Publications

Alexander Deiters, PhD

Lukasak B, Morihiro K, Deiters A. Aryl Azides as Phosphine-Activated Switches for Small Molecule Function. Sci Rep. 2019 Feb 6;9(1):1470. doi: 10.1038/s41598-018-37023-6. PubMed PMID: 30728367; PMCID: PMC6365568.
Goulden BD, Pacheco J, Dull A, Zewe JP, Deiters A, Hammond GRV. A high-avidity biosensor reveals plasma membrane PI(3,4)P2 is predominantly a class I PI3K signaling product. J Cell Biol. 2019 Mar 4;218(3):1066-1079. doi: 10.1083/jcb.201809026. PubMed PMID: 30591513; PMCID: PMC6400549.
Dagliyan O, Krokhotin A, Ozkan-Dagliyan I, Deiters A, Der CJ, Hahn KM, Dokholyan NV. Computational design of chemogenetic and optogenetic split proteins. Nat Commun. 2018 Oct 2;9(1):4042. doi: 10.1038/s41467-018-06531-4. PubMed PMID: 30279442; PMCID: PMC6168510.
Luo J, Samanta S, Convertino M, Dokholyan NV, Deiters A. Reversible and Tunable Photoswitching of Protein Function through Genetic Encoding of Azobenzene Amino Acids in Mammalian Cells. Chembiochem. 2018 Oct 18;19(20):2178-2185. doi: 10.1002/cbic.201800226. PubMed PMID: 30277634.
Hanna RD, Naro Y, Deiters A, Floreancig PE. Potent and Readily Accessible Bistramide A Analogues through Diverted Total Synthesis. Chemistry. 2018 Nov 2;24(61):16271-16275. doi: 10.1002/chem.201804417. PubMed PMID: 30175480.
Brown W, Liu J, Deiters A. Genetic Code Expansion in Animals. ACS Chem Biol. 2018 Sep 21;13(9):2375-2386. doi: 10.1021/acschembio.8b00520. PubMed PMID: 30125487.
Courtney T, Deiters A. Recent advances in the optical control of protein function through genetic code expansion. Curr Opin Chem Biol. 2018 Oct;4699-107. doi: 10.1016/j.cbpa.2018.07.011. PubMed PMID: 30056281.
Naro Y, Ankenbruck N, Thomas M, Tivon Y, Connelly CM, Gardner L, Deiters A. Small Molecule Inhibition of MicroRNA miR-21 Rescues Chemosensitivity of Renal-Cell Carcinoma to Topotecan. J Med Chem. 2018 Jul 26;61(14):5900-5909. doi: 10.1021/acs.jmedchem.7b01891. PubMed PMID: 29993250.
Deiters A. Special Issue on Optochemical and Optogenetic Control of Cellular Processes. Chembiochem. 2018 Jun 18;19(12):1198-1200. doi: 10.1002/cbic.201800277. PubMed PMID: 29873157.
Brown W, Liu J, Tsang M, Deiters A. Cell-Lineage Tracing in Zebrafish Embryos with an Expanded Genetic Code. Chembiochem. 2018 Jun 18;19(12):1244-1249. doi: 10.1002/cbic.201800040. PubMed PMID: 29701891; PMCID: PMC6021189.
Caldwell RM, Bermudez JG, Thai D, Aonbangkhen C, Schuster BS, Courtney T, Deiters A, Hammer DA, Chenoweth DM, Good MC. Optochemical Control of Protein Localization and Activity within Cell-like Compartments. Biochemistry. 2018 May 8;57(18):2590-2596. doi: 10.1021/acs.biochem.8b00131. PubMed PMID: 29671583.
Morihiro K, Ankenbruck N, Lukasak B, Deiters A. Small Molecule Release and Activation through DNA Computing. J Am Chem Soc. 2017 Oct 4;139(39):13909-13915. doi: 10.1021/jacs.7b07831. PubMed PMID: 28945369.
Liu J, Hemphill J, Samanta S, Tsang M, Deiters A. Genetic Code Expansion in Zebrafish Embryos and Its Application to Optical Control of Cell Signaling. J Am Chem Soc. 2017 Jul 12;139(27):9100-9103. doi: 10.1021/jacs.7b02145. PubMed PMID: 28657738; PMCID: PMC6022368.
Luo J, Torres-Kolbus J, Liu J, Deiters A. Genetic Encoding of Photocaged Tyrosines with Improved Light-Activation Properties for the Optical Control of Protease Function. Chembiochem. 2017 Jul 18;18(14):1442-1447. doi: 10.1002/cbic.201700147. PubMed PMID: 28608946.
Ankenbruck N, Courtney T, Naro Y, Deiters A. Optochemical Control of Biological Processes in Cells and Animals. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2768-2798. doi: 10.1002/anie.201700171. PubMed PMID: 28521066; PMCID: PMC6026863.
Luo J, Kong M, Liu L, Samanta S, Van Houten B, Deiters A. Optical Control of DNA Helicase Function through Genetic Code Expansion. Chembiochem. 2017 Mar 2;18(5):466-469. doi: 10.1002/cbic.201600624. PubMed PMID: 28120472; PMCID: PMC5516474.
Luo J, Liu Q, Morihiro K, Deiters A. Small-molecule control of protein function through Staudinger reduction. Nat Chem. 2016 Nov;8(11):1027-1034. doi: 10.1038/nchem.2573. PubMed PMID: 27768095; PMCID: PMC5119652.
Hanna RD, Naro Y, Deiters A, Floreancig PE. Alcohol, Aldehyde, and Ketone Liberation and Intracellular Cargo Release through Peroxide-Mediated α-Boryl Ether Fragmentation. J Am Chem Soc. 2016 Oct 12;138(40):13353-13360. doi: 10.1021/jacs.6b07890. PubMed PMID: 27636404.
Wang WW, Zeng Y, Wu B, Deiters A, Liu WR. A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes. ACS Chem Biol. 2016 Jul 15;11(7):1973-81. doi: 10.1021/acschembio.6b00243. PubMed PMID: 27152839; PMCID: PMC5478164.
Zhou W, Deiters A. Conditional Control of CRISPR/Cas9 Function. Angew Chem Int Ed Engl. 2016 Apr 25;55(18):5394-9. doi: 10.1002/anie.201511441. PubMed PMID: 26996256.
Brown KA, Deiters A. Genetic Code Expansion of Mammalian Cells with Unnatural Amino Acids. Curr Protoc Chem Biol. 2015 Sep 1;7(3):187-199. doi: 10.1002/9780470559277.ch150038. PubMed PMID: 26331526.
Naro Y, Thomas M, Stephens MD, Connelly CM, Deiters A. Aryl amide small-molecule inhibitors of microRNA miR-21 function. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4793-4796. doi: 10.1016/j.bmcl.2015.07.016. PubMed PMID: 26220158.
Govan JM, Young DD, Lively MO, Deiters A. Optically Triggered Immune Response through Photocaged Oligonucleotides. Tetrahedron Lett. 2015 Jun 3;56(23):3639-3642. doi: 10.1016/j.tetlet.2015.01.165. PubMed PMID: 26034339; PMCID: PMC4448726.
Hemphill J, Borchardt EK, Brown K, Asokan A, Deiters A. Optical Control of CRISPR/Cas9 Gene Editing. J Am Chem Soc. 2015 May 6;137(17):5642-5. doi: 10.1021/ja512664v. PubMed PMID: 25905628; PMCID: PMC4919123.
Hemphill J, Liu Q, Uprety R, Samanta S, Tsang M, Juliano RL, Deiters A. Conditional control of alternative splicing through light-triggered splice-switching oligonucleotides. J Am Chem Soc. 2015 Mar 18;137(10):3656-62. doi: 10.1021/jacs.5b00580. PubMed PMID: 25734836; PMCID: PMC5545098.
Brown KA, Zou Y, Shirvanyants D, Zhang J, Samanta S, Mantravadi PK, Dokholyan NV, Deiters A. Light-cleavable rapamycin dimer as an optical trigger for protein dimerization. Chem Commun (Camb). 2015 Apr 4;51(26):5702-5. doi: 10.1039/c4cc09442e. PubMed PMID: 25716548.
Prokup A, Hemphill J, Liu Q, Deiters A. Optically Controlled Signal Amplification for DNA Computation. ACS Synth Biol. 2015 Oct 16;4(10):1064-9. doi: 10.1021/sb500279w. PubMed PMID: 25621535.

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