Publications

George Michalopoulos, MD, PhD

Yu YP, Liu P, Nelson J, Hamilton RL, Bhargava R, Michalopoulos G, Chen Q, Zhang J, Ma D, Pennathur A, Luketich J, Nalesnik M, Tseng G, Luo JH. Identification of recurrent fusion genes across multiple cancer types. Sci Rep. 2019 Jan 31;9(1):1074. doi: 10.1038/s41598-019-38550-6. PubMed PMID: 30705370; PMCID: PMC6355770.
Koral K, Haynes M, Bowen WC, Orr A, Mars W, Michalopoulos GK. Lymphocyte-Specific Protein-1 Controls Sorafenib Sensitivity and Hepatocellular Proliferation through Extracellular Signal-Regulated Kinase 1/2 Activation. Am J Pathol. 2018 Sep;188(9):2074-2086. doi: 10.1016/j.ajpath.2018.06.005. PubMed PMID: 30126548.
Tsagianni A, Mars WM, Bhushan B, Bowen WC, Orr A, Stoops J, Paranjpe S, Tseng GC, Liu S, Michalopoulos GK. Combined Systemic Disruption of MET and Epidermal Growth Factor Receptor Signaling Causes Liver Failure in Normal Mice. Am J Pathol. 2018 Oct;188(10):2223-2235. doi: 10.1016/j.ajpath.2018.06.009. PubMed PMID: 30031724; PMCID: PMC6168971.
Michalopoulos GK. The Regenerative Altruism of Hepatocytes and Cholangiocytes. Cell Stem Cell. 2018 Jul 5;23(1):11-12. doi: 10.1016/j.stem.2018.06.006. PubMed PMID: 29979985.
Bhushan B, Stoops JW, Mars WM, Orr A, Bowen WC, Paranjpe S, Michalopoulos GK. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69(4):1702-1718. doi: 10.1002/hep.30109. PubMed PMID: 29888801; PMCID: PMC6289897.
Xue Y, Mars WM, Bowen W, Singhi AD, Stoops J, Michalopoulos GK. Hepatitis C Virus Mimics Effects of Glypican-3 on CD81 and Promotes Development of Hepatocellular Carcinomas via Activation of Hippo Pathway in Hepatocytes. Am J Pathol. 2018 Jun;188(6):1469-1477. doi: 10.1016/j.ajpath.2018.02.013. PubMed PMID: 29577937; PMCID: PMC5975625.
Chartoumpekis DV, Yagishita Y, Fazzari M, Palliyaguru DL, Rao UN, Zaravinos A, Khoo NK, Schopfer FJ, Weiss KR, Michalopoulos GK, Sipula I, O'Doherty RM, Kensler TW, Wakabayashi N. Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice. JCI Insight. 2018 Mar 8;3(5): doi: 10.1172/jci.insight.97735. PubMed PMID: 29515034; PMCID: PMC5922294.
Chartoumpekis DV, Palliyaguru DL, Wakabayashi N, Fazzari M, Khoo NKH, Schopfer FJ, Sipula I, Yagishita Y, Michalopoulos GK, O'Doherty RM, Kensler TW. Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E180-E195. doi: 10.1152/ajpendo.00311.2017. PubMed PMID: 29486138; PMCID: PMC6139497.
Doffou M, Adams G, Bowen WC, Paranjpe S, Parihar HS, Nguyen H, Michalopoulos GK, Bhave VS. Oct4 Is Crucial for Transdifferentiation of Hepatocytes to Biliary Epithelial Cells in an In Vitro Organoid Culture Model. Gene Expr. 2018 Mar 21;18(1):51-62. doi: 10.3727/105221617X15124876321401. PubMed PMID: 29212575; PMCID: PMC5885146.
Kader M, Alaoui-El-Azher M, Vorhauer J, Kode BB, Wells JZ, Stolz D, Michalopoulos G, Wells A, Scott M, Ismail N. MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. PLoS Pathog. 2017 Oct;13(10):e1006644. doi: 10.1371/journal.ppat.1006644. PubMed PMID: 29049365; PMCID: PMC5663626.
Chen ZH, Yu YP, Zuo ZH, Nelson JB, Michalopoulos GK, Monga S, Liu S, Tseng G, Luo JH. Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene. Nat Biotechnol. 2017 Jun;35(6):543-550. doi: 10.1038/nbt.3843. PubMed PMID: 28459452; PMCID: PMC5462845.
Khan Z, Orr A, Michalopoulos GK, Ranganathan S. Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease. Pediatr Dev Pathol. 2017 Jan-Feb;20(1):16-27. doi: 10.1177/1093526616686244. PubMed PMID: 28276299; PMCID: PMC5040613.
Chen ZH, Yu YP, Tao J, Liu S, Tseng G, Nalesnik M, Hamilton R, Bhargava R, Nelson JB, Pennathur A, Monga SP, Luketich JD, Michalopoulos GK, Luo JH. MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice. Gastroenterology. 2017 Oct;153(4):1120-1132.e15. doi: 10.1053/j.gastro.2016.12.036. PubMed PMID: 28245430; PMCID: PMC5572118.
Michalopoulos GK. Hepatostat: Liver regeneration and normal liver tissue maintenance. Hepatology. 2017 Apr;65(4):1384-1392. doi: 10.1002/hep.28988. PubMed PMID: 27997988.
Paranjpe S, Bowen WC, Mars WM, Orr A, Haynes MM, DeFrances MC, Liu S, Tseng GC, Tsagianni A, Michalopoulos GK. Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation. Hepatology. 2016 Nov;64(5):1711-1724. doi: 10.1002/hep.28721. PubMed PMID: 27397846; PMCID: PMC5074871.
Yu C, Yan S, Khambu B, Chen X, Dong Z, Luo J, Michalopoulos GK, Wu S, Yin XM. Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers. PLoS One. 2016;11(5):e0155211. doi: 10.1371/journal.pone.0155211. PubMed PMID: 27196317; PMCID: PMC4873180.
Michalopoulos GK, Khan Z. Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease. Gastroenterology. 2015 Oct;149(4):876-882. doi: 10.1053/j.gastro.2015.08.004. PubMed PMID: 26278502; PMCID: PMC4584191.
Kang LI, Isse K, Koral K, Bowen WC, Muratoglu S, Strickland DK, Michalopoulos GK, Mars WM. Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1. Lab Invest. 2015 Oct;95(10):1117-29. doi: 10.1038/labinvest.2015.94. PubMed PMID: 26237273; PMCID: PMC4586397.

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