Oncology Data Services offers extensive support for data management and database development across clinical and translational research initiatives. We leverage the substantial data assets of the Hillman Cancer Center and UPMC to provide expert consultation on data acquisition and management. By aligning with researchers’ distinct requirements, we streamline access to pertinent data sources. Our robust database management methodology integrates data standards and harmonization practices, upholding data quality and consistency in accordance with FAIR principles. This systematic approach facilitates the creation of specialized disease registries and optimized pipelines for data sharing and analysis, thereby contributing to impactful research outcomes.