Publications

Peng WY, Abere B, Shi H, Toland S, Smithgall TE, Moore PS, Chang Y. Membrane-bound Merkel cell polyomavirus middle T protein constitutively activates PLCγ1 signaling through Src-family kinases. Proc Natl Acad Sci U S A. 2023-12-19;120(51):e2316467120. doi: 10.1073/pnas.2316467120. PubMed PMID: 38079542; PMCID: PMC10740393.

Zhang X, Meng W, Feng J, Gao X, Qin C, Feng P, Huang Y, Gao SJ. METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle. Cell Death Dis. 2023-09-06;14(9):591. doi: 10.1038/s41419-023-06121-3. PubMed PMID: 37673880; PMCID: PMC10482891.

Das A, Meng W, Liu Z, Hasib MM, Galloway H, Ramos da Silva S, Chen L, Sica GL, Paniz-Mondolfi A, Bryce C, Grimes Z, Sordillo EM, Cordon-Cardo C, Rivera KP, Flores M, Chiu YC, Huang Y, Gao SJ. Molecular and immune signatures, and pathological trajectories of fatal COVID-19 lungs defined by in situ spatial single-cell transcriptome analysis. J Med Virol. 2023-08-01;95(8):e29009. doi: 10.1002/jmv.29009. PubMed PMID: 37563850; PMCID: PMC10442191.

Wan L, Toland S, Robinson-McCarthy LR, Lee N, Schaich MA, Hengel SR, Li X, Bernstein KA, Van Houten B, Chang Y, Moore PS. Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity. Proc Natl Acad Sci U S A. 2023-07-25;120(30):e2308010120. doi: 10.1073/pnas.2308010120. PubMed PMID: 37459531; PMCID: PMC10372695.

Li T, Gao SJ. KSHV hijacks FoxO1 to promote cell proliferation and cellular transformation by antagonizing oxidative stress. J Med Virol. 2023-03-01;95(3):e28676. doi: 10.1002/jmv.28676. PubMed PMID: 36929740; PMCID: PMC10285692.

Radovic S, Meng W, Chen L, Paniz Mondolfi AE, Bryce C, Grimes Z, Sordillo EM, Cordon-Cardo C, Guo H, Huang Y, Gao SJ. SARS-CoV-2 infection of kidney tissues from severe COVID-19 patients. J Med Virol. 2023-02-01;95(2):e28566. doi: 10.1002/jmv.28566. PubMed PMID: 36756942; PMCID: PMC10388714.

Zhang GF, Meng W, Chen L, Ding L, Sun S, Wang X, Huang Y, Guo H, Gao SJ. Infectivity of pseudotyped SARS-CoV-2 variants of concern in different human cell types and inhibitory effects of recombinant spike protein and entry-related cellular factors. J Med Virol. 2023-01-01;95(1):e28437. doi: 10.1002/jmv.28437. PubMed PMID: 36573430; PMCID: PMC9880647.

Meng W, Guo S, Cao S, Shuda M, Robinson-McCarthy LR, McCarthy KR, Shuda Y, Paniz Mondolfi AE, Bryce C, Grimes Z, Sordillo EM, Cordon-Cardo C, Li P, Zhang H, Perlman S, Guo H, Gao SJ, Chang Y, Moore PS. Development and characterization of a new monoclonal antibody against SARS-CoV-2 NSP12 (RdRp). J Med Virol. 2023-01-01;95(1):e28246. doi: 10.1002/jmv.28246. PubMed PMID: 36271490; PMCID: PMC9874566.

Zhang GF, Meng W, Chen L, Ding L, Feng J, Perez J, Ali A, Sun S, Liu Z, Huang Y, Guo H, Gao SJ. Neutralizing antibodies to SARS-CoV-2 variants of concern including Delta and Omicron in subjects receiving mRNA-1273, BNT162b2, and Ad26.COV2.S vaccines. J Med Virol. 2022-12-01;94(12):5678-5690. doi: 10.1002/jmv.28032. PubMed PMID: 35902378; PMCID: PMC9353285.

Gao SJ, Guo H, Luo G. Omicron variant (B.1.1.529) of SARS-CoV-2, a global urgent public health alert! J Med Virol. 2022-04-01;94(4):1255-1256. doi: 10.1002/jmv.27491. PubMed PMID: 34850421; PMCID: PMC9015397.

Zhang F, Li W, Feng J, Ramos da Silva S, Ju E, Zhang H, Chang Y, Moore PS, Guo H, Gao SJ. SARS-CoV-2 pseudovirus infectivity and expression of viral entry-related factors ACE2, TMPRSS2, Kim-1, and NRP-1 in human cells from the respiratory, urinary, digestive, reproductive, and immune systems. J Med Virol. 2021-12-01;93(12):6671-6685. doi: 10.1002/jmv.27244. PubMed PMID: 34324210; PMCID: PMC8426707.

Herrera-Ortíz A, Meng W, Gao SJ. Nitric oxide is induced and required for efficient Kaposi's sarcoma-associated herpesvirus lytic replication. J Med Virol. 2021-11-01;93(11):6323-6332. doi: 10.1002/jmv.27228. PubMed PMID: 34297418; PMCID: PMC8446322.

Ju E, Li T, Ramos da Silva S, Markazi A, Gao SJ. Reversible switching of primary cells between normal and malignant state by oncogenic virus KSHV and CRISPR/Cas9-mediated targeting of a major viral latent protein. J Med Virol. 2021-08-01;93(8):5065-5075. doi: 10.1002/jmv.27046. PubMed PMID: 33942339; PMCID: PMC9016784.

Li T, Wang X, Ju E, da Silva SR, Chen L, Zhang X, Wei S, Gao SJ. RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation. Nat Commun. 2021-02-16;12(1):1055. doi: 10.1038/s41467-021-21206-3. PubMed PMID: 33594058; PMCID: PMC7887217.

Luo GG, Gao SJ. Global health concerns stirred by emerging viral infections. J Med Virol. 2020-04-01;92(4):399-400. doi: 10.1002/jmv.25683. PubMed PMID: 31967329; PMCID: PMC7166855.

Ju E, Li T, Liu Z, da Silva SR, Wei S, Zhang X, Wang X, Gao SJ. Specific Inhibition of Viral MicroRNAs by Carbon Dots-Mediated Delivery of Locked Nucleic Acids for Therapy of Virus-Induced Cancer. ACS Nano. 2020-01-28;14(1):476-487. doi: 10.1021/acsnano.9b06333. PubMed PMID: 31895530; PMCID: PMC7119180.

Harold A, Amako Y, Hachisuka J, Bai Y, Li MY, Kubat L, Gravemeyer J, Franks J, Gibbs JR, Park HJ, Ezhkova E, Becker JC, Shuda M. Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition. Proc Natl Acad Sci U S A. 2019-10-01;116(40):20104-20114. doi: 10.1073/pnas.1907154116. PubMed PMID: 31527246; PMCID: PMC6778204.

Ju E, Li T, Ramos da Silva S, Gao SJ. Gold Nanocluster-Mediated Efficient Delivery of Cas9 Protein through pH-Induced Assembly-Disassembly for Inactivation of Virus Oncogenes. ACS Appl Mater Interfaces. 2019-09-25;11(38):34717-34724. doi: 10.1021/acsami.9b12335. PubMed PMID: 31469541; PMCID: PMC6763369.

Li T, Ju E, Gao SJ. Kaposi sarcoma-associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesis. J Clin Invest. 2019-07-15;129(8):3310-3323. doi: 10.1172/JCI127166. PubMed PMID: 31305263; PMCID: PMC6668677.

Ramos da Silva S, Cheng F, Huang IC, Jung JU, Gao SJ. Efficiencies and kinetics of infection in different cell types/lines by African and Asian strains of Zika virus. J Med Virol. 2019-02-01;91(2):179-189. doi: 10.1002/jmv.25306. PubMed PMID: 30192399; PMCID: PMC6294704.

Toptan T, Abere B, Nalesnik MA, Swerdlow SH, Ranganathan S, Lee N, Shair KH, Moore PS, Chang Y. Circular DNA tumor viruses make circular RNAs. Proc Natl Acad Sci U S A. 2018-09-11;115(37):E8737-E8745. doi: 10.1073/pnas.1811728115. PubMed PMID: 30150410; PMCID: PMC6140489.

Kwun HJ, Chang Y, Moore PS. Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence. Proc Natl Acad Sci U S A. 2017-05-16;114(20):E4040-E4047. doi: 10.1073/pnas.1703879114. PubMed PMID: 28461484; PMCID: PMC5441811.

Velásquez C, Cheng E, Shuda M, Lee-Oesterreich PJ, Pogge von Strandmann L, Gritsenko MA, Jacobs JM, Moore PS, Chang Y. Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation. Proc Natl Acad Sci U S A. 2016-07-26;113(30):8466-71. doi: 10.1073/pnas.1607768113. PubMed PMID: 27402756; PMCID: PMC4968757.

Shuda M, Velásquez C, Cheng E, Cordek DG, Kwun HJ, Chang Y, Moore PS. CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci U S A. 2015-05-12;112(19):5875-82. doi: 10.1073/pnas.1505787112. PubMed PMID: 25883264; PMCID: PMC4434708.

Kwun HJ, Toptan T, Ramos da Silva S, Atkins JF, Moore PS, Chang Y. Human DNA tumor viruses generate alternative reading frame proteins through repeat sequence recoding. Proc Natl Acad Sci U S A. 2014-10-14;111(41):E4342-9. doi: 10.1073/pnas.1416122111. PubMed PMID: 25271323; PMCID: PMC4205619.

Moore PS, Chang Y. The conundrum of causality in tumor virology: the cases of KSHV and MCV. Semin Cancer Biol. 2014-06-01;264-12. doi: 10.1016/j.semcancer.2013.11.001. PubMed PMID: 24304907; PMCID: PMC4040341.