Muoio D, Laspata N, Dannenberg RL, Curry C, Darkoa-Larbi S, Hedglin M, Uttam S, Fouquerel E. PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress. Nat Commun. 2024-04-02;15(1):2857. doi: 10.1038/s41467-024-47222-7. nihFormattedCitation: Muoio D, Laspata N, Dannenberg RL, Curry C, Darkoa-Larbi S, Hedglin M, Uttam S, Fouquerel E. PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress. Nat Commun. 2024;15(1):2857. PMCID: PMC10987537.. PubMed PMID: 38565848; PMCID: PMC10987537.
Duncan AW. Pathological polyploidy and liver repair failure in RAD51-deficient mice. Hepatology. 2024-03-28; doi: 10.1097/HEP.0000000000000871. nihFormattedCitation: Duncan AW. Pathological polyploidy and liver repair failure in RAD51-deficient mice. Hepatology. 2024;.. PubMed PMID: 38546299.
Chao Y, Chen Y, Zheng W, Demanelis K, Liu Y, Connelly JA, Wang H, Li S, Wang QJ. Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer. Oncogene. 2024-03-01; doi: 10.1038/s41388-024-02939-z. nihFormattedCitation: Chao Y, Chen Y, Zheng W, Demanelis K, Liu Y, Connelly JA, Wang H, Li S, Wang QJ. Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer. Oncogene. 2024;.. PubMed PMID: 38273024.
Johnson SA, Paul T, Sanford SL, Schnable BL, Detwiler AC, Thosar SA, Van Houten B, Myong S, Opresko PL. BG4 antibody can recognize telomeric G-quadruplexes harboring destabilizing base modifications and lesions. Nucleic Acids Res. 2024-02-28; doi: 10.1093/nar/gkad1209. nihFormattedCitation: Johnson SA, Paul T, Sanford SL, Schnable BL, Detwiler AC, Thosar SA, Van Houten B, Myong S, Opresko PL. BG4 antibody can recognize telomeric G-quadruplexes harboring destabilizing base modifications and lesions. Nucleic Acids Res. 2024;. PMCID: PMC10939409.. PubMed PMID: 38153143; PMCID: PMC10939409.
Thosar SA, Barnes RP, Detwiler A, Bhargava R, Wondisford A, O'Sullivan RJ, Opresko PL. Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair. Cell Rep. 2024-01-23;43(1):113656. doi: 10.1016/j.celrep.2023.113656. nihFormattedCitation: Thosar SA, Barnes RP, Detwiler A, Bhargava R, Wondisford A, O'Sullivan RJ, Opresko PL. Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair. Cell Rep. 2024;43(1):113656. PMCID: PMC10851105.. PubMed PMID: 38194346; PMCID: PMC10851105.
Pifer PM, Yang L, Kumar M, Xie T, Frederick M, Hefner A, Beadle B, Molkentine D, Molkentine J, Dhawan A, Abdelhakiem M, Osman AA, Leibowitz BJ, Myers JN, Pickering CR, Sandulache VC, Heymach J, Skinner HD. FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner. Clin Cancer Res. 2024-01-05; doi: 10.1158/1078-0432.CCR-23-0964. nihFormattedCitation: Pifer PM, Yang L, Kumar M, Xie T, Frederick M, Hefner A, Beadle B, Molkentine D, Molkentine J, Dhawan A, Abdelhakiem M, Osman AA, Leibowitz BJ, Myers JN, Pickering CR, Sandulache VC, Heymach J, Skinner HD. FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner. Clin Cancer Res. 2024;. PMCID: PMC10767302.. PubMed PMID: 37819945; PMCID: PMC10767302.
Wu L, Lin Q, Chatla S, Amarachintha SP, Wilson AF, Atale N, Gao ZJ, Joseph J, Wolff E, Du W. LepR+ niche cell-derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging. Blood. 2023-11-02; doi: 10.1182/blood.2022018212. nihFormattedCitation: Wu L, Lin Q, Chatla S, Amarachintha SP, Wilson AF, Atale N, Gao ZJ, Joseph J, Wolff E, Du W. LepR+ niche cell-derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging. Blood. 2023;. PMCID: PMC10656728.. PubMed PMID: 37584437; PMCID: PMC10656728.
Sullivan DI, Bello FM, Silva AG, Redding KM, Giordano L, Hinchie AM, Loughridge KE, Mora AL, Königshoff M, Kaufman BA, Jurczak MJ, Alder JK. Intact mitochondrial function in the setting of telomere-induced senescence. Aging Cell. 2023-10-01;e13941. doi: 10.1111/acel.13941. nihFormattedCitation: Sullivan DI, Bello FM, Silva AG, Redding KM, Giordano L, Hinchie AM, Loughridge KE, Mora AL, Königshoff M, Kaufman BA, Jurczak MJ, Alder JK. Intact mitochondrial function in the setting of telomere-induced senescence. Aging Cell. 2023;:e13941. PMCID: PMC10577573.. PubMed PMID: 37688329; PMCID: PMC10577573.
Hong L, Braden DC, Zhao Y, Skoko JJ, Chang F, Woodcock SR, Uvalle C, Casey A, Wood K, Salvatore SR, Asan A, Harkness T, Fagunloye A, Razzaghi M, Straub A, Spies M, Brown DD, Lee AV, Schopfer F, Freeman BA, Neumann CA. Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies. Redox Biol. 2023-10-01;66102856. doi: 10.1016/j.redox.2023.102856. nihFormattedCitation: Hong L, Braden DC, Zhao Y, Skoko JJ, Chang F, Woodcock SR, Uvalle C, Casey A, Wood K, Salvatore SR, Asan A, Harkness T, Fagunloye A, Razzaghi M, Straub A, Spies M, Brown DD, Lee AV, Schopfer F, Freeman BA, Neumann CA. Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies. Redox Biol. 2023;66:102856. PMCID: PMC10472314.. PubMed PMID: 37633047; PMCID: PMC10472314.
Dar HH, Mikulska-Ruminska K, Tyurina YY, Luci DK, Yasgar A, Samovich SN, Kapralov AA, Souryavong AB, Tyurin VA, Amoscato AA, Epperly MW, Shurin GV, Standley M, Holman TR, St Croix CM, Watkins SC, VanDemark AP, Rana S, Zakharov AV, Simeonov A, Marugan J, Mallampalli RK, Wenzel SE, Greenberger JS, Rai G, Bayir H, Bahar I, Kagan VE. Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators. Proc Natl Acad Sci U S A. 2023-06-20;120(25):e2218896120. doi: 10.1073/pnas.2218896120. nihFormattedCitation: Dar HH, Mikulska-Ruminska K, Tyurina YY, Luci DK, Yasgar A, Samovich SN, Kapralov AA, Souryavong AB, Tyurin VA, Amoscato AA, Epperly MW, Shurin GV, Standley M, Holman TR, St Croix CM, Watkins SC, VanDemark AP, Rana S, Zakharov AV, Simeonov A, Marugan J, Mallampalli RK, Wenzel SE, Greenberger JS, Rai G, Bayir H, Bahar I, Kagan VE. Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators. Proc Natl Acad Sci U S A. 2023;120(25):e2218896120. PMCID: PMC10288584.. PubMed PMID: 37327313; PMCID: PMC10288584.
Ellison MA, Namjilsuren S, Shirra MK, Blacksmith MS, Schusteff RA, Kerr EM, Fang F, Xiang Y, Shi Y, Arndt KM. Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae. Nucleic Acids Res. 2023-06-09;51(10):4814-4830. doi: 10.1093/nar/gkad180. nihFormattedCitation: Ellison MA, Namjilsuren S, Shirra MK, Blacksmith MS, Schusteff RA, Kerr EM, Fang F, Xiang Y, Shi Y, Arndt KM. Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae. Nucleic Acids Res. 2023;51(10):4814-4830. PMCID: PMC10250246.. PubMed PMID: 36928138; PMCID: PMC10250246.
Jang S, Raja SJ, Roginskaya V, Schaich MA, Watkins SC, Van Houten B. UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties. Nucleic Acids Res. 2023-06-09;51(10):4881-4898. doi: 10.1093/nar/gkad206. nihFormattedCitation: Jang S, Raja SJ, Roginskaya V, Schaich MA, Watkins SC, Van Houten B. UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties. Nucleic Acids Res. 2023;51(10):4881-4898. PMCID: PMC10250209.. PubMed PMID: 36971122; PMCID: PMC10250209.
Fetian T, McShane BM, Horan NL, Shodja DN, True JD, Mosley AL, Arndt KM. Paf1 complex subunit Rtf1 stimulates H2B ubiquitylation by interacting with the highly conserved N-terminal helix of Rad6. Proc Natl Acad Sci U S A. 2023-05-30;120(22):e2220041120. doi: 10.1073/pnas.2220041120. nihFormattedCitation: Fetian T, McShane BM, Horan NL, Shodja DN, True JD, Mosley AL, Arndt KM. Paf1 complex subunit Rtf1 stimulates H2B ubiquitylation by interacting with the highly conserved N-terminal helix of Rad6. Proc Natl Acad Sci U S A. 2023;120(22):e2220041120. PMCID: PMC10235976.. PubMed PMID: 37216505; PMCID: PMC10235976.
Tyurina YY, Kapralov AA, Tyurin VA, Shurin G, Amoscato AA, Rajasundaram D, Tian H, Bunimovich YL, Nefedova Y, Herrick WG, Parchment RE, Doroshow JH, Bayir H, Srivastava AK, Kagan VE. Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo. Redox Biol. 2023-05-01;61102650. doi: 10.1016/j.redox.2023.102650. nihFormattedCitation: Tyurina YY, Kapralov AA, Tyurin VA, Shurin G, Amoscato AA, Rajasundaram D, Tian H, Bunimovich YL, Nefedova Y, Herrick WG, Parchment RE, Doroshow JH, Bayir H, Srivastava AK, Kagan VE. Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo. Redox Biol. 2023;61:102650. PMCID: PMC9996109.. PubMed PMID: 36870109; PMCID: PMC9996109.
Schaich MA, Schnable BL, Kumar N, Roginskaya V, Jakielski RC, Urban R, Zhong Z, Kad NM, Van Houten B. Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE). Nucleic Acids Res. 2023-04-24;51(7):e39. doi: 10.1093/nar/gkad095. nihFormattedCitation: Schaich MA, Schnable BL, Kumar N, Roginskaya V, Jakielski RC, Urban R, Zhong Z, Kad NM, Van Houten B. Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE). Nucleic Acids Res. 2023;51(7):e39. PMCID: PMC10123111.. PubMed PMID: 36861323; PMCID: PMC10123111.
Laspata N, Kaur P, Mersaoui SY, Muoio D, Liu ZS, Bannister MH, Nguyen HD, Curry C, Pascal JM, Poirier GG, Wang H, Masson JY, Fouquerel E. PARP1 associates with R-loops to promote their resolution and genome stability. Nucleic Acids Res. 2023-03-21;51(5):2215-2237. doi: 10.1093/nar/gkad066. nihFormattedCitation: Laspata N, Kaur P, Mersaoui SY, Muoio D, Liu ZS, Bannister MH, Nguyen HD, Curry C, Pascal JM, Poirier GG, Wang H, Masson JY, Fouquerel E. PARP1 associates with R-loops to promote their resolution and genome stability. Nucleic Acids Res. 2023;51(5):2215-2237. PMCID: PMC10018367.. PubMed PMID: 36794853; PMCID: PMC10018367.
Zuo Z, Liu J, Sun Z, Cheng YW, Ewing M, Bugge TH, Finkel T, Leppla SH, Liu S. ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth. Proc Natl Acad Sci U S A. 2023-01-03;120(1):e2211927120. doi: 10.1073/pnas.2211927120. nihFormattedCitation: Zuo Z, Liu J, Sun Z, Cheng YW, Ewing M, Bugge TH, Finkel T, Leppla SH, Liu S. ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth. Proc Natl Acad Sci U S A. 2023;120(1):e2211927120. PMCID: PMC9910475.. PubMed PMID: 36574698; PMCID: PMC9910475.
Hao S, Tong J, Jha A, Risnik D, Lizardo D, Lu X, Goel A, Opresko PL, Yu J, Zhang L. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer. Proc Natl Acad Sci U S A. 2022-12-20;119(51):e2211775119. doi: 10.1073/pnas.2211775119. nihFormattedCitation: Hao S, Tong J, Jha A, Risnik D, Lizardo D, Lu X, Goel A, Opresko PL, Yu J, Zhang L. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer. Proc Natl Acad Sci U S A. 2022;119(51):e2211775119. PMCID: PMC9907101.. PubMed PMID: 36508676; PMCID: PMC9907101.
Jang S, Kumar N, Schaich MA, Zhong Z, van Loon B, Watkins SC, Van Houten B. Cooperative interaction between AAG and UV-DDB in the removal of modified bases. Nucleic Acids Res. 2022-12-09;50(22):12856-12871. doi: 10.1093/nar/gkac1145. nihFormattedCitation: Jang S, Kumar N, Schaich MA, Zhong Z, van Loon B, Watkins SC, Van Houten B. Cooperative interaction between AAG and UV-DDB in the removal of modified bases. Nucleic Acids Res. 2022;50(22):12856-12871. PMCID: PMC9825174.. PubMed PMID: 36511855; PMCID: PMC9825174.
Chun-On P, Hinchie AM, Beale HC, Gil Silva AA, Rush E, Sander C, Connelly CJ, Seynnaeve BKN, Kirkwood JM, Vaske OM, Greider CW, Alder JK. TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma. Science. 2022-11-11;378(6620):664-668. doi: 10.1126/science.abq0607. nihFormattedCitation: Chun-On P, Hinchie AM, Beale HC, Gil Silva AA, Rush E, Sander C, Connelly CJ, Seynnaeve BKN, Kirkwood JM, Vaske OM, Greider CW, Alder JK. TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma. Science. 2022;378(6620):664-668. PMCID: PMC10590476.. PubMed PMID: 36356143; PMCID: PMC10590476.
Kaminski N, Wondisford AR, Kwon Y, Lynskey ML, Bhargava R, Barroso-González J, García-Expósito L, He B, Xu M, Mellacheruvu D, Watkins SC, Modesti M, Miller KM, Nesvizhskii AI, Zhang H, Sung P, O'Sullivan RJ. RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA. Mol Cell. 2022-11-03;82(21):4001-4017.e7. doi: 10.1016/j.molcel.2022.09.025. nihFormattedCitation: Kaminski N, Wondisford AR, Kwon Y, Lynskey ML, Bhargava R, Barroso-González J, García-Expósito L, He B, Xu M, Mellacheruvu D, Watkins SC, Modesti M, Miller KM, Nesvizhskii AI, Zhang H, Sung P, O'Sullivan RJ. RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA. Mol Cell. 2022;82(21):4001-4017.e7. PMCID: PMC9713952.. PubMed PMID: 36265488; PMCID: PMC9713952.
Li X, Chatla S, Wilson AF, Wu L, Atale N, Du W. Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice. Haematologica. 2022-11-01;107(11):2576-2588. doi: 10.3324/haematol.2021.280404. nihFormattedCitation: Li X, Chatla S, Wilson AF, Wu L, Atale N, Du W. Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice. Haematologica. 2022;107(11):2576-2588. PMCID: PMC9614537.. PubMed PMID: 35443564; PMCID: PMC9614537.
Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Harkness T, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022-10-01;56102443. doi: 10.1016/j.redox.2022.102443. nihFormattedCitation: Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Harkness T, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022;56:102443. PMCID: PMC9450138.. PubMed PMID: 36058112; PMCID: PMC9450138.
Alder JK, Armanios M. Telomere-mediated lung disease. Physiol Rev. 2022-10-01;102(4):1703-1720. doi: 10.1152/physrev.00046.2021. nihFormattedCitation: Alder JK, Armanios M. Telomere-mediated lung disease. Physiol Rev. 2022;102(4):1703-1720. PMCID: PMC9306791.. PubMed PMID: 35532056; PMCID: PMC9306791.
Prakash R, Rawal Y, Sullivan MR, Grundy MK, Bret H, Mihalevic MJ, Rein HL, Baird JM, Darrah K, Zhang F, Wang R, Traina TA, Radke MR, Kaufmann SH, Swisher EM, Guérois R, Modesti M, Sung P, Jasin M, Bernstein KA. Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants. Proc Natl Acad Sci U S A. 2022-09-20;119(38):e2202727119. doi: 10.1073/pnas.2202727119. nihFormattedCitation: Prakash R, Rawal Y, Sullivan MR, Grundy MK, Bret H, Mihalevic MJ, Rein HL, Baird JM, Darrah K, Zhang F, Wang R, Traina TA, Radke MR, Kaufmann SH, Swisher EM, Guérois R, Modesti M, Sung P, Jasin M, Bernstein KA. Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants. Proc Natl Acad Sci U S A. 2022;119(38):e2202727119. PMCID: PMC9499524.. PubMed PMID: 36099300; PMCID: PMC9499524.
Barnes RP, de Rosa M, Thosar SA, Detwiler AC, Roginskaya V, Van Houten B, Bruchez MP, Stewart-Ornstein J, Opresko PL. Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening. Nat Struct Mol Biol. 2022-07-01;29(7):639-652. doi: 10.1038/s41594-022-00790-y. nihFormattedCitation: Barnes RP, de Rosa M, Thosar SA, Detwiler AC, Roginskaya V, Van Houten B, Bruchez MP, Stewart-Ornstein J, Opresko PL. Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening. Nat Struct Mol Biol. 2022;29(7):639-652. PMCID: PMC9287163.. PubMed PMID: 35773409; PMCID: PMC9287163.
Lin Q, Wu L, Chatla S, Chowdhury FA, Atale N, Joseph J, Du W. Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis. J Clin Invest. 2022-06-15;132(12): doi: 10.1172/JCI155914. nihFormattedCitation: Lin Q, Wu L, Chatla S, Chowdhury FA, Atale N, Joseph J, Du W. Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis. J Clin Invest. 2022;132(12). PMCID: PMC9197516.. PubMed PMID: 35703178; PMCID: PMC9197516.
Thota PN, Nasibli J, Kumar P, Sanaka MR, Chak A, Zhang X, Liu X, Uttam S, Liu Y. Prediction of neoplastic progression in Barrett's esophagus using nanoscale nuclear architecture mapping: a pilot study. Gastrointest Endosc. 2022-06-01;95(6):1239-1246. doi: 10.1016/j.gie.2022.01.007. nihFormattedCitation: Thota PN, Nasibli J, Kumar P, Sanaka MR, Chak A, Zhang X, Liu X, Uttam S, Liu Y. Prediction of neoplastic progression in Barrett's esophagus using nanoscale nuclear architecture mapping: a pilot study. Gastrointest Endosc. 2022;95(6):1239-1246. PMCID: PMC9296222.. PubMed PMID: 35065946; PMCID: PMC9296222.
Tong J, Tan X, Song X, Gao M, Risnik D, Hao S, Ermine K, Wang P, Li H, Huang Y, Yu J, Zhang L. CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. Cancer Res. 2022-04-01;82(7):1340-1352. doi: 10.1158/0008-5472.CAN-21-3062. nihFormattedCitation: Tong J, Tan X, Song X, Gao M, Risnik D, Hao S, Ermine K, Wang P, Li H, Huang Y, Yu J, Zhang L. CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. Cancer Res. 2022;82(7):1340-1352. PMCID: PMC8983601.. PubMed PMID: 35149588; PMCID: PMC8983601.
Lamade AM, Wu L, Dar HH, Mentrup HL, Shrivastava IH, Epperly MW, St Croix CM, Tyurina YY, Anthonymuthu TS, Yang Q, Kapralov AA, Huang Z, Mao G, Amoscato AA, Hier ZE, Artyukhova MA, Shurin G, Rosenbaum JC, Gough PJ, Bertin J, VanDemark AP, Watkins SC, Mollen KP, Bahar I, Greenberger JS, Kagan VE, Whalen MJ, Bayır H. Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death. Redox Biol. 2022-04-01;50102232. doi: 10.1016/j.redox.2022.102232. nihFormattedCitation: Lamade AM, Wu L, Dar HH, Mentrup HL, Shrivastava IH, Epperly MW, St Croix CM, Tyurina YY, Anthonymuthu TS, Yang Q, Kapralov AA, Huang Z, Mao G, Amoscato AA, Hier ZE, Artyukhova MA, Shurin G, Rosenbaum JC, Gough PJ, Bertin J, VanDemark AP, Watkins SC, Mollen KP, Bahar I, Greenberger JS, Kagan VE, Whalen MJ, Bayır H. Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death. Redox Biol. 2022;50:102232. PMCID: PMC8804265.. PubMed PMID: 35101798; PMCID: PMC8804265.
Xu J, Sun X, Kim K, Brand RM, Hartman D, Ma H, Brand RE, Bai M, Liu Y. Ultrastructural visualization of chromatin in cancer pathogenesis using a simple small-molecule fluorescent probe. Sci Adv. 2022-03-04;8(9):eabm8293. doi: 10.1126/sciadv.abm8293. nihFormattedCitation: Xu J, Sun X, Kim K, Brand RM, Hartman D, Ma H, Brand RE, Bai M, Liu Y. Ultrastructural visualization of chromatin in cancer pathogenesis using a simple small-molecule fluorescent probe. Sci Adv. 2022;8(9):eabm8293. PMCID: PMC8896800.. PubMed PMID: 35245126; PMCID: PMC8896800.
Molkentine DP, Molkentine JM, Bridges KA, Valdecanas DR, Dhawan A, Bahri R, Hefner AJ, Kumar M, Yang L, Abdelhakiem M, Pifer PM, Sandulache V, Sheth A, Beadle BM, Thames HD, Mason KA, Pickering CR, Meyn RE, Skinner HD. p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade. Cancer Res. 2022-03-01;82(5):916-928. doi: 10.1158/0008-5472.CAN-21-2101. nihFormattedCitation: Molkentine DP, Molkentine JM, Bridges KA, Valdecanas DR, Dhawan A, Bahri R, Hefner AJ, Kumar M, Yang L, Abdelhakiem M, Pifer PM, Sandulache V, Sheth A, Beadle BM, Thames HD, Mason KA, Pickering CR, Meyn RE, Skinner HD. p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade. Cancer Res. 2022;82(5):916-928. PMCID: PMC9136619.. PubMed PMID: 34965932; PMCID: PMC9136619.
Kumar N, Theil AF, Roginskaya V, Ali Y, Calderon M, Watkins SC, Barnes RP, Opresko PL, Pines A, Lans H, Vermeulen W, Van Houten B. Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins. Nat Commun. 2022-02-21;13(1):974. doi: 10.1038/s41467-022-28642-9. nihFormattedCitation: Kumar N, Theil AF, Roginskaya V, Ali Y, Calderon M, Watkins SC, Barnes RP, Opresko PL, Pines A, Lans H, Vermeulen W, Van Houten B. Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins. Nat Commun. 2022;13(1):974. PMCID: PMC8861037.. PubMed PMID: 35190564; PMCID: PMC8861037.
Hamsanathan S, Anthonymuthu T, Han S, Shinglot H, Siefken E, Sims A, Sen P, Pepper HL, Snyder NW, Bayir H, Kagan V, Gurkar AU. Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60. Sci Adv. 2022-02-18;8(7):eabl6083. doi: 10.1126/sciadv.abl6083. nihFormattedCitation: Hamsanathan S, Anthonymuthu T, Han S, Shinglot H, Siefken E, Sims A, Sen P, Pepper HL, Snyder NW, Bayir H, Kagan V, Gurkar AU. Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60. Sci Adv. 2022;8(7):eabl6083. PMCID: PMC8849393.. PubMed PMID: 35171671; PMCID: PMC8849393.
Wilson SR, Duncan AW. Single-Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution. Gastroenterology. 2022-01-01;162(1):46-48. doi: 10.1053/j.gastro.2021.09.065. nihFormattedCitation: Wilson SR, Duncan AW. Single-Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution. Gastroenterology. 2022;162(1):46-48. PMCID: PMC8981166.. PubMed PMID: 34626601; PMCID: PMC8981166.
Kaur P, Barnes R, Pan H, Detwiler AC, Liu M, Mahn C, Hall J, Messenger Z, You C, Piehler J, Smart RC, Riehn R, Opresko PL, Wang H. TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA. Nucleic Acids Res. 2021-12-16;49(22):13000-13018. doi: 10.1093/nar/gkab1142. nihFormattedCitation: Kaur P, Barnes R, Pan H, Detwiler AC, Liu M, Mahn C, Hall J, Messenger Z, You C, Piehler J, Smart RC, Riehn R, Opresko PL, Wang H. TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA. Nucleic Acids Res. 2021;49(22):13000-13018. PMCID: PMC8682769.. PubMed PMID: 34883513; PMCID: PMC8682769.
Wu L, Chatla S, Lin Q, Chowdhury FA, Geldenhuys W, Du W. Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia. Nat Commun. 2021-11-26;12(1):6936. doi: 10.1038/s41467-021-27300-w. nihFormattedCitation: Wu L, Chatla S, Lin Q, Chowdhury FA, Geldenhuys W, Du W. Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia. Nat Commun. 2021;12(1):6936. PMCID: PMC8626516.. PubMed PMID: 34836965; PMCID: PMC8626516.
Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, Hefner A, Gao M, Bahri R, Dhawan A, Frederick MJ, Seth S, Abdelhakiem M, Beadle BM, Johnson F, Wang J, Shen L, Heffernan T, Sheth A, Ferris RL, Myers JN, Pickering CR, Skinner HD. Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function. Nat Commun. 2021-11-03;12(1):6340. doi: 10.1038/s41467-021-26570-8. nihFormattedCitation: Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, Hefner A, Gao M, Bahri R, Dhawan A, Frederick MJ, Seth S, Abdelhakiem M, Beadle BM, Johnson F, Wang J, Shen L, Heffernan T, Sheth A, Ferris RL, Myers JN, Pickering CR, Skinner HD. Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function. Nat Commun. 2021;12(1):6340. PMCID: PMC8566594.. PubMed PMID: 34732714; PMCID: PMC8566594.
Leibowitz BJ, Zhao G, Wei L, Ruan H, Epperly M, Chen L, Lu X, Greenberger JS, Zhang L, Yu J. Interferon b drives intestinal regeneration after radiation. Sci Adv. 2021-10-08;7(41):eabi5253. doi: 10.1126/sciadv.abi5253. nihFormattedCitation: Leibowitz BJ, Zhao G, Wei L, Ruan H, Epperly M, Chen L, Lu X, Greenberger JS, Zhang L, Yu J. Interferon b drives intestinal regeneration after radiation. Sci Adv. 2021;7(41):eabi5253. PMCID: PMC8494436.. PubMed PMID: 34613772; PMCID: PMC8494436.
Dar HH, Anthonymuthu TS, Ponomareva LA, Souryavong AB, Shurin GV, Kapralov AO, Tyurin VA, Lee JS, Mallampalli RK, Wenzel SE, Bayir H, Kagan VE. A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO(•) sabotage of theft-ferroptosis. Redox Biol. 2021-09-01;45102045. doi: 10.1016/j.redox.2021.102045. nihFormattedCitation: Dar HH, Anthonymuthu TS, Ponomareva LA, Souryavong AB, Shurin GV, Kapralov AO, Tyurin VA, Lee JS, Mallampalli RK, Wenzel SE, Bayir H, Kagan VE. A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO(•) sabotage of theft-ferroptosis. Redox Biol. 2021;45:102045. PMCID: PMC8227829.. PubMed PMID: 34167028; PMCID: PMC8227829.
Jang S, Schaich MA, Khuu C, Schnable BL, Majumdar C, Watkins SC, David SS, Van Houten B. Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover. Nucleic Acids Res. 2021-08-20;49(14):8177-8188. doi: 10.1093/nar/gkab591. nihFormattedCitation: Jang S, Schaich MA, Khuu C, Schnable BL, Majumdar C, Watkins SC, David SS, Van Houten B. Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover. Nucleic Acids Res. 2021;49(14):8177-8188. PMCID: PMC8373069.. PubMed PMID: 34232996; PMCID: PMC8373069.
Ferro-Novick S, Reggiori F, Brodsky JL. ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease. Trends Biochem Sci. 2021-08-01;46(8):630-639. doi: 10.1016/j.tibs.2020.12.013. nihFormattedCitation: Ferro-Novick S, Reggiori F, Brodsky JL. ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease. Trends Biochem Sci. 2021;46(8):630-639. PMCID: PMC8286283.. PubMed PMID: 33509650; PMCID: PMC8286283.
Kaplan CD, Arndt KM. A PICture is worth a thousand words (and ten references). Cell. 2021-07-22;184(15):3850-3851. doi: 10.1016/j.cell.2021.06.030. nihFormattedCitation: Kaplan CD, Arndt KM. A PICture is worth a thousand words (and ten references). Cell. 2021;184(15):3850-3851.. PubMed PMID: 34297929.
Wan L, Yin J, Skoko J, Schwartz R, Zhang M, LeDuc PR, Neumann CA. 3D Collagen Vascular Tumor-on-a-Chip Mimetics for Dynamic Combinatorial Drug Screening. Mol Cancer Ther. 2021-06-01;20(6):1210-1219. doi: 10.1158/1535-7163.MCT-20-0880. nihFormattedCitation: Wan L, Yin J, Skoko J, Schwartz R, Zhang M, LeDuc PR, Neumann CA. 3D Collagen Vascular Tumor-on-a-Chip Mimetics for Dynamic Combinatorial Drug Screening. Mol Cancer Ther. 2021;20(6):1210-1219. PMCID: PMC8172531.. PubMed PMID: 33785649; PMCID: PMC8172531.
Sparvero LJ, Tian H, Amoscato AA, Sun WY, Anthonymuthu TS, Tyurina YY, Kapralov O, Javadov S, He RR, Watkins SC, Winograd N, Kagan VE, Bayır H. Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB-SIMS). Angew Chem Int Ed Engl. 2021-05-17;60(21):11784-11788. doi: 10.1002/anie.202102001. nihFormattedCitation: Sparvero LJ, Tian H, Amoscato AA, Sun WY, Anthonymuthu TS, Tyurina YY, Kapralov O, Javadov S, He RR, Watkins SC, Winograd N, Kagan VE, Bayır H. Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB-SIMS). Angew Chem Int Ed Engl. 2021;60(21):11784-11788. PMCID: PMC8243396.. PubMed PMID: 33684237; PMCID: PMC8243396.
Sun WY, Tyurin VA, Mikulska-Ruminska K, Shrivastava IH, Anthonymuthu TS, Zhai YJ, Pan MH, Gong HB, Lu DH, Sun J, Duan WJ, Korolev S, Abramov AY, Angelova PR, Miller I, Beharier O, Mao GW, Dar HH, Kapralov AA, Amoscato AA, Hastings TG, Greenamyre TJ, Chu CT, Sadovsky Y, Bahar I, Bayır H, Tyurina YY, He RR, Kagan VE. Phospholipase iPLA(2)β averts ferroptosis by eliminating a redox lipid death signal. Nat Chem Biol. 2021-04-01;17(4):465-476. doi: 10.1038/s41589-020-00734-x. nihFormattedCitation: Sun WY, Tyurin VA, Mikulska-Ruminska K, Shrivastava IH, Anthonymuthu TS, Zhai YJ, Pan MH, Gong HB, Lu DH, Sun J, Duan WJ, Korolev S, Abramov AY, Angelova PR, Miller I, Beharier O, Mao GW, Dar HH, Kapralov AA, Amoscato AA, Hastings TG, Greenamyre TJ, Chu CT, Sadovsky Y, Bahar I, Bayır H, Tyurina YY, He RR, Kagan VE. Phospholipase iPLA(2)β averts ferroptosis by eliminating a redox lipid death signal. Nat Chem Biol. 2021;17(4):465-476. PMCID: PMC8152680.. PubMed PMID: 33542532; PMCID: PMC8152680.
Stewart-Ornstein J, Iwamoto Y, Miller MA, Prytyskach MA, Ferretti S, Holzer P, Kallen J, Furet P, Jambhekar A, Forrester WC, Weissleder R, Lahav G. p53 dynamics vary between tissues and are linked with radiation sensitivity. Nat Commun. 2021-02-09;12(1):898. doi: 10.1038/s41467-021-21145-z. nihFormattedCitation: Stewart-Ornstein J, Iwamoto Y, Miller MA, Prytyskach MA, Ferretti S, Holzer P, Kallen J, Furet P, Jambhekar A, Forrester WC, Weissleder R, Lahav G. p53 dynamics vary between tissues and are linked with radiation sensitivity. Nat Commun. 2021;12(1):898. PMCID: PMC7873198.. PubMed PMID: 33563973; PMCID: PMC7873198.
Anthonymuthu TS, Tyurina YY, Sun WY, Mikulska-Ruminska K, Shrivastava IH, Tyurin VA, Cinemre FB, Dar HH, VanDemark AP, Holman TR, Sadovsky Y, Stockwell BR, He RR, Bahar I, Bayır H, Kagan VE. Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis. Redox Biol. 2021-01-01;38101744. doi: 10.1016/j.redox.2020.101744. nihFormattedCitation: Anthonymuthu TS, Tyurina YY, Sun WY, Mikulska-Ruminska K, Shrivastava IH, Tyurin VA, Cinemre FB, Dar HH, VanDemark AP, Holman TR, Sadovsky Y, Stockwell BR, He RR, Bahar I, Bayır H, Kagan VE. Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis. Redox Biol. 2021;38:101744. PMCID: PMC7596334.. PubMed PMID: 33126055; PMCID: PMC7596334.
Lizardo DY, Kuang C, Hao S, Yu J, Huang Y, Zhang L. Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside. Biochim Biophys Acta Rev Cancer. 2020-12-01;1874(2):188447. doi: 10.1016/j.bbcan.2020.188447. nihFormattedCitation: Lizardo DY, Kuang C, Hao S, Yu J, Huang Y, Zhang L. Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside. Biochim Biophys Acta Rev Cancer. 2020;1874(2):188447. PMCID: PMC7886024.. PubMed PMID: 33035640; PMCID: PMC7886024.
Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ. Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol. 2020-12-01;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. nihFormattedCitation: Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ. Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol. 2020;27(12):1152-1164. PMCID: PMC7809635.. PubMed PMID: 33046907; PMCID: PMC7809635.
Bonilla B, Hengel SR, Grundy MK, Bernstein KA. RAD51 Gene Family Structure and Function. Annu Rev Genet. 2020-11-23;5425-46. doi: 10.1146/annurev-genet-021920-092410. nihFormattedCitation: Bonilla B, Hengel SR, Grundy MK, Bernstein KA. RAD51 Gene Family Structure and Function. Annu Rev Genet. 2020;54:25-46. PMCID: PMC7703940.. PubMed PMID: 32663049; PMCID: PMC7703940.
Kumar N, Raja S, Van Houten B. The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage. Nucleic Acids Res. 2020-11-18;48(20):11227-11243. doi: 10.1093/nar/gkaa777. nihFormattedCitation: Kumar N, Raja S, Van Houten B. The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage. Nucleic Acids Res. 2020;48(20):11227-11243. PMCID: PMC7672477.. PubMed PMID: 33010169; PMCID: PMC7672477.
Sanford SL, Welfer GA, Freudenthal BD, Opresko PL. Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs. Nat Commun. 2020-10-20;11(1):5288. doi: 10.1038/s41467-020-19115-y. nihFormattedCitation: Sanford SL, Welfer GA, Freudenthal BD, Opresko PL. Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs. Nat Commun. 2020;11(1):5288. PMCID: PMC7576608.. PubMed PMID: 33082336; PMCID: PMC7576608.
Liu J, Zuo Z, Sastalla I, Liu C, Jang JY, Sekine Y, Li Y, Pirooznia M, Leppla SH, Finkel T, Liu S. Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors. Cell Host Microbe. 2020-09-09;28(3):402-410.e5. doi: 10.1016/j.chom.2020.05.012. nihFormattedCitation: Liu J, Zuo Z, Sastalla I, Liu C, Jang JY, Sekine Y, Li Y, Pirooznia M, Leppla SH, Finkel T, Liu S. Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors. Cell Host Microbe. 2020;28(3):402-410.e5. PMCID: PMC7486266.. PubMed PMID: 32544461; PMCID: PMC7486266.
Song X, Shen L, Tong J, Kuang C, Zeng S, Schoen RE, Yu J, Pei H, Zhang L. Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer. Theranostics. 2020-07-09;10(18):8098-8110. doi: 10.7150/thno.45363. nihFormattedCitation: Song X, Shen L, Tong J, Kuang C, Zeng S, Schoen RE, Yu J, Pei H, Zhang L. Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer. Theranostics. 2020;10(18):8098-8110. PMCID: PMC7381732.. PubMed PMID: 32724460; PMCID: PMC7381732.
Xu J, Ma H, Ma H, Jiang W, Mela CA, Duan M, Zhao S, Gao C, Hahm ER, Lardo SM, Troy K, Sun M, Pai R, Stolz DB, Zhang L, Singh S, Brand RE, Hartman DJ, Hu J, Hainer SJ, Liu Y. Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis. Nat Commun. 2020-04-20;11(1):1899. doi: 10.1038/s41467-020-15718-7. nihFormattedCitation: Xu J, Ma H, Ma H, Jiang W, Mela CA, Duan M, Zhao S, Gao C, Hahm ER, Lardo SM, Troy K, Sun M, Pai R, Stolz DB, Zhang L, Singh S, Brand RE, Hartman DJ, Hu J, Hainer SJ, Liu Y. Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis. Nat Commun. 2020;11(1):1899. PMCID: PMC7171144.. PubMed PMID: 32313005; PMCID: PMC7171144.
Beckwitt EC, Jang S, Carnaval Detweiler I, Kuper J, Sauer F, Simon N, Bretzler J, Watkins SC, Carell T, Kisker C, Van Houten B. Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search. Nat Commun. 2020-03-13;11(1):1356. doi: 10.1038/s41467-020-15168-1. nihFormattedCitation: Beckwitt EC, Jang S, Carnaval Detweiler I, Kuper J, Sauer F, Simon N, Bretzler J, Watkins SC, Carell T, Kisker C, Van Houten B. Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search. Nat Commun. 2020;11(1):1356. PMCID: PMC7069974.. PubMed PMID: 32170071; PMCID: PMC7069974.
Hoang SM, O'Sullivan RJ. Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends. Trends Cancer. 2020-03-01;6(3):247-260. doi: 10.1016/j.trecan.2019.12.009. nihFormattedCitation: Hoang SM, O'Sullivan RJ. Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends. Trends Cancer. 2020;6(3):247-260. PMCID: PMC7199893.. PubMed PMID: 32101727; PMCID: PMC7199893.
Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stoyanovsky DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI, Bayır H, Kagan VE. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020-03-01;16(3):278-290. doi: 10.1038/s41589-019-0462-8. nihFormattedCitation: Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stoyanovsky DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI, Bayır H, Kagan VE. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020;16(3):278-290. PMCID: PMC7233108.. PubMed PMID: 32080625; PMCID: PMC7233108.
Betegon M, Brodsky JL. Unlocking the door for ERAD. Nat Cell Biol. 2020-03-01;22(3):263-265. doi: 10.1038/s41556-020-0476-1. nihFormattedCitation: Betegon M, Brodsky JL. Unlocking the door for ERAD. Nat Cell Biol. 2020;22(3):263-265. PMCID: PMC7199279.. PubMed PMID: 32103187; PMCID: PMC7199279.
Moiseeva TN, Qian C, Sugitani N, Osmanbeyoglu HU, Bakkenist CJ. WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells. Proc Natl Acad Sci U S A. 2019-11-26;116(48):23891-23893. doi: 10.1073/pnas.1915108116. nihFormattedCitation: Moiseeva TN, Qian C, Sugitani N, Osmanbeyoglu HU, Bakkenist CJ. WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells. Proc Natl Acad Sci U S A. 2019;116(48):23891-23893. PMCID: PMC6883772.. PubMed PMID: 31712441; PMCID: PMC6883772.
Martino J, Brunette GJ, Barroso-González J, Moiseeva TN, Smith CM, Bakkenist CJ, O'Sullivan RJ, Bernstein KA. The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination. Nucleic Acids Res. 2019-11-04;47(19):10151-10165. doi: 10.1093/nar/gkz738. nihFormattedCitation: Martino J, Brunette GJ, Barroso-González J, Moiseeva TN, Smith CM, Bakkenist CJ, O'Sullivan RJ, Bernstein KA. The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination. Nucleic Acids Res. 2019;47(19):10151-10165. PMCID: PMC6821187.. PubMed PMID: 31665741; PMCID: PMC6821187.
Sun Z, Brodsky JL. Protein quality control in the secretory pathway. J Cell Biol. 2019-10-07;218(10):3171-3187. doi: 10.1083/jcb.201906047. nihFormattedCitation: Sun Z, Brodsky JL. Protein quality control in the secretory pathway. J Cell Biol. 2019;218(10):3171-3187. PMCID: PMC6781448.. PubMed PMID: 31537714; PMCID: PMC6781448.
Barroso-González J, García-Expósito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, de Vitis M, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ. RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Mol Cell. 2019-10-03;76(1):11-26.e7. doi: 10.1016/j.molcel.2019.06.043. nihFormattedCitation: Barroso-González J, García-Expósito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, de Vitis M, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ. RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Mol Cell. 2019;76(1):11-26.e7. PMCID: PMC6778027.. PubMed PMID: 31400850; PMCID: PMC6778027.
Brunette GJ, Jamalruddin MA, Baldock RA, Clark NL, Bernstein KA. Evolution-based screening enables genome-wide prioritization and discovery of DNA repair genes. Proc Natl Acad Sci U S A. 2019-09-24;116(39):19593-19599. doi: 10.1073/pnas.1906559116. nihFormattedCitation: Brunette GJ, Jamalruddin MA, Baldock RA, Clark NL, Bernstein KA. Evolution-based screening enables genome-wide prioritization and discovery of DNA repair genes. Proc Natl Acad Sci U S A. 2019;116(39):19593-19599. PMCID: PMC6765268.. PubMed PMID: 31501324; PMCID: PMC6765268.
Cucinotta CE, Hildreth AE, McShane BM, Shirra MK, Arndt KM. The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo. Nucleic Acids Res. 2019-09-19;47(16):8410-8423. doi: 10.1093/nar/gkz549. nihFormattedCitation: Cucinotta CE, Hildreth AE, McShane BM, Shirra MK, Arndt KM. The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo. Nucleic Acids Res. 2019;47(16):8410-8423. PMCID: PMC6895269.. PubMed PMID: 31226204; PMCID: PMC6895269.
Qian W, Kumar N, Roginskaya V, Fouquerel E, Opresko PL, Shiva S, Watkins SC, Kolodieznyi D, Bruchez MP, Van Houten B. Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction. Proc Natl Acad Sci U S A. 2019-09-10;116(37):18435-18444. doi: 10.1073/pnas.1910574116. nihFormattedCitation: Qian W, Kumar N, Roginskaya V, Fouquerel E, Opresko PL, Shiva S, Watkins SC, Kolodieznyi D, Bruchez MP, Van Houten B. Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction. Proc Natl Acad Sci U S A. 2019;116(37):18435-18444. PMCID: PMC6744920.. PubMed PMID: 31451640; PMCID: PMC6744920.
Rosenbaum JC, Bonilla B, Hengel SR, Mertz TM, Herken BW, Kazemier HG, Pressimone CA, Ratterman TC, MacNary E, De Magis A, Kwon Y, Godin SK, Van Houten B, Normolle DP, Sung P, Das SR, Paeschke K, Roberts SA, VanDemark AP, Bernstein KA. The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway. Nat Commun. 2019-08-05;10(1):3515. doi: 10.1038/s41467-019-11374-8. nihFormattedCitation: Rosenbaum JC, Bonilla B, Hengel SR, Mertz TM, Herken BW, Kazemier HG, Pressimone CA, Ratterman TC, MacNary E, De Magis A, Kwon Y, Godin SK, Van Houten B, Normolle DP, Sung P, Das SR, Paeschke K, Roberts SA, VanDemark AP, Bernstein KA. The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway. Nat Commun. 2019;10(1):3515. PMCID: PMC6683157.. PubMed PMID: 31383866; PMCID: PMC6683157.
Jang S, Kumar N, Beckwitt EC, Kong M, Fouquerel E, Rapić-Otrin V, Prasad R, Watkins SC, Khuu C, Majumdar C, David SS, Wilson SH, Bruchez MP, Opresko PL, Van Houten B. Damage sensor role of UV-DDB during base excision repair. Nat Struct Mol Biol. 2019-08-01;26(8):695-703. doi: 10.1038/s41594-019-0261-7. nihFormattedCitation: Jang S, Kumar N, Beckwitt EC, Kong M, Fouquerel E, Rapić-Otrin V, Prasad R, Watkins SC, Khuu C, Majumdar C, David SS, Wilson SH, Bruchez MP, Opresko PL, Van Houten B. Damage sensor role of UV-DDB during base excision repair. Nat Struct Mol Biol. 2019;26(8):695-703. PMCID: PMC6684372.. PubMed PMID: 31332353; PMCID: PMC6684372.
Fouquerel E, Barnes RP, Uttam S, Watkins SC, Bruchez MP, Opresko PL. Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis. Mol Cell. 2019-07-11;75(1):117-130.e6. doi: 10.1016/j.molcel.2019.04.024. nihFormattedCitation: Fouquerel E, Barnes RP, Uttam S, Watkins SC, Bruchez MP, Opresko PL. Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis. Mol Cell. 2019;75(1):117-130.e6. PMCID: PMC6625854.. PubMed PMID: 31101499; PMCID: PMC6625854.
Liu Y, Ramos-Womack M, Han C, Reilly P, Brackett KL, Rogers W, Williams TM, Andolfatto P, Stern DL, Rebeiz M. Changes throughout a Genetic Network Mask the Contribution of Hox Gene Evolution. Curr Biol. 2019-07-08;29(13):2157-2166.e6. doi: 10.1016/j.cub.2019.05.074. nihFormattedCitation: Liu Y, Ramos-Womack M, Han C, Reilly P, Brackett KL, Rogers W, Williams TM, Andolfatto P, Stern DL, Rebeiz M. Changes throughout a Genetic Network Mask the Contribution of Hox Gene Evolution. Curr Biol. 2019;29(13):2157-2166.e6. PMCID: PMC6624651.. PubMed PMID: 31257142; PMCID: PMC6624651.
Moiseeva TN, Yin Y, Calderon MJ, Qian C, Schamus-Haynes S, Sugitani N, Osmanbeyoglu HU, Rothenberg E, Watkins SC, Bakkenist CJ. An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication. Proc Natl Acad Sci U S A. 2019-07-02;116(27):13374-13383. doi: 10.1073/pnas.1903418116. nihFormattedCitation: Moiseeva TN, Yin Y, Calderon MJ, Qian C, Schamus-Haynes S, Sugitani N, Osmanbeyoglu HU, Rothenberg E, Watkins SC, Bakkenist CJ. An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication. Proc Natl Acad Sci U S A. 2019;116(27):13374-13383. PMCID: PMC6613105.. PubMed PMID: 31209037; PMCID: PMC6613105.
Nechemia-Arbely Y, Miga KH, Shoshani O, Aslanian A, McMahon MA, Lee AY, Fachinetti D, Yates JR 3rd, Ren B, Cleveland DW. DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres. Nat Cell Biol. 2019-06-01;21(6):743-754. doi: 10.1038/s41556-019-0331-4. nihFormattedCitation: Nechemia-Arbely Y, Miga KH, Shoshani O, Aslanian A, McMahon MA, Lee AY, Fachinetti D, Yates JR 3rd, Ren B, Cleveland DW. DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres. Nat Cell Biol. 2019;21(6):743-754. PMCID: PMC7015266.. PubMed PMID: 31160708; PMCID: PMC7015266.
Chen D, Ni HM, Wang L, Ma X, Yu J, Ding WX, Zhang L. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology. 2019-05-01;69(5):2164-2179. doi: 10.1002/hep.30422. nihFormattedCitation: Chen D, Ni HM, Wang L, Ma X, Yu J, Ding WX, Zhang L. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology. 2019;69(5):2164-2179. PMCID: PMC6461480.. PubMed PMID: 30552702; PMCID: PMC6461480.
Ma H, Xu J, Liu Y. WindSTORM: Robust online image processing for high-throughput nanoscopy. Sci Adv. 2019-04-01;5(4):eaaw0683. doi: 10.1126/sciadv.aaw0683. nihFormattedCitation: Ma H, Xu J, Liu Y. WindSTORM: Robust online image processing for high-throughput nanoscopy. Sci Adv. 2019;5(4):eaaw0683. PMCID: PMC6486217.. PubMed PMID: 31032419; PMCID: PMC6486217.
Tan X, Tong J, Wang YJ, Fletcher R, Schoen RE, Yu J, Shen L, Zhang L. BET Inhibitors Potentiate Chemotherapy and Killing of SPOP-Mutant Colon Cancer Cells via Induction of DR5. Cancer Res. 2019-03-15;79(6):1191-1203. doi: 10.1158/0008-5472.CAN-18-3223. nihFormattedCitation: Tan X, Tong J, Wang YJ, Fletcher R, Schoen RE, Yu J, Shen L, Zhang L. BET Inhibitors Potentiate Chemotherapy and Killing of SPOP-Mutant Colon Cancer Cells via Induction of DR5. Cancer Res. 2019;79(6):1191-1203. PMCID: PMC6420862.. PubMed PMID: 30674532; PMCID: PMC6420862.
Clump DA, Pickering CR, Skinner HD. Predicting Outcome in Head and Neck Cancer: miRNAs with Potentially Big Effects. Clin Cancer Res. 2019-03-01;25(5):1441-1442. doi: 10.1158/1078-0432.CCR-18-3078. nihFormattedCitation: Clump DA, Pickering CR, Skinner HD. Predicting Outcome in Head and Neck Cancer: miRNAs with Potentially Big Effects. Clin Cancer Res. 2019;25(5):1441-1442. PMCID: PMC6415532.. PubMed PMID: 30413524; PMCID: PMC6415532.
Wilkinson PD, Delgado ER, Alencastro F, Leek MP, Roy N, Weirich MP, Stahl EC, Otero PA, Chen MI, Brown WK, Duncan AW. The Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice. Hepatology. 2019-03-01;69(3):1242-1258. doi: 10.1002/hep.30286. nihFormattedCitation: Wilkinson PD, Delgado ER, Alencastro F, Leek MP, Roy N, Weirich MP, Stahl EC, Otero PA, Chen MI, Brown WK, Duncan AW. The Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice. Hepatology. 2019;69(3):1242-1258. PMCID: PMC6532408.. PubMed PMID: 30244478; PMCID: PMC6532408.
Steward DL, Carty SE, Sippel RS, Yang SP, Sosa JA, Sipos JA, Figge JJ, Mandel S, Haugen BR, Burman KD, Baloch ZW, Lloyd RV, Seethala RR, Gooding WE, Chiosea SI, Gomes-Lima C, Ferris RL, Folek JM, Khawaja RA, Kundra P, Loh KS, Marshall CB, Mayson S, McCoy KL, Nga ME, Ngiam KY, Nikiforova MN, Poehls JL, Ringel MD, Yang H, Yip L, Nikiforov YE. Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study. JAMA Oncol. 2019-02-01;5(2):204-212. doi: 10.1001/jamaoncol.2018.4616. nihFormattedCitation: Steward DL, Carty SE, Sippel RS, Yang SP, Sosa JA, Sipos JA, Figge JJ, Mandel S, Haugen BR, Burman KD, Baloch ZW, Lloyd RV, Seethala RR, Gooding WE, Chiosea SI, Gomes-Lima C, Ferris RL, Folek JM, Khawaja RA, Kundra P, Loh KS, Marshall CB, Mayson S, McCoy KL, Nga ME, Ngiam KY, Nikiforova MN, Poehls JL, Ringel MD, Yang H, Yip L, Nikiforov YE. Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study. JAMA Oncol. 2019;5(2):204-212. PMCID: PMC6439562.. PubMed PMID: 30419129; PMCID: PMC6439562.
Hopkins BL, Neumann CA. Redoxins as gatekeepers of the transcriptional oxidative stress response. Redox Biol. 2019-02-01;21101104. doi: 10.1016/j.redox.2019.101104. nihFormattedCitation: Hopkins BL, Neumann CA. Redoxins as gatekeepers of the transcriptional oxidative stress response. Redox Biol. 2019;21:101104. PMCID: PMC6351230.. PubMed PMID: 30690320; PMCID: PMC6351230.
Anthonymuthu TS, Kenny EM, Shrivastava I, Tyurina YY, Hier ZE, Ting HC, Dar HH, Tyurin VA, Nesterova A, Amoscato AA, Mikulska-Ruminska K, Rosenbaum JC, Mao G, Zhao J, Conrad M, Kellum JA, Wenzel SE, VanDemark AP, Bahar I, Kagan VE, Bayır H. Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE. J Am Chem Soc. 2018-12-26;140(51):17835-17839. doi: 10.1021/jacs.8b09913. nihFormattedCitation: Anthonymuthu TS, Kenny EM, Shrivastava I, Tyurina YY, Hier ZE, Ting HC, Dar HH, Tyurin VA, Nesterova A, Amoscato AA, Mikulska-Ruminska K, Rosenbaum JC, Mao G, Zhao J, Conrad M, Kellum JA, Wenzel SE, VanDemark AP, Bahar I, Kagan VE, Bayır H. Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE. J Am Chem Soc. 2018;140(51):17835-17839. PMCID: PMC6622169.. PubMed PMID: 30525572; PMCID: PMC6622169.
Teng Y, Yadav T, Duan M, Tan J, Xiang Y, Gao B, Xu J, Liang Z, Liu Y, Nakajima S, Shi Y, Levine AS, Zou L, Lan L. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun. 2018-10-08;9(1):4115. doi: 10.1038/s41467-018-06586-3. nihFormattedCitation: Teng Y, Yadav T, Duan M, Tan J, Xiang Y, Gao B, Xu J, Liang Z, Liu Y, Nakajima S, Shi Y, Levine AS, Zou L, Lan L. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun. 2018;9(1):4115. PMCID: PMC6175878.. PubMed PMID: 30297739; PMCID: PMC6175878.
Dar HH, Tyurina YY, Mikulska-Ruminska K, Shrivastava I, Ting HC, Tyurin VA, Krieger J, St Croix CM, Watkins S, Bayir E, Mao G, Armbruster CR, Kapralov A, Wang H, Parsek MR, Anthonymuthu TS, Ogunsola AF, Flitter BA, Freedman CJ, Gaston JR, Holman TR, Pilewski JM, Greenberger JS, Mallampalli RK, Doi Y, Lee JS, Bahar I, Bomberger JM, Bayır H, Kagan VE. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. J Clin Invest. 2018-10-01;128(10):4639-4653. doi: 10.1172/JCI99490. nihFormattedCitation: Dar HH, Tyurina YY, Mikulska-Ruminska K, Shrivastava I, Ting HC, Tyurin VA, Krieger J, St Croix CM, Watkins S, Bayir E, Mao G, Armbruster CR, Kapralov A, Wang H, Parsek MR, Anthonymuthu TS, Ogunsola AF, Flitter BA, Freedman CJ, Gaston JR, Holman TR, Pilewski JM, Greenberger JS, Mallampalli RK, Doi Y, Lee JS, Bahar I, Bomberger JM, Bayır H, Kagan VE. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. J Clin Invest. 2018;128(10):4639-4653. PMCID: PMC6159971.. PubMed PMID: 30198910; PMCID: PMC6159971.
Vendetti FP, Karukonda P, Clump DA, Teo T, Lalonde R, Nugent K, Ballew M, Kiesel BF, Beumer JH, Sarkar SN, Conrads TP, O'Connor MJ, Ferris RL, Tran PT, Delgoffe GM, Bakkenist CJ. ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation. J Clin Invest. 2018-08-31;128(9):3926-3940. doi: 10.1172/JCI96519. nihFormattedCitation: Vendetti FP, Karukonda P, Clump DA, Teo T, Lalonde R, Nugent K, Ballew M, Kiesel BF, Beumer JH, Sarkar SN, Conrads TP, O'Connor MJ, Ferris RL, Tran PT, Delgoffe GM, Bakkenist CJ. ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation. J Clin Invest. 2018;128(9):3926-3940. PMCID: PMC6118586.. PubMed PMID: 29952768; PMCID: PMC6118586.
Tong J, Zheng X, Tan X, Fletcher R, Nikolovska-Coleska Z, Yu J, Zhang L. Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins. Cancer Res. 2018-08-15;78(16):4704-4715. doi: 10.1158/0008-5472.CAN-18-0399. nihFormattedCitation: Tong J, Zheng X, Tan X, Fletcher R, Nikolovska-Coleska Z, Yu J, Zhang L. Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins. Cancer Res. 2018;78(16):4704-4715. PMCID: PMC6298746.. PubMed PMID: 29895675; PMCID: PMC6298746.
Nikiforov YE, Baloch ZW, Hodak SP, Giordano TJ, Lloyd RV, Seethala RR, Wenig BM. Change in Diagnostic Criteria for Noninvasive Follicular Thyroid Neoplasm With Papillarylike Nuclear Features. JAMA Oncol. 2018-08-01;4(8):1125-1126. doi: 10.1001/jamaoncol.2018.1446. nihFormattedCitation: Nikiforov YE, Baloch ZW, Hodak SP, Giordano TJ, Lloyd RV, Seethala RR, Wenig BM. Change in Diagnostic Criteria for Noninvasive Follicular Thyroid Neoplasm With Papillarylike Nuclear Features. JAMA Oncol. 2018;4(8):1125-1126. PMCID: PMC6584712.. PubMed PMID: 29902314; PMCID: PMC6584712.
Van Houten B, Kad NM. Single-cell mutagenic responses and cell death revealed in real time. Proc Natl Acad Sci U S A. 2018-07-10;115(28):7168-7170. doi: 10.1073/pnas.1808986115. nihFormattedCitation: Van Houten B, Kad NM. Single-cell mutagenic responses and cell death revealed in real time. Proc Natl Acad Sci U S A. 2018;115(28):7168-7170. PMCID: PMC6048557.. PubMed PMID: 29946022; PMCID: PMC6048557.
Watkins SC, St Croix CM. Light sheet imaging comes of age. J Cell Biol. 2018-05-07;217(5):1567-1569. doi: 10.1083/jcb.201804016. nihFormattedCitation: Watkins SC, St Croix CM. Light sheet imaging comes of age. J Cell Biol. 2018;217(5):1567-1569. PMCID: PMC5940317.. PubMed PMID: 29653995; PMCID: PMC5940317.
Preston GM, Guerriero CJ, Metzger MB, Michaelis S, Brodsky JL. Substrate Insolubility Dictates Hsp104-Dependent Endoplasmic-Reticulum-Associated Degradation. Mol Cell. 2018-04-19;70(2):242-253.e6. doi: 10.1016/j.molcel.2018.03.016. nihFormattedCitation: Preston GM, Guerriero CJ, Metzger MB, Michaelis S, Brodsky JL. Substrate Insolubility Dictates Hsp104-Dependent Endoplasmic-Reticulum-Associated Degradation. Mol Cell. 2018;70(2):242-253.e6. PMCID: PMC5912696.. PubMed PMID: 29677492; PMCID: PMC5912696.
Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J, Zhang L. PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A. 2018-04-10;115(15):3930-3935. doi: 10.1073/pnas.1717190115. nihFormattedCitation: Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J, Zhang L. PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A. 2018;115(15):3930-3935. PMCID: PMC5899441.. PubMed PMID: 29581256; PMCID: PMC5899441.
Fletcher R, Wang YJ, Schoen RE, Finn OJ, Yu J, Zhang L. Colorectal cancer prevention: Immune modulation taking the stage. Biochim Biophys Acta Rev Cancer. 2018-04-01;1869(2):138-148. doi: 10.1016/j.bbcan.2017.12.002. nihFormattedCitation: Fletcher R, Wang YJ, Schoen RE, Finn OJ, Yu J, Zhang L. Colorectal cancer prevention: Immune modulation taking the stage. Biochim Biophys Acta Rev Cancer. 2018;1869(2):138-148. PMCID: PMC5955808.. PubMed PMID: 29391185; PMCID: PMC5955808.
Efanov AA, Brenner AV, Bogdanova TI, Kelly LM, Liu P, Little MP, Wald AI, Hatch M, Zurnadzy LY, Nikiforova MN, Drozdovitch V, Leeman-Neill R, Mabuchi K, Tronko MD, Chanock SJ, Nikiforov YE. Investigation of the Relationship Between Radiation Dose and Gene Mutations and Fusions in Post-Chernobyl Thyroid Cancer. J Natl Cancer Inst. 2018-04-01;110(4):371-378. doi: 10.1093/jnci/djx209. nihFormattedCitation: Efanov AA, Brenner AV, Bogdanova TI, Kelly LM, Liu P, Little MP, Wald AI, Hatch M, Zurnadzy LY, Nikiforova MN, Drozdovitch V, Leeman-Neill R, Mabuchi K, Tronko MD, Chanock SJ, Nikiforov YE. Investigation of the Relationship Between Radiation Dose and Gene Mutations and Fusions in Post-Chernobyl Thyroid Cancer. J Natl Cancer Inst. 2018;110(4):371-378. PMCID: PMC6059206.. PubMed PMID: 29165687; PMCID: PMC6059206.
Leibowitz BJ, Yang L, Wei L, Buchanan ME, Rachid M, Parise RA, Beumer JH, Eiseman JL, Schoen RE, Zhang L, Yu J. Targeting p53-dependent stem cell loss for intestinal chemoprotection. Sci Transl Med. 2018-02-07;10(427): doi: 10.1126/scitranslmed.aam7610. nihFormattedCitation: Leibowitz BJ, Yang L, Wei L, Buchanan ME, Rachid M, Parise RA, Beumer JH, Eiseman JL, Schoen RE, Zhang L, Yu J. Targeting p53-dependent stem cell loss for intestinal chemoprotection. Sci Transl Med. 2018;10(427). PMCID: PMC5827930.. PubMed PMID: 29437148; PMCID: PMC5827930.
Liu L, Kong M, Gassman NR, Freudenthal BD, Prasad R, Zhen S, Watkins SC, Wilson SH, Van Houten B. PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1. Nucleic Acids Res. 2017-12-15;45(22):12834-12847. doi: 10.1093/nar/gkx1047. nihFormattedCitation: Liu L, Kong M, Gassman NR, Freudenthal BD, Prasad R, Zhen S, Watkins SC, Wilson SH, Van Houten B. PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1. Nucleic Acids Res. 2017;45(22):12834-12847. PMCID: PMC5728402.. PubMed PMID: 29121337; PMCID: PMC5728402.
Moiseeva T, Hood B, Schamus S, O'Connor MJ, Conrads TP, Bakkenist CJ. ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1. Nat Commun. 2017-11-09;8(1):1392. doi: 10.1038/s41467-017-01401-x. nihFormattedCitation: Moiseeva T, Hood B, Schamus S, O'Connor MJ, Conrads TP, Bakkenist CJ. ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1. Nat Commun. 2017;8(1):1392. PMCID: PMC5680267.. PubMed PMID: 29123096; PMCID: PMC5680267.
Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell. 2017-10-19;171(3):628-641.e26. doi: 10.1016/j.cell.2017.09.044. nihFormattedCitation: Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell. 2017;171(3):628-641.e26. PMCID: PMC5683852.. PubMed PMID: 29053969; PMCID: PMC5683852.
Sun Z, Brodsky JL. Guardians of the ERAD Galaxy. Cell. 2017-10-05;171(2):267-268. doi: 10.1016/j.cell.2017.09.023. nihFormattedCitation: Sun Z, Brodsky JL. Guardians of the ERAD Galaxy. Cell. 2017;171(2):267-268.. PubMed PMID: 28985557.
Beckwitt EC, Van Houten B. Molecular cartography of mutational landscapes in melanomas. EMBO J. 2017-10-02;36(19):2812-2814. doi: 10.15252/embj.201797944. nihFormattedCitation: Beckwitt EC, Van Houten B. Molecular cartography of mutational landscapes in melanomas. EMBO J. 2017;36(19):2812-2814. PMCID: PMC5623845.. PubMed PMID: 28931563; PMCID: PMC5623845.
Van Oss SB, Cucinotta CE, Arndt KM. Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation. Trends Biochem Sci. 2017-10-01;42(10):788-798. doi: 10.1016/j.tibs.2017.08.003. nihFormattedCitation: Van Oss SB, Cucinotta CE, Arndt KM. Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation. Trends Biochem Sci. 2017;42(10):788-798. PMCID: PMC5658044.. PubMed PMID: 28870425; PMCID: PMC5658044.
Gao Y, Li C, Wei L, Teng Y, Nakajima S, Chen X, Xu J, Leger B, Ma H, Spagnol ST, Wan Y, Dahl KN, Liu Y, Levine AS, Lan L. SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming. Cancer Res. 2017-05-15;77(10):2674-2685. doi: 10.1158/0008-5472.CAN-16-3128. nihFormattedCitation: Gao Y, Li C, Wei L, Teng Y, Nakajima S, Chen X, Xu J, Leger B, Ma H, Spagnol ST, Wan Y, Dahl KN, Liu Y, Levine AS, Lan L. SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming. Cancer Res. 2017;77(10):2674-2685. PMCID: PMC5500382.. PubMed PMID: 28416484; PMCID: PMC5500382.
Tong J, Wang P, Tan S, Chen D, Nikolovska-Coleska Z, Zou F, Yu J, Zhang L. Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017-05-01;77(9):2512-2521. doi: 10.1158/0008-5472.CAN-16-3242. nihFormattedCitation: Tong J, Wang P, Tan S, Chen D, Nikolovska-Coleska Z, Zou F, Yu J, Zhang L. Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017;77(9):2512-2521. PMCID: PMC5626525.. PubMed PMID: 28202514; PMCID: PMC5626525.
Yang L, Sun L, Teng Y, Chen H, Gao Y, Levine AS, Nakajima S, Lan L. Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage. Nucleic Acids Res. 2017-04-20;45(7):3906-3921. doi: 10.1093/nar/gkx083. nihFormattedCitation: Yang L, Sun L, Teng Y, Chen H, Gao Y, Levine AS, Nakajima S, Lan L. Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage. Nucleic Acids Res. 2017;45(7):3906-3921. PMCID: PMC5397190.. PubMed PMID: 28160604; PMCID: PMC5397190.
Sun L, Nakajima S, Teng Y, Chen H, Yang L, Chen X, Gao B, Levine AS, Lan L. WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1. Nucleic Acids Res. 2017-04-20;45(7):3844-3859. doi: 10.1093/nar/gkx065. nihFormattedCitation: Sun L, Nakajima S, Teng Y, Chen H, Yang L, Chen X, Gao B, Levine AS, Lan L. WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1. Nucleic Acids Res. 2017;45(7):3844-3859. PMCID: PMC5397154.. PubMed PMID: 28158503; PMCID: PMC5397154.
