Publications

Jeffrey Brodsky

Cui Y, Parashar S, Zahoor M, Needham PG, Mari M, Zhu M, Chen S, Ho HC, Reggiori F, Farhan H, Brodsky JL, Ferro-Novick S. A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation. Science. 2019 Jul 5;365(6448):53-60. doi: 10.1126/science.aau9263. PubMed PMID: 31273116; PMCID: PMC7062386.
Werner HM, Estabrooks SK, Preston GM, Brodsky JL, Horne WS. Exploring the Functional Consequences of Protein Backbone Alteration in Ubiquitin through Native Chemical Ligation. Chembiochem. 2019 Sep 16;20(18):2346-2350. doi: 10.1002/cbic.201900225. PubMed PMID: 31059184; PMCID: PMC6752966.
Doonan LM, Guerriero CJ, Preston GM, Buck TM, Khazanov N, Fisher EA, Senderowitz H, Brodsky JL. Hsp104 facilitates the endoplasmic-reticulum-associated degradation of disease-associated and aggregation-prone substrates. Protein Sci. 2019 Jul;28(7):1290-1306. doi: 10.1002/pro.3636. PubMed PMID: 31050848; PMCID: PMC6566541.
Needham PG, Guerriero CJ, Brodsky JL. Chaperoning Endoplasmic Reticulum-Associated Degradation (ERAD) and Protein Conformational Diseases. Cold Spring Harb Perspect Biol. 2019 Aug 1;11(8): doi: 10.1101/cshperspect.a033928. PubMed PMID: 30670468; PMCID: PMC6671943.
Pabon NA, Xia Y, Estabrooks SK, Ye Z, Herbrand AK, Süß E, Biondi RM, Assimon VA, Gestwicki JE, Brodsky JL, Camacho CJ, Bar-Joseph Z. Predicting protein targets for drug-like compounds using transcriptomics. PLoS Comput Biol. 2018 Dec;14(12):e1006651. doi: 10.1371/journal.pcbi.1006651. PubMed PMID: 30532261; PMCID: PMC6300300.
Chiang AN, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried JL, Mazzone CS, Newhouse DW, Kendsersky NM, Yates ME, Manos-Turvey A, Needham PG, Outeiro TF, Wipf P, Brodsky JL. Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. Bioorg Med Chem. 2019 Jan 1;27(1):79-91. doi: 10.1016/j.bmc.2018.11.011. PubMed PMID: 30528127; PMCID: PMC6298824.
Sannino S, Guerriero CJ, Sabnis AJ, Stolz DB, Wallace CT, Wipf P, Watkins SC, Bivona TG, Brodsky JL. Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells. J Cell Sci. 2018 Sep 5;131(17): doi: 10.1242/jcs.217760. PubMed PMID: 30131440; PMCID: PMC6140321.
Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky JL, Frost A, Borner GH, Weissman JS. The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. Elife. 2018 May 29;7 doi: 10.7554/eLife.37018. PubMed PMID: 29809151; PMCID: PMC5995541.
Joshi S, Wang T, Araujo TLS, Sharma S, Brodsky JL, Chiosis G. Adapting to stress - chaperome networks in cancer. Nat Rev Cancer. 2018 Sep;18(9):562-575. doi: 10.1038/s41568-018-0020-9. PubMed PMID: 29795326; PMCID: PMC6108944.
Hager NA, Krasowski CJ, Mackie TD, Kolb AR, Needham PG, Augustine AA, Dempsey A, Szent-Gyorgyi C, Bruchez MP, Bain DJ, Kwiatkowski AV, O'Donnell AF, Brodsky JL. Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model. J Biol Chem. 2018 Jul 13;293(28):11006-11021. doi: 10.1074/jbc.RA117.001293. PubMed PMID: 29784874; PMCID: PMC6052216.
Sun Z, Brodsky JL. The degradation pathway of a model misfolded protein is determined by aggregation propensity. Mol Biol Cell. 2018 Jun 15;29(12):1422-1434. doi: 10.1091/mbc.E18-02-0117. PubMed PMID: 29688814; PMCID: PMC6014095.
Preston GM, Guerriero CJ, Metzger MB, Michaelis S, Brodsky JL. Substrate Insolubility Dictates Hsp104-Dependent Endoplasmic-Reticulum-Associated Degradation. Mol Cell. 2018 Apr 19;70(2):242-253.e6. doi: 10.1016/j.molcel.2018.03.016. PubMed PMID: 29677492; PMCID: PMC5912696.
Nakasone MA, Lewis TA, Walker O, Thakur A, Mansour W, Castañeda CA, Goeckeler-Fried JL, Parlati F, Chou TF, Hayat O, Zhang D, Camara CM, Bonn SM, Nowicka UK, Krueger S, Glickman MH, Brodsky JL, Deshaies RJ, Fushman D. Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway. Structure. 2017 Dec 5;25(12):1839-1855.e11. doi: 10.1016/j.str.2017.10.007. PubMed PMID: 29153505; PMCID: PMC5731780.
Sannino S, Brodsky JL. Targeting protein quality control pathways in breast cancer. BMC Biol. 2017 Nov 16;15(1):109. doi: 10.1186/s12915-017-0449-4. PubMed PMID: 29145850; PMCID: PMC5689203.
Gleixner AM, Hutchison DF, Sannino S, Bhatia TN, Leak LC, Flaherty PT, Wipf P, Brodsky JL, Leak RK. N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione. Mol Pharmacol. 2017 Nov;92(5):564-575. doi: 10.1124/mol.117.109926. PubMed PMID: 28830914; PMCID: PMC5635514.
Zacchi LF, Dittmar JC, Mihalevic MJ, Shewan AM, Schulz BL, Brodsky JL, Bernstein KA. Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE. Dis Model Mech. 2017 Sep 1;10(9):1129-1140. doi: 10.1242/dmm.029926. PubMed PMID: 28768697; PMCID: PMC5611967.
O'Donnell BM, Mackie TD, Brodsky JL. Linking chanelopathies with endoplasmic reticulum associated degradation. Channels (Austin). 2017 Nov 2;11(6):499-501. doi: 10.1080/19336950.2017.1357944. PubMed PMID: 28723237; PMCID: PMC5786258.
Guerriero CJ, Reutter KR, Augustine AA, Preston GM, Weiberth KF, Mackie TD, Cleveland-Rubeor HC, Bethel NP, Callenberg KM, Nakatsukasa K, Grabe M, Brodsky JL. Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates. Mol Biol Cell. 2017 Jul 15;28(15):2076-2090. doi: 10.1091/mbc.E17-03-0184. PubMed PMID: 28539401; PMCID: PMC5509421.
Ye Z, Needham PG, Estabrooks SK, Whitaker SK, Garcia BL, Misra S, Brodsky JL, Camacho CJ. Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase. Sci Rep. 2017 May 11;7(1):1789. doi: 10.1038/s41598-017-01880-4. PubMed PMID: 28496195; PMCID: PMC5431976.
Preston GM, Brodsky JL. The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation. Biochem J. 2017 Feb 15;474(4):445-469. doi: 10.1042/BCJ20160582. PubMed PMID: 28159894; PMCID: PMC5425155.
Braganza A, Li J, Zeng X, Yates NA, Dey NB, Andrews J, Clark J, Zamani L, Wang XH, St Croix C, O'Sullivan R, Garcia-Exposito L, Brodsky JL, Sobol RW. UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase. J Biol Chem. 2017 Feb 10;292(6):2470-2484. doi: 10.1074/jbc.M116.766824. PubMed PMID: 28003368; PMCID: PMC5313114.
Buck TM, Jordahl AS, Yates ME, Preston GM, Cook E, Kleyman TR, Brodsky JL. Interactions between intersubunit transmembrane domains regulate the chaperone-dependent degradation of an oligomeric membrane protein. Biochem J. 2017 Feb 1;474(3):357-376. doi: 10.1042/BCJ20160760. PubMed PMID: 27903760; PMCID: PMC5423784.
Manos-Turvey A, Al-Ashtal HA, Needham PG, Hartline CB, Prichard MN, Wipf P, Brodsky JL. Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5087-5091. doi: 10.1016/j.bmcl.2016.08.080. PubMed PMID: 27624078; PMCID: PMC5050167.
Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9015-20. doi: 10.1073/pnas.1603883113. PubMed PMID: 27450084; PMCID: PMC4987817.
Prosser DC, Pannunzio AE, Brodsky JL, Thorner J, Wendland B, O'Donnell AF. α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis. J Cell Sci. 2015 Nov 15;128(22):4220-34. doi: 10.1242/jcs.175372. PubMed PMID: 26459639; PMCID: PMC4712785.
Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle T Jr, Lu P, Brodsky JL, Hackam DJ. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100. doi: 10.1016/j.tetlet.2014.11.048. PubMed PMID: 26236050; PMCID: PMC4518473.
Marcoline FV, Bethel N, Guerriero CJ, Brodsky JL, Grabe M. Membrane Protein Properties Revealed through Data-Rich Electrostatics Calculations. Structure. 2015 Aug 4;23(8):1526-1537. doi: 10.1016/j.str.2015.05.014. PubMed PMID: 26118532; PMCID: PMC4527966.
Needham PG, Patel HJ, Chiosis G, Thibodeau PH, Brodsky JL. Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions. J Mol Biol. 2015 Sep 11;427(18):2948-65. doi: 10.1016/j.jmb.2015.04.010. PubMed PMID: 25913688; PMCID: PMC4569534.
Posimo JM, Weilnau JN, Gleixner AM, Broeren MT, Weiland NL, Brodsky JL, Wipf P, Leak RK. Heat shock protein defenses in the neocortex and allocortex of the telencephalon. Neurobiol Aging. 2015 May;36(5):1924-37. doi: 10.1016/j.neurobiolaging.2015.02.011. PubMed PMID: 25771395; PMCID: PMC4417007.
Buck TM, Jordan R, Lyons-Weiler J, Adelman JL, Needham PG, Kleyman TR, Brodsky JL. Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae. Physiol Genomics. 2015 Jun;47(6):198-214. doi: 10.1152/physiolgenomics.00101.2014. PubMed PMID: 25759377; PMCID: PMC4451388.
An P, Brodsky JL, Pipas JM. The conserved core enzymatic activities and the distinct dynamics of polyomavirus large T antigens. Arch Biochem Biophys. 2015 May 1;57323-31. doi: 10.1016/j.abb.2015.02.033. PubMed PMID: 25752954; PMCID: PMC4865250.
Li H, Wu HC, Liu Z, Zacchi LF, Brodsky JL, Zolkiewski M. Intracellular complexes of the early-onset torsion dystonia-associated AAA+ ATPase TorsinA. Springerplus. 2014;3743. doi: 10.1186/2193-1801-3-743. PubMed PMID: 25674472; PMCID: PMC4320221.
Crum TS, Gleixner AM, Posimo JM, Mason DM, Broeren MT, Heinemann SD, Wipf P, Brodsky JL, Leak RK. Heat shock protein responses to aging and proteotoxicity in the olfactory bulb. J Neurochem. 2015 Jun;133(6):780-794. doi: 10.1111/jnc.13041. PubMed PMID: 25640060; PMCID: PMC4464935.
Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, Haystead TA. Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. Chem Biol. 2014 Dec 18;21(12):1648-59. doi: 10.1016/j.chembiol.2014.10.016. PubMed PMID: 25500222; PMCID: PMC4272656.
Brodsky JL, Clark PL. Protein folding in the cell, from atom to organism. FASEB J. 2014 Dec;28(12):5034-8. doi: 10.1096/fj.14-1202ufm. PubMed PMID: 25451678; PMCID: PMC6190966.
Ireland AW, Gobillot TA, Gupta T, Seguin SP, Liang M, Resnick L, Goldberg MT, Manos-Turvey A, Pipas JM, Wipf P, Brodsky JL. Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target. Bioorg Med Chem. 2014 Nov 15;22(22):6490-6502. doi: 10.1016/j.bmc.2014.09.019. PubMed PMID: 25440730; PMCID: PMC4293281.
Buck TM, Brodsky JL. Escaping the endoplasmic reticulum: why does a molecular chaperone leave home for greener pastures? EMBO J. 2015 Jan 2;34(1):1-3. doi: 10.15252/embj.201490462. PubMed PMID: 25425576; PMCID: PMC4291476.
Surlow BA, Cooley BM, Needham PG, Brodsky JL, Patton-Vogt J. Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation. J Biol Chem. 2014 Nov 7;289(45):31591-604. doi: 10.1074/jbc.M114.581157. PubMed PMID: 25258318; PMCID: PMC4223355.
Nakatsukasa K, Kamura T, Brodsky JL. Recent technical developments in the study of ER-associated degradation. Curr Opin Cell Biol. 2014 Aug;2982-91. doi: 10.1016/j.ceb.2014.04.008. PubMed PMID: 24867671; PMCID: PMC4130770.

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