Publications

Lin Zhang, PhD

Tan X, Tong J, Wang YJ, Fletcher R, Schoen RE, Yu J, Shen L, Zhang L. BET Inhibitors Potentiate Chemotherapy and Killing of SPOP-Mutant Colon Cancer Cells via Induction of DR5. Cancer Res. 2019 Mar 15;79(6):1191-1203. doi: 10.1158/0008-5472.CAN-18-3223. PubMed PMID: 30674532; PMCID: PMC6420862.
Chen D, Ni HM, Wang L, Ma X, Yu J, Ding WX, Zhang L. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology. 2019 May;69(5):2164-2179. doi: 10.1002/hep.30422. PubMed PMID: 30552702; PMCID: PMC6461480.
Wang YJ, Fletcher R, Yu J, Zhang L. Immunogenic effects of chemotherapy-induced tumor cell death. Genes Dis. 2018 Sep;5(3):194-203. doi: 10.1016/j.gendis.2018.05.003. PubMed PMID: 30320184; PMCID: PMC6176216.
Tong J, Zheng X, Tan X, Fletcher R, Nikolovska-Coleska Z, Yu J, Zhang L. Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins. Cancer Res. 2018 Aug 15;78(16):4704-4715. doi: 10.1158/0008-5472.CAN-18-0399. PubMed PMID: 29895675; PMCID: PMC6298746.
Knickelbein K, Tong J, Chen D, Wang YJ, Misale S, Bardelli A, Yu J, Zhang L. Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. Oncogene. 2018 Aug;37(33):4599-4610. doi: 10.1038/s41388-018-0289-x. PubMed PMID: 29755130; PMCID: PMC6195818.
Kao YC, Owosho AA, Sung YS, Zhang L, Fujisawa Y, Lee JC, Wexler L, Argani P, Swanson D, Dickson BC, Fletcher CDM, Antonescu CR. BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas. Am J Surg Pathol. 2018 May;42(5):604-615. doi: 10.1097/PAS.0000000000000965. PubMed PMID: 29300189; PMCID: PMC5893395.
Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J, Zhang L. PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3930-3935. doi: 10.1073/pnas.1717190115. PubMed PMID: 29581256; PMCID: PMC5899441.
Li X, Li M, Ruan H, Qiu W, Xu X, Lin Z, Yu J. Correction: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. Oncotarget. 2018 Jan 23;9(6):7271. doi: 10.18632/oncotarget.24288. PubMed PMID: 29467964; PMCID: PMC5805550.
Leibowitz BJ, Yang L, Wei L, Buchanan ME, Rachid M, Parise RA, Beumer JH, Eiseman JL, Schoen RE, Zhang L, Yu J. Targeting p53-dependent stem cell loss for intestinal chemoprotection. Sci Transl Med. 2018 Feb 7;10(427): doi: 10.1126/scitranslmed.aam7610. PubMed PMID: 29437148; PMCID: PMC5827930.
Wei L, Leibowitz BJ, Epperly M, Bi C, Li A, Steinman J, Wipf P, Li S, Zhang L, Greenberger J, Yu J. The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice. Sci Rep. 2018 Feb 1;8(1):2072. doi: 10.1038/s41598-018-20370-9. PubMed PMID: 29391546; PMCID: PMC5794877.
Fletcher R, Wang YJ, Schoen RE, Finn OJ, Yu J, Zhang L. Colorectal cancer prevention: Immune modulation taking the stage. Biochim Biophys Acta Rev Cancer. 2018 Apr;1869(2):138-148. doi: 10.1016/j.bbcan.2017.12.002. PubMed PMID: 29391185; PMCID: PMC5955808.
Argani P, Kao YC, Zhang L, Bacchi C, Matoso A, Alaggio R, Epstein JI, Antonescu CR. Primary Renal Sarcomas With BCOR-CCNB3 Gene Fusion: A Report of 2 Cases Showing Histologic Overlap With Clear Cell Sarcoma of Kidney, Suggesting Further Link Between BCOR-related Sarcomas of the Kidney and Soft Tissues. Am J Surg Pathol. 2017 Dec;41(12):1702-1712. doi: 10.1097/PAS.0000000000000926. PubMed PMID: 28817404; PMCID: PMC5680139.
Tian L, Eldridge L, Chaudhari P, Zhang L, Anders RA, Schwarz KB, Ye Z, Jang YY. Derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient. Stem Cell Res. 2017 Oct;2425-28. doi: 10.1016/j.scr.2017.08.001. PubMed PMID: 29034890; PMCID: PMC5881114.
Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, Zhong M, Yuan H, Zhang L, Billiar TR, Lotze MT, Zeh HJ 3rd, Kang R, Kroemer G, Tang D. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep. 2017 Aug 15;20(7):1692-1704. doi: 10.1016/j.celrep.2017.07.055. PubMed PMID: 28813679.
Yang S, Zhang L, Thomas S, Hu Y, Li S, Cipollo J, Zhang H. Modification of Sialic Acids on Solid Phase: Accurate Characterization of Protein Sialylation. Anal Chem. 2017 Jun 20;89(12):6330-6335. doi: 10.1021/acs.analchem.7b01048. PubMed PMID: 28505427; PMCID: PMC5583724.
Tong J, Tan S, Nikolovska-Coleska Z, Yu J, Zou F, Zhang L. FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors. Mol Cancer Ther. 2017 Sep;16(9):1979-1988. doi: 10.1158/1535-7163.MCT-17-0032. PubMed PMID: 28619760; PMCID: PMC5587378.
Tong J, Wang P, Tan S, Chen D, Nikolovska-Coleska Z, Zou F, Yu J, Zhang L. Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017 May 1;77(9):2512-2521. doi: 10.1158/0008-5472.CAN-16-3242. PubMed PMID: 28202514; PMCID: PMC5626525.
Li X, Li M, Ruan H, Qiu W, Xu X, Zhang L, Yu J. Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. Oncotarget. 2017 Feb 7;8(6):9280-9292. doi: 10.18632/oncotarget.14063. PubMed PMID: 28030835; PMCID: PMC5354731.
Kao YC, Sung YS, Zhang L, Jungbluth AA, Huang SC, Argani P, Agaram NP, Zin A, Alaggio R, Antonescu CR. BCOR Overexpression Is a Highly Sensitive Marker in Round Cell Sarcomas With BCOR Genetic Abnormalities. Am J Surg Pathol. 2016 Dec;40(12):1670-1678. doi: 10.1097/PAS.0000000000000697. PubMed PMID: 27428733; PMCID: PMC5106294.
Van Der Kraak L, Goel G, Ramanan K, Kaltenmeier C, Zhang L, Normolle DP, Freeman GJ, Tang D, Nason KS, Davison JM, Luketich JD, Dhupar R, Lotze MT. 5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers. J Immunother Cancer. 2016;465. doi: 10.1186/s40425-016-0163-8. PubMed PMID: 27777774; PMCID: PMC5067917.
Kao YC, Sung YS, Zhang L, Huang SC, Argani P, Chung CT, Graf NS, Wright DC, Kellie SJ, Agaram NP, Ludwig K, Zin A, Alaggio R, Antonescu CR. Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney. Am J Surg Pathol. 2016 Aug;40(8):1009-20. doi: 10.1097/PAS.0000000000000629. PubMed PMID: 26945340; PMCID: PMC4942366.
He K, Chen D, Ruan H, Li X, Tong J, Xu X, Zhang L, Yu J. BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. Oncotarget. 2016 Jul 26;7(30):47699-47710. doi: 10.18632/oncotarget.10277. PubMed PMID: 27351224; PMCID: PMC5216972.
Chen D, Yu J, Zhang L. Necroptosis: an alternative cell death program defending against cancer. Biochim Biophys Acta. 2016 Apr;1865(2):228-36. doi: 10.1016/j.bbcan.2016.03.003. PubMed PMID: 26968619; PMCID: PMC4860077.
Misale S, Bozic I, Tong J, Peraza-Penton A, Lallo A, Baldi F, Lin KH, Truini M, Trusolino L, Bertotti A, Di Nicolantonio F, Nowak MA, Zhang L, Wood KC, Bardelli A. Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers. Nat Commun. 2015 Sep 22;68305. doi: 10.1038/ncomms9305. PubMed PMID: 26392303; PMCID: PMC4595628.
Chen X, Song X, Yue W, Chen D, Yu J, Yao Z, Zhang L. Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer. Oncotarget. 2015 Jun 20;6(17):15022-34. doi: 10.18632/oncotarget.3609. PubMed PMID: 25909283; PMCID: PMC4558133.
Wang X, Wei L, Cramer JM, Leibowitz BJ, Judge C, Epperly M, Greenberger J, Wang F, Li L, Stelzner MG, Dunn JCY, Martin MG, Lagasse E, Zhang L, Yu J. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10;58566. doi: 10.1038/srep08566. PubMed PMID: 25858503; PMCID: PMC4392360.
Knickelbein K, Zhang L. Mutant KRAS as a critical determinant of the therapeutic response of colorectal cancer. Genes Dis. 2015 Mar;2(1):4-12. doi: 10.1016/j.gendis.2014.10.002. PubMed PMID: 25815366; PMCID: PMC4372129.
Argani P, Lewin JR, Edmonds P, Netto GJ, Prieto-Granada C, Zhang L, Jungbluth AA, Antonescu CR. Primary renal sclerosing epithelioid fibrosarcoma: report of 2 cases with EWSR1-CREB3L1 gene fusion. Am J Surg Pathol. 2015 Mar;39(3):365-73. doi: 10.1097/PAS.0000000000000338. PubMed PMID: 25353281; PMCID: PMC4326586.

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