Publications

Wen Xie, MD, PhD

Wan Z, Sun J, Xu J, Moharil P, Chen J, Xu J, Zhu J, Li J, Huang Y, Xu P, Ma X, Xie W, Lu B, Li S. Dual functional immunostimulatory polymeric prodrug carrier with pendent indoximod for enhanced cancer immunochemotherapy. Acta Biomater. 2019 May;90300-313. doi: 10.1016/j.actbio.2019.03.048. PubMed PMID: 30930305; PMCID: PMC6513707.
Barbosa ACS, Feng Y, Yu C, Huang M, Xie W. Estrogen sulfotransferase in the metabolism of estrogenic drugs and in the pathogenesis of diseases. Expert Opin Drug Metab Toxicol. 2019 Apr;15(4):329-339. doi: 10.1080/17425255.2019.1588884. PubMed PMID: 30822161; PMCID: PMC6428602.
Guo GL, Xie W. Metformin action through the microbiome and bile acids. Nat Med. 2018 Dec;24(12):1789-1790. doi: 10.1038/s41591-018-0273-6. PubMed PMID: 30523325.
Chen L, Liu Q, Tang Q, Kuang J, Li H, Pu S, Wu T, Yang X, Li R, Zhang J, Zhang Z, Huang Y, Li Y, Zou M, Jiang W, Li T, Gong M, Zhang L, Wang H, Qu A, Xie W, He J. Hepatocyte-specific Sirt6 deficiency impairs ketogenesis. J Biol Chem. 2019 Feb 1;294(5):1579-1589. doi: 10.1074/jbc.RA118.005309. PubMed PMID: 30530497; PMCID: PMC6364758.
Xu D, Huang S, Wang H, Xie W. Regulation of brain drug metabolizing enzymes and transporters by nuclear receptors. Drug Metab Rev. 2018 Nov;50(4):407-414. doi: 10.1080/03602532.2018.1554673. PubMed PMID: 30501435.
Lu P, Cai X, Guo Y, Xu M, Tian J, Locker J, Xie W. Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b. Toxicol Sci. 2019 Feb 1;167(2):581-592. doi: 10.1093/toxsci/kfy263. PubMed PMID: 30346592; PMCID: PMC6358271.
Zhu J, Wang P, Li F, Lu J, Shehu AI, Xie W, McMahon D, Ma X. CYP1A1 and 1B1-mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor. Biochem Pharmacol. 2018 Dec;158174-184. doi: 10.1016/j.bcp.2018.10.012. PubMed PMID: 30342022; PMCID: PMC6263788.
Bi Y, Jiang M, Guo W, Guan X, Xu M, Ren S, Yang D, Gaikwad NW, Selcer KW, Xie W. Sex-Dimorphic and Sex Hormone-Dependent Role of Steroid Sulfatase in Adipose Inflammation and Energy Homeostasis. Endocrinology. 2018 Sep 1;159(9):3365-3377. doi: 10.1210/en.2018-00531. PubMed PMID: 30060148; PMCID: PMC6112598.
Evers R, Piquette-Miller M, Polli JW, Russel FGM, Sprowl JA, Tohyama K, Ware JA, de Wildt SN, Xie W, Brouwer KLR, International Transporter Consortium.. Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium. Clin Pharmacol Ther. 2018 Nov;104(5):900-915. doi: 10.1002/cpt.1115. PubMed PMID: 29756222; PMCID: PMC6424581.
Hogle BC, Guan X, Folan MM, Xie W. PXR as a mediator of herb-drug interaction. J Food Drug Anal. 2018 Apr;26(2S):S26-S31. doi: 10.1016/j.jfda.2017.11.007. PubMed PMID: 29703383.
Kong B, Sun R, Huang M, Chow MD, Zhong XB, Xie W, Lee YH, Guo GL. Fibroblast Growth Factor 15-Dependent and Bile Acid-Independent Promotion of Liver Regeneration in Mice. Hepatology. 2018 Nov;68(5):1961-1976. doi: 10.1002/hep.30041. PubMed PMID: 29672888; PMCID: PMC6195490.
Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, Jia L, Li S, Cancer Genome Atlas Research Network., Xie W, Yang D. lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Cancer Cell. 2018 Apr 9;33(4):706-720.e9. doi: 10.1016/j.ccell.2018.03.006. PubMed PMID: 29622465; PMCID: PMC6143179.
Kim YC, Seok S, Byun S, Kong B, Zhang Y, Guo G, Xie W, Ma J, Kemper B, Kemper JK. AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle. Nat Commun. 2018 Feb 7;9(1):540. doi: 10.1038/s41467-018-03060-y. PubMed PMID: 29416063; PMCID: PMC5803255.
Garbacz WG, Jiang M, Xie W. Sex-Dependent Role of Estrogen Sulfotransferase and Steroid Sulfatase in Metabolic Homeostasis. Adv Exp Med Biol. 2017;1043455-469. doi: 10.1007/978-3-319-70178-3_21. PubMed PMID: 29224107.
Garbacz WG, Jiang M, Xu M, Yamauchi J, Dong HH, Xie W. Sex- and Tissue-Specific Role of Estrogen Sulfotransferase in Energy Homeostasis and Insulin Sensitivity. Endocrinology. 2017 Nov 1;158(11):4093-4104. doi: 10.1210/en.2017-00571. PubMed PMID: 28938414; PMCID: PMC5695832.
Li J, Ghazwani M, Liu K, Huang Y, Chang N, Fan J, He F, Li L, Bu S, Xie W, Ma X, Li S. Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism. PLoS One. 2017;12(8):e0182679. doi: 10.1371/journal.pone.0182679. PubMed PMID: 28797105; PMCID: PMC5552314.
Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1. PLoS One. 2017;12(8):e0181052. doi: 10.1371/journal.pone.0181052. PubMed PMID: 28797077; PMCID: PMC5552280.
Cui H, Gu X, Chen J, Xie Y, Ke S, Wu J, Golovko A, Morpurgo B, Yan C, Phillips TD, Xie W, Luo J, Zhou Z, Tian Y. Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage. Toxicol Lett. 2017 Jun 5;27567-76. doi: 10.1016/j.toxlet.2017.03.028. PubMed PMID: 28428138.
Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB. Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO). Acta Pharm Sin B. 2017 Mar;7(2):241-248. doi: 10.1016/j.apsb.2016.12.006. PubMed PMID: 28388695; PMCID: PMC5343155.
Niu Y, Xu M, Slagle BL, Huang H, Li S, Guo GL, Shi G, Qin W, Xie W. Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis. Hepatology. 2017 Mar;65(3):893-906. doi: 10.1002/hep.28924. PubMed PMID: 28102638; PMCID: PMC5319891.
Chen Y, Xia R, Huang Y, Zhao W, Li J, Zhang X, Wang P, Venkataramanan R, Fan J, Xie W, Ma X, Lu B, Li S. An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy. Nat Commun. 2016 Nov 7;713443. doi: 10.1038/ncomms13443. PubMed PMID: 27819653; PMCID: PMC5103075.
Wei Y, Tang C, Sant V, Li S, Poloyac SM, Xie W. A Molecular Aspect in the Regulation of Drug Metabolism: Does PXR-Induced Enzyme Expression Always Lead to Functional Changes in Drug Metabolism? Curr Pharmacol Rep. 2016 Aug;2(4):187-192. doi: 10.1007/s40495-016-0062-1. PubMed PMID: 27795941; PMCID: PMC5082989.
Yan J, Xie W. A brief history of the discovery of PXR and CAR as xenobiotic receptors. Acta Pharm Sin B. 2016 Sep;6(5):450-452. doi: 10.1016/j.apsb.2016.06.011. PubMed PMID: 27709013; PMCID: PMC5045536.
Guo Y, Hu B, Xie Y, Billiar TR, Sperry JL, Huang M, Xie W. Regulation of drug-metabolizing enzymes by local and systemic liver injuries. Expert Opin Drug Metab Toxicol. 2016;12(3):245-51. doi: 10.1517/17425255.2016.1139574. PubMed PMID: 26751558; PMCID: PMC4861312.
Xie Y, Wang H, Cheng X, Wu Y, Cao L, Wu M, Xie W, Wang G, Hao H. Farnesoid X receptor activation promotes cell proliferation via PDK4-controlled metabolic reprogramming. Sci Rep. 2016 Jan 5;618751. doi: 10.1038/srep18751. PubMed PMID: 26728993; PMCID: PMC4700422.
Yu L, Wang Z, Huang M, Li Y, Zeng K, Lei J, Hu H, Chen B, Lu J, Xie W, Zeng S. Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor. Biochim Biophys Acta. 2016 Sep;1859(9):1100-1111. doi: 10.1016/j.bbagrm.2015.10.001. PubMed PMID: 26455953.
Liu K, Yan J, Sachar M, Zhang X, Guan M, Xie W, Ma X. A metabolomic perspective of griseofulvin-induced liver injury in mice. Biochem Pharmacol. 2015 Dec 1;98(3):493-501. doi: 10.1016/j.bcp.2015.09.002. PubMed PMID: 26343413; PMCID: PMC4699580.
Jiang M, Klein M, Zanger UM, Mohammad MK, Cave MC, Gaikwad NW, Dias NJ, Selcer KW, Guo Y, He J, Zhang X, Shen Q, Qin W, Li J, Li S, Xie W. Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. J Hepatol. 2016 Jan;64(1):44-52. doi: 10.1016/j.jhep.2015.07.022. PubMed PMID: 26220752; PMCID: PMC4691383.
Wang YM, Chai SC, Lin W, Chai X, Elias A, Wu J, Ong SS, Pondugula SR, Beard JA, Schuetz EG, Zeng S, Xie W, Chen T. Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo. Biochem Pharmacol. 2015 Aug 15;96(4):357-68. doi: 10.1016/j.bcp.2015.06.018. PubMed PMID: 26119819; PMCID: PMC4526351.
Huss JM, Garbacz WG, Xie W. Constitutive activities of estrogen-related receptors: Transcriptional regulation of metabolism by the ERR pathways in health and disease. Biochim Biophys Acta. 2015 Sep;1852(9):1912-27. doi: 10.1016/j.bbadis.2015.06.016. PubMed PMID: 26115970.
Cheng Q, Inaba Y, Lu P, Xu M, He J, Zhao Y, Guo GL, Kuruba R, de la Vega R, Evans RW, Li S, Xie W. Chronic activation of FXR in transgenic mice caused perinatal toxicity and sensitized mice to cholesterol toxicity. Mol Endocrinol. 2015 Apr;29(4):571-82. doi: 10.1210/me.2014-1337. PubMed PMID: 25719402; PMCID: PMC4399273.
Li L, Li H, Garzel B, Yang H, Sueyoshi T, Li Q, Shu Y, Zhang J, Hu B, Heyward S, Moeller T, Xie W, Negishi M, Wang H. SLC13A5 is a novel transcriptional target of the pregnane X receptor and sensitizes drug-induced steatosis in human liver. Mol Pharmacol. 2015 Apr;87(4):674-82. doi: 10.1124/mol.114.097287. PubMed PMID: 25628225; PMCID: PMC4366797.

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