Shivendra Singh

Singh KB, Hahm ER, Kim SH, Wendell SG, Singh SV. A novel metabolic function of Myc in regulation of fatty acid synthesis in prostate cancer. Oncogene. 2021 Jan;40(3):592-602. doi: 10.1038/s41388-020-01553-z. PubMed PMID: 33199826; PMCID: PMC7855479.
Hahm ER, Kim SH, Singh KB, Singh SV. RNA-seq reveals novel cancer-selective and disease subtype-independent mechanistic targets of withaferin A in human breast cancer cells. Mol Carcinog. 2021 Jan;60(1):3-14. doi: 10.1002/mc.23266. PubMed PMID: 33150660; PMCID: PMC7736309.
Hahm ER, Lee J, Abella T, Singh SV. Withaferin A inhibits expression of ataxia telangiectasia and Rad3-related kinase and enhances sensitivity of human breast cancer cells to cisplatin. Mol Carcinog. 2019 Nov;58(11):2139-2148. doi: 10.1002/mc.23104. PubMed PMID: 31441116; PMCID: PMC6800812.
Singh KB, Hahm ER, Pore SK, Singh SV. Leelamine Is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo. Mol Cancer Ther. 2019 Oct;18(10):1800-1810. doi: 10.1158/1535-7163.MCT-19-0046. PubMed PMID: 31395683; PMCID: PMC6774899.
Kido L, Hahm ER, Cagnon V, Maróstica M Jr, Singh S. Effect of Piceatannol on Cell Cycle Progression in Prostate Cancer Cells (P05-005-19). Curr Dev Nutr. 2019 Jun;3(Suppl 1): doi: 10.1093/cdn/nzz030.P05-005-19. PubMed PMID: 31224409; PMCID: PMC6574592.
Braganza A, Quesnelle K, Bickta J, Reyes C, Wang Y, Jessup M, St Croix C, Arlotti J, Singh SV, Shiva S. Myoglobin induces mitochondrial fusion, thereby inhibiting breast cancer cell proliferation. J Biol Chem. 2019 May 3;294(18):7269-7282. doi: 10.1074/jbc.RA118.006673. PubMed PMID: 30872402; PMCID: PMC6509513.
Kim SH, Singh SV. Role of Krüppel-like Factor 4-p21CIP1 Axis in Breast Cancer Stem-like Cell Inhibition by Benzyl Isothiocyanate. Cancer Prev Res (Phila). 2019 Mar;12(3):125-134. doi: 10.1158/1940-6207.CAPR-18-0393. PubMed PMID: 30723175; PMCID: PMC6401216.
Roy R, Hahm ER, White AG, Anderson CJ, Singh SV. AKT-dependent sugar addiction by benzyl isothiocyanate in breast cancer cells. Mol Carcinog. 2019 Jun;58(6):996-1007. doi: 10.1002/mc.22988. PubMed PMID: 30720225; PMCID: PMC6525032.
Sehrawat A, Samanta SK, Hahm ER, St Croix C, Watkins S, Singh SV. Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics. Mitochondrion. 2019 Jul;47282-293. doi: 10.1016/j.mito.2019.01.003. PubMed PMID: 30685490; PMCID: PMC6599725.
Singh KB, Ji X, Singh SV. Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer. Mol Cancer Ther. 2018 Oct;17(10):2079-2090. doi: 10.1158/1535-7163.MCT-18-0117. PubMed PMID: 30030299; PMCID: PMC6168419.
Tahata S, Singh SV, Lin Y, Hahm ER, Beumer JH, Christner SM, Rao UN, Sander C, Tarhini AA, Tawbi H, Ferris LK, Wilson M, Rose A, Dietz CM, Hughes E, Fahey JW, Leachman SA, Cassidy PB, Butterfield LH, Zarour HM, Kirkwood JM. Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi. Cancer Prev Res (Phila). 2018 Jul;11(7):429-438. doi: 10.1158/1940-6207.CAPR-17-0268. PubMed PMID: 29691233; PMCID: PMC6030491.
Singh KB, Kim SH, Hahm ER, Pore SK, Jacobs BL, Singh SV. Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism. Carcinogenesis. 2018 May 28;39(6):826-837. doi: 10.1093/carcin/bgy051. PubMed PMID: 29668854; PMCID: PMC5972626.
Samanta SK, Lee J, Hahm ER, Singh SV. Peptidyl-prolyl cis/trans isomerase Pin1 regulates withaferin A-mediated cell cycle arrest in human breast cancer cells. Mol Carcinog. 2018 Jul;57(7):936-946. doi: 10.1002/mc.22814. PubMed PMID: 29603395; PMCID: PMC5986602.
Singh KB, Hahm ER, Rigatti LH, Normolle DP, Yuan JM, Singh SV. Inhibition of Glycolysis in Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate. Cancer Prev Res (Phila). 2018 Jun;11(6):337-346. doi: 10.1158/1940-6207.CAPR-17-0389. PubMed PMID: 29545400; PMCID: PMC5984685.
Pore SK, Hahm ER, Latoche JD, Anderson CJ, Shuai Y, Singh SV. Prevention of breast cancer-induced osteolytic bone resorption by benzyl isothiocyanate. Carcinogenesis. 2018 Feb 9;39(2):134-145. doi: 10.1093/carcin/bgx114. PubMed PMID: 29040431; PMCID: PMC5862255.
Jiang C, Ding Z, Joy M, Chakraborty S, Kim SH, Bottcher R, Condeelis J, Singh S, Roy P. A balanced level of profilin-1 promotes stemness and tumor-initiating potential of breast cancer cells. Cell Cycle. 2017;16(24):2366-2373. doi: 10.1080/15384101.2017.1346759. PubMed PMID: 28699810; PMCID: PMC5788419.
Shyanti RK, Sehrawat A, Singh SV, Mishra JPN, Singh RP. Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells. Toxicol In Vitro. 2017 Oct;4474-84. doi: 10.1016/j.tiv.2017.06.016. PubMed PMID: 28633979.
Singh KB, Singh SV. Fatty Acid Synthesis Intermediates Represent Novel Noninvasive Biomarkers of Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate. Cancer Prev Res (Phila). 2017 May;10(5):279-289. doi: 10.1158/1940-6207.CAPR-17-0001. PubMed PMID: 28292742; PMCID: PMC5439500.
Samanta SK, Sehrawat A, Kim SH, Hahm ER, Shuai Y, Roy R, Pore SK, Singh KB, Christner SM, Beumer JH, Davidson NE, Singh SV. Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A. J Natl Cancer Inst. 2017 Jun;109(6): doi: 10.1093/jnci/djw293. PubMed PMID: 28040797; PMCID: PMC5928779.
Sehrawat A, Roy R, Pore SK, Hahm ER, Samanta SK, Singh KB, Kim SH, Singh K, Singh SV. Mitochondrial dysfunction in cancer chemoprevention by phytochemicals from dietary and medicinal plants. Semin Cancer Biol. 2017 Dec;47147-153. doi: 10.1016/j.semcancer.2016.11.009. PubMed PMID: 27867044; PMCID: PMC5435556.
Palliyaguru DL, Chartoumpekis DV, Wakabayashi N, Skoko JJ, Yagishita Y, Singh SV, Kensler TW. Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms. Free Radic Biol Med. 2016 Dec;101116-128. doi: 10.1016/j.freeradbiomed.2016.10.003. PubMed PMID: 27717869; PMCID: PMC5154810.
Kumari V, Dyba MA, Holland RJ, Liang YH, Singh SV, Ji X. Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical. PLoS One. 2016;11(9):e0163821. doi: 10.1371/journal.pone.0163821. PubMed PMID: 27684484; PMCID: PMC5042466.
Sehrawat A, Croix CS, Baty CJ, Watkins S, Tailor D, Singh RP, Singh SV. Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate. Mitochondrion. 2016 Sep;3067-77. doi: 10.1016/j.mito.2016.06.006. PubMed PMID: 27374852; PMCID: PMC5023488.
Hahm ER, Singh KB, Singh SV. c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells. Cell Cycle. 2016 Sep;15(17):2309-20. doi: 10.1080/15384101.2016.1201253. PubMed PMID: 27341160; PMCID: PMC5004679.
Sehrawat A, Kim SH, Hahm ER, Arlotti JA, Eiseman J, Shiva SS, Rigatti LH, Singh SV. Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation. Mol Carcinog. 2017 Feb;56(2):337-348. doi: 10.1002/mc.22497. PubMed PMID: 27149078; PMCID: PMC5097706.
Kim SH, Kaschula CH, Priedigkeit N, Lee AV, Singh SV. Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide. J Biol Chem. 2016 Jun 24;291(26):13495-508. doi: 10.1074/jbc.M116.715219. PubMed PMID: 27129776; PMCID: PMC4919436.
Kim SH, Hahm ER, Arlotti JA, Samanta SK, Moura MB, Thorne SH, Shuai Y, Anderson CJ, White AG, Lokshin A, Lee J, Singh SV. Withaferin A inhibits in vivo growth of breast cancer cells accelerated by Notch2 knockdown. Breast Cancer Res Treat. 2016 May;157(1):41-54. doi: 10.1007/s10549-016-3795-y. PubMed PMID: 27097807; PMCID: PMC4867258.
Vyas AR, Moura MB, Hahm ER, Singh KB, Singh SV. Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like Traits. J Cell Biochem. 2016 Nov;117(11):2482-95. doi: 10.1002/jcb.25541. PubMed PMID: 26990292; PMCID: PMC5014708.
Palliyaguru DL, Singh SV, Kensler TW. Withania somnifera: From prevention to treatment of cancer. Mol Nutr Food Res. 2016 Jun;60(6):1342-53. doi: 10.1002/mnfr.201500756. PubMed PMID: 26718910; PMCID: PMC4899165.
Amjad AI, Parikh RA, Appleman LJ, Hahm ER, Singh K, Singh SV. Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside. Curr Pharmacol Rep. 2015 Nov 1;1(6):382-390. doi: 10.1007/s40495-015-0034-x. PubMed PMID: 26557472; PMCID: PMC4635516.
Sehrawat A, Singh SV. Short-form RON overexpression augments benzyl isothiocyanate-induced apoptosis in human breast cancer cells. Mol Carcinog. 2016 May;55(5):473-85. doi: 10.1002/mc.22295. PubMed PMID: 25857724; PMCID: PMC4596738.
Sakao K, Vyas AR, Chinni SR, Amjad AI, Parikh R, Singh SV. CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells. Cancer Prev Res (Phila). 2015 May;8(5):365-74. doi: 10.1158/1940-6207.CAPR-14-0386. PubMed PMID: 25712054; PMCID: PMC4417382.
Kim SH, Singh SV. The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate. Breast Cancer Res Treat. 2015 Feb;149(3):681-92. doi: 10.1007/s10549-015-3279-5. PubMed PMID: 25663545; PMCID: PMC4329083.
Hahm ER, Sakao K, Singh SV. Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells. Prostate. 2014 Sep;74(12):1209-21. doi: 10.1002/pros.22837. PubMed PMID: 25043291; PMCID: PMC4156520.
Sehrawat A, Sakao K, Singh SV. Notch2 activation is protective against anticancer effects of zerumbone in human breast cancer cells. Breast Cancer Res Treat. 2014 Aug;146(3):543-55. doi: 10.1007/s10549-014-3059-7. PubMed PMID: 25038880; PMCID: PMC4140010.
Kim SH, Singh SV. Mammary cancer chemoprevention by withaferin A is accompanied by in vivo suppression of self-renewal of cancer stem cells. Cancer Prev Res (Phila). 2014 Jul;7(7):738-47. doi: 10.1158/1940-6207.CAPR-13-0445. PubMed PMID: 24824039; PMCID: PMC4083822.
Hahm ER, Lee J, Singh SV. Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells. Mol Carcinog. 2014 Nov;53(11):907-16. doi: 10.1002/mc.22050. PubMed PMID: 24019090; PMCID: PMC3859703.

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