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Oleg Akilov, MD, PhD
Program(s): Cancer Immunology and Immunotherapy
Contact:
3601 Fifth Avenue, 5th Floor
Pittsburgh PA
Phone: 412-647-4200
Summary

Oleg E. Akilov, MD, PhD, is an Assistant Professor of the Department of Dermatology at the University of Pittsburgh and a Director of the Cutaneous Lymphoma Program and Extracorporeal Photopheresis Unit. Dr. Akilov directs Cutaneous Lymphoma Program providing the full spectrum of management of all stages of cutaneous lymphoma. He serves as a principal investigator on multiple clinical trials in cutaneous lymphoma. Additionally, Dr. Akilov is very enthusiastic about resident education and mentoring future dermatologists.

Daniel Altschuler, PhD
Program(s): Cancer Therapeutics
Contact:
Biomedical Science Tower, E-1348
200 Lothrop Street
Pittsburgh PA
Phone: 412-648-9751
Summary

Dr. Altschuler's laboratory studies mechanisms of signal transduction by the second messenger cAMP in cell proliferation. cAMP-dependent protein kinase (PKA) and Exchange protein activated by cAMP (Epac) represent the main effectors of cAMP action. Both pathways converge at the level of the small GTPase Rap1b, via its Epac-mediated activation and PKA-mediated phosphorylation. The role of Rap1 activation (Epac) and phosphorylation (PKA) coordinating the early rate-limiting events in cAMP-dependent cell proliferation are studied using a multidisciplinary approach including molecular and cellular biology techniques in vitro, as well as in vivo validation using transgenic/knock in technologies in endocrine tumor models.

Leonard Appleman, MD, PhD
Program(s): Cancer Therapeutics
Contact:
UPMC Cancer Pavilion
5230 Center Ave., Suite 567
Pittsburgh PA
Phone: 412-648-6507
Research Interests and Keywords:
  • Kidney cancer and other genitourinary malignancies
  • experimental cancer therapeutics
Maninjay Atianand, PhD, MBBS
Program(s): Cancer Immunology and Immunotherapy
Contact:
200 Lothrop St
W1046 BST
Pittsburgh PA
Phone: 412-383-0472
Jonathan Alder, PhD
Program(s): Genome Stability
Contact:
BST W1246
200 Lothrop St.
Pittsburgh PA
Phone: 412-624-8681
Nduka Amankulor, MD
Program(s): Cancer Biology
Contact:
5150 Centre Ave.
Pittsburgh PA
Phone: 412-647-7614
Research Interests and Keywords:
  • Microenvironment and immune escape in glioblastoma
  • oligodendroglioma
  • brain and spine metastases
Karen Arndt, PhD
Program(s): Genome Stability
Contact:
A316 Langley Hall
4249 Fifth Ave
Pittsburgh PA
Phone: 412-624-6963
Research Interests and Keywords:
  • Gene expression
  • cellular transcription
  • mRNA synthesis
  • RNA polymerase II
  • chromatin
Summary
A critical question to ask, particularly in this genomic era, is how organisms interpret the vast amounts of information encoded in their genomes. The Arndt lab studies the first step in gene expression, the synthesis of mRNA by RNA polymerase II, with a focus on the mechanisms that regulate transcription in the chromatin environment of a eukaryotic cell. The fundamental importance of understanding transcriptional regulation is evident from the large number of human developmental defects and diseases, including cancer and AIDS, that arise when cellular transcription factors are altered by mutation or commandeered by viral proteins.
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