Publications

Zhou Wang, PhD

Xu Y, Song Q, Pascal LE, Zhong M, Zhou Y, Zhou J, Deng FM, Huang J, Wang Z. DHX15 is up-regulated in castration-resistant prostate cancer and required for androgen receptor sensitivity to low DHT concentrations. Prostate. 2019 May;79(6):657-666. doi: 10.1002/pros.23773. PubMed PMID: 30714180.
Zhong M, Pascal LE, Cheng E, Masoodi KZ, Chen W, Green A, Cross BW, Parrinello E, Rigatti LH, Wang Z. Concurrent EAF2 and ELL2 loss phenocopies individual EAF2 or ELL2 loss in prostate cancer cells and murine prostate. Am J Clin Exp Urol. 2018;6(6):234-244. PubMed PMID: 30697579; PMCID: PMC6334201.
Funahashi Y, Takahashi R, Mizoguchi S, Suzuki T, Takaoka E, Ni J, Wang Z, DeFranco DB, de Groat WC, Tyagi P, Yoshimura N. Bladder overactivity and afferent hyperexcitability induced by prostate-to-bladder cross-sensitization in rats with prostatic inflammation. J Physiol. 2019 Apr;597(7):2063-2078. doi: 10.1113/JP277452. PubMed PMID: 30666643; PMCID: PMC6441933.
Matejcic M, Saunders EJ, Dadaev T, Brook MN, Wang K, Sheng X, Olama AAA, Schumacher FR, Ingles SA, Govindasami K, Benlloch S, Berndt SI, Albanes D, Koutros S, Muir K, Stevens VL, Gapstur SM, Tangen CM, Batra J, Clements J, Gronberg H, Pashayan N, Schleutker J, Wolk A, West C, Mucci L, Kraft P, Cancel-Tassin G, Sorensen KD, Maehle L, Grindedal EM, Strom SS, Neal DE, Hamdy FC, Donovan JL, Travis RC, Hamilton RJ, Rosenstein B, Lu YJ, Giles GG, Kibel AS, Vega A, Bensen JT, Kogevinas M, Penney KL, Park JY, Stanford JL, Cybulski C, Nordestgaard BG, Brenner H, Maier C, Kim J, Teixeira MR, Neuhausen SL, De Ruyck K, Razack A, Newcomb LF, Lessel D, Kaneva R, Usmani N, Claessens F, Townsend PA, Gago-Dominguez M, Roobol MJ, Menegaux F, Khaw KT, Cannon-Albright LA, Pandha H, Thibodeau SN, Schaid DJ, PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium., Wiklund F, Chanock SJ, Easton DF, Eeles RA, Kote-Jarai Z, Conti DV, Haiman CA. Germline variation at 8q24 and prostate cancer risk in men of European ancestry. Nat Commun. 2018 Nov 5;9(1):4616. doi: 10.1038/s41467-018-06863-1. PubMed PMID: 30397198; PMCID: PMC6218483.
Dong J, Wu Z, Wang D, Pascal LE, Nelson JB, Wipf P, Wang Z. Hsp70 Binds to the Androgen Receptor N-terminal Domain and Modulates the Receptor Function in Prostate Cancer Cells. Mol Cancer Ther. 2019 Jan;18(1):39-50. doi: 10.1158/1535-7163.MCT-18-0432. PubMed PMID: 30297360; PMCID: PMC6318070.
Korkut A, Zaidi S, Kanchi RS, Rao S, Gough NR, Schultz A, Li X, Lorenzi PL, Berger AC, Robertson G, Kwong LN, Datto M, Roszik J, Ling S, Ravikumar V, Manyam G, Rao A, Shelley S, Liu Y, Ju Z, Hansel D, de Velasco G, Pennathur A, Andersen JB, O'Rourke CJ, Ohshiro K, Jogunoori W, Nguyen BN, Li S, Osmanbeyoglu HU, Ajani JA, Mani SA, Houseman A, Wiznerowicz M, Chen J, Gu S, Ma W, Zhang J, Tong P, Cherniack AD, Deng C, Resar L, Cancer Genome Atlas Research Network., Weinstein JN, Mishra L, Akbani R. A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily. Cell Syst. 2018 Oct 24;7(4):422-437.e7. doi: 10.1016/j.cels.2018.08.010. PubMed PMID: 30268436; PMCID: PMC6370347.
Yang T, Jing Y, Dong J, Yu X, Zhong M, Pascal LE, Wang D, Zhang Z, Qiao B, Wang Z. Regulation of ELL2 stability and polyubiquitination by EAF2 in prostate cancer cells. Prostate. 2018 Nov;78(15):1201-1212. doi: 10.1002/pros.23695. PubMed PMID: 30009504.
Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, Kovatich AJ, Benz CC, Levine DA, Lee AV, Omberg L, Wolf DM, Shriver CD, Thorsson V, Cancer Genome Atlas Research Network., Hu H. An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics. Cell. 2018 Apr 5;173(2):400-416.e11. doi: 10.1016/j.cell.2018.02.052. PubMed PMID: 29625055; PMCID: PMC6066282.
Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, Jia L, Li S, Cancer Genome Atlas Research Network., Xie W, Yang D. lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Cancer Cell. 2018 Apr 9;33(4):706-720.e9. doi: 10.1016/j.ccell.2018.03.006. PubMed PMID: 29622465; PMCID: PMC6143179.
Li F, Pascal LE, Zhou J, Zhou Y, Wang K, Parwani AV, Dhir R, Guo P, He D, Nelson JB, Wang Z. BCL-2 and BCL-XL expression are down-regulated in benign prostate hyperplasia nodules and not affected by finasteride and/or celecoxib. Am J Clin Exp Urol. 2018;6(1):1-10. PubMed PMID: 29531971; PMCID: PMC5840285.
Pascal LE, Wang Y, Zhong M, Wang D, Chakka AB, Yang Z, Li F, Song Q, Rigatti LH, Chaparala S, Chandran U, Parwani AV, Wang Z. EAF2 and p53 Co-Regulate STAT3 Activation in Prostate Cancer. Neoplasia. 2018 Apr;20(4):351-363. doi: 10.1016/j.neo.2018.01.011. PubMed PMID: 29518696; PMCID: PMC5909677.
Zang Y, Pascal LE, Zhou Y, Qiu X, Wei L, Ai J, Nelson JB, Zhong M, Xue B, Wang S, Yang D, Lan L, Shan Y, Wang Z. ELL2 regulates DNA non-homologous end joining (NHEJ) repair in prostate cancer cells. Cancer Lett. 2018 Feb 28;415198-207. doi: 10.1016/j.canlet.2017.11.028. PubMed PMID: 29179998; PMCID: PMC5761340.
Wang Y, Pascal LE, Zhong M, Ai J, Wang D, Jing Y, Pilch J, Song Q, Rigatti LH, Graham LE, Nelson JB, Parwani AV, Wang Z. Combined Loss of EAF2 and p53 Induces Prostate Carcinogenesis in Male Mice. Endocrinology. 2017 Dec 1;158(12):4189-4205. doi: 10.1210/en.2017-00409. PubMed PMID: 29029019; PMCID: PMC5711381.
Masoodi KZ, Eisermann K, Yang Z, Dar JA, Pascal LE, Nguyen M, O'Malley K, Parrinello E, Feturi FG, Kenefake AN, Nelson JB, Johnston PA, Wipf P, Wang Z. Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone. Endocrinology. 2017 Oct 1;158(10):3152-3161. doi: 10.1210/en.2017-00408. PubMed PMID: 28977599; PMCID: PMC5659684.
Pascal LE, Masoodi KZ, Liu J, Qiu X, Song Q, Wang Y, Zang Y, Yang T, Wang Y, Rigatti LH, Chandran U, Colli LM, Vencio RZN, Lu Y, Zhang J, Wang Z. Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia. J Endocrinol. 2017 Nov;235(2):123-136. doi: 10.1530/JOE-17-0112. PubMed PMID: 28870994; PMCID: PMC5679084.
Masoodi KZ, Xu Y, Dar JA, Eisermann K, Pascal LE, Parrinello E, Ai J, Johnston PA, Nelson JB, Wipf P, Wang Z. Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-based Small Molecules. Mol Cancer Ther. 2017 Oct;16(10):2120-2129. doi: 10.1158/1535-7163.MCT-17-0176. PubMed PMID: 28655783; PMCID: PMC5628124.
Mizoguchi S, Mori K, Wang Z, Liu T, Funahashi Y, Sato F, DeFranco DB, Yoshimura N, Mimata H. Effects of Estrogen Receptor β Stimulation in a Rat Model of Non-Bacterial Prostatic Inflammation. Prostate. 2017 May;77(7):803-811. doi: 10.1002/pros.23320. PubMed PMID: 28181685; PMCID: PMC5968815.
Qiu X, Pascal LE, Song Q, Zang Y, Ai J, O'Malley KJ, Nelson JB, Wang Z. Physical and Functional Interactions between ELL2 and RB in the Suppression of Prostate Cancer Cell Proliferation, Migration, and Invasion. Neoplasia. 2017 Mar;19(3):207-215. doi: 10.1016/j.neo.2017.01.001. PubMed PMID: 28167296; PMCID: PMC5293724.
Johnson JK, Skoda EM, Zhou J, Parrinello E, Wang D, O'Malley K, Eyer BR, Kazancioglu M, Eisermann K, Johnston PA, Nelson JB, Wang Z, Wipf P. Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer. ACS Med Chem Lett. 2016 Aug 11;7(8):785-90. doi: 10.1021/acsmedchemlett.6b00186. PubMed PMID: 27563404; PMCID: PMC4983742.
Johnston PA, Nguyen MM, Dar JA, Ai J, Wang Y, Masoodi KZ, Shun T, Shinde S, Camarco DP, Hua Y, Huryn DM, Wilson GM, Lazo JS, Nelson JB, Wipf P, Wang Z. Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells. Assay Drug Dev Technol. 2016 May;14(4):226-39. doi: 10.1089/adt.2016.716. PubMed PMID: 27187604; PMCID: PMC4876501.
Yu X, Ai J, Cai L, Jing Y, Wang D, Dong J, Pascal LE, Zhang J, Luo R, Wang Z. Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells. Oncotarget. 2016 May 17;7(20):29245-54. doi: 10.18632/oncotarget.8588. PubMed PMID: 27058417; PMCID: PMC5045393.
Zang Y, Dong Y, Yang D, Xue B, Li F, Gu P, Zhao H, Wang S, Zhou S, Ying R, Wang Z, Shan Y. Expression and prognostic significance of ELL-associated factor 2 in human prostate cancer. Int Urol Nephrol. 2016 May;48(5):695-700. doi: 10.1007/s11255-015-1210-y. PubMed PMID: 26895851; PMCID: PMC4911596.
Wang D, Nguyen MM, Masoodi KZ, Singh P, Jing Y, O'Malley K, Dar JA, Dhir R, Wang Z. Splicing Factor Prp8 Interacts With NES(AR) and Regulates Androgen Receptor in Prostate Cancer Cells. Mol Endocrinol. 2015 Dec;29(12):1731-42. doi: 10.1210/me.2015-1112. PubMed PMID: 26371515; PMCID: PMC4664230.
Eisermann K, Dar JA, Dong J, Wang D, Masoodi KZ, Wang Z. Poly (A) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor. PLoS One. 2015;10(7):e0128495. doi: 10.1371/journal.pone.0128495. PubMed PMID: 26176602; PMCID: PMC4503479.
Kashyap M, Pore S, Wang Z, Gingrich J, Yoshimura N, Tyagi P. Inflammasomes are important mediators of prostatic inflammation associated with BPH. J Inflamm (Lond). 2015;1237. doi: 10.1186/s12950-015-0082-3. PubMed PMID: 25991911; PMCID: PMC4436794.
Guo W, Keener AL, Jing Y, Cai L, Ai J, Zhang J, Fisher AL, Fu G, Wang Z. FOXA1 modulates EAF2 regulation of AR transcriptional activity, cell proliferation, and migration in prostate cancer cells. Prostate. 2015 Jun 15;75(9):976-87. doi: 10.1002/pros.22982. PubMed PMID: 25808853; PMCID: PMC4424106.

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