.00555. PubMed PMID: 28555136; PMCID: PMC5430078.
Kinner-Bibeau LB, Sedlacek AL, Messmer MN, Watkins SC, Binder RJ. HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells. Nat Commun. 2017 May 31;815648. doi: 10.1038/ncomms15648. PubMed PMID: 28561043; PMCID: PMC5460028.
Budiu RA, Vlad AM, Nazario L, Bathula C, Cooper KL, Edmed J, Thaker PH, Urban J, Kalinski P, Lee AV, Elishaev EL, Conrads TP, Flint MS. Restraint and Social Isolation Stressors Differentially Regulate Adaptive Immunity and Tumor Angiogenesis in a Breast Cancer Mouse Model. Cancer Clin Oncol. 2017 May;6(1):12-24. doi: 10.5539/cco.v6n1p12. PubMed PMID: 28603578; PMCID: PMC5464739.
Concha-Benavente F, Ferris RL. Reversing EGFR Mediated Immunoescape by Targeted Monoclonal Antibody Therapy. Front Pharmacol. 2017;8332. doi: 10.3389/fphar.2017.00332. PubMed PMID: 28611673; PMCID: PMC5447743.
Sweet RA, Nickerson KM, Cullen JL, Wang Y, Shlomchik MJ. B Cell-Extrinsic Myd88 and Fcer1g Negatively Regulate Autoreactive and Normal B Cell Immune Responses. J Immunol. 2017 Aug 1;199(3):885-893. doi: 10.4049/jimmunol.1600861. PubMed PMID: 28659358; PMCID: PMC5547912.
Mazorra Z, Lavastida A, Concha-Benavente F, Valdés A, Srivastava RM, García-Bates TM, Hechavarría E, González Z, González A, Lugiollo M, Cuevas I, Frómeta C, Mestre BF, Barroso MC, Crombet T, Ferris RL. Nimotuzumab Induces NK Cell Activation, Cytotoxicity, Dendritic Cell Maturation and Expansion of EGFR-Specific T Cells in Head and Neck Cancer Patients. Front Pharmacol. 2017;8382. doi: 10.3389/fphar.2017.00382. PubMed PMID: 28674498; PMCID: PMC5474456.
Liu Z, Hao X, Zhang Y, Zhang J, Carey CD, Falo LD Jr, Storkus WJ, You Z. Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist α-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity. Oncoimmunology. 2017;6(6):e1315487. doi: 10.1080/2162402X.2017.1315487. PubMed PMID: 28680744; PMCID: PMC5486177.
Weinstein AM, Chen L, Brzana EA, Patil PR, Taylor JL, Fabian KL, Wallace CT, Jones SD, Watkins SC, Lu B, Stroncek DF, Denning TL, Fu YX, Cohen PA, Storkus WJ. Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment. Oncoimmunology. 2017;6(6):e1322238. doi: 10.1080/2162402X.2017.1322238. PubMed PMID: 28680760; PMCID: PMC5486180.
Zakiryanova GK, Kustova E, Urazalieva NT, Amirbekov A, Baimuchametov ET, Nakisbekov NN, Shurin MR. Alterations of oncogenes expression in NK cells in patients with cancer. Immun Inflamm Dis. 2017 Dec;5(4):493-502. doi: 10.1002/iid3.179. PubMed PMID: 28695716; PMCID: PMC5691306.
Cramer JD, Speedy SE, Ferris RL, Rademaker AW, Patel UA, Samant S. National evaluation of multidisciplinary quality metrics for head and neck cancer. Cancer. 2017 Nov 15;123(22):4372-4381. doi: 10.1002/cncr.30902. PubMed PMID: 28727137.
Bettini ML, Chou PC, Guy CS, Lee T, Vignali KM, Vignali DAA. Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development. J Immunol. 2017 Sep 1;199(5):1555-1560. doi: 10.4049/jimmunol.1700069. PubMed PMID: 28733484; PMCID: PMC5568475.
Hong CS, Funk S, Whiteside TL. Isolation of Biologically Active Exosomes from Plasma of Patients with Cancer. Methods Mol Biol. 2017;1633257-265. doi: 10.1007/978-1-4939-7142-8_16. PubMed PMID: 28735492.
Whiteside TL. Head and Neck Carcinoma Immunotherapy: Facts and Hopes. Clin Cancer Res. 2018 Jan 1;24(1):6-13. doi: 10.1158/1078-0432.CCR-17-1261. PubMed PMID: 28751445; PMCID: PMC5754223.
Harrington KJ, Ferris RL, Blumenschein G Jr, Colevas AD, Fayette J, Licitra L, Kasper S, Even C, Vokes EE, Worden F, Saba NF, Kiyota N, Haddad R, Tahara M, Grünwald V, Shaw JW, Monga M, Lynch M, Taylor F, DeRosa M, Morrissey L, Cocks K, Gillison ML, Guigay J. Nivolumab versus standard, single-agent therapy of investigator's choice in recurrent or metastatic squamous cell carcinoma of the head and neck (CheckMate 141): health-related quality-of-life results from a randomised, phase 3 trial. Lancet Oncol. 2017 Aug;18(8):1104-1115. doi: 10.1016/S1470-2045(17)30421-7. PubMed PMID: 28651929; PMCID: PMC6461049.
Kubik M, Mandal R, Albergotti W, Duvvuri U, Ferris RL, Kim S. Effect of transcervical arterial ligation on the severity of postoperative hemorrhage after transoral robotic surgery. Head Neck. 2017 Aug;39(8):1510-1515. doi: 10.1002/hed.24677. PubMed PMID: 28570011; PMCID: PMC5789773.
Silva GO, Michael ZP, Bian L, Shurin GV, Mulato M, Shurin MR, Star A. Nanoelectronic Discrimination of Nonmalignant and Malignant Cells Using Nanotube Field-Effect Transistors. ACS Sens. 2017 Aug 25;2(8):1128-1132. doi: 10.1021/acssensors.7b00383. PubMed PMID: 28758384; PMCID: PMC6538068.
Albergotti WG, Jordan J, Anthony K, Abberbock S, Wasserman-Wincko T, Kim S, Ferris RL, Duvvuri U. A prospective evaluation of short-term dysphagia after transoral robotic surgery for squamous cell carcinoma of the oropharynx. Cancer. 2017 Aug 15;123(16):3132-3140. doi: 10.1002/cncr.30712. PubMed PMID: 28467606; PMCID: PMC5544540.
Kikuchi M, Clump DA, Srivastava RM, Sun L, Zeng D, Diaz-Perez JA, Anderson CJ, Edwards WB, Ferris RL. Preclinical immunoPET/CT imaging using Zr-89-labeled anti-PD-L1 monoclonal antibody for assessing radiation-induced PD-L1 upregulation in head and neck cancer and melanoma. Oncoimmunology. 2017;6(7):e1329071. doi: 10.1080/2162402X.2017.1329071. PubMed PMID: 28811971; PMCID: PMC5543907.
Chen Q, Xu B, Lan L, Yang D, Yang M, Jiang J, Lu B, Shen Y. High mRNA expression level of IL-6R was associated with better prognosis for patients with ovarian cancer: a pooled meta-analysis. Sci Rep. 2017 Aug 18;7(1):8769. doi: 10.1038/s41598-017-09333-8. PubMed PMID: 28821817; PMCID: PMC5562889.
Meng W, Zhang B, Schwartz GW, Rosenfeld AM, Ren D, Thome JJC, Carpenter DJ, Matsuoka N, Lerner H, Friedman AL, Granot T, Farber DL, Shlomchik MJ, Hershberg U, Luning Prak ET. An atlas of B-cell clonal distribution in the human body. Nat Biotechnol. 2017 Sep;35(9):879-884. doi: 10.1038/nbt.3942. PubMed PMID: 28829438; PMCID: PMC5679700.
Chen L, Xiong Y, Li J, Zheng X, Zhou Q, Turner A, Wu C, Lu B, Jiang J. PD-L1 Expression Promotes Epithelial to Mesenchymal Transition in Human Esophageal Cancer. Cell Physiol Biochem. 2017;42(6):2267-2280. doi: 10.1159/000480000. PubMed PMID: 28848143.
Boyiadzis M, Agha M, Redner RL, Sehgal A, Im A, Hou JZ, Farah R, Dorritie KA, Raptis A, Lim SH, Wang H, Lapteva N, Mei Z, Butterfield LH, Rooney CM, Whiteside TL. Phase 1 clinical trial of adoptive immunotherapy using "off-the-shelf" activated natural killer cells in patients with refractory and relapsed acute myeloid leukemia. Cytotherapy. 2017 Oct;19(10):1225-1232. doi: 10.1016/j.jcyt.2017.07.008. PubMed PMID: 28864289.
Smith T, Lin X, Mello M, Marquardt K, Cheung J, Lu B, Sherman LA, Verdeil G. Peripheral Deletion of CD8 T Cells Requires p38 MAPK in Cross-Presenting Dendritic Cells. J Immunol. 2017 Oct 15;199(8):2713-2720. doi: 10.4049/jimmunol.1700427. PubMed PMID: 28864471; PMCID: PMC5679299.
Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH, Vignali DAA, Stohlman SA, Baldwin WM 3rd, Min B. Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10190-10195. doi: 10.1073/pnas.1703100114. PubMed PMID: 28874534; PMCID: PMC5617261.
Kansy BA, Concha-Benavente F, Srivastava RM, Jie HB, Shayan G, Lei Y, Moskovitz J, Moy J, Li J, Brandau S, Lang S, Schmitt NC, Freeman GJ, Gooding WE, Clump DA, Ferris RL. PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer. Cancer Res. 2017 Nov 15;77(22):6353-6364. doi: 10.1158/0008-5472.CAN-16-3167. PubMed PMID: 28904066; PMCID: PMC5690836.
Vargo JA, Ward MC, Caudell JJ, Riaz N, Dunlap NE, Isrow D, Zakem SJ, Dault J, Awan MJ, Higgins KA, Hassanadeh C, Beitler JJ, Reddy CA, Marcrom S, Boggs DH, Bonner JA, Yao M, Machtay M, Siddiqui F, Trotti AM, Lee NY, Koyfman SA, Ferris RL, Heron DE. A Multi-institutional Comparison of SBRT and IMRT for Definitive Reirradiation of Recurrent or Second Primary Head and Neck Cancer. Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):595-605. doi: 10.1016/j.ijrobp.2017.04.017. PubMed PMID: 28899556.
Muller L, Simms P, Hong CS, Nishimura MI, Jackson EK, Watkins SC, Whiteside TL. Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms. Oncoimmunology. 2017;6(8):e1261243. doi: 10.1080/2162402X.2016.1261243. PubMed PMID: 28919985; PMCID: PMC5593709.
Zhang H, Kim S, Chen Z, Nannapaneni S, Chen AY, Moore CE, Sica G, Mosunjac M, Nguyen MLT, D'Souza G, Carey TE, Peterson LA, McHugh JB, Graham M, Komarck CM, Wolf GT, Walline HM, Bellile E, Riddell J 4th, Pai SI, Sidransky D, Westra WH, William WN Jr, Lee JJ, El-Naggar AK, Ferris RL, Seethala R, Grandis JR, Chen ZG, Saba NF, Shin DM, Head and Neck Cancer SPORE HIV supplement consortium.. Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma. Head Neck. 2017 Dec;39(12):2433-2443. doi: 10.1002/hed.24911. PubMed PMID: 28945296; PMCID: PMC5808949.
Lang Kuhs KA, Kreimer AR, Trivedi S, Holzinger D, Pawlita M, Pfeiffer RM, Gibson SP, Schmitt NC, Hildesheim A, Waterboer T, Ferris RL. Human papillomavirus 16 E6 antibodies are sensitive for human papillomavirus-driven oropharyngeal cancer and are associated with recurrence. Cancer. 2017 Nov 15;123(22):4382-4390. doi: 10.1002/cncr.30966. PubMed PMID: 28950407; PMCID: PMC5743332.
Kiyota N, Hasegawa Y, Takahashi S, Yokota T, Yen CJ, Iwae S, Shimizu Y, Hong RL, Goto M, Kang JH, Sum Kenneth Li W, Ferris RL, Gillison M, Namba Y, Monga M, Lynch M, Tahara M. A randomized, open-label, Phase III clinical trial of nivolumab vs. therapy of investigator's choice in recurrent squamous cell carcinoma of the head and neck: A subanalysis of Asian patients versus the global population in checkmate 141. Oral Oncol. 2017 Oct;73138-146. doi: 10.1016/j.oraloncology.2017.07.023. PubMed PMID: 28939066.
Pietrowska M, Funk S, Gawin M, Marczak Ł, Abramowicz A, Widłak P, Whiteside T. Isolation of Exosomes for the Purpose of Protein Cargo Analysis with the Use of Mass Spectrometry. Methods Mol Biol. 2017;1654291-307. doi: 10.1007/978-1-4939-7231-9_22. PubMed PMID: 28986800.
Gleber-Netto FO, Zhao M, Trivedi S, Wang J, Jasser S, McDowell C, Kadara H, Zhang J, Wang J, William WN Jr, Lee JJ, Nguyen ML, Pai SI, Walline HM, Shin DM, Ferris RL, Carey TE, Myers JN, Pickering CR, Head and Neck Cancer Specialized Program of Research Excellence (SPORE) Human Immunodeficiency Virus (HIV) Supplement Consortium.. Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer. 2018 Jan 1;124(1):84-94. doi: 10.1002/cncr.31063. PubMed PMID: 29053175; PMCID: PMC5785080.
Shayan G, Kansy BA, Gibson SP, Srivastava RM, Bryan JK, Bauman JE, Ohr J, Kim S, Duvvuri U, Clump DA, Heron DE, Johnson JT, Hershberg RM, Ferris RL. Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 Stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals. Clin Cancer Res. 2018 Jan 1;24(1):62-72. doi: 10.1158/1078-0432.CCR-17-0357. PubMed PMID: 29061643; PMCID: PMC5754237.
Prabhu AV, Sturgis CD, Lai C, Maxwell JH, Merzianu M, Hernandez-Prera JC, Purgina B, Thompson LDR, Tuluc M, Yang X, Seethala RR, Ferris RL, Chiosea SI. Improving margin revision: Characterization of tumor bed margins in early oral tongue cancer. Oral Oncol. 2017 Dec;75184-188. doi: 10.1016/j.oraloncology.2017.10.013. PubMed PMID: 29074194; PMCID: PMC5774620.
Persky MJ, Albergotti WG, Rath TJ, Kubik MW, Abberbock S, Geltzeiler M, Kim S, Duvvuri U, Ferris RL. Positive Margins by Oropharyngeal Subsite in Transoral Robotic Surgery for T1/T2 Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2018 Apr;158(4):660-666. doi: 10.1177/0194599817742852. PubMed PMID: 29182490; PMCID: PMC5880728.
Hong CS, Sharma P, Yerneni SS, Simms P, Jackson EK, Whiteside TL, Boyiadzis M. Circulating exosomes carrying an immunosuppressive cargo interfere with cellular immunotherapy in acute myeloid leukemia. Sci Rep. 2017 Oct 31;7(1):14684. doi: 10.1038/s41598-017-14661-w. PubMed PMID: 29089618; PMCID: PMC5666018.
Roberts AW, Lee BL, Deguine J, John S, Shlomchik MJ, Barton GM. Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells. Immunity. 2017 Nov 21;47(5):913-927.e6. doi: 10.1016/j.immuni.2017.10.006. PubMed PMID: 29150239; PMCID: PMC5728676.
Ling DC, Bakkenist CJ, Ferris RL, Clump DA. Role of Immunotherapy in Head and Neck Cancer. Semin Radiat Oncol. 2018 Jan;28(1):12-16. doi: 10.1016/j.semradonc.2017.08.009. PubMed PMID: 29173750.
Crompton JG, Klemen N, Kammula US. Metastasectomy for Tumor-Infiltrating Lymphocytes: An Emerging Operative Indication in Surgical Oncology. Ann Surg Oncol. 2018 Feb;25(2):565-572. doi: 10.1245/s10434-017-6266-8. PubMed PMID: 29188500; PMCID: PMC5758677.
Ferris RL, Lenz HJ, Trotta AM, García-Foncillas J, Schulten J, Audhuy F, Merlano M, Milano G. Rationale for combination of therapeutic antibodies targeting tumor cells and immune checkpoint receptors: Harnessing innate and adaptive immunity through IgG1 isotype immune effector stimulation. Cancer Treat Rev. 2018 Feb;6348-60. doi: 10.1016/j.ctrv.2017.11.008. PubMed PMID: 29223828.
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Pai SI, Jack Lee J, Carey TE, Westra WH, Ferrone S, Moore C, Mosunjac MB, Shin DM, Ferris RL, HNC SPORE HIV supplement consortium.. HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers. Oral Oncol. 2018 Feb;7792-97. doi: 10.1016/j.oraloncology.2017.12.014. PubMed PMID: 29362132; PMCID: PMC5786382.
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Lu S, Concha-Benavente F, Shayan G, Srivastava RM, Gibson SP, Wang L, Gooding WE, Ferris RL. STING activation enhances cetuximab-mediated NK cell activation and DC maturation and correlates with HPV+ status in head and neck cancer. Oral Oncol. 2018 Mar;78186-193. doi: 10.1016/j.oraloncology.2018.01.019. PubMed PMID: 29496049; PMCID: PMC5877820.
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Moskovitz J, Moy J, Ferris RL. Immunotherapy for Head and Neck Squamous Cell Carcinoma. Curr Oncol Rep. 2018 Mar 3;20(2):22. doi: 10.1007/s11912-018-0654-5. PubMed PMID: 29502288; PMCID: PMC5835060.
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Cramer JD, Reddy A, Ferris RL, Duvvuri U, Samant S. Comparison of the seventh and eighth edition american joint committee on cancer oral cavity staging systems. Laryngoscope. 2018 Oct;128(10):2351-2360. doi: 10.1002/lary.27205. PubMed PMID: 29658104.
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Liu Z, McMichael EL, Shayan G, Li J, Chen K, Srivastava R, Kane LP, Lu B, Ferris RL. Novel Effector Phenotype of Tim-3+ Regulatory T Cells Leads to Enhanced Suppressive Function in Head and Neck Cancer Patients. Clin Cancer Res. 2018 Sep 15;24(18):4529-4538. doi: 10.1158/1078-0432.CCR-17-1350. PubMed PMID: 29712685; PMCID: PMC6139056.
Du T, Zhu L, Levine KM, Tasdemir N, Lee AV, Vignali DAA, Houten BV, Tseng GC, Oesterreich S. Invasive lobular and ductal breast carcinoma differ in immune response, protein translation efficiency and metabolism. Sci Rep. 2018 May 8;8(1):7205. doi: 10.1038/s41598-018-25357-0. PubMed PMID: 29739984; PMCID: PMC5940770.
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Albergotti WG, Abberbock S, Mathews F, Ferris RL, Johnson JT, Duvvuri U, Kim S. Oligometastatic status as predictor of survival in metastatic human papillomavirus-positive oropharyngeal carcinoma. Head Neck. 2018 Aug;40(8):1685-1690. doi: 10.1002/hed.25171. PubMed PMID: 29756301.
Tan YS, Sansanaphongpricha K, Xie Y, Donnelly CR, Luo X, Heath BR, Zhao X, Bellile E, Hu H, Chen H, Polverini PJ, Chen Q, Young S, Carey TE, Nör JE, Ferris RL, Wolf GT, Sun D, Lei YL. Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine. Clin Cancer Res. 2018 Sep 1;24(17):4242-4255. doi: 10.1158/1078-0432.CCR-17-2807. PubMed PMID: 29769207; PMCID: PMC6125216.
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Boyiadzis M, Whiteside TL. Exosomes in acute myeloid leukemia inhibit hematopoiesis. Curr Opin Hematol. 2018 Jul;25(4):279-284. doi: 10.1097/MOH.0000000000000439. PubMed PMID: 29846239.
Theodoraki MN, Yerneni S, Sarkar SN, Orr B, Muthuswamy R, Voyten J, Modugno F, Jiang W, Grimm M, Basse PH, Bartlett DL, Edwards RP, Kalinski P. Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment. Cancer Res. 2018 Aug 1;78(15):4292-4302. doi: 10.1158/0008-5472.CAN-17-3985. PubMed PMID: 29853604.
Theodoraki MN, Yerneni SS, Brunner C, Theodorakis J, Hoffmann TK, Whiteside TL. Plasma-derived Exosomes Reverse Epithelial-to-Mesenchymal Transition after Photodynamic Therapy of Patients with Head and Neck Cancer. Oncoscience. 2018 Mar;5(3-4):75-87. doi: 10.18632/oncoscience.410. PubMed PMID: 29854876; PMCID: PMC5978437.
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Podojil JR, Chiang MY, Ifergan I, Copeland R, Liu LN, Maloveste S, Langermann S, Liebenson D, Balabanov R, Chi H, Chen L, Vignali DAA, Miller SD. B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex. J Immunol. 2018 Aug 1;201(3):897-907. doi: 10.4049/jimmunol.1700811. PubMed PMID: 29898965.
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Choi J, Beaino W, Fecek RJ, Fabian KPL, Laymon CM, Kurland BF, Storkus WJ, Anderson CJ. Combined VLA-4-Targeted Radionuclide Therapy and Immunotherapy in a Mouse Model of Melanoma. J Nucl Med. 2018 Dec;59(12):1843-1849. doi: 10.2967/jnumed.118.209510. PubMed PMID: 29959213; PMCID: PMC6278902.
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Albers AE, Qian X, Kaufmann AM, Mytilineos D, Ferris RL, Hoffmann TK, DeLeo AB. Phenotype of p53 wild-type epitope-specific T cells in the circulation of patients with head and neck cancer. Sci Rep. 2018 Jul 16;8(1):10716. doi: 10.1038/s41598-018-29067-5. PubMed PMID: 30013227; PMCID: PMC6048165.
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Ludwig N, Yerneni SS, Razzo BM, Whiteside TL. Exosomes from HNSCC Promote Angiogenesis through Reprogramming of Endothelial Cells. Mol Cancer Res. 2018 Nov;16(11):1798-1808. doi: 10.1158/1541-7786.MCR-18-0358. PubMed PMID: 30042174.
Overacre-Delgoffe AE, Vignali DAA. Treg Fragility: A Prerequisite for Effective Antitumor Immunity? Cancer Immunol Res. 2018 Aug;6(8):882-887. doi: 10.1158/2326-6066.CIR-18-0066. PubMed PMID: 30068755; PMCID: PMC6080214.
Qin Y, Vasilatos SN, Chen L, Wu H, Cao Z, Fu Y, Huang M, Vlad AM, Lu B, Oesterreich S, Davidson NE, Huang Y. Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade. Oncogene. 2019 Jan;38(3):390-405. doi: 10.1038/s41388-018-0451-5. PubMed PMID: 30111819; PMCID: PMC6336685.
Geltzeiler M, Bertolet M, Albergotti W, Gleysteen J, Olson B, Persky M, Gross N, Li R, Andersen P, Kim S, Ferris RL, Duvvuri U, Clayburgh D. Staging HPV-related oropharyngeal cancer: Validation of AJCC-8 in a surgical cohort. Oral Oncol. 2018 Sep;8482-87. doi: 10.1016/j.oraloncology.2018.07.013. PubMed PMID: 30115481.
Tilstra JS, Avery L, Menk AV, Gordon RA, Smita S, Kane LP, Chikina M, Delgoffe GM, Shlomchik MJ. Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted. J Clin Invest. 2018 Nov 1;128(11):4884-4897. doi: 10.1172/JCI120859. PubMed PMID: 30130253; PMCID: PMC6205402.
Xu B, Chen Q, Yue C, Lan L, Jiang J, Shen Y, Lu B. Prognostic value of IL-6R mRNA in lung adenocarcinoma and squamous cell carcinoma. Oncol Lett. 2018 Sep;16(3):2935-2948. doi: 10.3892/ol.2018.9044. PubMed PMID: 30127882; PMCID: PMC6096061.
Zhou Y, Shurin GV, Zhong H, Bunimovich YL, Han B, Shurin MR. Schwann Cells Augment Cell Spreading and Metastasis of Lung Cancer. Cancer Res. 2018 Oct 15;78(20):5927-5939. doi: 10.1158/0008-5472.CAN-18-1702. PubMed PMID: 30135194.
Shu SL, Yang Y, Allen CL, Maguire O, Minderman H, Sen A, Ciesielski MJ, Collins KA, Bush PJ, Singh P, Wang X, Morgan M, Qu J, Bankert RB, Whiteside TL, Wu Y, Ernstoff MS. Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA favours a pre-metastatic microenvironment. Sci Rep. 2018 Aug 27;8(1):12905. doi: 10.1038/s41598-018-31323-7. PubMed PMID: 30150674; PMCID: PMC6110845.
Banerjee I, Behl B, Mendonca M, Shrivastava G, Russo AJ, Menoret A, Ghosh A, Vella AT, Vanaja SK, Sarkar SN, Fitzgerald KA, Rathinam VAK. Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis. Immunity. 2018 Sep 18;49(3):413-426.e5. doi: 10.1016/j.immuni.2018.07.006. PubMed PMID: 30170814; PMCID: PMC6347470.
Ma W, Concha-Benavente F, Santegoets SJAM, Welters MJP, Ehsan I, Ferris RL, van der Burg SH. EGFR signaling suppresses type 1 cytokine-induced T-cell attracting chemokine secretion in head and neck cancer. PLoS One. 2018;13(9):e0203402. doi: 10.1371/journal.pone.0203402. PubMed PMID: 30192802; PMCID: PMC6128559.
Wang Y, Sedlacek AL, Pawaria S, Xu H, Scott MJ, Binder RJ. Cutting Edge: The Heat Shock Protein gp96 Activates Inflammasome-Signaling Platforms in APCs. J Immunol. 2018 Oct 15;201(8):2209-2214. doi: 10.4049/jimmunol.1800505. PubMed PMID: 30209191; PMCID: PMC6176107.
Chen Y, Sun J, Huang Y, Lu B, Li S. Improved Cancer Immunochemotherapy via Optimal Co-delivery of Chemotherapeutic and Immunomodulatory Agents. Mol Pharm. 2018 Nov 5;15(11):5162-5173. doi: 10.1021/acs.molpharmaceut.8b00717. PubMed PMID: 30222360; PMCID: PMC6452437.
Burkert SC, Shurin GV, White DL, He X, Kapralov AA, Kagan VE, Shurin MR, Star A. Targeting myeloid regulators by paclitaxel-loaded enzymatically degradable nanocups. Nanoscale. 2018 Sep 27;10(37):17990-18000. doi: 10.1039/c8nr04437f. PubMed PMID: 30226240; PMCID: PMC6563927.
Concha-Benavente F, Kansy B, Moskovitz J, Moy J, Chandran U, Ferris RL. PD-L1 Mediates Dysfunction in Activated PD-1+ NK Cells in Head and Neck Cancer Patients. Cancer Immunol Res. 2018 Dec;6(12):1548-1560. doi: 10.1158/2326-6066.CIR-18-0062. PubMed PMID: 30282672; PMCID: PMC6512340.
Cramer JD, Sridharan S, Ferris RL, Duvvuri U, Samant S. Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Stage I to II Oral Cavity Cancer. Laryngoscope. 2019 Jan;129(1):162-169. doi: 10.1002/lary.27323. PubMed PMID: 30284248.
Andersen CL, Boisen MM, Sikora MJ, Ma T, Tseng G, Suryawanshi S, Vlad A, Elishaev E, Edwards RP, Oesterreich S. The Evolution of Estrogen Receptor Signaling in the Progression of Endometriosis to Endometriosis-Associated Ovarian Cancer. Horm Cancer. 2018 Dec;9(6):399-407. doi: 10.1007/s12672-018-0350-9. PubMed PMID: 30302736.
Chen Y, Sun J, Huang Y, Liu Y, Liang L, Yang D, Lu B, Li S. Targeted codelivery of doxorubicin and IL-36γ expression plasmid for an optimal chemo-gene combination therapy against cancer lung metastasis. Nanomedicine. 2019 Jan;15(1):129-141. doi: 10.1016/j.nano.2018.09.005. PubMed PMID: 30308300; PMCID: PMC6289619.
Weinstein AM, Giraldo NA, Petitprez F, Julie C, Lacroix L, Peschaud F, Emile JF, Marisa L, Fridman WH, Storkus WJ, Sautès-Fridman C. Association of IL-36γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer. Cancer Immunol Immunother. 2019 Jan;68(1):109-120. doi: 10.1007/s00262-018-2259-0. PubMed PMID: 30315348.
Tarhini A, Lin Y, Lin H, Rahman Z, Vallabhaneni P, Mendiratta P, Pingpank JF, Holtzman MP, Yusko EC, Rytlewski JA, Rao UNM, Ferris RL, Kirkwood JM. Neoadjuvant ipilimumab (3 mg/kg or 10 mg/kg) and high dose IFN-α2b in locally/regionally advanced melanoma: safety, efficacy and impact on T-cell repertoire. J Immunother Cancer. 2018 Oct 23;6(1):112. doi: 10.1186/s40425-018-0428-5. PubMed PMID: 30352626; PMCID: PMC6199801.
Zandberg DP, Ferris RL. Window Studies in Squamous Cell Carcinoma of the Head and Neck: Values and Limits. Curr Treat Options Oncol. 2018 Oct 27;19(12):68. doi: 10.1007/s11864-018-0587-0. PubMed PMID: 30367283; PMCID: PMC6564676.
Ludwig S, Sharma P, Theodoraki MN, Pietrowska M, Yerneni SS, Lang S, Ferrone S, Whiteside TL. Molecular and Functional Profiles of Exosomes From HPV(+) and HPV(-) Head and Neck Cancer Cell Lines. Front Oncol. 2018;8445. doi: 10.3389/fonc.2018.00445. PubMed PMID: 30370252; PMCID: PMC6194188.
Cheng H, Yang X, Si H, Saleh AD, Xiao W, Coupar J, Gollin SM, Ferris RL, Issaeva N, Yarbrough WG, Prince ME, Carey TE, Van Waes C, Chen Z. Genomic and Transcriptomic Characterization Links Cell Lines with Aggressive Head and Neck Cancers. Cell Rep. 2018 Oct 30;25(5):1332-1345.e5. doi: 10.1016/j.celrep.2018.10.007. PubMed PMID: 30380422; PMCID: PMC6280671.
Kansy BA, Shayan G, Jie HB, Gibson SP, Lei YL, Brandau S, Lang S, Schmitt NC, Ding F, Lin Y, Ferris RL. T cell receptor richness in peripheral blood increases after cetuximab therapy and correlates with therapeutic response. Oncoimmunology. 2018;7(11):e1494112. doi: 10.1080/2162402X.2018.1494112. PubMed PMID: 30377562; PMCID: PMC6205044.
Abramowicz A, Marczak L, Wojakowska A, Zapotoczny S, Whiteside TL, Widlak P, Pietrowska M. Harmonization of exosome isolation from culture supernatants for optimized proteomics analysis. PLoS One. 2018;13(10):e0205496. doi: 10.1371/journal.pone.0205496. PubMed PMID: 30379855; PMCID: PMC6209201.
Gregg RW, Sarkar SN, Shoemaker JE. Mathematical modeling of the cGAS pathway reveals robustness of DNA sensing to TREX1 feedback. J Theor Biol. 2019 Feb 7;462148-157. doi: 10.1016/j.jtbi.2018.11.001. PubMed PMID: 30395807.
Whiteside TL. The potential of tumor-derived exosomes for noninvasive cancer monitoring: an update. Expert Rev Mol Diagn. 2018 Nov 8;1-12. doi: 10.1080/14737159.2018.1544494. PubMed PMID: 30406709; PMCID: PMC6506389.
Hartman DJ, Ahmad F, Ferris RL, Rimm DL, Pantanowitz L. Utility of CD8 score by automated quantitative image analysis in head and neck squamous cell carcinoma. Oral Oncol. 2018 Nov;86278-287. doi: 10.1016/j.oraloncology.2018.10.005. PubMed PMID: 30409313; PMCID: PMC6260977.
Steward DL, Carty SE, Sippel RS, Yang SP, Sosa JA, Sipos JA, Figge JJ, Mandel S, Haugen BR, Burman KD, Baloch ZW, Lloyd RV, Seethala RR, Gooding WE, Chiosea SI, Gomes-Lima C, Ferris RL, Folek JM, Khawaja RA, Kundra P, Loh KS, Marshall CB, Mayson S, McCoy KL, Nga ME, Ngiam KY, Nikiforova MN, Poehls JL, Ringel MD, Yang H, Yip L, Nikiforov YE. Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study. JAMA Oncol. 2018 Nov 8; doi: 10.1001/jamaoncol.2018.4616. PubMed PMID: 30419129; PMCID: PMC6439562.
Seethala RR, Altemani A, Ferris RL, Fonseca I, Gnepp DR, Ha P, Nagao T, Skalova A, Stenman G, Thompson LDR. Data Set for the Reporting of Carcinomas of the Major Salivary Glands: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting. Arch Pathol Lab Med. 2019 May;143(5):578-586. doi: 10.5858/arpa.2018-0422-SA. PubMed PMID: 30500293.
Grabosch S, Bulatovic M, Zeng F, Ma T, Zhang L, Ross M, Brozick J, Fang Y, Tseng G, Kim E, Gambotto A, Elishaev E, P Edwards R, Vlad AM. Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles. Oncogene. 2019 Mar;38(13):2380-2393. doi: 10.1038/s41388-018-0581-9. PubMed PMID: 30518877; PMCID: PMC6440870.
Cramer JD, Ferris RL, Kim S, Duvvuri U. Primary surgery for human papillomavirus-associated oropharyngeal cancer: Survival outcomes with or without adjuvant treatment. Oral Oncol. 2018 Dec;87170-176. doi: 10.1016/j.oraloncology.2018.10.039. PubMed PMID: 30527235; PMCID: PMC6533632.
Garcia-Bates TM, Palma ML, Shen C, Gambotto A, Macatangay BJC, Ferris RL, Rinaldo CR, Mailliard RB. Contrasting Roles of the PD-1 Signaling Pathway in Dendritic Cell-Mediated Induction and Regulation of HIV-1-Specific Effector T Cell Functions. J Virol. 2019 Mar 1;93(5): doi: 10.1128/JVI.02035-18. PubMed PMID: 30541848; PMCID: PMC6384070.
Kaplanov I, Carmi Y, Kornetsky R, Shemesh A, Shurin GV, Shurin MR, Dinarello CA, Voronov E, Apte RN. Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1361-1369. doi: 10.1073/pnas.1812266115. PubMed PMID: 30545915; PMCID: PMC6347724.
Meltzer CJ, Irish J, Angelos P, Busaidy NL, Davies L, Dwojak S, Ferris RL, Haugen BR, Harrell RM, Haymart MR, McIver B, Mechanick JI, Monteiro E, Morris JC 3rd, Morris LGT, Odell M, Scharpf J, Shaha A, Shin JJ, Shonka DC Jr, Thompson GB, Tuttle RM, Urken ML, Wiseman SM, Wong RJ, Randolph G. American Head and Neck Society Endocrine Section clinical consensus statement: North American quality statements and evidence-based multidisciplinary workflow algorithms for the evaluation and management of thyroid nodules. Head Neck. 2019 Apr;41(4):843-856. doi: 10.1002/hed.25526. PubMed PMID: 30561068.
Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, Chen L, Chen Y, Zhu G, Yin W, Zheng L, Zhou T, Badri T, Yao S, Zhu S, Boto A, Sznol M, Melero I, Vignali DAA, Schalper K, Chen L. Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell. 2019 Jan 10;176(1-2):334-347.e12. doi: 10.1016/j.cell.2018.11.010. PubMed PMID: 30580966; PMCID: PMC6365968.
Martyn GV, Shurin GV, Keskinov AA, Bunimovich YL, Shurin MR. Schwann cells shape the neuro-immune environs and control cancer progression. Cancer Immunol Immunother. 2019 Jan 3; doi: 10.1007/s00262-018-02296-3. PubMed PMID: 30607548.
Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Berghe TV, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M. To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death Differ. 2019 Mar;26(3):395-408. doi: 10.1038/s41418-018-0261-x. PubMed PMID: 30622307; PMCID: PMC6370810.
Guo ZS, Lu B, Guo Z, Giehl E, Feist M, Dai E, Liu W, Storkus WJ, He Y, Liu Z, Bartlett DL. Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics. J Immunother Cancer. 2019 Jan 9;7(1):6. doi: 10.1186/s40425-018-0495-7. PubMed PMID: 30626434; PMCID: PMC6325819.
Ghosh A, Shao L, Sampath P, Zhao B, Patel NV, Zhu J, Behl B, Parise RA, Beumer JH, O'Sullivan RJ, DeLuca NA, Thorne SH, Rathinam VAK, Li P, Sarkar SN. Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production. Immunity. 2019 Jan 15;50(1):51-63.e5. doi: 10.1016/j.immuni.2018.12.013. PubMed PMID: 30635239; PMCID: PMC6342484.
Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, Carbone CJ, Yu Q, Katlinski KV, Katlinskaya YV, Handa S, Haas V, Volk SW, Brice AK, Wals K, Matheson NJ, Antrobus R, Ludwig S, Whiteside TL, Sander C, Tarhini AA, Kirkwood JM, Lehner PJ, Guo W, Rui H, Minn AJ, Koumenis C, Diehl JA, Fuchs SY. An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. Cancer Cell. 2019 Jan 14;35(1):33-45.e6. doi: 10.1016/j.ccell.2018.12.001. PubMed PMID: 30645975; PMCID: PMC6336114.
Nikiforova MN, Nikitski AV, Panebianco F, Kaya C, Yip L, Williams M, Chiosea SI, Seethala RR, Roy S, Condello V, Santana-Santos L, Wald AI, Carty SE, Ferris RL, El-Naggar AK, Nikiforov YE. GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland. Thyroid. 2019 Feb;29(2):161-173. doi: 10.1089/thy.2018.0791. PubMed PMID: 30648929; PMCID: PMC6389773.
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Hedberg ML, Peyser ND, Bauman JE, Gooding WE, Li H, Bhola NE, Zhu TR, Zeng Y, Brand TM, Kim MO, Jordan RCK, VandenBerg S, Olivas V, Bivona TG, Chiosea SI, Wang L, Mills GB, Johnson JT, Duvvuri U, Ferris RL, Ha P, Johnson DE, Grandis JR. Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer. J Exp Med. 2019 Feb 4;216(2):419-427. doi: 10.1084/jem.20181936. PubMed PMID: 30683736; PMCID: PMC6363423.
Najjar YG, Menk AV, Sander C, Rao U, Karunamurthy A, Bhatia R, Zhai S, Kirkwood JM, Delgoffe GM. Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma. JCI Insight. 2019 Mar 7;4(5): doi: 10.1172/jci.insight.124989. PubMed PMID: 30721155; PMCID: PMC6483505.
Zakiryanova GK, Kustova E, Urazalieva NT, Baimuchametov ET, Nakisbekov NN, Shurin MR. Abnormal Expression of c-Myc Oncogene in NK Cells in Patients with Cancer. Int J Mol Sci. 2019 Feb 11;20(3): doi: 10.3390/ijms20030756. PubMed PMID: 30754645; PMCID: PMC6387292.
Cramer JD, Samant S, Heron DE, Ferris RL, Kim S. Impact of postoperative radiation therapy for deeply invasive oral cavity cancer upstaged to stage III. Head Neck. 2019 May;41(5):1178-1183. doi: 10.1002/hed.25498. PubMed PMID: 30773733; PMCID: PMC6533633.
Tassler AB, Gooding WE, Ferris RL. Hypopharyngeal cancer treatment: Does initial surgery confer survival benefit? Head Neck. 2019 Feb 19; doi: 10.1002/hed.25687. PubMed PMID: 30779398.
Hollande C, Boussier J, Ziai J, Nozawa T, Bondet V, Phung W, Lu B, Duffy D, Paradis V, Mallet V, Eberl G, Sandoval W, Schartner JM, Pol S, Barreira da Silva R, Albert ML. Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth. Nat Immunol. 2019 Mar;20(3):257-264. doi: 10.1038/s41590-019-0321-5. PubMed PMID: 30778250.
Faden DL, Concha-Benavente F, Chakka AB, McMichael EL, Chandran U, Ferris RL. Immunogenomic correlates of response to cetuximab monotherapy in head and neck squamous cell carcinoma. Head Neck. 2019 Mar 4; doi: 10.1002/hed.25726. PubMed PMID: 30828910.
Ludwig N, Razzo BM, Yerneni SS, Whiteside TL. Optimization of cell culture conditions for exosome isolation using mini-size exclusion chromatography (mini-SEC). Exp Cell Res. 2019 May 15;378(2):149-157. doi: 10.1016/j.yexcr.2019.03.014. PubMed PMID: 30857972.
Shlomchik MJ, Luo W, Weisel F. Linking signaling and selection in the germinal center. Immunol Rev. 2019 Mar;288(1):49-63. doi: 10.1111/imr.12744. PubMed PMID: 30874353; PMCID: PMC6422174.
Shu S, Yang Y, Allen CL, Maguire O, Minderman H, Sen A, Ciesielski MJ, Collins KA, Bush PJ, Singh P, Wang X, Morgan M, Qu J, Bankert RB, Whiteside TL, Wu Y, Ernstoff MS. Publisher Correction: Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA favours a pre-metastatic microenvironment. Sci Rep. 2019 Mar 15;9(1):4959. doi: 10.1038/s41598-018-37179-1. PubMed PMID: 30874569; PMCID: PMC6420661.
Farooq S, Khandavilli S, Dretzke J, Moore D, Nankivell PC, Sharma N, Almeida JR, Winter SC, Simon C, Paleri V, De M, Siddiq S, Holsinger C, Ferris RL, Mehanna H. Transoral tongue base mucosectomy for the identification of the primary site in the work-up of cancers of unknown origin: Systematic review and meta-analysis. Oral Oncol. 2019 Apr;9197-106. doi: 10.1016/j.oraloncology.2019.02.018. PubMed PMID: 30926070.
Wan Z, Sun J, Xu J, Moharil P, Chen J, Xu J, Zhu J, Li J, Huang Y, Xu P, Ma X, Xie W, Lu B, Li S. Dual functional immunostimulatory polymeric prodrug carrier with pendent indoximod for enhanced cancer immunochemotherapy. Acta Biomater. 2019 May;90300-313. doi: 10.1016/j.actbio.2019.03.048. PubMed PMID: 30930305; PMCID: PMC6513707.
Sawant DV, Yano H, Chikina M, Zhang Q, Liao M, Liu C, Callahan DJ, Sun Z, Sun T, Tabib T, Pennathur A, Corry DB, Luketich JD, Lafyatis R, Chen W, Poholek AC, Bruno TC, Workman CJ, Vignali DAA. Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion. Nat Immunol. 2019 Jun;20(6):724-735. doi: 10.1038/s41590-019-0346-9. PubMed PMID: 30936494; PMCID: PMC6531353.
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