Investigators
Find a Member
Results
Sadeesh Ramakrishnan
Program: Cancer Biology
Summary
Non-alcoholic fatty liver (NAFLD)-related HCC develops without liver cirrhosis and alcohol consumption. Perturbations in liver lipid disposal pathways, in particular dysregulation of hepatic ketogenesis, contributes to the pathogenesis of NAFLD and fibrosis. Conversely, ketogenic diet (KD) supplementation decreases liver lipid accumulation, inflammation, and fibrosis in NAFLD models. Our lab is interested in understanding how ketone bodies or ketogenesis regulate NAFLD-related HCC. We have liver specific ketogenesis insufficient and ketolysis insufficient mice to test our…
Charles Rinaldo
Program: Cancer Virology|Cancer Virology
Summary
Dr. Rinaldo's research is focused on the relation of disease progression to dendritic cell function and reactivity of CD8 killer T cells to HIV and human herpesvirus 8 (HHV-8, or KSHV, the cause of Kaposi's sarcoma).
Margaret Rosenzweig
Program: Biobehavioral Cancer Control
Summary
Our team’s research is focused on the factors that ensure that all women with breast cancer receive timely diagnoses, treatment, and support. Our research, education, and outreach initiatives are directed toward Black women with breast cancer, women with metastatic breast cancer, and community engagement to address racial and economic breast cancer survival disparity. Our team is well-published, with over 130 publications and multiple national and international presentations disseminating the results of our research. The Symptom Experience, Management, and Outcomes…
Partha Roy
Program: Cancer Biology
Summary
The major focus of the research in the Roy laboratory is studying the role of actin-binding proteins and actin-regulated transcription factors in physiological and pathological events. Specific focus areas are actin-binding proteins (profilin, Ena/VASP) and their regulation, MRTF-SRF transcriptional axis, fundamental mechanisms of cell migration, cancer biology (breast and renal cancer), cell signaling, vascular-immune cell crosstalk, and angiogenesis (in both developmental and pathological settings). We seek to a.) Understand the molecular mechanisms of various aspects of cancer metastasis,…
J. Peter Rubin
Program: Cancer Biology
Summary
Dr. Rubin is a noted expert on adult stem cells derived from fat tissue and advanced reconstructive surgery. Dr. Rubin leads a program that is devising innovative strategies for the use of adipose (fat)-derived stem cells to not only address problems of tissue regeneration but also other diseases that benefit from stem cell-based therapies. He is co-director of the Adipose Stem Cell Center and co-director of the UPMC Aesthetic Plastic Surgery Center. His laboratory research focuses on applications of adult adipose-derived stem cells for restoring damaged tissues after trauma and cancer…
Jenny Ruiz
Program: Biobehavioral Cancer Control
Summary
I am a pediatric hematologist-oncologist and a health services researcher. My research focuses on investigating social and structural drivers of health (SDOH) as it relates to pediatric cancer access, care, and outcomes. Previous projects include investigating infectious complications in children with leukemia by an area-based measure of SDOH and clinical trial enrollment disparities. I am establishing my research program focused on caregiver-clinician communication in pediatric oncology.…
