Publications

Dario Vignali, PhD

Sawant DV, Yano H, Chikina M, Zhang Q, Liao M, Liu C, Callahan DJ, Sun Z, Sun T, Tabib T, Pennathur A, Corry DB, Luketich JD, Lafyatis R, Chen W, Poholek AC, Bruno TC, Workman CJ, Vignali DAA. Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion. Nat Immunol. 2019 Jun;20(6):724-735. doi: 10.1038/s41590-019-0346-9. PubMed PMID: 30936494.
Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, Chen L, Chen Y, Zhu G, Yin W, Zheng L, Zhou T, Badri T, Yao S, Zhu S, Boto A, Sznol M, Melero I, Vignali DAA, Schalper K, Chen L. Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell. 2019 Jan 10;176(1-2):334-347.e12. doi: 10.1016/j.cell.2018.11.010. PubMed PMID: 30580966; PMCID: PMC6365968.
Overacre-Delgoffe AE, Vignali DAA. Treg Fragility: A Prerequisite for Effective Antitumor Immunity? Cancer Immunol Res. 2018 Aug;6(8):882-887. doi: 10.1158/2326-6066.CIR-18-0066. PubMed PMID: 30068755; PMCID: PMC6080214.
Podojil JR, Chiang MY, Ifergan I, Copeland R, Liu LN, Maloveste S, Langermann S, Liebenson D, Balabanov R, Chi H, Chen L, Vignali DAA, Miller SD. B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex. J Immunol. 2018 Aug 1;201(3):897-907. doi: 10.4049/jimmunol.1700811. PubMed PMID: 29898965.
Du T, Zhu L, Levine KM, Tasdemir N, Lee AV, Vignali DAA, Houten BV, Tseng GC, Oesterreich S. Invasive lobular and ductal breast carcinoma differ in immune response, protein translation efficiency and metabolism. Sci Rep. 2018 May 8;8(1):7205. doi: 10.1038/s41598-018-25357-0. PubMed PMID: 29739984; PMCID: PMC5940770.
Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH, Vignali DAA, Stohlman SA, Baldwin WM 3rd, Min B. Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10190-10195. doi: 10.1073/pnas.1703100114. PubMed PMID: 28874534; PMCID: PMC5617261.
Bettini ML, Chou PC, Guy CS, Lee T, Vignali KM, Vignali DAA. Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development. J Immunol. 2017 Sep 1;199(5):1555-1560. doi: 10.4049/jimmunol.1700069. PubMed PMID: 28733484; PMCID: PMC5568475.
Overacre-Delgoffe AE, Chikina M, Dadey RE, Yano H, Brunazzi EA, Shayan G, Horne W, Moskovitz JM, Kolls JK, Sander C, Shuai Y, Normolle DP, Kirkwood JM, Ferris RL, Delgoffe GM, Bruno TC, Workman CJ, Vignali DAA. Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity. Cell. 2017 Jun 1;169(6):1130-1141.e11. doi: 10.1016/j.cell.2017.05.005. PubMed PMID: 28552348; PMCID: PMC5509332.
Vogel P, Janke L, Gravano DM, Lu M, Sawant DV, Bush D, Shuyu E, Vignali DAA, Pillai A, Rehg JE. Globule Leukocytes and Other Mast Cells in the Mouse Intestine. Vet Pathol. 2018 Jan;55(1):76-97. doi: 10.1177/0300985817705174. PubMed PMID: 28494703.
Andrews LP, Marciscano AE, Drake CG, Vignali DA. LAG3 (CD223) as a cancer immunotherapy target. Immunol Rev. 2017 Mar;276(1):80-96. doi: 10.1111/imr.12519. PubMed PMID: 28258692; PMCID: PMC5338468.
Visperas A, Vignali DA. Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them? J Immunol. 2016 Nov 15;197(10):3762-3770. doi: 10.4049/jimmunol.1601118. PubMed PMID: 27815439; PMCID: PMC5119643.
Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM. Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science. 2016 Sep 30;353(6307): doi: 10.1126/science.aah3374. PubMed PMID: 27708076; PMCID: PMC5510615.
Tomita Y, Satomi M, Bracamonte-Baran W, Jankowska Gan E, Workman AS, Workman CJ, Vignali DA, Burlingham WJ. Kinetics of Alloantigen-Specific Regulatory CD4 T Cell Development and Tissue Distribution After Donor-Specific Transfusion and Costimulatory Blockade. Transplant Direct. 2016 May;2(5):e73. doi: 10.1097/TXD.0000000000000580. PubMed PMID: 27500263; PMCID: PMC4946513.
Dobbins J, Gagnon E, Godec J, Pyrdol J, Vignali DA, Sharpe AH, Wucherpfennig KW. Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling. Sci Signal. 2016 Jul 26;9(438):ra75. doi: 10.1126/scisignal.aaf0626. PubMed PMID: 27460989; PMCID: PMC5929992.
Zhang Q, Vignali DA. Co-stimulatory and Co-inhibitory Pathways in Autoimmunity. Immunity. 2016 May 17;44(5):1034-51. doi: 10.1016/j.immuni.2016.04.017. PubMed PMID: 27192568; PMCID: PMC4873959.
Turnis ME, Sawant DV, Szymczak-Workman AL, Andrews LP, Delgoffe GM, Yano H, Beres AJ, Vogel P, Workman CJ, Vignali DA. Interleukin-35 Limits Anti-Tumor Immunity. Immunity. 2016 Feb 16;44(2):316-29. doi: 10.1016/j.immuni.2016.01.013. PubMed PMID: 26872697; PMCID: PMC4758699.
Liu C, Workman CJ, Vignali DA. Targeting regulatory T cells in tumors. FEBS J. 2016 Jul;283(14):2731-48. doi: 10.1111/febs.13656. PubMed PMID: 26787424.
Overacre AE, Vignali DA. T(reg) stability: to be or not to be. Curr Opin Immunol. 2016 Apr;3939-43. doi: 10.1016/j.coi.2015.12.009. PubMed PMID: 26774863; PMCID: PMC4801724.
Turnis ME, Andrews LP, Vignali DA. Inhibitory receptors as targets for cancer immunotherapy. Eur J Immunol. 2015 Jul;45(7):1892-905. doi: 10.1002/eji.201344413. PubMed PMID: 26018646; PMCID: PMC4549156.
Sawant DV, Hamilton K, Vignali DA. Interleukin-35: Expanding Its Job Profile. J Interferon Cytokine Res. 2015 Jul;35(7):499-512. doi: 10.1089/jir.2015.0015. PubMed PMID: 25919641; PMCID: PMC4507123.
Dixon KO, van der Kooij SW, Vignali DA, van Kooten C. Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members. Eur J Immunol. 2015 Jun;45(6):1736-47. doi: 10.1002/eji.201445217. PubMed PMID: 25820702; PMCID: PMC4617619.

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