Sidrah Khan,

Summary

My research program focuses on inflammation-driven colorectal carcinogenesis, with particular emphasis on colitis-associated cancer. We study how innate immune signaling pathways, including cGAS-STING, regulate epithelial integrity, autophagy, and tumor–immune interactions within the colonic microenvironment. Using murine models, spatial transcriptomics, and human tissue from both civilian and Veteran populations, our goal is to define how chronic inflammation and environmental toxic exposures contribute to tumor initiation and progression. Ultimately, our work aims to identify biologically actionable targets and improve prevention and treatment strategies for high-risk populations.