Publications

Yi Huang, MD, PhD

Li Y, Chu J, Feng W, Yang M, Zhang Y, Zhang Y, Qin Y, Xu J, Li J, Vasilatos SN, Fu Z, Huang Y, Yin Y. EPHA5 mediates trastuzumab resistance in HER2-positive breast cancers through regulating cancer stem cell-like properties. FASEB J. 2019 Apr;33(4):4851-4865. doi: 10.1096/fj.201701561RRRR. PubMed PMID: 30620624.
Asan A, Skoko JJ, Woodcock CC, Wingert BM, Woodcock SR, Normolle D, Huang Y, Stark JM, Camacho CJ, Freeman BA, Neumann CA. Electrophilic fatty acids impair RAD51 function and potentiate the effects of DNA-damaging agents on growth of triple-negative breast cells. J Biol Chem. 2019 Jan 11;294(2):397-404. doi: 10.1074/jbc.AC118.005899. PubMed PMID: 30478172; PMCID: PMC6333886.
Yang F, Wang F, Liu Y, Wang S, Li X, Huang Y, Xia Y, Cao C. Sulforaphane induces autophagy by inhibition of HDAC6-mediated PTEN activation in triple negative breast cancer cells. Life Sci. 2018 Nov 15;213149-157. doi: 10.1016/j.lfs.2018.10.034. PubMed PMID: 30352240.
Qin Y, Vasilatos SN, Chen L, Wu H, Cao Z, Fu Y, Huang M, Vlad AM, Lu B, Oesterreich S, Davidson NE, Huang Y. Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade. Oncogene. 2019 Jan;38(3):390-405. doi: 10.1038/s41388-018-0451-5. PubMed PMID: 30111819; PMCID: PMC6336685.
Xu J, Ma H, Jin J, Uttam S, Fu R, Huang Y, Liu Y. Super-Resolution Imaging of Higher-Order Chromatin Structures at Different Epigenomic States in Single Mammalian Cells. Cell Rep. 2018 Jul 24;24(4):873-882. doi: 10.1016/j.celrep.2018.06.085. PubMed PMID: 30044984; PMCID: PMC6154382.
Chu J, Li Y, Fan X, Ma J, Li J, Lu G, Zhang Y, Huang Y, Li W, Huang X, Fu Z, Yin Y, Yuan H. MiR-4319 Suppress the Malignancy of Triple-Negative Breast Cancer by Regulating Self-Renewal and Tumorigenesis of Stem Cells. Cell Physiol Biochem. 2018;48(2):593-604. doi: 10.1159/000491888. PubMed PMID: 30021199.
Li Y, Chu J, Li J, Feng W, Yang F, Wang Y, Zhang Y, Sun C, Yang M, Vasilatos SN, Huang Y, Fu Z, Yin Y. Cancer/testis antigen-Plac1 promotes invasion and metastasis of breast cancer through Furin/NICD/PTEN signaling pathway. Mol Oncol. 2018 Aug;12(8):1233-1248. doi: 10.1002/1878-0261.12311. PubMed PMID: 29704427; PMCID: PMC6068355.
Cao C, Wu H, Vasilatos SN, Chandran U, Qin Y, Wan Y, Oesterreich S, Davidson NE, Huang Y. HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells. Int J Cancer. 2018 Sep 15;143(6):1388-1401. doi: 10.1002/ijc.31419. PubMed PMID: 29633255; PMCID: PMC6105499.
Huang Y, Yin Y, Sun M. Targeting LSD2 in breast cancer. Aging (Albany NY). 2018 Jan 20;10(1):11-12. doi: 10.18632/aging.101371. PubMed PMID: 29356682; PMCID: PMC5811254.
Woodcock CC, Huang Y, Woodcock SR, Salvatore SR, Singh B, Golin-Bisello F, Davidson NE, Neumann CA, Freeman BA, Wendell SG. Nitro-fatty acid inhibition of triple-negative breast cancer cell viability, migration, invasion, and tumor growth. J Biol Chem. 2018 Jan 26;293(4):1120-1137. doi: 10.1074/jbc.M117.814368. PubMed PMID: 29158255; PMCID: PMC5787792.
Chen L, Vasilatos SN, Qin Y, Katz TA, Cao C, Wu H, Tasdemir N, Levine KM, Oesterreich S, Davidson NE, Huang Y. Functional characterization of lysine-specific demethylase 2 (LSD2/KDM1B) in breast cancer progression. Oncotarget. 2017 Oct 10;8(47):81737-81753. doi: 10.18632/oncotarget.19387. PubMed PMID: 29137219; PMCID: PMC5669845.
Li Y, Li J, Wang Y, Zhang Y, Chu J, Sun C, Fu Z, Huang Y, Zhang H, Yuan H, Yin Y. Roles of cancer/testis antigens (CTAs) in breast cancer. Cancer Lett. 2017 Jul 28;39964-73. doi: 10.1016/j.canlet.2017.02.031. PubMed PMID: 28274891.
Ma H, Xu J, Jin J, Huang Y, Liu Y. A Simple Marker-Assisted 3D Nanometer Drift Correction Method for Superresolution Microscopy. Biophys J. 2017 May 23;112(10):2196-2208. doi: 10.1016/j.bpj.2017.04.025. PubMed PMID: 28538156; PMCID: PMC5444076.
Huang Y, Zhu H. Protein Array-based Approaches for Biomarker Discovery in Cancer. Genomics Proteomics Bioinformatics. 2017 Apr;15(2):73-81. doi: 10.1016/j.gpb.2017.03.001. PubMed PMID: 28392481; PMCID: PMC5414965.
Peng Y, Zhang X, Ma Q, Yan R, Qin Y, Zhao Y, Cheng Y, Yang M, Wang Q, Feng X, Huang Y, Huang W, Zhao Z, Wang L, Wei Y, He Z, Fan X, Li S, Jin Z, Meltzer SJ. MiRNA-194 activates the Wnt/β-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU. Cancer Lett. 2017 Jan 28;385117-127. doi: 10.1016/j.canlet.2016.10.035. PubMed PMID: 27810403.
Huang Y, Davidson NE. Targeting tumorigenicity of breast cancer stem-like cells using combination epigenetic therapy: something old and something new. J Thorac Dis. 2016 Nov;8(11):2971-2974. doi: 10.21037/jtd.2016.11.18. PubMed PMID: 28066560; PMCID: PMC5179425.
Zhou Z, Luo A, Shrivastava I, He M, Huang Y, Bahar I, Liu Z, Wan Y. Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis. EBioMedicine. 2017 Feb;1548-61. doi: 10.1016/j.ebiom.2016.12.014. PubMed PMID: 28040451; PMCID: PMC5233825.
Lu X, Yan C, Huang Y, Shi D, Fu Z, Qiu J, Yin Y. Mouse double minute 2 (MDM2) upregulates Snail expression and induces epithelial-to-mesenchymal transition in breast cancer cells in vitro and in vivo. Oncotarget. 2016 Jun 14;7(24):37177-37191. doi: 10.18632/oncotarget.9287. PubMed PMID: 27184007; PMCID: PMC5095067.
Zhang X, Peng Y, Jin Z, Huang W, Cheng Y, Liu Y, Feng X, Yang M, Huang Y, Zhao Z, Wang L, Wei Y, Fan X, Zheng D, Meltzer SJ. Integrated miRNA profiling and bioinformatics analyses reveal potential causative miRNAs in gastric adenocarcinoma. Oncotarget. 2015 Oct 20;6(32):32878-89. doi: 10.18632/oncotarget.5419. PubMed PMID: 26460735; PMCID: PMC4741736.
Grasso CS, Tang Y, Truffaux N, Berlow NE, Liu L, Debily MA, Quist MJ, Davis LE, Huang EC, Woo PJ, Ponnuswami A, Chen S, Johung TB, Sun W, Kogiso M, Du Y, Qi L, Huang Y, Hütt-Cabezas M, Warren KE, Le Dret L, Meltzer PS, Mao H, Quezado M, van Vuurden DG, Abraham J, Fouladi M, Svalina MN, Wang N, Hawkins C, Nazarian J, Alonso MM, Raabe EH, Hulleman E, Spellman PT, Li XN, Keller C, Pal R, Grill J, Monje M. Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med. 2015 Jun;21(6):555-9. doi: 10.1038/nm.3855. PubMed PMID: 25939062; PMCID: PMC4862411.
Li F, Chen G, Sheng C, Gusdon AM, Huang Y, Lv Z, Xu H, Xing M, Qu S. BRAFV600E mutation in papillary thyroid microcarcinoma: a meta-analysis. Endocr Relat Cancer. 2015 Apr;22(2):159-68. doi: 10.1530/ERC-14-0531. PubMed PMID: 25593071; PMCID: PMC4629836.
Katz TA, Huang Y, Davidson NE, Jankowitz RC. Epigenetic reprogramming in breast cancer: from new targets to new therapies. Ann Med. 2014 Sep;46(6):397-408. doi: 10.3109/07853890.2014.923740. PubMed PMID: 25058177.
Katz TA, Vasilatos SN, Harrington E, Oesterreich S, Davidson NE, Huang Y. Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells. Breast Cancer Res Treat. 2014 Jul;146(1):99-108. doi: 10.1007/s10549-014-3012-9. PubMed PMID: 24924415.

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