Publications

Bruce Freeman, PhD

Jobbagy S, Vitturi DA, Salvatore SR, Turell L, Pires MF, Kansanen E, Batthyany C, Lancaster JR Jr, Freeman BA, Schopfer FJ. Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis. Redox Biol. 2019 Feb;21101050. doi: 10.1016/j.redox.2018.11.008. PubMed PMID: 30654300; PMCID: PMC6348771.
Asan A, Skoko JJ, Woodcock CC, Wingert BM, Woodcock SR, Normolle D, Huang Y, Stark JM, Camacho CJ, Freeman BA, Neumann CA. Electrophilic fatty acids impair RAD51 function and potentiate the effects of DNA-damaging agents on growth of triple-negative breast cells. J Biol Chem. 2019 Jan 11;294(2):397-404. doi: 10.1074/jbc.AC118.005899. PubMed PMID: 30478172; PMCID: PMC6333886.
Rodriguez-Duarte J, Dapueto R, Galliussi G, Turell L, Kamaid A, Khoo NKH, Schopfer FJ, Freeman BA, Escande C, Batthyány C, Ferrer-Sueta G, López GV. Electrophilic nitroalkene-tocopherol derivatives: synthesis, physicochemical characterization and evaluation of anti-inflammatory signaling responses. Sci Rep. 2018 Aug 24;8(1):12784. doi: 10.1038/s41598-018-31218-7. PubMed PMID: 30143727; PMCID: PMC6109136.
Freeman BA, O'Donnell VB, Schopfer FJ. The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling. Nitric Oxide. 2018 Jul 1;77106-111. doi: 10.1016/j.niox.2018.05.002. PubMed PMID: 29742447; PMCID: PMC5983901.
Li S, Chang Z, Zhu T, Villacorta L, Li Y, Freeman BA, Chen YE, Zhang J. Transcriptomic sequencing reveals diverse adaptive gene expression responses of human vascular smooth muscle cells to nitro-conjugated linoleic acid. Physiol Genomics. 2018 Apr 1;50(4):287-295. doi: 10.1152/physiolgenomics.00090.2017. PubMed PMID: 29473818; PMCID: PMC5966802.
Villacorta L, Minarrieta L, Salvatore SR, Khoo NK, Rom O, Gao Z, Berman RC, Jobbagy S, Li L, Woodcock SR, Chen YE, Freeman BA, Ferreira AM, Schopfer FJ, Vitturi DA. In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation. Redox Biol. 2018 May;15522-531. doi: 10.1016/j.redox.2018.01.005. PubMed PMID: 29413964; PMCID: PMC5881417.
Khoo NKH, Li L, Salvatore SR, Schopfer FJ, Freeman BA. Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships. Sci Rep. 2018 Feb 2;8(1):2295. doi: 10.1038/s41598-018-20460-8. PubMed PMID: 29396403; PMCID: PMC5797128.
Woodcock CC, Huang Y, Woodcock SR, Salvatore SR, Singh B, Golin-Bisello F, Davidson NE, Neumann CA, Freeman BA, Wendell SG. Nitro-fatty acid inhibition of triple-negative breast cancer cell viability, migration, invasion, and tumor growth. J Biol Chem. 2018 Jan 26;293(4):1120-1137. doi: 10.1074/jbc.M117.814368. PubMed PMID: 29158255; PMCID: PMC5787792.
Mathers AR, Carey CD, Killeen ME, Salvatore SR, Ferris LK, Freeman BA, Schopfer FJ, Falo LD Jr. Topical electrophilic nitro-fatty acids potentiate cutaneous inflammation. Free Radic Biol Med. 2018 Feb 1;11531-42. doi: 10.1016/j.freeradbiomed.2017.11.009. PubMed PMID: 29132974; PMCID: PMC5767521.
Ambrozova G, Fidlerova T, Verescakova H, Koudelka A, Rudolph TK, Woodcock SR, Freeman BA, Kubala L, Pekarova M. Nitro-oleic acid inhibits vascular endothelial inflammatory responses and the endothelial-mesenchymal transition. Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2428-2437. doi: 10.1016/j.bbagen.2016.07.010. PubMed PMID: 27431604; PMCID: PMC5010974.
Zhou C, Ramaswamy SS, Johnson DE, Vitturi DA, Schopfer FJ, Freeman BA, Hudmon A, Levitan ES. Novel Roles for Peroxynitrite in Angiotensin II and CaMKII Signaling. Sci Rep. 2016 Apr 15;623416. doi: 10.1038/srep23416. PubMed PMID: 27079272; PMCID: PMC4832198.
Ambrozova G, Martiskova H, Koudelka A, Ravekes T, Rudolph TK, Klinke A, Rudolph V, Freeman BA, Woodcock SR, Kubala L, Pekarova M. Nitro-oleic acid modulates classical and regulatory activation of macrophages and their involvement in pro-fibrotic responses. Free Radic Biol Med. 2016 Jan;90252-260. doi: 10.1016/j.freeradbiomed.2015.11.026. PubMed PMID: 26620549; PMCID: PMC4748956.
Fazzari M, Khoo N, Woodcock SR, Li L, Freeman BA, Schopfer FJ. Generation and esterification of electrophilic fatty acid nitroalkenes in triacylglycerides. Free Radic Biol Med. 2015 Oct;87113-24. doi: 10.1016/j.freeradbiomed.2015.05.033. PubMed PMID: 26066303; PMCID: PMC4615386.
Vitturi DA, Minarrieta L, Salvatore SR, Postlethwait EM, Fazzari M, Ferrer-Sueta G, Lancaster JR Jr, Freeman BA, Schopfer FJ. Convergence of biological nitration and nitrosation via symmetrical nitrous anhydride. Nat Chem Biol. 2015 Jul;11(7):504-10. doi: 10.1038/nchembio.1814. PubMed PMID: 26006011; PMCID: PMC4472503.
Wendell SG, Golin-Bisello F, Wenzel S, Sobol RW, Holguin F, Freeman BA. 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids. J Biol Chem. 2015 Feb 27;290(9):5868-80. doi: 10.1074/jbc.M114.635151. PubMed PMID: 25586183; PMCID: PMC4342494.

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