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Research

Home › 2022 Research Highlights

2022 Research Highlights

Your input is important in helping to select 3-5 research publications that best represent the impact of UPMC Hillman Cancer Center over the past year.

Name*
Which of the following 3-5 research publications best represent the impact of our cancer center over the past year?*
Limit your selection to no more than 5 and remember to consider diversity of research and researchers in your selection.
- Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer Immunity, Dec 2021
- Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing Nature Comm, Dec 2021
- Naive T-cell depletion to prevent chronic graft-versus-host disease J Clin Oncol, Jan 2022
- Improved prognosis and evidence of enhanced immunogenicity in tumor and circulation of high-risk melanoma patients with unknown primary J Immunother Cancer, Jan 2022
- Effects of the WRITE symptoms intervention on symptoms and quality of life among patients with recurrent ovarian cancers: An NRG Oncology/GOG study (GOG 0529) J Clin. Oncol., Feb 2022
- Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins Nat Commun, Feb 2022
- Patterns and trends in receipt of opioids among patients receiving treatment for cancer in a large health system JNCCN, Mar 2022
- Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1 Nature Med, Mar 2022
- Ultrastructural visualization of chromatin in cancer pathogenesis using a simple small-molecule fluorescent probe Sci Adv Mar 2022
- Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome Nat Cancer, Apr 2022
- ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation Nat Commun, Apr 2022
- Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial Lancet, Apr 2022
- A retrospective analysis of the impact of the COVID-19 pandemic on staging at presentation of patients with invasive melanoma J Am Acad Dermatol, May 2022
- Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening Nature Structural & Molecular Biology, June 2022
- Adaptive dynamic therapy and survivorship for operable pancreatic cancer JAMA Netw Open, June 2022
- HuR-dependent SOD2 protein synthesis is an early adaption to anchorage-independence Redox Biology, July 2022
- Counting advanced precancerous lesions as true positives when determining colorectal cancer screening test specificity J Natl Cancer Inst, July 2022
- Tumor microenvironment signals reshape chromatin landscapes to limit the functional potential of exhausted T cells Sci Immunol, Aug 2022
- Sensory nerves impede the formation of tertiary lymphoid structures and development of protective antimelanoma immune responses Cancer Immunol Res, Sept 2022
- Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-a/b expression Cell Reports, Sept 2022
- Phase I trial of ribociclib with platinum chemotherapy in ovarian cancer JCI Insight, Sept 2022
- Ewing sarcoma and osteosarcoma have distinct immune signatures and intercellular communication networks Clin Cancer Res, Sept 2022
- Serological profiling using an Epstein-Barr virus mammalian expression library identifies EBNA1 IgA as a pre-diagnostic marker for nasopharyngeal carcinoma Clin Cancer Res, Sept 2022
- Combination dabrafenib and trametinib versus combination nivolumab and ipilimumab for patients with advanced BRAF-mutant melanoma: The DREAMseq Trial―ECOG-ACRIN EA6134 Journal of Clinical Oncology, Oct 2022.
- RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA Molecular Cell, Oct 2022.
- Prospective, multi-institutional, real-time next-generation sequencing of pancreatic cyst fluid reveals diverse genomic alterations that improve the clinical management of pancreatic cysts. Gastroenterology, Oct 2022.
- Interpretable deep learning for chromatin-informed inference of transcriptional programs driven by somatic alterations across cancers Nucleic Acids Research, Oct 2022.
If there are other research publications you think should be included to highlight the work across our cancer center, please provide the citation and link to the publication.

2022 Research Highlights

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