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Results

Oleg Akilov
Program(s): Cancer Immunology and Immunotherapy
Summary

Oleg E. Akilov, MD, PhD, is an Assistant Professor of the Department of Dermatology at the University of Pittsburgh and a Director of the Cutaneous Lymphoma Program and Extracorporeal Photopheresis Unit. Dr. Akilov directs Cutaneous Lymphoma Program providing the full spectrum of management of all stages of cutaneous lymphoma. He serves as a principal investigator on multiple clinical trials in cutaneous lymphoma. Additionally, Dr. Akilov is very enthusiastic about resident education and mentoring future dermatologists.

Daniel Altschuler
Program(s): Cancer Therapeutics
Contact:
Biomedical Science Tower, E-1348
200 Lothrop Street
Pittsburgh PA
Phone: 412-648-9751
Summary

Dr. Altschuler's laboratory studies mechanisms of signal transduction by the second messenger cAMP in cell proliferation. cAMP-dependent protein kinase (PKA) and Exchange protein activated by cAMP (Epac) represent the main effectors of cAMP action. Both pathways converge at the level of the small GTPase Rap1b, via its Epac-mediated activation and PKA-mediated phosphorylation. The role of Rap1 activation (Epac) and phosphorylation (PKA) coordinating the early rate-limiting events in cAMP-dependent cell proliferation are studied using a multidisciplinary approach including molecular and cellular biology techniques in vitro, as well as in vivo validation using transgenic/knock in technologies in endocrine tumor models.

Carolyn Anderson, PhD
Program(s): Cancer Immunology and Immunotherapy
Contact:
100 Technology Drive
Bridgeside Point Suite 452
Pittsburgh PA
Research Interests and Keywords:
  • Radiopharmaceuticals
  • metal radionuclides
  • diagnostic imaging
  • cancer imaging
  • radiotherapy
  • molecular imaging
  • positron emission tomography (PET)
  • cancer metastasis
Summary
The major focus of the Anderson Lab is the development, evaluation and application of radiopharmaceuticals containing metal radionuclides for diagnostic imaging and radiotherapy. We are particularly interested in 64Cu (T1/2 = 12.7 hours), in large part because it emits beta+ particles for positron emission tomography (PET) imaging and beta- particles for targeted radiotherapy. We are also investigating 68Ga (T1/2 = 68 min) as a generator-produced positron-emitting radionuclide. The agents we are studying are 64Cu- and 68Ga-labeled chelator-peptide and monoclonal antibody conjugates for imaging and/or therapy of various types of cancer. One area of investigation in our laboratory is the development of radiolabeled alpha vs. beta 3 integrin ligands as PET agents for imaging bone metastasis. We have developed one agent, 64Cu-CB-TE2A-c(RGDyK), that specifically binds to alpha vs. beta 3 integrin in osteoclasts, which are bone resorbing cells that are present in high concentration in osteolytic bone lesions. This agent may be able to earlier detect painful, debilitating bone lesions associated with breast cancer, and multiple myeloma, as well as be used to determine early response to treatment of bone lesions associated with these diseases. Another area of focus for our lab is investigating imaging agents that target cell types, other than tumor cells, involved in cancer metastasis. For example, we are targeting integrin alpha 4 beta 1 as a marker of bone marrow derived cells that home to sites of metastasis prior to tumor cells as part of the pre-metastatic niche. We are also investigating immune cell types, such as macrophages, neutrophils and T-cells and their role in cancer and other diseases.
Karen Arndt
Program(s): Genome Stability
Contact:
A316 Langley Hall
4249 Fifth Ave
Pittsburgh PA
Phone: 412-624-6963
Research Interests and Keywords:
  • Gene expression
  • cellular transcription
  • mRNA synthesis
  • RNA polymerase II
  • chromatin
Summary
A critical question to ask, particularly in this genomic era, is how organisms interpret the vast amounts of information encoded in their genomes. The Arndt lab studies the first step in gene expression, the synthesis of mRNA by RNA polymerase II, with a focus on the mechanisms that regulate transcription in the chromatin environment of a eukaryotic cell. The fundamental importance of understanding transcriptional regulation is evident from the large number of human developmental defects and diseases, including cancer and AIDS, that arise when cellular transcription factors are altered by mutation or commandeered by viral proteins.
Jonathan Alder, , PhD
Program(s): Genome Stability
Contact:
BST W1246
200 Lothrop St.
Pittsburgh PA
Phone: 412-624-8681
Nduka Amankulor
Program(s): Cancer Biology
Research Interests and Keywords:
  • Microenvironment and immune escape in glioblastoma
  • oligodendroglioma
  • brain and spine metastases
Leonard Appleman, MD, PhD
Program(s): Cancer Therapeutics
Contact:
UPMC Cancer Pavilion
5230 Center Ave., Suite 567
Pittsburgh PA
Phone: 412-648-6507
Research Interests and Keywords:
  • Kidney cancer and other genitourinary malignancies
  • experimental cancer therapeutics
Maninjay Atianand
Program(s): Cancer Immunology and Immunotherapy
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