Publications

Aging and Cancer

Maxwell JH, Mehta V, Wang H, Cunningham D, Duvvuri U, Kim S, Johnson JT, Ferris RL. Quality of life in head and neck cancer patients: impact of HPV and primary treatment modality. Laryngoscope. 2014 Jul;124(7):1592-7. doi: 10.1002/lary.24508. PubMed PMID: 24353066.
Van Houten B, Kad N. Investigation of bacterial nucleotide excision repair using single-molecule techniques. DNA Repair (Amst). 2014 Aug;2041-48. doi: 10.1016/j.dnarep.2013.10.012. PubMed PMID: 24472181; PMCID: PMC5053424.
Lin J, Kaur P, Countryman P, Opresko PL, Wang H. Unraveling secrets of telomeres: one molecule at a time. DNA Repair (Amst). 2014 Aug;20142-153. doi: 10.1016/j.dnarep.2014.01.012. PubMed PMID: 24569170; PMCID: PMC4833095.
Hughes CD, Simons M, Mackenzie CE, Van Houten B, Kad NM. Single molecule techniques in DNA repair: a primer. DNA Repair (Amst). 2014 Aug;202-13. doi: 10.1016/j.dnarep.2014.02.003. PubMed PMID: 24819596; PMCID: PMC5125534.
Hwang H, Kreig A, Calvert J, Lormand J, Kwon Y, Daley JM, Sung P, Opresko PL, Myong S. Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteins. Structure. 2014 Jun 10;22(6):842-53. doi: 10.1016/j.str.2014.03.013. PubMed PMID: 24836024; PMCID: PMC4067947.
Berhane H, Shinde A, Kalash R, Xu K, Epperly MW, Goff J, Franicola D, Zhang X, Dixon T, Shields D, Wang H, Wipf P, Li S, Gao X, Greenberger JS. Amelioration of radiation-induced oral cavity mucositis and distant bone marrow suppression in fanconi anemia Fancd2-/- (FVB/N) mice by intraoral GS-nitroxide JP4-039. Radiat Res. 2014 Jul;182(1):35-49. doi: 10.1667/RR13633.1. PubMed PMID: 24932534; PMCID: PMC4101533.
Tang D, Kang R, Van Houten B, Zeh HJ, Billiar TR, Lotze MT. High mobility group box 1 (HMGB1) phenotypic role revealed with stress. Mol Med. 2014 Aug 19;20359-62. doi: 10.2119/molmed.2014.00063. PubMed PMID: 24937773; PMCID: PMC4153844.
Qian W, Wang J, Roginskaya V, McDermott LA, Edwards RP, Stolz DB, Llambi F, Green DR, Van Houten B. Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells. Oncotarget. 2014 Jun 30;5(12):4180-94. doi: 10.18632/oncotarget.1944. PubMed PMID: 24952704; PMCID: PMC4147315.
Shinde A, Epperly MW, Cao S, Franicola D, Shields D, Wang H, Wipf P, Sprachman MM, Greenberger JS. Effects of the bifunctional sulfoxide MMS350, a radiation mitigator, on hematopoiesis in long-term bone marrow cultures and on radioresistance of marrow stromal cell lines. In Vivo. 2014 Jul-Aug;28(4):457-65. PubMed PMID: 24982210; PMCID: PMC6591577.
Epperly MW, Goff JP, Franicola D, Wang H, Wipf P, Li S, Greenberger JS. Esophageal radioprotection by swallowed JP4-039/F15 in thoracic-irradiated mice with transgenic lung tumors. In Vivo. 2014 Jul-Aug;28(4):435-40. PubMed PMID: 24982207; PMCID: PMC6436097.
Murphy CT, Gupta A, Armitage BA, Opresko PL. Hybridization of G-quadruplex-forming peptide nucleic acids to guanine-rich DNA templates inhibits DNA polymerase η extension. Biochemistry. 2014 Aug 19;53(32):5315-22. doi: 10.1021/bi5006859. PubMed PMID: 25068499.
Pham HH, Murphy CT, Sureshkumar G, Ly DH, Opresko PL, Armitage BA. Cooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis. Org Biomol Chem. 2014 Oct 7;12(37):7345-7354. doi: 10.1039/c4ob00953c. PubMed PMID: 25115693; PMCID: PMC4162129.
Nakajima EC, Laymon C, Oborski M, Hou W, Wang L, Grandis JR, Ferris RL, Mountz JM, Van Houten B. Quantifying metabolic heterogeneity in head and neck tumors in real time: 2-DG uptake is highest in hypoxic tumor regions. PLoS One. 2014;9(8):e102452. doi: 10.1371/journal.pone.0102452. PubMed PMID: 25127378; PMCID: PMC4134191.
de Moura MB, Uppala R, Zhang Y, Van Houten B, Goetzman ES. Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells. PLoS One. 2014;9(8):e106028. doi: 10.1371/journal.pone.0106028. PubMed PMID: 25165814; PMCID: PMC4148395.
Shinde A, Epperly MW, Cao S, Holt D, Goff J, Shields D, Franicola D, Wipf P, Wang H, Greenberger JS. Improved hematopoiesis in GS-nitroxide (JP4-039)-treated mouse long-term bone marrow cultures and radioresistance of derived bone marrow stromal cell lines. In Vivo. 2014 Sep-Oct;28(5):699-708. PubMed PMID: 25189880; PMCID: PMC6477534.
Fouquerel E, Goellner EM, Yu Z, Gagné JP, Barbi de Moura M, Feinstein T, Wheeler D, Redpath P, Li J, Romero G, Migaud M, Van Houten B, Poirier GG, Sobol RW. ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion. Cell Rep. 2014 Sep 25;8(6):1819-1831. doi: 10.1016/j.celrep.2014.08.036. PubMed PMID: 25220464; PMCID: PMC4177344.
Chen D, Ming L, Zou F, Peng Y, Van Houten B, Yu J, Zhang L. TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. 2014 Sep 30;5(18):8107-22. doi: 10.18632/oncotarget.2440. PubMed PMID: 25237903; PMCID: PMC4226670.
Hwang H, Opresko P, Myong S. Single-molecule real-time detection of telomerase extension activity. Sci Rep. 2014 Sep 29;46391. doi: 10.1038/srep06391. PubMed PMID: 25263700; PMCID: PMC4178293.
Pope-Varsalona H, Liu FJ, Guzik L, Opresko PL. Polymerase η suppresses telomere defects induced by DNA damaging agents. Nucleic Acids Res. 2014 Dec 1;42(21):13096-109. doi: 10.1093/nar/gku1030. PubMed PMID: 25355508; PMCID: PMC4245935.
Rhieu BH, Shinde A, Epperly MW, Dixon T, Wang H, Chaillet R, Greenberger JS. Organ-specific responses of total body irradiated doxycycline-inducible manganese superoxide dismutase Tet/Tet mice. In Vivo. 2014 Nov-Dec;28(6):1033-43. PubMed PMID: 25398796; PMCID: PMC6436100.
Chen X, Velmurugu Y, Zheng G, Park B, Shim Y, Kim Y, Liu L, Van Houten B, He C, Ansari A, Min JH. Kinetic gating mechanism of DNA damage recognition by Rad4/XPC. Nat Commun. 2015 Jan 6;65849. doi: 10.1038/ncomms6849. PubMed PMID: 25562780; PMCID: PMC4354021.
Qian W, Salamoun J, Wang J, Roginskaya V, Van Houten B, Wipf P. The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak. Bioorg Med Chem Lett. 2015 Feb 15;25(4):856-63. doi: 10.1016/j.bmcl.2014.12.072. PubMed PMID: 25582599; PMCID: PMC4318771.
Maxwell JH, Rath TJ, Byrd JK, Albergotti WG, Wang H, Duvvuri U, Kim S, Johnson JT, Branstetter BF 4th, Ferris RL. Accuracy of computed tomography to predict extracapsular spread in p16-positive squamous cell carcinoma. Laryngoscope. 2015 Jul;125(7):1613-8. doi: 10.1002/lary.25140. PubMed PMID: 25946149.
Gomez-Casal R, Bhattacharya C, Epperly MW, Basse PH, Wang H, Wang X, Proia DA, Greenberger JS, Socinski MA, Levina V. The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells. Cancers (Basel). 2015 May 22;7(2):876-907. doi: 10.3390/cancers7020814. PubMed PMID: 26010604; PMCID: PMC4491689.
Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P. Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4828-4833. doi: 10.1016/j.bmcl.2015.06.073. PubMed PMID: 26159482; PMCID: PMC4607627.
Parikh D, Fouquerel E, Murphy CT, Wang H, Opresko PL. Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts. Nat Commun. 2015 Sep 9;68214. doi: 10.1038/ncomms9214. PubMed PMID: 26351258; PMCID: PMC4566151.
Dickson R, Kim JO, Huq MS, Bednarz G, Suyama J, Yealy DM, Wang H, Greenberger JS. A Mobile Alert System for Preparing the Delivery of Radiation Mitigators. In Vivo. 2015 Sep-Oct;29(5):505-13. PubMed PMID: 26359406.
Gomez-Casal R, Epperly MW, Wang H, Proia DA, Greenberger JS, Levina V. Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition. Oncotarget. 2015 Dec 29;6(42):44306-22. doi: 10.18632/oncotarget.6248. PubMed PMID: 26517240; PMCID: PMC4792558.
Simons M, Pollard MR, Hughes CD, Ward AD, Van Houten B, Towrie M, Botchway SW, Parker AW, Kad NM. Directly interrogating single quantum dot labelled UvrA2 molecules on DNA tightropes using an optically trapped nanoprobe. Sci Rep. 2015 Dec 22;518486. doi: 10.1038/srep18486. PubMed PMID: 26691010; PMCID: PMC4686980.
Van Houten B, Hunter SE, Meyer JN. Mitochondrial DNA damage induced autophagy, cell death, and disease. Front Biosci (Landmark Ed). 2016 Jan 1;2142-54. doi: 10.2741/4375. PubMed PMID: 26709760; PMCID: PMC4750375.
Xie Y, Wang H, Cheng X, Wu Y, Cao L, Wu M, Xie W, Wang G, Hao H. Farnesoid X receptor activation promotes cell proliferation via PDK4-controlled metabolic reprogramming. Sci Rep. 2016 Jan 5;618751. doi: 10.1038/srep18751. PubMed PMID: 26728993; PMCID: PMC4700422.
Shinde A, Berhane H, Rhieu BH, Kalash R, Xu K, Goff J, Epperly MW, Franicola D, Zhang X, Dixon T, Shields D, Wang H, Wipf P, Parmar K, Guinan E, Kagan V, Tyurin V, Ferris RL, Zhang X, Li S, Greenberger JS. Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice. Radiat Res. 2016 Feb;185(2):134-50. doi: 10.1667/RR14035.1. PubMed PMID: 26789701; PMCID: PMC4773657.
Mehta K, Appleman L, Wang H, Tarhini AA, Parikh RA. Annual Hospital Volume of High Dose Interleukin-2 and Inpatient Mortality in Melanoma and Renal Cell Carcinoma Patients. PLoS One. 2016;11(1):e0147153. doi: 10.1371/journal.pone.0147153. PubMed PMID: 26799322; PMCID: PMC4723120.
Kaur P, Wu D, Lin J, Countryman P, Bradford KC, Erie DA, Riehn R, Opresko PL, Wang H. Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2. Sci Rep. 2016 Feb 9;620513. doi: 10.1038/srep20513. PubMed PMID: 26856421; PMCID: PMC4746636.
Lee S, Opresko P, Pappo A, Kirkwood JM, Bahrami A. Association of TERT promoter mutations with telomerase expression in melanoma. Pigment Cell Melanoma Res. 2016 May;29(3):391-3. doi: 10.1111/pcmr.12471. PubMed PMID: 26928778; PMCID: PMC5248652.
Opresko PL, Shay JW. Telomere-associated aging disorders. Ageing Res Rev. 2017 Jan;3352-66. doi: 10.1016/j.arr.2016.05.009. PubMed PMID: 27215853.
Fouquerel E, Parikh D, Opresko P. DNA damage processing at telomeres: The ends justify the means. DNA Repair (Amst). 2016 Aug;44159-168. doi: 10.1016/j.dnarep.2016.05.022. PubMed PMID: 27233113.
Houten BV, Kuper J, Kisker C. Role of XPD in cellular functions: To TFIIH and beyond. DNA Repair (Amst). 2016 Aug;44136-142. doi: 10.1016/j.dnarep.2016.05.019. PubMed PMID: 27262611.
Lin J, Countryman P, Chen H, Pan H, Fan Y, Jiang Y, Kaur P, Miao W, Gurgel G, You C, Piehler J, Kad NM, Riehn R, Opresko PL, Smith S, Tao YJ, Wang H. Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing. Nucleic Acids Res. 2016 Jul 27;44(13):6363-76. doi: 10.1093/nar/gkw518. PubMed PMID: 27298259; PMCID: PMC5291270.
Tippana R, Hwang H, Opresko PL, Bohr VA, Myong S. Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8448-53. doi: 10.1073/pnas.1603724113. PubMed PMID: 27407146; PMCID: PMC4968719.
Sallmyr A, Matsumoto Y, Roginskaya V, Van Houten B, Tomkinson AE. Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1-Dependent Apoptosis in Cancer Cells. Cancer Res. 2016 Sep 15;76(18):5431-41. doi: 10.1158/0008-5472.CAN-15-3243. PubMed PMID: 27503931; PMCID: PMC5036517.
Zhang X, Hou W, Epperly MW, Rigatti L, Wang H, Franicola D, Sivanathan A, Greenberger JS. Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2-/- mouse long-term bone marrow cultures. Oncotarget. 2016 Oct 18;7(42):68449-68472. doi: 10.18632/oncotarget.12036. PubMed PMID: 27637088; PMCID: PMC5356567.
Kong M, Liu L, Chen X, Driscoll KI, Mao P, Böhm S, Kad NM, Watkins SC, Bernstein KA, Wyrick JJ, Min JH, Van Houten B. Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process. Mol Cell. 2016 Oct 20;64(2):376-387. doi: 10.1016/j.molcel.2016.09.005. PubMed PMID: 27720644; PMCID: PMC5123691.
Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL. Oxidative guanine base damage regulates human telomerase activity. Nat Struct Mol Biol. 2016 Dec;23(12):1092-1100. doi: 10.1038/nsmb.3319. PubMed PMID: 27820808; PMCID: PMC5140714.
Garcia-Exposito L, Bournique E, Bergoglio V, Bose A, Barroso-Gonzalez J, Zhang S, Roncaioli JL, Lee M, Wallace CT, Watkins SC, Opresko PL, Hoffmann JS, O'Sullivan RJ. Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres. Cell Rep. 2016 Nov 8;17(7):1858-1871. doi: 10.1016/j.celrep.2016.10.048. PubMed PMID: 27829156; PMCID: PMC5406014.
Kad NM, Van Houten B. DNA repair: Clamping down on copy errors. Nature. 2016 Nov 24;539(7630):498-499. doi: 10.1038/nature20475. PubMed PMID: 27851733; PMCID: PMC5641404.
Fouquerel E, Opresko PL. Convergence of The Nobel Fields of Telomere Biology and DNA Repair. Photochem Photobiol. 2017 Jan;93(1):229-237. doi: 10.1111/php.12672. PubMed PMID: 27861975; PMCID: PMC5315637.
Kong M, Van Houten B. Rad4 recognition-at-a-distance: Physical basis of conformation-specific anomalous diffusion of DNA repair proteins. Prog Biophys Mol Biol. 2017 Aug;12793-104. doi: 10.1016/j.pbiomolbio.2016.12.004. PubMed PMID: 27939760; PMCID: PMC5462892.
Zhao J, Fuhrmann-Stroissnigg H, Gurkar AU, Flores RR, Dorronsoro A, Stolz DB, St Croix CM, Niedernhofer LJ, Robbins PD. Quantitative Analysis of Cellular Senescence in Culture and In Vivo. Curr Protoc Cytom. 2017 Jan 5;799.51.1-9.51.25. doi: 10.1002/cpcy.16. PubMed PMID: 28055114.
Epperly MW, Sacher JR, Krainz T, Zhang X, Wipf P, Liang M, Fisher R, Li S, Wang H, Greenberger JS. Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators. In Vivo. 2017 Jan 2;31(1):39-43. doi: 10.21873/invivo.11022. PubMed PMID: 28064218; PMCID: PMC5267945.
Luo J, Kong M, Liu L, Samanta S, Van Houten B, Deiters A. Optical Control of DNA Helicase Function through Genetic Code Expansion. Chembiochem. 2017 Mar 2;18(5):466-469. doi: 10.1002/cbic.201600624. PubMed PMID: 28120472; PMCID: PMC5516474.
Epperly MW, Rhieu BH, Franicola D, Dixon T, Cao S, Zhang X, Shields D, Wang H, Wipf P, Greenberger JS. Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350. In Vivo. 2017 Mar-Apr;31(2):159-168. doi: 10.21873/invivo.11040. PubMed PMID: 28358695; PMCID: PMC5411740.
Capello M, Bantis LE, Scelo G, Zhao Y, Li P, Dhillon DS, Patel NJ, Kundnani DL, Wang H, Abbruzzese JL, Maitra A, Tempero MA, Brand R, Firpo MA, Mulvihill SJ, Katz MH, Brennan P, Feng Z, Taguchi A, Hanash SM. Sequential Validation of Blood-Based Protein Biomarker Candidates for Early-Stage Pancreatic Cancer. J Natl Cancer Inst. 2017 Apr 1;109(4): doi: 10.1093/jnci/djw266. PubMed PMID: 28376157; PMCID: PMC5441297.
Liu D, Wang H, Schwender H, Marazita ML, Wang Z, Yuan Y, Wang P, Liang KY, Wu-Chou YH, Wang M, Shi B, Zhu H, Wu T, Beaty TH. Gene-gene interaction of single nucleotide polymorphisms in 16p13.3 may contribute to the risk of non-syndromic cleft lip with or without cleft palate in Chinese case-parent trios. Am J Med Genet A. 2017 Jun;173(6):1489-1494. doi: 10.1002/ajmg.a.38190. PubMed PMID: 28402597; PMCID: PMC5559727.
Epperly MW, Zhang X, Fisher R, Hou W, Franicola D, Shields D, Quickel M, Hankey-Giblin P, Wang H, Greenberger JS. Reduced Competitive Repopulation Capacity of Multipotential Hematopoietic Stem Cells in the Bone Marrow of Friend Virus-infected Fv2-resistant Mice. In Vivo. 2017 May-Jun;31(3):313-320. doi: 10.21873/invivo.11061. PubMed PMID: 28438857; PMCID: PMC5461439.
Kong M, Beckwitt EC, Springall L, Kad NM, Van Houten B. Single-Molecule Methods for Nucleotide Excision Repair: Building a System to Watch Repair in Real Time. Methods Enzymol. 2017;592213-257. doi: 10.1016/bs.mie.2017.03.027. PubMed PMID: 28668122; PMCID: PMC5656006.
Beckwitt EC, Kong M, Van Houten B. Studying protein-DNA interactions using atomic force microscopy. Semin Cell Dev Biol. 2018 Jan;73220-230. doi: 10.1016/j.semcdb.2017.06.028. PubMed PMID: 28673677; PMCID: PMC5762137.
Jenkins FJ, Kerr CM, Fouquerel E, Bovbjerg DH, Opresko PL. Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization. J Vis Exp. 2017 Jul 10;(125): doi: 10.3791/56001. PubMed PMID: 28715381; PMCID: PMC5612054.
Zhou J, Chan J, Lambelé M, Yusufzai T, Stumpff J, Opresko PL, Thali M, Wallace SS. NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis. Cell Rep. 2017 Aug 29;20(9):2044-2056. doi: 10.1016/j.celrep.2017.08.020. PubMed PMID: 28854357; PMCID: PMC5606162.
Boyiadzis M, Agha M, Redner RL, Sehgal A, Im A, Hou JZ, Farah R, Dorritie KA, Raptis A, Lim SH, Wang H, Lapteva N, Mei Z, Butterfield LH, Rooney CM, Whiteside TL. Phase 1 clinical trial of adoptive immunotherapy using "off-the-shelf" activated natural killer cells in patients with refractory and relapsed acute myeloid leukemia. Cytotherapy. 2017 Oct;19(10):1225-1232. doi: 10.1016/j.jcyt.2017.07.008. PubMed PMID: 28864289.
Beckwitt EC, Van Houten B. Molecular cartography of mutational landscapes in melanomas. EMBO J. 2017 Oct 2;36(19):2812-2814. doi: 10.15252/embj.201797944. PubMed PMID: 28931563; PMCID: PMC5623845.
Eiseman JL, Sciullo M, Wang H, Beumer JH, Horn CC. Estimation of body surface area in the musk shrew ( Suncus murinus): a small animal for testing chemotherapy-induced emesis. Lab Anim. 2017 Oct;51(5):534-537. doi: 10.1177/0023677217695851. PubMed PMID: 28948895; PMCID: PMC5654602.
Lee HT, Bose A, Lee CY, Opresko PL, Myong S. Molecular mechanisms by which oxidative DNA damage promotes telomerase activity. Nucleic Acids Res. 2017 Nov 16;45(20):11752-11765. doi: 10.1093/nar/gkx789. PubMed PMID: 28981887; PMCID: PMC5714237.
Liu L, Kong M, Gassman NR, Freudenthal BD, Prasad R, Zhen S, Watkins SC, Wilson SH, Van Houten B. PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1. Nucleic Acids Res. 2017 Dec 15;45(22):12834-12847. doi: 10.1093/nar/gkx1047. PubMed PMID: 29121337; PMCID: PMC5728402.
Kaufman BA, Van Houten B. POLB: A new role of DNA polymerase beta in mitochondrial base excision repair. DNA Repair (Amst). 2017 Dec;60A1-A5. doi: 10.1016/j.dnarep.2017.11.002. PubMed PMID: 29129598; PMCID: PMC5713914.
Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, Greenberger JS. Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways. Radiat Res. 2018 Jan;189(1):68-83. doi: 10.1667/RR14787.1. PubMed PMID: 29140165; PMCID: PMC5808408.
Van Houten B, Santa-Gonzalez GA, Camargo M. DNA repair after oxidative stress: current challenges. Curr Opin Toxicol. 2018 Feb;79-16. doi: 10.1016/j.cotox.2017.10.009. PubMed PMID: 29159324; PMCID: PMC5693256.
Orenstein A, Berlyoung AS, Rastede EE, Pham HH, Fouquerel E, Murphy CT, Leibowitz BJ, Yu J, Srivastava T, Armitage BA, Opresko PL. γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue. Molecules. 2017 Dec 2;22(12): doi: 10.3390/molecules22122117. PubMed PMID: 29207465; PMCID: PMC5895088.
Springall L, Hughes CD, Simons M, Azinas S, Van Houten B, Kad NM. Recruitment of UvrBC complexes to UV-induced damage in the absence of UvrA increases cell survival. Nucleic Acids Res. 2018 Feb 16;46(3):1256-1265. doi: 10.1093/nar/gkx1244. PubMed PMID: 29240933; PMCID: PMC5814901.
Achkar T, Arjunan A, Wang H, Saul M, Davar D, Appleman LJ, Friedland D, Parikh RA. High-dose interleukin 2 in patients with metastatic renal cell carcinoma with sarcomatoid features. PLoS One. 2017;12(12):e0190084. doi: 10.1371/journal.pone.0190084. PubMed PMID: 29261796; PMCID: PMC5738119.
Strock SB, Alder JK, Kass DJ. From bad to worse: when lung cancer complicates idiopathic pulmonary fibrosis. J Pathol. 2018 Apr;244(4):383-385. doi: 10.1002/path.5027. PubMed PMID: 29282737; PMCID: PMC6491351.
Yuan JM, Beckman KB, Wang R, Bull C, Adams-Haduch J, Huang JY, Jin A, Opresko P, Newman AB, Zheng YL, Fenech M, Koh WP. Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study. Int J Cancer. 2018 Jun 1;142(11):2234-2243. doi: 10.1002/ijc.31251. PubMed PMID: 29318605; PMCID: PMC5893405.
Mehta K, Im A, Rahman F, Wang H, Veldkamp P. Epidemiology and Outcomes of Hematopoietic Stem Cell Transplantation in Human Immunodeficiency Virus-Positive Patients From 1998 to 2012: A Nationwide Analysis. Clin Infect Dis. 2018 Jun 18;67(1):128-133. doi: 10.1093/cid/ciy010. PubMed PMID: 29325063.
Leipnitz G, Mohsen AW, Karunanidhi A, Seminotti B, Roginskaya VY, Markantone DM, Grings M, Mihalik SJ, Wipf P, Van Houten B, Vockley J. Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency. Sci Rep. 2018 Jan 18;8(1):1165. doi: 10.1038/s41598-018-19543-3. PubMed PMID: 29348607; PMCID: PMC5773529.
Ma J, Salamoun J, Wipf P, Edwards R, Van Houten B, Qian W. Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential. Oncotarget. 2018 Jan 19;9(5):6042-6054. doi: 10.18632/oncotarget.23679. PubMed PMID: 29464053; PMCID: PMC5814193.
Sutera P, Bernard ME, Wang H, Bahary N, Burton S, Zeh H, Heron DE. Stereotactic Body Radiation Therapy for Locally Progressive and Recurrent Pancreatic Cancer after Prior Radiation. Front Oncol. 2018;852. doi: 10.3389/fonc.2018.00052. PubMed PMID: 29564223; PMCID: PMC5845878.
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