Publications

Aging and Cancer

Van Houten B, Kad N. Investigation of bacterial nucleotide excision repair using single-molecule techniques. DNA Repair (Amst). 2014 Aug;2041-48. doi: 10.1016/j.dnarep.2013.10.012. PubMed PMID: 24472181; PMCID: PMC5053424.
Chakraborty S, Umasankar PK, Preston GM, Khandelwal P, Apodaca G, Watkins SC, Traub LM. A phosphotyrosine switch for cargo sequestration at clathrin-coated buds. J Biol Chem. 2014 Jun 20;289(25):17497-514. doi: 10.1074/jbc.M114.556589. PubMed PMID: 24798335; PMCID: PMC4067187.
Hughes CD, Simons M, Mackenzie CE, Van Houten B, Kad NM. Single molecule techniques in DNA repair: a primer. DNA Repair (Amst). 2014 Aug;202-13. doi: 10.1016/j.dnarep.2014.02.003. PubMed PMID: 24819596; PMCID: PMC5125534.
Long OS, Benson JA, Kwak JH, Luke CJ, Gosai SJ, O'Reilly LP, Wang Y, Li J, Vetica AC, Miedel MT, Stolz DB, Watkins SC, Züchner S, Perlmutter DH, Silverman GA, Pak SC. A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover. Hum Mol Genet. 2014 Oct 1;23(19):5109-22. doi: 10.1093/hmg/ddu235. PubMed PMID: 24838286; PMCID: PMC4159155.
Tang D, Kang R, Van Houten B, Zeh HJ, Billiar TR, Lotze MT. High mobility group box 1 (HMGB1) phenotypic role revealed with stress. Mol Med. 2014 Aug 19;20359-62. doi: 10.2119/molmed.2014.00063. PubMed PMID: 24937773; PMCID: PMC4153844.
Muller L, Hong CS, Stolz DB, Watkins SC, Whiteside TL. Isolation of biologically-active exosomes from human plasma. J Immunol Methods. 2014 Sep;41155-65. doi: 10.1016/j.jim.2014.06.007. PubMed PMID: 24952243; PMCID: PMC4260336.
Qian W, Wang J, Roginskaya V, McDermott LA, Edwards RP, Stolz DB, Llambi F, Green DR, Van Houten B. Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells. Oncotarget. 2014 Jun 30;5(12):4180-94. doi: 10.18632/oncotarget.1944. PubMed PMID: 24952704; PMCID: PMC4147315.
Nakajima EC, Laymon C, Oborski M, Hou W, Wang L, Grandis JR, Ferris RL, Mountz JM, Van Houten B. Quantifying metabolic heterogeneity in head and neck tumors in real time: 2-DG uptake is highest in hypoxic tumor regions. PLoS One. 2014;9(8):e102452. doi: 10.1371/journal.pone.0102452. PubMed PMID: 25127378; PMCID: PMC4134191.
de Moura MB, Uppala R, Zhang Y, Van Houten B, Goetzman ES. Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells. PLoS One. 2014;9(8):e106028. doi: 10.1371/journal.pone.0106028. PubMed PMID: 25165814; PMCID: PMC4148395.
Fouquerel E, Goellner EM, Yu Z, Gagné JP, Barbi de Moura M, Feinstein T, Wheeler D, Redpath P, Li J, Romero G, Migaud M, Van Houten B, Poirier GG, Sobol RW. ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion. Cell Rep. 2014 Sep 25;8(6):1819-1831. doi: 10.1016/j.celrep.2014.08.036. PubMed PMID: 25220464; PMCID: PMC4177344.
Chen D, Ming L, Zou F, Peng Y, Van Houten B, Yu J, Zhang L. TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. 2014 Sep 30;5(18):8107-22. doi: 10.18632/oncotarget.2440. PubMed PMID: 25237903; PMCID: PMC4226670.
Yanamala N, Kapralov AA, Djukic M, Peterson J, Mao G, Klein-Seetharaman J, Stoyanovsky DA, Stursa J, Neuzil J, Kagan VE. Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate. J Biol Chem. 2014 Nov 21;289(47):32488-98. doi: 10.1074/jbc.M114.601377. PubMed PMID: 25278024; PMCID: PMC4239604.
Shao H, Li S, Watkins SC, Wells A. α-Actinin-4 is required for amoeboid-type invasiveness of melanoma cells. J Biol Chem. 2014 Nov 21;289(47):32717-28. doi: 10.1074/jbc.M114.579185. PubMed PMID: 25296750; PMCID: PMC4239623.
Ohkuri T, Ghosh A, Kosaka A, Zhu J, Ikeura M, David M, Watkins SC, Sarkar SN, Okada H. STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol Res. 2014 Dec;2(12):1199-208. doi: 10.1158/2326-6066.CIR-14-0099. PubMed PMID: 25300859; PMCID: PMC4258479.
Stoyanovsky DA, Jiang J, Murphy MP, Epperly M, Zhang X, Li S, Greenberger J, Kagan V, Bayır H. Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator. ACS Med Chem Lett. 2014 Dec 11;5(12):1304-1307. doi: 10.1021/ml5003635. PubMed PMID: 25530831; PMCID: PMC4266336.
Chen X, Velmurugu Y, Zheng G, Park B, Shim Y, Kim Y, Liu L, Van Houten B, He C, Ansari A, Min JH. Kinetic gating mechanism of DNA damage recognition by Rad4/XPC. Nat Commun. 2015 Jan 6;65849. doi: 10.1038/ncomms6849. PubMed PMID: 25562780; PMCID: PMC4354021.
Kagan VE, Tyurina YY, Tyurin VA, Mohammadyani D, Angeli JP, Baranov SV, Klein-Seetharaman J, Friedlander RM, Mallampalli RK, Conrad M, Bayir H. Cardiolipin signaling mechanisms: collapse of asymmetry and oxidation. Antioxid Redox Signal. 2015 Jun 20;22(18):1667-80. doi: 10.1089/ars.2014.6219. PubMed PMID: 25566681; PMCID: PMC4486147.
Qian W, Salamoun J, Wang J, Roginskaya V, Van Houten B, Wipf P. The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak. Bioorg Med Chem Lett. 2015 Feb 15;25(4):856-63. doi: 10.1016/j.bmcl.2014.12.072. PubMed PMID: 25582599; PMCID: PMC4318771.
Shvedova AA, Kisin ER, Yanamala N, Tkach AV, Gutkin DW, Star A, Shurin GV, Kagan VE, Shurin MR. MDSC and TGFβ Are Required for Facilitation of Tumor Growth in the Lungs of Mice Exposed to Carbon Nanotubes. Cancer Res. 2015 Apr 15;75(8):1615-23. doi: 10.1158/0008-5472.CAN-14-2376. PubMed PMID: 25744719; PMCID: PMC4401633.
Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, Koehn BH, Pfeifer D, Taylor PA, Prinz G, Dierbach H, Stickel N, Beck Y, Warncke M, Junt T, Schmitt-Graeff A, Nakae S, Follo M, Wertheimer T, Schwab L, Devlin J, Watkins SC, Duyster J, Ferrara JL, Turnquist HR, Zeiser R, Blazar BR. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood. 2015 May 14;125(20):3183-92. doi: 10.1182/blood-2014-10-606830. PubMed PMID: 25814531; PMCID: PMC4432012.
Jackson TC, Bayir H, Ikonomovic MD, Janesko-Feldman K, Mi Z, Gao T, Jackson EK, Kochanek PM. Detection of PHLPP1α/β in human and mouse brain by different anti-PHLPP1 antibodies. Sci Rep. 2015 Apr 1;59377. doi: 10.1038/srep09377. PubMed PMID: 25827478; PMCID: PMC4649889.
Seo W, Kapralov AA, Shurin GV, Shurin MR, Kagan VE, Star A. Payload drug vs. nanocarrier biodegradation by myeloperoxidase- and peroxynitrite-mediated oxidations: pharmacokinetic implications. Nanoscale. 2015 May 21;7(19):8689-94. doi: 10.1039/c5nr00251f. PubMed PMID: 25902750; PMCID: PMC4582775.
Bakan A, Kapralov AA, Bayir H, Hu F, Kagan VE, Bahar I. Inhibition of Peroxidase Activity of Cytochrome c: De Novo Compound Discovery and Validation. Mol Pharmacol. 2015 Sep;88(3):421-7. doi: 10.1124/mol.115.097816. PubMed PMID: 26078313; PMCID: PMC4551054.
Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P. Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4828-4833. doi: 10.1016/j.bmcl.2015.06.073. PubMed PMID: 26159482; PMCID: PMC4607627.
Pardee AD, Yano H, Weinstein AM, Ponce AA, Ethridge AD, Normolle DP, Vujanovic L, Mizejewski GJ, Watkins SC, Butterfield LH. Route of antigen delivery impacts the immunostimulatory activity of dendritic cell-based vaccines for hepatocellular carcinoma. J Immunother Cancer. 2015;332. doi: 10.1186/s40425-015-0077-x. PubMed PMID: 26199728; PMCID: PMC4509479.
Fortian A, Dionne LK, Hong SH, Kim W, Gygi SP, Watkins SC, Sorkin A. Endocytosis of Ubiquitylation-Deficient EGFR Mutants via Clathrin-Coated Pits is Mediated by Ubiquitylation. Traffic. 2015 Nov;16(11):1137-54. doi: 10.1111/tra.12314. PubMed PMID: 26251007; PMCID: PMC4607634.
Wallace CT, St Croix CM, Watkins SC. Data management and archiving in a large microscopy-and-imaging, multi-user facility: Problems and solutions. Mol Reprod Dev. 2015 Sep;82(9):630-4. doi: 10.1002/mrd.22538. PubMed PMID: 26284826; PMCID: PMC4878693.
Planas-Iglesias J, Dwarakanath H, Mohammadyani D, Yanamala N, Kagan VE, Klein-Seetharaman J. Cardiolipin Interactions with Proteins. Biophys J. 2015 Sep 15;109(6):1282-94. doi: 10.1016/j.bpj.2015.07.034. PubMed PMID: 26300339; PMCID: PMC4576322.
Rolyan H, Tyurina YY, Hernandez M, Amoscato AA, Sparvero LJ, Nmezi BC, Lu Y, Estécio MR, Lin K, Chen J, He RR, Gong P, Rigatti LH, Dupree J, Bayır H, Kagan VE, Casaccia P, Padiath QS. Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression. J Neurosci. 2015 Aug 26;35(34):12002-17. doi: 10.1523/JNEUROSCI.1668-15.2015. PubMed PMID: 26311780; PMCID: PMC4549407.
Balasubramanian K, Maeda A, Lee JS, Mohammadyani D, Dar HH, Jiang JF, St Croix CM, Watkins S, Tyurin VA, Tyurina YY, Klöditz K, Polimova A, Kapralova VI, Xiong Z, Ray P, Klein-Seetharaman J, Mallampalli RK, Bayir H, Fadeel B, Kagan VE. Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity. Sci Signal. 2015 Sep 22;8(395):ra95. doi: 10.1126/scisignal.aaa6179. PubMed PMID: 26396268; PMCID: PMC4760701.
Phinney DG, Di Giuseppe M, Njah J, Sala E, Shiva S, St Croix CM, Stolz DB, Watkins SC, Di YP, Leikauf GD, Kolls J, Riches DW, Deiuliis G, Kaminski N, Boregowda SV, McKenna DH, Ortiz LA. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nat Commun. 2015 Oct 7;68472. doi: 10.1038/ncomms9472. PubMed PMID: 26442449; PMCID: PMC4598952.
Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, Krämer A, Roncaioli JL, Sand F, Heuckmann JM, Ikram F, Schmidt R, Ackermann S, Engesser A, Kahlert Y, Vogel W, Altmüller J, Nürnberg P, Thierry-Mieg J, Thierry-Mieg D, Mariappan A, Heynck S, Mariotti E, Henrich KO, Gloeckner C, Bosco G, Leuschner I, Schweiger MR, Savelyeva L, Watkins SC, Shao C, Bell E, Höfer T, Achter V, Lang U, Theissen J, Volland R, Saadati M, Eggert A, de Wilde B, Berthold F, Peng Z, Zhao C, Shi L, Ortmann M, Büttner R, Perner S, Hero B, Schramm A, Schulte JH, Herrmann C, O'Sullivan RJ, Westermann F, Thomas RK, Fischer M. Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature. 2015 Oct 29;526(7575):700-4. doi: 10.1038/nature14980. PubMed PMID: 26466568; PMCID: PMC4881306.
Mandal A, Hoop CL, DeLucia M, Kodali R, Kagan VE, Ahn J, van der Wel PC. Structural Changes and Proapoptotic Peroxidase Activity of Cardiolipin-Bound Mitochondrial Cytochrome c. Biophys J. 2015 Nov 3;109(9):1873-84. doi: 10.1016/j.bpj.2015.09.016. PubMed PMID: 26536264; PMCID: PMC4643272.
Phong BL, Avery L, Sumpter TL, Gorman JV, Watkins SC, Colgan JD, Kane LP. Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation. J Exp Med. 2015 Dec 14;212(13):2289-304. doi: 10.1084/jem.20150388. PubMed PMID: 26598760; PMCID: PMC4689164.
Zou C, Synan MJ, Li J, Xiong S, Manni ML, Liu Y, Chen BB, Zhao Y, Shiva S, Tyurina YY, Jiang J, Lee JS, Das S, Ray A, Ray P, Kagan VE, Mallampalli RK. LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1. J Cell Sci. 2016 Jan 1;129(1):51-64. doi: 10.1242/jcs.176701. PubMed PMID: 26604221; PMCID: PMC4732295.
Barneda D, Planas-Iglesias J, Gaspar ML, Mohammadyani D, Prasannan S, Dormann D, Han GS, Jesch SA, Carman GM, Kagan V, Parker MG, Ktistakis NT, Klein-Seetharaman J, Dixon AM, Henry SA, Christian M. The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix. Elife. 2015 Nov 26;4e07485. doi: 10.7554/eLife.07485. PubMed PMID: 26609809; PMCID: PMC4755750.
Pasta S, Phillippi JA, Tsamis A, D'Amore A, Raffa GM, Pilato M, Scardulla C, Watkins SC, Wagner WR, Gleason TG, Vorp DA. Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parameters. Med Eng Phys. 2016 Feb;38(2):121-30. doi: 10.1016/j.medengphy.2015.11.001. PubMed PMID: 26669606; PMCID: PMC4755864.
Simons M, Pollard MR, Hughes CD, Ward AD, Van Houten B, Towrie M, Botchway SW, Parker AW, Kad NM. Directly interrogating single quantum dot labelled UvrA2 molecules on DNA tightropes using an optically trapped nanoprobe. Sci Rep. 2015 Dec 22;518486. doi: 10.1038/srep18486. PubMed PMID: 26691010; PMCID: PMC4686980.
Mao G, Qu F, St Croix CM, Tyurina YY, Planas-Iglesias J, Jiang J, Huang Z, Amoscato AA, Tyurin VA, Kapralov AA, Cheikhi A, Maguire J, Klein-Seetharaman J, Bayır H, Kagan VE. Mitochondrial Redox Opto-Lipidomics Reveals Mono-Oxygenated Cardiolipins as Pro-Apoptotic Death Signals. ACS Chem Biol. 2016 Feb 19;11(2):530-40. doi: 10.1021/acschembio.5b00737. PubMed PMID: 26697918; PMCID: PMC5741079.
Van Houten B, Hunter SE, Meyer JN. Mitochondrial DNA damage induced autophagy, cell death, and disease. Front Biosci (Landmark Ed). 2016 Jan 1;2142-54. PubMed PMID: 26709760; PMCID: PMC4750375.
Vlasova II, Kapralov AA, Michael ZP, Burkert SC, Shurin MR, Star A, Shvedova AA, Kagan VE. Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications. Toxicol Appl Pharmacol. 2016 May 15;29958-69. doi: 10.1016/j.taap.2016.01.002. PubMed PMID: 26768553; PMCID: PMC4811710.
Greenberger J, Kagan V, Bayir H, Wipf P, Epperly M. Antioxidant Approaches to Management of Ionizing Irradiation Injury. Antioxidants (Basel). 2015 Jan 23;4(1):82-101. doi: 10.3390/antiox4010082. PubMed PMID: 26785339; PMCID: PMC4665573.
Shinde A, Berhane H, Rhieu BH, Kalash R, Xu K, Goff J, Epperly MW, Franicola D, Zhang X, Dixon T, Shields D, Wang H, Wipf P, Parmar K, Guinan E, Kagan V, Tyurin V, Ferris RL, Zhang X, Li S, Greenberger JS. Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice. Radiat Res. 2016 Feb;185(2):134-50. doi: 10.1667/RR14035.1. PubMed PMID: 26789701; PMCID: PMC4773657.
Huang Z, Epperly M, Watkins SC, Greenberger JS, Kagan VE, Bayır H. Necrostatin-1 rescues mice from lethal irradiation. Biochim Biophys Acta. 2016 Apr;1862(4):850-856. doi: 10.1016/j.bbadis.2016.01.014. PubMed PMID: 26802452; PMCID: PMC4788560.
He J, Wang Y, Missinato MA, Onuoha E, Perkins LA, Watkins SC, St Croix CM, Tsang M, Bruchez MP. A genetically targetable near-infrared photosensitizer. Nat Methods. 2016 Mar;13(3):263-8. doi: 10.1038/nmeth.3735. PubMed PMID: 26808669; PMCID: PMC4916159.
Pinilla-Macua I, Watkins SC, Sorkin A. Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomes. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2122-7. doi: 10.1073/pnas.1520301113. PubMed PMID: 26858456; PMCID: PMC4776482.
Shvedova A, Pietroiusti A, Kagan V. Nanotoxicology ten years later: Lights and shadows. Toxicol Appl Pharmacol. 2016 May 15;2991-2. doi: 10.1016/j.taap.2016.02.014. PubMed PMID: 26908175; PMCID: PMC5370549.
Tejero J, Kapralov AA, Baumgartner MP, Sparacino-Watkins CE, Anthonymutu TS, Vlasova II, Camacho CJ, Gladwin MT, Bayir H, Kagan VE. Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences. Biochim Biophys Acta. 2016 May;1861(5):391-401. doi: 10.1016/j.bbalip.2016.02.022. PubMed PMID: 26928591; PMCID: PMC4821708.
Khare A, Raundhal M, Chakraborty K, Das S, Corey C, Kamga CK, Quesnelle K, St Croix C, Watkins SC, Morse C, Oriss TB, Huff R, Hannum R, Ray P, Shiva S, Ray A. Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation. Cell Rep. 2016 May 24;15(8):1700-14. doi: 10.1016/j.celrep.2016.04.060. PubMed PMID: 27184852; PMCID: PMC4880515.
Keskinov AA, Tapias V, Watkins SC, Ma Y, Shurin MR, Shurin GV. Impact of the Sensory Neurons on Melanoma Growth In Vivo. PLoS One. 2016;11(5):e0156095. doi: 10.1371/journal.pone.0156095. PubMed PMID: 27227315; PMCID: PMC4882065.
Buland JR, Wasserloos KJ, Tyurin VA, Tyurina YY, Amoscato AA, Mallampalli RK, Chen BB, Zhao J, Zhao Y, Ofori-Acquah S, Kagan VE, Pitt BR. Biosynthesis of oxidized lipid mediators via lipoprotein-associated phospholipase A2 hydrolysis of extracellular cardiolipin induces endothelial toxicity. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L303-16. doi: 10.1152/ajplung.00038.2016. PubMed PMID: 27233995; PMCID: PMC5142456.
Ma L, Umasankar PK, Wrobel AG, Lymar A, McCoy AJ, Holkar SS, Jha A, Pradhan-Sundd T, Watkins SC, Owen DJ, Traub LM. Transient Fcho1/2⋅Eps15/R⋅AP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding. Dev Cell. 2016 Jun 6;37(5):428-43. doi: 10.1016/j.devcel.2016.05.003. PubMed PMID: 27237791; PMCID: PMC4921775.
Houten BV, Kuper J, Kisker C. Role of XPD in cellular functions: To TFIIH and beyond. DNA Repair (Amst). 2016 Aug;44136-142. doi: 10.1016/j.dnarep.2016.05.019. PubMed PMID: 27262611.
Hagos FT, Daood MJ, Ocque JA, Nolin TD, Bayir H, Poloyac SM, Kochanek PM, Clark RS, Empey PE. Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine. Xenobiotica. 2017 Apr;47(4):346-353. doi: 10.1080/00498254.2016.1187777. PubMed PMID: 27278858; PMCID: PMC5572076.
Zerbato JM, Serrao E, Lenzi G, Kim B, Ambrose Z, Watkins SC, Engelman AN, Sluis-Cremer N. Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro. J Virol. 2016 Sep 15;90(18):8059-73. doi: 10.1128/JVI.00553-16. PubMed PMID: 27356901; PMCID: PMC5008097.
Sehrawat A, Croix CS, Baty CJ, Watkins S, Tailor D, Singh RP, Singh SV. Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate. Mitochondrion. 2016 Sep;3067-77. doi: 10.1016/j.mito.2016.06.006. PubMed PMID: 27374852; PMCID: PMC5023488.
Maguire JJ, Tyurina YY, Mohammadyani D, Kapralov AA, Anthonymuthu TS, Qu F, Amoscato AA, Sparvero LJ, Tyurin VA, Planas-Iglesias J, He RR, Klein-Seetharaman J, Bayır H, Kagan VE. Known unknowns of cardiolipin signaling: The best is yet to come. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jan;1862(1):8-24. doi: 10.1016/j.bbalip.2016.08.001. PubMed PMID: 27498292; PMCID: PMC5323096.
Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. Immunity. 2016 Aug 16;45(2):374-88. doi: 10.1016/j.immuni.2016.07.009. PubMed PMID: 27496732; PMCID: PMC5207350.
Sallmyr A, Matsumoto Y, Roginskaya V, Van Houten B, Tomkinson AE. Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1-Dependent Apoptosis in Cancer Cells. Cancer Res. 2016 Sep 15;76(18):5431-41. doi: 10.1158/0008-5472.CAN-15-3243. PubMed PMID: 27503931; PMCID: PMC5036517.
Helfield B, Chen X, Watkins SC, Villanueva FS. Biophysical insight into mechanisms of sonoporation. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9983-8. doi: 10.1073/pnas.1606915113. PubMed PMID: 27551081; PMCID: PMC5018802.
Klei LR, Hu D, Panek R, Alfano DN, Bridwell RE, Bailey KM, Oravecz-Wilson KI, Concel VJ, Hess EM, Van Beek M, Delekta PC, Gu S, Watkins SC, Ting AT, Gough PJ, Foley KP, Bertin J, McAllister-Lucas LM, Lucas PC. MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage. Cell Rep. 2016 Sep 27;17(1):221-232. doi: 10.1016/j.celrep.2016.08.080. PubMed PMID: 27681433; PMCID: PMC5087334.
Kong M, Liu L, Chen X, Driscoll KI, Mao P, Böhm S, Kad NM, Watkins SC, Bernstein KA, Wyrick JJ, Min JH, Van Houten B. Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process. Mol Cell. 2016 Oct 20;64(2):376-387. doi: 10.1016/j.molcel.2016.09.005. PubMed PMID: 27720644; PMCID: PMC5123691.
Ouyang Y, Bayer A, Chu T, Tyurin VA, Kagan VE, Morelli AE, Coyne CB, Sadovsky Y. Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity. Placenta. 2016 Nov;4786-95. doi: 10.1016/j.placenta.2016.09.008. PubMed PMID: 27780544; PMCID: PMC5123854.
Brand RM, Epperly MW, Stottlemyer JM, Skoda EM, Gao X, Li S, Huq S, Wipf P, Kagan VE, Greenberger JS, Falo LD Jr. A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage. J Invest Dermatol. 2017 Mar;137(3):576-586. doi: 10.1016/j.jid.2016.09.033. PubMed PMID: 27794421; PMCID: PMC5466072.
Garcia-Exposito L, Bournique E, Bergoglio V, Bose A, Barroso-Gonzalez J, Zhang S, Roncaioli JL, Lee M, Wallace CT, Watkins SC, Opresko PL, Hoffmann JS, O'Sullivan RJ. Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres. Cell Rep. 2016 Nov 8;17(7):1858-1871. doi: 10.1016/j.celrep.2016.10.048. PubMed PMID: 27829156; PMCID: PMC5406014.
Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayır H. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017 Jan;13(1):81-90. doi: 10.1038/nchembio.2238. PubMed PMID: 27842066; PMCID: PMC5506843.
Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trümbach D, Mao G, Qu F, Bayir H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017 Jan;13(1):91-98. doi: 10.1038/nchembio.2239. PubMed PMID: 27842070; PMCID: PMC5610546.
Kad NM, Van Houten B. DNA repair: Clamping down on copy errors. Nature. 2016 Nov 24;539(7630):498-499. doi: 10.1038/nature20475. PubMed PMID: 27851733; PMCID: PMC5641404.
Kong M, Van Houten B. Rad4 recognition-at-a-distance: Physical basis of conformation-specific anomalous diffusion of DNA repair proteins. Prog Biophys Mol Biol. 2017 Aug;12793-104. doi: 10.1016/j.pbiomolbio.2016.12.004. PubMed PMID: 27939760; PMCID: PMC5462892.
Zhao J, Fuhrmann-Stroissnigg H, Gurkar AU, Flores RR, Dorronsoro A, Stolz DB, St Croix CM, Niedernhofer LJ, Robbins PD. Quantitative Analysis of Cellular Senescence in Culture and In Vivo. Curr Protoc Cytom. 2017 Jan 5;799.51.1-9.51.25. doi: 10.1002/cpcy.16. PubMed PMID: 28055114.
Yilmaz E, Watkins SC, Gold MS. Paclitaxel-induced increase in mitochondrial volume mediates dysregulation of intracellular Ca2+ in putative nociceptive glabrous skin neurons from the rat. Cell Calcium. 2017 Mar;6216-28. doi: 10.1016/j.ceca.2017.01.005. PubMed PMID: 28109678; PMCID: PMC5365154.
Wang Y, Ballou B, Schmidt BF, Andreko S, St Croix CM, Watkins SC, Bruchez MP. Affibody-targeted fluorogen activating protein for in vivo tumor imaging. Chem Commun (Camb). 2017 Feb 7;53(12):2001-2004. doi: 10.1039/c6cc09137g. PubMed PMID: 28120951; PMCID: PMC5340305.
Luo J, Kong M, Liu L, Samanta S, Van Houten B, Deiters A. Optical Control of DNA Helicase Function through Genetic Code Expansion. Chembiochem. 2017 Mar 2;18(5):466-469. doi: 10.1002/cbic.201600624. PubMed PMID: 28120472; PMCID: PMC5516474.
Montecalvo A, Watkins SC, Orange J, Kane LP. Inducible turnover of optineurin regulates T cell activation. Mol Immunol. 2017 May;859-17. doi: 10.1016/j.molimm.2017.01.027. PubMed PMID: 28192730; PMCID: PMC5385146.
Kagan VE, Bayır H, Tyurina YY, Bolevich SB, Maguire JJ, Fadeel B, Balasubramanian K. Elimination of the unnecessary: Intra- and extracellular signaling by anionic phospholipids. Biochem Biophys Res Commun. 2017 Jan 15;482(3):482-490. doi: 10.1016/j.bbrc.2016.11.005. PubMed PMID: 28212735; PMCID: PMC5319735.
Muthuswamy R, Okada NJ, Jenkins FJ, McGuire K, McAuliffe PF, Zeh HJ, Bartlett DL, Wallace C, Watkins S, Henning JD, Bovbjerg DH, Kalinski P. Epinephrine promotes COX-2-dependent immune suppression in myeloid cells and cancer tissues. Brain Behav Immun. 2017 May;6278-86. doi: 10.1016/j.bbi.2017.02.008. PubMed PMID: 28212885.
Franks J, Wallace CT, Shibata M, Suga M, Erdman N, Stolz DB, Watkins SC. Correlative Fluorescence and Electron Microscopy in 3D-Scanning Electron Microscope Perspective. Curr Protoc Cytom. 2017 Apr 3;8012.45.1-12.45.15. doi: 10.1002/cpcy.18. PubMed PMID: 28369763.
Chiu CF, Dar HH, Kapralov AA, Robinson RAS, Kagan VE, Star A. Nanoemitters and innate immunity: the role of surfactants and bio-coronas in myeloperoxidase-catalyzed oxidation of pristine single-walled carbon nanotubes. Nanoscale. 2017 May 11;9(18):5948-5956. doi: 10.1039/c6nr07706d. PubMed PMID: 28440832; PMCID: PMC6584033.
Vujanovic L, Stahl EC, Pardee AD, Geller DA, Tsung A, Watkins SC, Gibson GA, Storkus WJ, Butterfield LH. Tumor-Derived α-Fetoprotein Directly Drives Human Natural Killer-Cell Activation and Subsequent Cell Death. Cancer Immunol Res. 2017 Jun;5(6):493-502. doi: 10.1158/2326-6066.CIR-16-0216. PubMed PMID: 28468916.
Kinner-Bibeau LB, Sedlacek AL, Messmer MN, Watkins SC, Binder RJ. HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells. Nat Commun. 2017 May 31;815648. doi: 10.1038/ncomms15648. PubMed PMID: 28561043; PMCID: PMC5460028.
Kong M, Beckwitt EC, Springall L, Kad NM, Van Houten B. Single-Molecule Methods for Nucleotide Excision Repair: Building a System to Watch Repair in Real Time. Methods Enzymol. 2017;592213-257. doi: 10.1016/bs.mie.2017.03.027. PubMed PMID: 28668122; PMCID: PMC5656006.
Beckwitt EC, Kong M, Van Houten B. Studying protein-DNA interactions using atomic force microscopy. Semin Cell Dev Biol. 2018 Jan;73220-230. doi: 10.1016/j.semcdb.2017.06.028. PubMed PMID: 28673677; PMCID: PMC5762137.
Weinstein AM, Chen L, Brzana EA, Patil PR, Taylor JL, Fabian KL, Wallace CT, Jones SD, Watkins SC, Lu B, Stroncek DF, Denning TL, Fu YX, Cohen PA, Storkus WJ. Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment. Oncoimmunology. 2017;6(6):e1322238. doi: 10.1080/2162402X.2017.1322238. PubMed PMID: 28680760; PMCID: PMC5486180.
Watson AM, Rose AH, Gibson GA, Gardner CL, Sun C, Reed DS, Lam LKM, St Croix CM, Strick PL, Klimstra WB, Watkins SC. Ribbon scanning confocal for high-speed high-resolution volume imaging of brain. PLoS One. 2017;12(7):e0180486. doi: 10.1371/journal.pone.0180486. PubMed PMID: 28686653; PMCID: PMC5501561.
Zhao J, Minami Y, Etling E, Coleman JM, Lauder SN, Tyrrell V, Aldrovandi M, O'Donnell V, Claesson HE, Kagan V, Wenzel S. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2017 Dec;57(6):692-701. doi: 10.1165/rcmb.2017-0031OC. PubMed PMID: 28723225; PMCID: PMC5765418.
Akiyama H, Ramirez NP, Gibson G, Kline C, Watkins S, Ambrose Z, Gummuluru S. Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon. J Virol. 2017 Nov 1;91(21): doi: 10.1128/JVI.00972-17. PubMed PMID: 28794041; PMCID: PMC5640826.
Tyurina YY, Shrivastava I, Tyurin VA, Mao G, Dar HH, Watkins S, Epperly M, Bahar I, Shvedova AA, Pitt B, Wenzel SE, Mallampalli RK, Sadovsky Y, Gabrilovich D, Greenberger JS, Bayır H, Kagan VE. "Only a Life Lived for Others Is Worth Living": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions. Antioxid Redox Signal. 2018 Nov 1;29(13):1333-1358. doi: 10.1089/ars.2017.7124. PubMed PMID: 28835115; PMCID: PMC6157439.
Helfield BL, Chen X, Qin B, Watkins SC, Villanueva FS. Mechanistic Insight into Sonoporation with Ultrasound-Stimulated Polymer Microbubbles. Ultrasound Med Biol. 2017 Nov;43(11):2678-2689. doi: 10.1016/j.ultrasmedbio.2017.07.017. PubMed PMID: 28847500; PMCID: PMC5644032.
Muller L, Simms P, Hong CS, Nishimura MI, Jackson EK, Watkins SC, Whiteside TL. Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms. Oncoimmunology. 2017;6(8):e1261243. doi: 10.1080/2162402X.2016.1261243. PubMed PMID: 28919985; PMCID: PMC5593709.
Beckwitt EC, Van Houten B. Molecular cartography of mutational landscapes in melanomas. EMBO J. 2017 Oct 2;36(19):2812-2814. doi: 10.15252/embj.201797944. PubMed PMID: 28931563; PMCID: PMC5623845.
Geric I, Tyurina YY, Krysko O, Krysko DV, De Schryver E, Kagan VE, Van Veldhoven PP, Baes M, Verheijden S. Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency. Immunology. 2018 Mar;153(3):342-356. doi: 10.1111/imm.12844. PubMed PMID: 28940384; PMCID: PMC5795189.
Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017 Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021. PubMed PMID: 28985560; PMCID: PMC5685180.
Pradhan-Sundd T, Zhou L, Vats R, Jiang A, Molina L, Singh S, Poddar M, Russell J, Stolz DB, Oertel M, Apte U, Watkins S, Ranganathan S, Nejak-Bowen KN, Sundd P, Monga SP. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology. 2018 Jun;67(6):2320-2337. doi: 10.1002/hep.29585. PubMed PMID: 29023813; PMCID: PMC5893443.
Krysko O, Aaes TL, Kagan VE, D'Herde K, Bachert C, Leybaert L, Vandenabeele P, Krysko DV. Necroptotic cell death in anti-cancer therapy. Immunol Rev. 2017 Nov;280(1):207-219. doi: 10.1111/imr.12583. PubMed PMID: 29027225.
Schlattner U, Tokarska-Schlattner M, Epand RM, Boissan M, Lacombe ML, Kagan VE. NME4/nucleoside diphosphate kinase D in cardiolipin signaling and mitophagy. Lab Invest. 2018 Feb;98(2):228-232. doi: 10.1038/labinvest.2017.113. PubMed PMID: 29035377.
Rudich P, Snoznik C, Watkins SC, Monaghan J, Pandey UB, Lamitina ST. Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans. Hum Mol Genet. 2017 Dec 15;26(24):4916-4928. doi: 10.1093/hmg/ddx372. PubMed PMID: 29036691; PMCID: PMC5886095.
Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell. 2017 Oct 19;171(3):628-641.e26. doi: 10.1016/j.cell.2017.09.044. PubMed PMID: 29053969; PMCID: PMC5683852.
Washington MA, Balmert SC, Fedorchak MV, Little SR, Watkins SC, Meyer TY. Monomer sequence in PLGA microparticles: Effects on acidic microclimates and in vivo inflammatory response. Acta Biomater. 2018 Jan;65259-271. doi: 10.1016/j.actbio.2017.10.043. PubMed PMID: 29101019.
Duangkhae P, Erdos G, Ryman KD, Watkins SC, Falo LD Jr, Marques ETA Jr, Barratt-Boyes SM. Interplay between Keratinocytes and Myeloid Cells Drives Dengue Virus Spread in Human Skin. J Invest Dermatol. 2018 Mar;138(3):618-626. doi: 10.1016/j.jid.2017.10.018. PubMed PMID: 29106931.
Liu L, Kong M, Gassman NR, Freudenthal BD, Prasad R, Zhen S, Watkins SC, Wilson SH, Van Houten B. PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1. Nucleic Acids Res. 2017 Dec 15;45(22):12834-12847. doi: 10.1093/nar/gkx1047. PubMed PMID: 29121337; PMCID: PMC5728402.
Kaufman BA, Van Houten B. POLB: A new role of DNA polymerase beta in mitochondrial base excision repair. DNA Repair (Amst). 2017 Dec;60A1-A5. doi: 10.1016/j.dnarep.2017.11.002. PubMed PMID: 29129598; PMCID: PMC5713914.
Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, Greenberger JS. Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways. Radiat Res. 2018 Jan;189(1):68-83. doi: 10.1667/RR14787.1. PubMed PMID: 29140165; PMCID: PMC5808408.
Van Houten B, Santa-Gonzalez GA, Camargo M. DNA repair after oxidative stress: current challenges. Curr Opin Toxicol. 2018 Feb;79-16. doi: 10.1016/j.cotox.2017.10.009. PubMed PMID: 29159324; PMCID: PMC5693256.
Geskin LJ, Akilov OE, Kwon S, Schowalter M, Watkins S, Whiteside TL, Butterfield LH, Falo LD Jr. Therapeutic reduction of cell-mediated immunosuppression in mycosis fungoides and Sézary syndrome. Cancer Immunol Immunother. 2018 Mar;67(3):423-434. doi: 10.1007/s00262-017-2090-z. PubMed PMID: 29204699.
Springall L, Hughes CD, Simons M, Azinas S, Van Houten B, Kad NM. Recruitment of UvrBC complexes to UV-induced damage in the absence of UvrA increases cell survival. Nucleic Acids Res. 2018 Feb 16;46(3):1256-1265. doi: 10.1093/nar/gkx1244. PubMed PMID: 29240933; PMCID: PMC5814901.
Liu B, Oltvai ZN, Bayır H, Silverman GA, Pak SC, Perlmutter DH, Bahar I. Quantitative assessment of cell fate decision between autophagy and apoptosis. Sci Rep. 2017 Dec 14;7(1):17605. doi: 10.1038/s41598-017-18001-w. PubMed PMID: 29242632; PMCID: PMC5730598.
Veglia F, Tyurin VA, Mohammadyani D, Blasi M, Duperret EK, Donthireddy L, Hashimoto A, Kapralov A, Amoscato A, Angelini R, Patel S, Alicea-Torres K, Weiner D, Murphy ME, Klein-Seetharaman J, Celis E, Kagan VE, Gabrilovich DI. Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer. Nat Commun. 2017 Dec 14;8(1):2122. doi: 10.1038/s41467-017-02186-9. PubMed PMID: 29242535; PMCID: PMC5730553.
Pinilla-Macua I, Grassart A, Duvvuri U, Watkins SC, Sorkin A. EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo. Elife. 2017 Dec 21;6 doi: 10.7554/eLife.31993. PubMed PMID: 29268862; PMCID: PMC5741375.
Perkins LA, Yan Q, Schmidt BF, Kolodieznyi D, Saurabh S, Larsen MB, Watkins SC, Kremer L, Bruchez MP. Genetically Targeted Ratiometric and Activated pH Indicator Complexes (TRApHIC) for Receptor Trafficking. Biochemistry. 2018 Feb 6;57(5):861-871. doi: 10.1021/acs.biochem.7b01135. PubMed PMID: 29283245.
Mohammadyani D, Yanamala N, Samhan-Arias AK, Kapralov AA, Stepanov G, Nuar N, Planas-Iglesias J, Sanghera N, Kagan VE, Klein-Seetharaman J. Structural characterization of cardiolipin-driven activation of cytochrome c into a peroxidase and membrane perturbation. Biochim Biophys Acta Biomembr. 2018 May;1860(5):1057-1068. doi: 10.1016/j.bbamem.2018.01.009. PubMed PMID: 29317202.
He YM, Li X, Perego M, Nefedova Y, Kossenkov AV, Jensen EA, Kagan V, Liu YF, Fu SY, Ye QJ, Zhou YH, Wei L, Gabrilovich DI, Zhou J. Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation. Nat Med. 2018 Feb;24(2):224-231. doi: 10.1038/nm.4467. PubMed PMID: 29334374; PMCID: PMC5803434.
Leipnitz G, Mohsen AW, Karunanidhi A, Seminotti B, Roginskaya VY, Markantone DM, Grings M, Mihalik SJ, Wipf P, Van Houten B, Vockley J. Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency. Sci Rep. 2018 Jan 18;8(1):1165. doi: 10.1038/s41598-018-19543-3. PubMed PMID: 29348607; PMCID: PMC5773529.
Ma J, Salamoun J, Wipf P, Edwards R, Van Houten B, Qian W. Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential. Oncotarget. 2018 Jan 19;9(5):6042-6054. doi: 10.18632/oncotarget.23679. PubMed PMID: 29464053; PMCID: PMC5814193.
Menk AV, Scharping NE, Rivadeneira DB, Calderon MJ, Watson MJ, Dunstane D, Watkins SC, Delgoffe GM. 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses. J Exp Med. 2018 Apr 2;215(4):1091-1100. doi: 10.1084/jem.20171068. PubMed PMID: 29511066; PMCID: PMC5881463.
Gaschler MM, Andia AA, Liu H, Csuka JM, Hurlocker B, Vaiana CA, Heindel DW, Zuckerman DS, Bos PH, Reznik E, Ye LF, Tyurina YY, Lin AJ, Shchepinov MS, Chan AY, Peguero-Pereira E, Fomich MA, Daniels JD, Bekish AV, Shmanai VV, Kagan VE, Mahal LK, Woerpel KA, Stockwell BR. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515. doi: 10.1038/s41589-018-0031-6. PubMed PMID: 29610484; PMCID: PMC5899674.
Ning J, Zhong Z, Fischer DK, Harris G, Watkins SC, Ambrose Z, Zhang P. Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid. J Virol. 2018 Jul 1;92(13): doi: 10.1128/JVI.00368-18. PubMed PMID: 29643241; PMCID: PMC6002704.
Watkins SC, St Croix CM. Light sheet imaging comes of age. J Cell Biol. 2018 May 7;217(5):1567-1569. doi: 10.1083/jcb.201804016. PubMed PMID: 29653995; PMCID: PMC5940317.
Choy CH, Saffi G, Gray MA, Wallace C, Dayam RM, Ou ZA, Lenk G, Puertollano R, Watkins SC, Botelho RJ. Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence. J Cell Sci. 2018 May 21;131(10): doi: 10.1242/jcs.213587. PubMed PMID: 29661845; PMCID: PMC6031331.
Du T, Zhu L, Levine KM, Tasdemir N, Lee AV, Vignali DAA, Houten BV, Tseng GC, Oesterreich S. Invasive lobular and ductal breast carcinoma differ in immune response, protein translation efficiency and metabolism. Sci Rep. 2018 May 8;8(1):7205. doi: 10.1038/s41598-018-25357-0. PubMed PMID: 29739984; PMCID: PMC5940770.
Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol. 2018 Jul;17259-273. doi: 10.1016/j.redox.2018.04.007. PubMed PMID: 29747066; PMCID: PMC6006678.
Kumar D, New J, Vishwakarma V, Joshi R, Enders J, Lin F, Dasari S, Gutierrez WR, Leef G, Ponnurangam S, Chavan H, Ganaden L, Thornton MM, Dai H, Tawfik O, Straub J, Shnayder Y, Kakarala K, Tsue TT, Girod DA, Van Houten B, Anant S, Krishnamurthy P, Thomas SM. Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression. Cancer Res. 2018 Jul 15;78(14):3769-3782. doi: 10.1158/0008-5472.CAN-17-1076. PubMed PMID: 29769197; PMCID: PMC6050074.
Hager NA, Krasowski CJ, Mackie TD, Kolb AR, Needham PG, Augustine AA, Dempsey A, Szent-Gyorgyi C, Bruchez MP, Bain DJ, Kwiatkowski AV, O'Donnell AF, Brodsky JL. Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model. J Biol Chem. 2018 Jul 13;293(28):11006-11021. doi: 10.1074/jbc.RA117.001293. PubMed PMID: 29784874; PMCID: PMC6052216.
Conrad M, Kagan VE, Bayir H, Pagnussat GC, Head B, Traber MG, Stockwell BR. Regulation of lipid peroxidation and ferroptosis in diverse species. Genes Dev. 2018 May 1;32(9-10):602-619. doi: 10.1101/gad.314674.118. PubMed PMID: 29802123; PMCID: PMC6004068.
Czerwińska J, Nowak M, Wojtczak P, Dziuban-Lech D, Cieśla JM, Kołata D, Gajewska B, Barańczyk-Kuźma A, Robinson AR, Shane HL, Gregg SQ, Rigatti LH, Yousefzadeh MJ, Gurkar AU, McGowan SJ, Kosicki K, Bednarek M, Zarakowska E, Gackowski D, Oliński R, Speina E, Niedernhofer LJ, Tudek B. ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. Free Radic Biol Med. 2018 Aug 20;12479-96. doi: 10.1016/j.freeradbiomed.2018.05.088. PubMed PMID: 29860127; PMCID: PMC6098728.
Zhang J, Tian XJ, Chen YJ, Wang W, Watkins S, Xing J. Pathway crosstalk enables cells to interpret TGF-β duration. NPJ Syst Biol Appl. 2018;418. doi: 10.1038/s41540-018-0060-5. PubMed PMID: 29872541; PMCID: PMC5972147.
Zhao J, Zhang L, Mu X, Doebelin C, Nguyen W, Wallace C, Reay DP, McGowan SJ, Corbo L, Clemens PR, Wilson GM, Watkins SC, Solt LA, Cameron MD, Huard J, Niedernhofer LJ, Kamenecka TM, Robbins PD. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun;16(6):e2004663. doi: 10.1371/journal.pbio.2004663. PubMed PMID: 29889904; PMCID: PMC6013238.
Niedernhofer LJ, Gurkar AU, Wang Y, Vijg J, Hoeijmakers JHJ, Robbins PD. Nuclear Genomic Instability and Aging. Annu Rev Biochem. 2018 Jun 20;87295-322. doi: 10.1146/annurev-biochem-062917-012239. PubMed PMID: 29925262.
Lou W, Ting HC, Reynolds CA, Tyurina YY, Tyurin VA, Li Y, Ji J, Yu W, Liang Z, Stoyanovsky DA, Anthonymuthu TS, Frasso MA, Wipf P, Greenberger JS, Bayır H, Kagan VE, Greenberg ML. Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1354-1368. doi: 10.1016/j.bbalip.2018.06.016. PubMed PMID: 29935382.
Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina YY, Bayır H, Abhari BA, Angeli JPF, Choi SM, Meul E, Heyninck K, Declerck K, Chirumamilla CS, Lahtela-Kakkonen M, Van Camp G, Krysko DV, Ekert PG, Fulda S, De Geest BG, Conrad M, Kagan VE, Vanden Berghe W, Vandenabeele P, Vanden Berghe T. Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma. J Clin Invest. 2018 Aug 1;128(8):3341-3355. doi: 10.1172/JCI99032. PubMed PMID: 29939160; PMCID: PMC6063467.
Van Houten B, Kad NM. Single-cell mutagenic responses and cell death revealed in real time. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7168-7170. doi: 10.1073/pnas.1808986115. PubMed PMID: 29946022; PMCID: PMC6048557.
Pradhan-Sundd T, Vats R, Russell JO, Singh S, Michael AA, Molina L, Kakar S, Cornuet P, Poddar M, Watkins SC, Nejak-Bowen KN, Monga SP, Sundd P. Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice. Gastroenterology. 2018 Oct;155(4):1218-1232.e24. doi: 10.1053/j.gastro.2018.06.048. PubMed PMID: 29964040; PMCID: PMC6174089.
Caves EA, Cook SA, Lee N, Stoltz D, Watkins S, Shair KHY. Air-Liquid Interface Method To Study Epstein-Barr Virus Pathogenesis in Nasopharyngeal Epithelial Cells. mSphere. 2018 Jul 18;3(4): doi: 10.1128/mSphere.00152-18. PubMed PMID: 30021875; PMCID: PMC6052337.
Gurkar AU, Robinson AR, Cui Y, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Wang Y, Kelley EE, Croix CMS, Niedernhofer LJ, Gill MS. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biol. 2018 Sep;18191-199. doi: 10.1016/j.redox.2018.06.005. PubMed PMID: 30031267; PMCID: PMC6076207.
Sannino S, Guerriero CJ, Sabnis AJ, Stolz DB, Wallace CT, Wipf P, Watkins SC, Bivona TG, Brodsky JL. Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells. J Cell Sci. 2018 Sep 5;131(17): doi: 10.1242/jcs.217760. PubMed PMID: 30131440; PMCID: PMC6140321.
Saydmohammed M, Yagi H, Calderon M, Clark MJ, Feinstein T, Sun M, Stolz DB, Watkins SC, Amack JD, Lo CW, Tsang M. Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality. Nat Commun. 2018 Aug 23;9(1):3381. doi: 10.1038/s41467-018-05866-2. PubMed PMID: 30139971; PMCID: PMC6107537.
Krainz T, Lamade AM, Du L, Maskrey TS, Calderon MJ, Watkins SC, Epperly MW, Greenberger JS, Bayır H, Wipf P, Clark RSB. Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor. ACS Chem Biol. 2018 Oct 19;13(10):2868-2879. doi: 10.1021/acschembio.8b00423. PubMed PMID: 30184433; PMCID: PMC6402482.
Du T, Sikora MJ, Levine KM, Tasdemir N, Riggins RB, Wendell SG, Van Houten B, Oesterreich S. Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer. Breast Cancer Res. 2018 Sep 4;20(1):106. doi: 10.1186/s13058-018-1041-8. PubMed PMID: 30180878; PMCID: PMC6124012.
Burkert SC, Shurin GV, White DL, He X, Kapralov AA, Kagan VE, Shurin MR, Star A. Targeting myeloid regulators by paclitaxel-loaded enzymatically degradable nanocups. Nanoscale. 2018 Sep 27;10(37):17990-18000. doi: 10.1039/c8nr04437f. PubMed PMID: 30226240; PMCID: PMC6563927.
Deng M, Tang Y, Li W, Wang X, Zhang R, Zhang X, Zhao X, Liu J, Tang C, Liu Z, Huang Y, Peng H, Xiao L, Tang D, Scott MJ, Wang Q, Liu J, Xiao X, Watkins S, Li J, Yang H, Wang H, Chen F, Tracey KJ, Billiar TR, Lu B. The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis. Immunity. 2018 Oct 16;49(4):740-753.e7. doi: 10.1016/j.immuni.2018.08.016. PubMed PMID: 30314759; PMCID: PMC6300139.
D'Aiuto L, McNulty J, Hartline C, Demers M, Kalkeri R, Wood J, McClain L, Chattopadhyay A, Zhi Y, Naciri J, Smith A, Yolken R, Chowdari K, Zepeda-Velazquez C, Dokuburra CB, Marques E, Ptak R, Kinchington P, Watkins S, Prichard M, Bloom D, Nimgaonkar V. R430: A potent inhibitor of DNA and RNA viruses. Sci Rep. 2018 Nov 9;8(1):16662. doi: 10.1038/s41598-018-33904-y. PubMed PMID: 30413769; PMCID: PMC6226428.
Seminotti B, Leipnitz G, Karunanidhi A, Kochersperger C, Roginskaya VY, Basu S, Wang Y, Wipf P, Van Houten B, Mohsen AW, Vockley J. Mitochondrial energetics is impaired in very long-chain acyl-CoA dehydrogenase deficiency and can be rescued by treatment with mitochondria-targeted electron scavengers. Hum Mol Genet. 2019 Mar 15;28(6):928-941. doi: 10.1093/hmg/ddy403. PubMed PMID: 30445591; PMCID: PMC6400046.
Zhang L, Zhao J, Gurkar A, Niedernhofer LJ, Robbins PD. Methods to Quantify the NF-κB Pathway During Senescence. Methods Mol Biol. 2019;1896231-250. doi: 10.1007/978-1-4939-8931-7_18. PubMed PMID: 30474851.
Kenny EM, Fidan E, Yang Q, Anthonymuthu TS, New LA, Meyer EA, Wang H, Kochanek PM, Dixon CE, Kagan VE, Bayir H. Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury. Crit Care Med. 2019 Mar;47(3):410-418. doi: 10.1097/CCM.0000000000003555. PubMed PMID: 30531185; PMCID: PMC6449247.
Anthonymuthu TS, Kenny EM, Shrivastava I, Tyurina YY, Hier ZE, Ting HC, Dar HH, Tyurin VA, Nesterova A, Amoscato AA, Mikulska-Ruminska K, Rosenbaum JC, Mao G, Zhao J, Conrad M, Kellum JA, Wenzel SE, VanDemark AP, Bahar I, Kagan VE, Bayır H. Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE. J Am Chem Soc. 2018 Dec 26;140(51):17835-17839. doi: 10.1021/jacs.8b09913. PubMed PMID: 30525572; PMCID: PMC6622169.
Baranov SV, Baranova OV, Yablonska S, Suofu Y, Vazquez AL, Kozai TDY, Cui XT, Ferrando LM, Larkin TM, Tyurina YY, Kagan VE, Carlisle DL, Kristal BS, Friedlander RM. Mitochondria modulate programmed neuritic retraction. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):650-659. doi: 10.1073/pnas.1811021116. PubMed PMID: 30584104; PMCID: PMC6329959.
Surve SV, Myers PJ, Clayton SA, Watkins SC, Lazzara MJ, Sorkin A. Localization dynamics of endogenous fluorescently labeled RAF1 in EGF-stimulated cells. Mol Biol Cell. 2019 Feb 15;30(4):506-523. doi: 10.1091/mbc.E18-08-0512. PubMed PMID: 30586319; PMCID: PMC6594441.
Chao H, Lin C, Zuo Q, Liu Y, Xiao M, Xu X, Li Z, Bao Z, Chen H, You Y, Kochanek PM, Yin H, Liu N, Kagan VE, Bayır H, Ji J. Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury. J Neurosci. 2019 Mar 6;39(10):1930-1943. doi: 10.1523/JNEUROSCI.3415-17.2018. PubMed PMID: 30626699; PMCID: PMC6407296.
Klein HL, Ang KKH, Arkin MR, Beckwitt EC, Chang YH, Fan J, Kwon Y, Morten MJ, Mukherjee S, Pambos OJ, El Sayyed H, Thrall ES, Vieira-da-Rocha JP, Wang Q, Wang S, Yeh HY, Biteen JS, Chi P, Heyer WD, Kapanidis AN, Loparo JJ, Strick TR, Sung P, Van Houten B, Niu H, Rothenberg E. Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes. Microb Cell. 2019 Jan 7;6(1):65-101. doi: 10.15698/mic2019.01.665. PubMed PMID: 30652106; PMCID: PMC6334232.
Tian H, Sparvero LJ, Blenkinsopp P, Amoscato AA, Watkins SC, Bayır H, Kagan VE, Winograd N. Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular Level. Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3156-3161. doi: 10.1002/anie.201814256. PubMed PMID: 30680861; PMCID: PMC6622167.
Sehrawat A, Samanta SK, Hahm ER, St Croix C, Watkins S, Singh SV. Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics. Mitochondrion. 2019 Jul;47282-293. doi: 10.1016/j.mito.2019.01.003. PubMed PMID: 30685490; PMCID: PMC6599725.
Mikulska-Ruminska K, Shrivastava I, Krieger J, Zhang S, Li H, Bayır H, Wenzel SE, VanDemark AP, Kagan VE, Bahar I. Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members. J Chem Inf Model. 2019 May 28;59(5):2496-2508. doi: 10.1021/acs.jcim.9b00006. PubMed PMID: 30762363; PMCID: PMC6541894.
Raza Q, Choi JY, Li Y, O'Dowd RM, Watkins SC, Chikina M, Hong Y, Clark NL, Kwiatkowski AV. Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila. PLoS Genet. 2019 Feb;15(2):e1007720. doi: 10.1371/journal.pgen.1007720. PubMed PMID: 30763317; PMCID: PMC6375579.
D'Aiuto L, Bloom DC, Naciri JN, Smith A, Edwards TG, McClain L, Callio JA, Jessup M, Wood J, Chowdari K, Demers M, Abrahamson EE, Ikonomovic MD, Viggiano L, De Zio R, Watkins S, Kinchington PR, Nimgaonkar VL. Modeling Herpes Simplex Virus 1 Infections in Human Central Nervous System Neuronal Cells Using Two- and Three-Dimensional Cultures Derived from Induced Pluripotent Stem Cells. J Virol. 2019 May 1;93(9): doi: 10.1128/JVI.00111-19. PubMed PMID: 30787148; PMCID: PMC6475775.
Fischer DK, Saito A, Kline C, Cohen R, Watkins SC, Yamashita M, Ambrose Z. CA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity Phenotypes. J Virol. 2019 May 1;93(9): doi: 10.1128/JVI.00214-19. PubMed PMID: 30814280; PMCID: PMC6475785.
Anthonymuthu TS, Kenny EM, Lamade AM, Gidwani H, Krehel NM, Misse A, Gao X, Amoscato AA, Straub AC, Kagan VE, Dezfulian C, Bayır H. Lipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest. Crit Care Med. 2019 Apr;47(4):e292-e300. doi: 10.1097/CCM.0000000000003636. PubMed PMID: 30855329; PMCID: PMC6622168.
Li M, Mandal A, Tyurin VA, DeLucia M, Ahn J, Kagan VE, van der Wel PCA. Surface-Binding to Cardiolipin Nanodomains Triggers Cytochrome c Pro-apoptotic Peroxidase Activity via Localized Dynamics. Structure. 2019 May 7;27(5):806-815.e4. doi: 10.1016/j.str.2019.02.007. PubMed PMID: 30879887; PMCID: PMC6615723.
Tyurina YY, Tyurin VA, Anthonymuthu T, Amoscato AA, Sparvero LJ, Nesterova AM, Baynard ML, Sun W, He R, Khaitovich P, Vladimirov YA, Gabrilovich DI, Bayır H, Kagan VE. "Redox lipidomics technology: Looking for a needle in a haystack". Chem Phys Lipids. 2019 Jul;22193-107. doi: 10.1016/j.chemphyslip.2019.03.012. PubMed PMID: 30928338.
Singh M, Tian XJ, Donnenberg VS, Watson AM, Zhang J, Stabile LP, Watkins SC, Xing J, Sant S. Targeting the Temporal Dynamics of Hypoxia-Induced Tumor-Secreted Factors Halts Tumor Migration. Cancer Res. 2019 Jun 1;79(11):2962-2977. doi: 10.1158/0008-5472.CAN-18-3151. PubMed PMID: 30952634; PMCID: PMC6548579.
Hamsanathan S, Alder JK, Sellares J, Rojas M, Gurkar AU, Mora AL. Cellular Senescence: The Trojan Horse in Chronic Lung Diseases. Am J Respir Cell Mol Biol. 2019 Jul;61(1):21-30. doi: 10.1165/rcmb.2018-0410TR. PubMed PMID: 30965013; PMCID: PMC6604222.
Veglia F, Tyurin VA, Blasi M, De Leo A, Kossenkov AV, Donthireddy L, To TKJ, Schug Z, Basu S, Wang F, Ricciotti E, DiRusso C, Murphy ME, Vonderheide RH, Lieberman PM, Mulligan C, Nam B, Hockstein N, Masters G, Guarino M, Lin C, Nefedova Y, Black P, Kagan VE, Gabrilovich DI. Fatty acid transport protein 2 reprograms neutrophils in cancer. Nature. 2019 May;569(7754):73-78. doi: 10.1038/s41586-019-1118-2. PubMed PMID: 30996346; PMCID: PMC6557120.
Wang W, Taft DA, Chen YJ, Zhang J, Wallace CT, Xu M, Watkins SC, Xing J. Learn to segment single cells with deep distance estimator and deep cell detector. Comput Biol Med. 2019 May;108133-141. doi: 10.1016/j.compbiomed.2019.04.006. PubMed PMID: 31005005.
Larsen MB, Perez Verdaguer M, Schmidt BF, Bruchez MP, Watkins SC, Sorkin A. Generation of endogenous pH-sensitive EGF receptor and its application in high-throughput screening for proteins involved in clathrin-mediated endocytosis. Elife. 2019 May 8;8 doi: 10.7554/eLife.46135. PubMed PMID: 31066673; PMCID: PMC6533059.
Tyurina YY, St Croix CM, Watkins SC, Watson AM, Epperly MW, Anthonymuthu TS, Kisin ER, Vlasova II, Krysko O, Krysko DV, Kapralov AA, Dar HH, Tyurin VA, Amoscato AA, Popova EN, Bolevich SB, Timashev PS, Kellum JA, Wenzel SE, Mallampalli RK, Greenberger JS, Bayir H, Shvedova AA, Kagan VE. Redox (phospho)lipidomics of signaling in inflammation and programmed cell death. J Leukoc Biol. 2019 Jul;106(1):57-81. doi: 10.1002/JLB.3MIR0119-004RR. PubMed PMID: 31071242; PMCID: PMC6626990.
Fouquerel E, Barnes RP, Uttam S, Watkins SC, Bruchez MP, Opresko PL. Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis. Mol Cell. 2019 Jul 11;75(1):117-130.e6. doi: 10.1016/j.molcel.2019.04.024. PubMed PMID: 31101499; PMCID: PMC6625854.
Piccirillo AR, Hyzny EJ, Beppu LY, Menk AV, Wallace CT, Hawse WF, Buechel HM, Wong BH, Foo JC, Cazenave-Gassiot A, Wenk MR, Delgoffe GM, Watkins SC, Silver DL, D'Cruz LM. The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8+ Memory T Cell Maintenance and Secondary Response to Infection. J Immunol. 2019 Jul 1;203(1):117-126. doi: 10.4049/jimmunol.1801585. PubMed PMID: 31127034; PMCID: PMC6581627.
Moiseeva TN, Yin Y, Calderon MJ, Qian C, Schamus-Haynes S, Sugitani N, Osmanbeyoglu HU, Rothenberg E, Watkins SC, Bakkenist CJ. An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13374-13383. doi: 10.1073/pnas.1903418116. PubMed PMID: 31209037; PMCID: PMC6613105.
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