Publications

Christopher Bakkenist, PhD

Leonard BC, Lee ED, Bhola NE, Li H, Sogaard KK, Bakkenist CJ, Grandis JR, Johnson DE. ATR inhibition sensitizes HPV- and HPV+ head and neck squamous cell carcinoma to cisplatin. Oral Oncol. 2019 Aug;9535-42. doi: 10.1016/j.oraloncology.2019.05.028. PubMed PMID: 31345392.
Shao L, Hou W, Scharping NE, Vendetti FP, Srivastava R, Roy CN, Menk AV, Wang Y, Chauvin JM, Karukonda P, Thorne SH, Hornung V, Zarour HM, Bakkenist CJ, Delgoffe GM, Sarkar SN. IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell. Cancer Immunol Res. 2019 Aug;7(8):1258-1266. doi: 10.1158/2326-6066.CIR-18-0711. PubMed PMID: 31239318; PMCID: PMC6677597.
Moiseeva TN, Yin Y, Calderon MJ, Qian C, Schamus-Haynes S, Sugitani N, Osmanbeyoglu HU, Rothenberg E, Watkins SC, Bakkenist CJ. An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13374-13383. doi: 10.1073/pnas.1903418116. PubMed PMID: 31209037; PMCID: PMC6613105.
Bakkenist CJ, Czambel RK, Lin Y, Yates NA, Zeng X, Shogan J, Schmitz JC. Quantitative analysis of ATM phosphorylation in lymphocytes. DNA Repair (Amst). 2019 Jun 4;801-7. doi: 10.1016/j.dnarep.2019.06.002. PubMed PMID: 31176958.
Morosky S, Wells AI, Lemon K, Evans AS, Schamus S, Bakkenist CJ, Coyne CB. The neonatal Fc receptor is a pan-echovirus receptor. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3758-3763. doi: 10.1073/pnas.1817341116. PubMed PMID: 30808762; PMCID: PMC6397586.
Menolfi D, Jiang W, Lee BJ, Moiseeva T, Shao Z, Estes V, Frattini MG, Bakkenist CJ, Zha S. Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA. Nat Commun. 2018 Dec 17;9(1):5351. doi: 10.1038/s41467-018-07798-3. PubMed PMID: 30559436; PMCID: PMC6297235.
Bakkenist CJ, Lee JJ, Schmitz JC. ATM Is Required for the Repair of Oxaliplatin-Induced DNA Damage in Colorectal Cancer. Clin Colorectal Cancer. 2018 Dec;17(4):255-257. doi: 10.1016/j.clcc.2018.09.001. PubMed PMID: 30316683; PMCID: PMC6561466.
Moiseeva TN, Bakkenist CJ. Regulation of the initiation of DNA replication in human cells. DNA Repair (Amst). 2018 Dec;7299-106. doi: 10.1016/j.dnarep.2018.09.003. PubMed PMID: 30266203; PMCID: PMC6261693.
Vendetti FP, Karukonda P, Clump DA, Teo T, Lalonde R, Nugent K, Ballew M, Kiesel BF, Beumer JH, Sarkar SN, Conrads TP, O'Connor MJ, Ferris RL, Tran PT, Delgoffe GM, Bakkenist CJ. ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation. J Clin Invest. 2018 Aug 31;128(9):3926-3940. doi: 10.1172/JCI96519. PubMed PMID: 29952768; PMCID: PMC6118586.
Evdokimova VN, Gandhi M, Nikitski AV, Bakkenist CJ, Nikiforov YE. Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements. Oncotarget. 2018 Mar 2;9(17):13612-13622. doi: 10.18632/oncotarget.24434. PubMed PMID: 29568381; PMCID: PMC5862602.
Moiseeva T, Hood B, Schamus S, O'Connor MJ, Conrads TP, Bakkenist CJ. ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1. Nat Commun. 2017 Nov 9;8(1):1392. doi: 10.1038/s41467-017-01401-x. PubMed PMID: 29123096; PMCID: PMC5680267.
Kiesel BF, Scemama J, Parise RA, Villaruz L, Iffland A, Doyle A, Ivy P, Chu E, Bakkenist CJ, Beumer JH. LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma. J Pharm Biomed Anal. 2017 Nov 30;146244-250. doi: 10.1016/j.jpba.2017.08.037. PubMed PMID: 28888173; PMCID: PMC5632222.
Zhang Y, Hu K, Beumer JH, Bakkenist CJ, D'Argenio DZ. RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology. DNA Repair (Amst). 2017 Apr;5224-30. doi: 10.1016/j.dnarep.2017.02.004. PubMed PMID: 28254357; PMCID: PMC5396547.
Kiesel BF, Shogan JC, Rachid M, Parise RA, Vendetti FP, Bakkenist CJ, Beumer JH. LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma. J Pharm Biomed Anal. 2017 May 10;138158-165. doi: 10.1016/j.jpba.2017.01.055. PubMed PMID: 28213176; PMCID: PMC5357441.
Vendetti FP, Leibowitz BJ, Barnes J, Schamus S, Kiesel BF, Abberbock S, Conrads T, Clump DA, Cadogan E, O'Connor MJ, Yu J, Beumer JH, Bakkenist CJ. Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation. Sci Rep. 2017 Feb 1;741892. doi: 10.1038/srep41892. PubMed PMID: 28145510; PMCID: PMC5286430.
Villaruz LC, Jones H, Dacic S, Abberbock S, Kurland BF, Stabile LP, Siegfried JM, Conrads TP, Smith NR, O'Connor MJ, Pierce AJ, Bakkenist CJ. ATM protein is deficient in over 40% of lung adenocarcinomas. Oncotarget. 2016 Sep 6;7(36):57714-57725. doi: 10.18632/oncotarget.9757. PubMed PMID: 27259260; PMCID: PMC5295384.
Moiseeva TN, Gamper AM, Hood BL, Conrads TP, Bakkenist CJ. Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. DNA Repair (Amst). 2016 Jul;439-17. doi: 10.1016/j.dnarep.2016.04.007. PubMed PMID: 27235625; PMCID: PMC4917431.
Bakkenist CJ, Beumer JH, Schmitz JC. ATM serine-1981 phosphorylation is a plausible biomarker. Cell Cycle. 2015;14(20):3207-8. doi: 10.1080/15384101.2015.1084205. PubMed PMID: 26517194; PMCID: PMC4825586.
Vendetti FP, Lau A, Schamus S, Conrads TP, O'Connor MJ, Bakkenist CJ. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo. Oncotarget. 2015 Dec 29;6(42):44289-305. doi: 10.18632/oncotarget.6247. PubMed PMID: 26517239; PMCID: PMC4792557.
Beumer JH, Fu KY, Anyang BN, Siegfried JM, Bakkenist CJ. Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma. BMC Cancer. 2015 Oct 5;15649. doi: 10.1186/s12885-015-1649-3. PubMed PMID: 26438152; PMCID: PMC4595318.
Bakkenist CJ, Kastan MB. Chromatin perturbations during the DNA damage response in higher eukaryotes. DNA Repair (Amst). 2015 Dec;368-12. doi: 10.1016/j.dnarep.2015.09.002. PubMed PMID: 26391293; PMCID: PMC4727245.
Bakkenist CJ, Czambel RK, Hershberger PA, Tawbi H, Beumer JH, Schmitz JC. A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells. Oncoscience. 2015;2(5):542-54. doi: 10.18632/oncoscience.162. PubMed PMID: 26097887; PMCID: PMC4468340.
Teng PN, Bateman NW, Darcy KM, Hamilton CA, Maxwell GL, Bakkenist CJ, Conrads TP. Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells. Gynecol Oncol. 2015 Mar;136(3):554-61. doi: 10.1016/j.ygyno.2014.12.035. PubMed PMID: 25560806; PMCID: PMC4382918.
Forero A, Giacobbi NS, McCormick KD, Gjoerup OV, Bakkenist CJ, Pipas JM, Sarkar SN. Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase. J Immunol. 2014 Jun 15;192(12):5933-42. doi: 10.4049/jimmunol.1303470. PubMed PMID: 24799566; PMCID: PMC4078001.

<< Investigators Search

Top