Members of CBP engage in research that examines the most fundamental aspects of cancer biology. The goal of this basic research program, in the broadest sense, is to make new discoveries about the molecular and cellular basis of cancer development and progression. A strong foundation in basic research is crucial for advancing cancer care and clinical outcomes, as basic research findings provide a source of new therapeutic targets as well as new strategies for prevention, diagnosis, and treatment of cancer.
Hormone Response and Signaling
A significant amount of interaction occurs between cancer cells and the tissue microenvironment. CBP members within this research theme focus on how this interaction modulates signal transduction pathways within the cancer cells. In particular, they are interested in steroid signaling, especially estrogen and androgen in breast, lung and prostate cancer, and resistance to hormonal therapies. As well, CBP members aim to understand the ole of membrane and membrane receptors in activating downstream signaling pathways that lead to cancer progression.
The focus of this research theme is to better understand the biology of metastasis, including the role of cancer heterogeneity in tumor progression, using in vitro and in vivo model systems. CBP members also use clinical specimens to better understand the mechanisms underlying resistance to therapy.
CBP members within this theme focus their efforts on analyzing Big Data to identify the patterns and trends associated with cancer development and progression. Also of interest is using computational techniques to identify genetic and epigenetic drivers as well as how tumors evolve over time and in response to therapies.