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Kevin Quann
Program: Cancer Immunology and Immunotherapy
Summary
My longstanding goal is to establish an independent research program in the areas of allogeneic hematopoietic stem cell transplantation (alloSCT) and adoptive cell therapy for the treatment of hematologic malignancies. Currently, I am focusing my research efforts on identifying the antigenic drivers of favorable (graft-vs-leukemia; GVL) and pathogenic (graft-vs-host disease; GVHD) alloimmune responses in alloSCT. Using a novel T-cell receptor (TCR) cloning platform, I have developed a high-throughput screening system for testing alloreactive donor-derived TCRs against informatically predicted…