UPCI’s Pittsburgh Genome Resource Repository (PGRR) Offers a Powerful Tool for Cancer Researchers

Publically available genomic datasets, such as The Cancer Genome Atlas (TCGA) of the National Cancer Institute (NCI), are highly informative and can be used for numerous research purposes including discovery of new biomarkers, validation of new methods, and development of new therapeutic approaches for precision cancer medicine. The Pittsburgh Genome Resource Repository (PGRR) is an invaluable tool that offers UPCI investigators a mechanism for accessing and analyzing TCGA datasets from a virtualized central location using common tools and platforms, providing data management and computing infrastructure to support biomedical investigation using this “big data.”

The PGRR was developed through a collaboration between experts from the University of Pittsburgh Cancer Institute (UPCI), the University of Pittsburgh Institute for Personalized Medicine (IPM), the University of Pittsburgh Department of Biomedical Informatics (DBMI), the University of Pittsburgh Center for Simulation and Modeling (SaM), the Pittsburgh Supercomputing Center (PSC), and UPMC.

Watch Rebecca Jacobson, MD, MS, Professor of Biomedical Informatics and Chief Information Officer of the IPM, and William LaFramboise, PhD, Associate Professor of Pathology and Director of the UPCI Cancer Genomics Facility, discuss the PGRR and several examples of functional applications in cancer research.