Publications

Alexander Sorkin

Larsen MB, Perez Verdaguer M, Schmidt BF, Bruchez MP, Watkins SC, Sorkin A. Generation of endogenous pH-sensitive EGF receptor and its application in high-throughput screening for proteins involved in clathrin-mediated endocytosis. Elife. 2019 May 8;8 doi: 10.7554/eLife.46135. PubMed PMID: 31066673; PMCID: PMC6533059.
Surve SV, Myers PJ, Clayton SA, Watkins SC, Lazzara MJ, Sorkin A. Localization dynamics of endogenous fluorescently labeled RAF1 in EGF-stimulated cells. Mol Biol Cell. 2019 Feb 15;30(4):506-523. doi: 10.1091/mbc.E18-08-0512. PubMed PMID: 30586319; PMCID: PMC6594441.
Pinilla-Macua I, Grassart A, Duvvuri U, Watkins SC, Sorkin A. EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo. Elife. 2017 Dec 21;6 doi: 10.7554/eLife.31993. PubMed PMID: 29268862; PMCID: PMC5741375.
Martínez-Mármol R, Styrczewska K, Pérez-Verdaguer M, Vallejo-Gracia A, Comes N, Sorkin A, Felipe A. Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation. Sci Rep. 2017 Feb 10;742395. doi: 10.1038/srep42395. PubMed PMID: 28186199; PMCID: PMC5301257.
Pinilla-Macua I, Watkins SC, Sorkin A. Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomes. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2122-7. doi: 10.1073/pnas.1520301113. PubMed PMID: 26858456; PMCID: PMC4776482.
Martínez-Mármol R, Comes N, Styrczewska K, Pérez-Verdaguer M, Vicente R, Pujadas L, Soriano E, Sorkin A, Felipe A. Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis. Cell Mol Life Sci. 2016 Apr;73(7):1515-28. doi: 10.1007/s00018-015-2082-0. PubMed PMID: 26542799; PMCID: PMC4836834.
Pinilla-Macua I, Sorkin A. Methods to study endocytic trafficking of the EGF receptor. Methods Cell Biol. 2015;130347-67. doi: 10.1016/bs.mcb.2015.05.008. PubMed PMID: 26360045; PMCID: PMC4836846.
Fortian A, Dionne LK, Hong SH, Kim W, Gygi SP, Watkins SC, Sorkin A. Endocytosis of Ubiquitylation-Deficient EGFR Mutants via Clathrin-Coated Pits is Mediated by Ubiquitylation. Traffic. 2015 Nov;16(11):1137-54. doi: 10.1111/tra.12314. PubMed PMID: 26251007; PMCID: PMC4607634.
Tomas A, Vaughan SO, Burgoyne T, Sorkin A, Hartley JA, Hochhauser D, Futter CE. WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway. Nat Commun. 2015 Jun 12;67324. doi: 10.1038/ncomms8324. PubMed PMID: 26066081; PMCID: PMC4490399.

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