Genotoxic%20Stress%20Responses
Chao Y, Chen Y, Zheng W, Demanelis K, Liu Y, Connelly JA, Wang H, Li S, Wang QJ. Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer. Oncogene. 2024-03-01; doi: 10.1038/s41388-024-02939-z. PubMed PMID: 38273024.
Johnson SA, Paul T, Sanford SL, Schnable BL, Detwiler AC, Thosar SA, Van Houten B, Myong S, Opresko PL. BG4 antibody can recognize telomeric G-quadruplexes harboring destabilizing base modifications and lesions. Nucleic Acids Res. 2024-02-28; doi: 10.1093/nar/gkad1209. PubMed PMID: 38153143; PMCID: PMC10939409.
Thosar SA, Barnes RP, Detwiler A, Bhargava R, Wondisford A, O'Sullivan RJ, Opresko PL. Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair. Cell Rep. 2024-01-23;43(1):113656. doi: 10.1016/j.celrep.2023.113656. PubMed PMID: 38194346; PMCID: PMC10851105.
Pifer PM, Yang L, Kumar M, Xie T, Frederick M, Hefner A, Beadle B, Molkentine D, Molkentine J, Dhawan A, Abdelhakiem M, Osman AA, Leibowitz BJ, Myers JN, Pickering CR, Sandulache VC, Heymach J, Skinner HD. FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner. Clin Cancer Res. 2024-01-05; doi: 10.1158/1078-0432.CCR-23-0964. PubMed PMID: 37819945; PMCID: PMC10767302.
Kagan VE, Tyurina YY, Mikulska-Ruminska K, Damschroder D, Vieira Neto E, Lasorsa A, Kapralov AA, Tyurin VA, Amoscato AA, Samovich SN, Souryavong AB, Dar HH, Ramim A, Liang Z, Lazcano P, Ji J, Schmidtke MW, Kiselyov K, Korkmaz A, Vladimirov GK, Artyukhova MA, Rampratap P, Cole LK, Niyatie A, Baker EK, Peterson J, Hatch GM, Atkinson J, Vockley J, Kühn B, Wessells R, van der Wel PCA, Bahar I, Bayir H, Greenberg ML. Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome. Nat Metab. 2023-12-01; doi: 10.1038/s42255-023-00926-4. PubMed PMID: 37996701.
Hong L, Braden DC, Zhao Y, Skoko JJ, Chang F, Woodcock SR, Uvalle C, Casey A, Wood K, Salvatore SR, Asan A, Harkness T, Fagunloye A, Razzaghi M, Straub A, Spies M, Brown DD, Lee AV, Schopfer F, Freeman BA, Neumann CA. Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies. Redox Biol. 2023-10-01;66102856. doi: 10.1016/j.redox.2023.102856. PubMed PMID: 37633047; PMCID: PMC10472314.
Dar HH, Mikulska-Ruminska K, Tyurina YY, Luci DK, Yasgar A, Samovich SN, Kapralov AA, Souryavong AB, Tyurin VA, Amoscato AA, Epperly MW, Shurin GV, Standley M, Holman TR, St Croix CM, Watkins SC, VanDemark AP, Rana S, Zakharov AV, Simeonov A, Marugan J, Mallampalli RK, Wenzel SE, Greenberger JS, Rai G, Bayir H, Bahar I, Kagan VE. Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators. Proc Natl Acad Sci U S A. 2023-06-20;120(25):e2218896120. doi: 10.1073/pnas.2218896120. PubMed PMID: 37327313; PMCID: PMC10288584.
Ellison MA, Namjilsuren S, Shirra MK, Blacksmith MS, Schusteff RA, Kerr EM, Fang F, Xiang Y, Shi Y, Arndt KM. Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae. Nucleic Acids Res. 2023-06-09;51(10):4814-4830. doi: 10.1093/nar/gkad180. PubMed PMID: 36928138; PMCID: PMC10250246.
Jang S, Raja SJ, Roginskaya V, Schaich MA, Watkins SC, Van Houten B. UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties. Nucleic Acids Res. 2023-06-09;51(10):4881-4898. doi: 10.1093/nar/gkad206. PubMed PMID: 36971122; PMCID: PMC10250209.
Fetian T, McShane BM, Horan NL, Shodja DN, True JD, Mosley AL, Arndt KM. Paf1 complex subunit Rtf1 stimulates H2B ubiquitylation by interacting with the highly conserved N-terminal helix of Rad6. Proc Natl Acad Sci U S A. 2023-05-30;120(22):e2220041120. doi: 10.1073/pnas.2220041120. PubMed PMID: 37216505; PMCID: PMC10235976.
Bayır H, Dixon SJ, Tyurina YY, Kellum JA, Kagan VE. Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney. Nat Rev Nephrol. 2023-05-01;19(5):315-336. doi: 10.1038/s41581-023-00689-x. PubMed PMID: 36922653.
Tyurina YY, Kapralov AA, Tyurin VA, Shurin G, Amoscato AA, Rajasundaram D, Tian H, Bunimovich YL, Nefedova Y, Herrick WG, Parchment RE, Doroshow JH, Bayir H, Srivastava AK, Kagan VE. Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo. Redox Biol. 2023-05-01;61102650. doi: 10.1016/j.redox.2023.102650. PubMed PMID: 36870109; PMCID: PMC9996109.
Schaich MA, Schnable BL, Kumar N, Roginskaya V, Jakielski RC, Urban R, Zhong Z, Kad NM, Van Houten B. Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE). Nucleic Acids Res. 2023-04-24;51(7):e39. doi: 10.1093/nar/gkad095. PubMed PMID: 36861323; PMCID: PMC10123111.
Brieño-Enríquez MA, Faykoo-Martinez M, Goben M, Grenier JK, McGrath A, Prado AM, Sinopoli J, Wagner K, Walsh PT, Lopa SH, Laird DJ, Cohen PE, Wilson MD, Holmes MM, Place NJ. Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats. Nat Commun. 2023-02-21;14(1):670. doi: 10.1038/s41467-023-36284-8. PubMed PMID: 36810851; PMCID: PMC9944903.
Zuo Z, Liu J, Sun Z, Cheng YW, Ewing M, Bugge TH, Finkel T, Leppla SH, Liu S. ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth. Proc Natl Acad Sci U S A. 2023-01-03;120(1):e2211927120. doi: 10.1073/pnas.2211927120. PubMed PMID: 36574698; PMCID: PMC9910475.
Hao S, Tong J, Jha A, Risnik D, Lizardo D, Lu X, Goel A, Opresko PL, Yu J, Zhang L. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer. Proc Natl Acad Sci U S A. 2022-12-20;119(51):e2211775119. doi: 10.1073/pnas.2211775119. PubMed PMID: 36508676; PMCID: PMC9907101.
Jang S, Kumar N, Schaich MA, Zhong Z, van Loon B, Watkins SC, Van Houten B. Cooperative interaction between AAG and UV-DDB in the removal of modified bases. Nucleic Acids Res. 2022-12-09;50(22):12856-12871. doi: 10.1093/nar/gkac1145. PubMed PMID: 36511855; PMCID: PMC9825174.
Kaminski N, Wondisford AR, Kwon Y, Lynskey ML, Bhargava R, Barroso-González J, García-Expósito L, He B, Xu M, Mellacheruvu D, Watkins SC, Modesti M, Miller KM, Nesvizhskii AI, Zhang H, Sung P, O'Sullivan RJ. RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA. Mol Cell. 2022-11-03;82(21):4001-4017.e7. doi: 10.1016/j.molcel.2022.09.025. PubMed PMID: 36265488; PMCID: PMC9713952.
Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Harkness T, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022-10-01;56102443. doi: 10.1016/j.redox.2022.102443. PubMed PMID: 36058112; PMCID: PMC9450138.
Prakash R, Rawal Y, Sullivan MR, Grundy MK, Bret H, Mihalevic MJ, Rein HL, Baird JM, Darrah K, Zhang F, Wang R, Traina TA, Radke MR, Kaufmann SH, Swisher EM, Guérois R, Modesti M, Sung P, Jasin M, Bernstein KA. Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants. Proc Natl Acad Sci U S A. 2022-09-20;119(38):e2202727119. doi: 10.1073/pnas.2202727119. PubMed PMID: 36099300; PMCID: PMC9499524.
Barnes RP, de Rosa M, Thosar SA, Detwiler AC, Roginskaya V, Van Houten B, Bruchez MP, Stewart-Ornstein J, Opresko PL. Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening. Nat Struct Mol Biol. 2022-07-01;29(7):639-652. doi: 10.1038/s41594-022-00790-y. PubMed PMID: 35773409; PMCID: PMC9287163.
Thota PN, Nasibli J, Kumar P, Sanaka MR, Chak A, Zhang X, Liu X, Uttam S, Liu Y. Prediction of neoplastic progression in Barrett's esophagus using nanoscale nuclear architecture mapping: a pilot study. Gastrointest Endosc. 2022-06-01;95(6):1239-1246. doi: 10.1016/j.gie.2022.01.007. PubMed PMID: 35065946; PMCID: PMC9296222.
Tong J, Tan X, Song X, Gao M, Risnik D, Hao S, Ermine K, Wang P, Li H, Huang Y, Yu J, Zhang L. CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. Cancer Res. 2022-04-01;82(7):1340-1352. doi: 10.1158/0008-5472.CAN-21-3062. PubMed PMID: 35149588; PMCID: PMC8983601.
Lamade AM, Wu L, Dar HH, Mentrup HL, Shrivastava IH, Epperly MW, St Croix CM, Tyurina YY, Anthonymuthu TS, Yang Q, Kapralov AA, Huang Z, Mao G, Amoscato AA, Hier ZE, Artyukhova MA, Shurin G, Rosenbaum JC, Gough PJ, Bertin J, VanDemark AP, Watkins SC, Mollen KP, Bahar I, Greenberger JS, Kagan VE, Whalen MJ, Bayır H. Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death. Redox Biol. 2022-04-01;50102232. doi: 10.1016/j.redox.2022.102232. PubMed PMID: 35101798; PMCID: PMC8804265.
Xu J, Sun X, Kim K, Brand RM, Hartman D, Ma H, Brand RE, Bai M, Liu Y. Ultrastructural visualization of chromatin in cancer pathogenesis using a simple small-molecule fluorescent probe. Sci Adv. 2022-03-04;8(9):eabm8293. doi: 10.1126/sciadv.abm8293. PubMed PMID: 35245126; PMCID: PMC8896800.
Molkentine DP, Molkentine JM, Bridges KA, Valdecanas DR, Dhawan A, Bahri R, Hefner AJ, Kumar M, Yang L, Abdelhakiem M, Pifer PM, Sandulache V, Sheth A, Beadle BM, Thames HD, Mason KA, Pickering CR, Meyn RE, Skinner HD. p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade. Cancer Res. 2022-03-01;82(5):916-928. doi: 10.1158/0008-5472.CAN-21-2101. PubMed PMID: 34965932; PMCID: PMC9136619.
Kumar N, Theil AF, Roginskaya V, Ali Y, Calderon M, Watkins SC, Barnes RP, Opresko PL, Pines A, Lans H, Vermeulen W, Van Houten B. Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins. Nat Commun. 2022-02-21;13(1):974. doi: 10.1038/s41467-022-28642-9. PubMed PMID: 35190564; PMCID: PMC8861037.
Kaur P, Barnes R, Pan H, Detwiler AC, Liu M, Mahn C, Hall J, Messenger Z, You C, Piehler J, Smart RC, Riehn R, Opresko PL, Wang H. TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA. Nucleic Acids Res. 2021-12-16;49(22):13000-13018. doi: 10.1093/nar/gkab1142. PubMed PMID: 34883513; PMCID: PMC8682769.
Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, Hefner A, Gao M, Bahri R, Dhawan A, Frederick MJ, Seth S, Abdelhakiem M, Beadle BM, Johnson F, Wang J, Shen L, Heffernan T, Sheth A, Ferris RL, Myers JN, Pickering CR, Skinner HD. Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function. Nat Commun. 2021-11-03;12(1):6340. doi: 10.1038/s41467-021-26570-8. PubMed PMID: 34732714; PMCID: PMC8566594.
Leibowitz BJ, Zhao G, Wei L, Ruan H, Epperly M, Chen L, Lu X, Greenberger JS, Zhang L, Yu J. Interferon b drives intestinal regeneration after radiation. Sci Adv. 2021-10-08;7(41):eabi5253. doi: 10.1126/sciadv.abi5253. PubMed PMID: 34613772; PMCID: PMC8494436.
Dar HH, Anthonymuthu TS, Ponomareva LA, Souryavong AB, Shurin GV, Kapralov AO, Tyurin VA, Lee JS, Mallampalli RK, Wenzel SE, Bayir H, Kagan VE. A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO(•) sabotage of theft-ferroptosis. Redox Biol. 2021-09-01;45102045. doi: 10.1016/j.redox.2021.102045. PubMed PMID: 34167028; PMCID: PMC8227829.
Jang S, Schaich MA, Khuu C, Schnable BL, Majumdar C, Watkins SC, David SS, Van Houten B. Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover. Nucleic Acids Res. 2021-08-20;49(14):8177-8188. doi: 10.1093/nar/gkab591. PubMed PMID: 34232996; PMCID: PMC8373069.
Ferro-Novick S, Reggiori F, Brodsky JL. ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease. Trends Biochem Sci. 2021-08-01;46(8):630-639. doi: 10.1016/j.tibs.2020.12.013. PubMed PMID: 33509650; PMCID: PMC8286283.
Kaplan CD, Arndt KM. A PICture is worth a thousand words (and ten references). Cell. 2021-07-22;184(15):3850-3851. doi: 10.1016/j.cell.2021.06.030. PubMed PMID: 34297929.
Wan L, Yin J, Skoko J, Schwartz R, Zhang M, LeDuc PR, Neumann CA. 3D Collagen Vascular Tumor-on-a-Chip Mimetics for Dynamic Combinatorial Drug Screening. Mol Cancer Ther. 2021-06-01;20(6):1210-1219. doi: 10.1158/1535-7163.MCT-20-0880. PubMed PMID: 33785649; PMCID: PMC8172531.
Sparvero LJ, Tian H, Amoscato AA, Sun WY, Anthonymuthu TS, Tyurina YY, Kapralov O, Javadov S, He RR, Watkins SC, Winograd N, Kagan VE, Bayır H. Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB-SIMS). Angew Chem Int Ed Engl. 2021-05-17;60(21):11784-11788. doi: 10.1002/anie.202102001. PubMed PMID: 33684237; PMCID: PMC8243396.
Sun WY, Tyurin VA, Mikulska-Ruminska K, Shrivastava IH, Anthonymuthu TS, Zhai YJ, Pan MH, Gong HB, Lu DH, Sun J, Duan WJ, Korolev S, Abramov AY, Angelova PR, Miller I, Beharier O, Mao GW, Dar HH, Kapralov AA, Amoscato AA, Hastings TG, Greenamyre TJ, Chu CT, Sadovsky Y, Bahar I, Bayır H, Tyurina YY, He RR, Kagan VE. Phospholipase iPLA(2)β averts ferroptosis by eliminating a redox lipid death signal. Nat Chem Biol. 2021-04-01;17(4):465-476. doi: 10.1038/s41589-020-00734-x. PubMed PMID: 33542532; PMCID: PMC8152680.
Stewart-Ornstein J, Iwamoto Y, Miller MA, Prytyskach MA, Ferretti S, Holzer P, Kallen J, Furet P, Jambhekar A, Forrester WC, Weissleder R, Lahav G. p53 dynamics vary between tissues and are linked with radiation sensitivity. Nat Commun. 2021-02-09;12(1):898. doi: 10.1038/s41467-021-21145-z. PubMed PMID: 33563973; PMCID: PMC7873198.
Anthonymuthu TS, Tyurina YY, Sun WY, Mikulska-Ruminska K, Shrivastava IH, Tyurin VA, Cinemre FB, Dar HH, VanDemark AP, Holman TR, Sadovsky Y, Stockwell BR, He RR, Bahar I, Bayır H, Kagan VE. Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis. Redox Biol. 2021-01-01;38101744. doi: 10.1016/j.redox.2020.101744. PubMed PMID: 33126055; PMCID: PMC7596334.
Lizardo DY, Kuang C, Hao S, Yu J, Huang Y, Zhang L. Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside. Biochim Biophys Acta Rev Cancer. 2020-12-01;1874(2):188447. doi: 10.1016/j.bbcan.2020.188447. PubMed PMID: 33035640; PMCID: PMC7886024.
Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ. Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol. 2020-12-01;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. PubMed PMID: 33046907; PMCID: PMC7809635.
Bonilla B, Hengel SR, Grundy MK, Bernstein KA. RAD51 Gene Family Structure and Function. Annu Rev Genet. 2020-11-23;5425-46. doi: 10.1146/annurev-genet-021920-092410. PubMed PMID: 32663049; PMCID: PMC7703940.
Kumar N, Raja S, Van Houten B. The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage. Nucleic Acids Res. 2020-11-18;48(20):11227-11243. doi: 10.1093/nar/gkaa777. PubMed PMID: 33010169; PMCID: PMC7672477.
Sanford SL, Welfer GA, Freudenthal BD, Opresko PL. Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs. Nat Commun. 2020-10-20;11(1):5288. doi: 10.1038/s41467-020-19115-y. PubMed PMID: 33082336; PMCID: PMC7576608.
Liu J, Zuo Z, Sastalla I, Liu C, Jang JY, Sekine Y, Li Y, Pirooznia M, Leppla SH, Finkel T, Liu S. Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors. Cell Host Microbe. 2020-09-09;28(3):402-410.e5. doi: 10.1016/j.chom.2020.05.012. PubMed PMID: 32544461; PMCID: PMC7486266.
Song X, Shen L, Tong J, Kuang C, Zeng S, Schoen RE, Yu J, Pei H, Zhang L. Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer. Theranostics. 2020-07-09;10(18):8098-8110. doi: 10.7150/thno.45363. PubMed PMID: 32724460; PMCID: PMC7381732.
Xu J, Ma H, Ma H, Jiang W, Mela CA, Duan M, Zhao S, Gao C, Hahm ER, Lardo SM, Troy K, Sun M, Pai R, Stolz DB, Zhang L, Singh S, Brand RE, Hartman DJ, Hu J, Hainer SJ, Liu Y. Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis. Nat Commun. 2020-04-20;11(1):1899. doi: 10.1038/s41467-020-15718-7. PubMed PMID: 32313005; PMCID: PMC7171144.
Beckwitt EC, Jang S, Carnaval Detweiler I, Kuper J, Sauer F, Simon N, Bretzler J, Watkins SC, Carell T, Kisker C, Van Houten B. Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search. Nat Commun. 2020-03-13;11(1):1356. doi: 10.1038/s41467-020-15168-1. PubMed PMID: 32170071; PMCID: PMC7069974.
Hoang SM, O'Sullivan RJ. Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends. Trends Cancer. 2020-03-01;6(3):247-260. doi: 10.1016/j.trecan.2019.12.009. PubMed PMID: 32101727; PMCID: PMC7199893.
Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stoyanovsky DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI, Bayır H, Kagan VE. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020-03-01;16(3):278-290. doi: 10.1038/s41589-019-0462-8. PubMed PMID: 32080625; PMCID: PMC7233108.
Betegon M, Brodsky JL. Unlocking the door for ERAD. Nat Cell Biol. 2020-03-01;22(3):263-265. doi: 10.1038/s41556-020-0476-1. PubMed PMID: 32103187; PMCID: PMC7199279.
Moiseeva TN, Qian C, Sugitani N, Osmanbeyoglu HU, Bakkenist CJ. WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells. Proc Natl Acad Sci U S A. 2019-11-26;116(48):23891-23893. doi: 10.1073/pnas.1915108116. PubMed PMID: 31712441; PMCID: PMC6883772.
Martino J, Brunette GJ, Barroso-González J, Moiseeva TN, Smith CM, Bakkenist CJ, O'Sullivan RJ, Bernstein KA. The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination. Nucleic Acids Res. 2019-11-04;47(19):10151-10165. doi: 10.1093/nar/gkz738. PubMed PMID: 31665741; PMCID: PMC6821187.
Sun Z, Brodsky JL. Protein quality control in the secretory pathway. J Cell Biol. 2019-10-07;218(10):3171-3187. doi: 10.1083/jcb.201906047. PubMed PMID: 31537714; PMCID: PMC6781448.
Barroso-González J, García-Expósito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, de Vitis M, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ. RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Mol Cell. 2019-10-03;76(1):11-26.e7. doi: 10.1016/j.molcel.2019.06.043. PubMed PMID: 31400850; PMCID: PMC6778027.
Brunette GJ, Jamalruddin MA, Baldock RA, Clark NL, Bernstein KA. Evolution-based screening enables genome-wide prioritization and discovery of DNA repair genes. Proc Natl Acad Sci U S A. 2019-09-24;116(39):19593-19599. doi: 10.1073/pnas.1906559116. PubMed PMID: 31501324; PMCID: PMC6765268.
Cucinotta CE, Hildreth AE, McShane BM, Shirra MK, Arndt KM. The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo. Nucleic Acids Res. 2019-09-19;47(16):8410-8423. doi: 10.1093/nar/gkz549. PubMed PMID: 31226204; PMCID: PMC6895269.
Qian W, Kumar N, Roginskaya V, Fouquerel E, Opresko PL, Shiva S, Watkins SC, Kolodieznyi D, Bruchez MP, Van Houten B. Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction. Proc Natl Acad Sci U S A. 2019-09-10;116(37):18435-18444. doi: 10.1073/pnas.1910574116. PubMed PMID: 31451640; PMCID: PMC6744920.
Van Houten B. Huntington's Disease: Astrocytes Shift to Fatty Acid Metabolism. Trends Endocrinol Metab. 2019-09-01;30(9):575-577. doi: 10.1016/j.tem.2019.07.019. PubMed PMID: 31399292; PMCID: PMC10164354.
Rosenbaum JC, Bonilla B, Hengel SR, Mertz TM, Herken BW, Kazemier HG, Pressimone CA, Ratterman TC, MacNary E, De Magis A, Kwon Y, Godin SK, Van Houten B, Normolle DP, Sung P, Das SR, Paeschke K, Roberts SA, VanDemark AP, Bernstein KA. The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway. Nat Commun. 2019-08-05;10(1):3515. doi: 10.1038/s41467-019-11374-8. PubMed PMID: 31383866; PMCID: PMC6683157.
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