Selected Member Publications

Lotze MT, Olejniczak SH, Skokos D. CD28 co-stimulation: novel insights and applications in cancer immunotherapy. Nat Rev Immunol. 2024-12-01; doi: 10.1038/s41577-024-01061-1. nihFormattedCitation: Lotze MT, Olejniczak SH, Skokos D. CD28 co-stimulation: novel insights and applications in cancer immunotherapy. Nat Rev Immunol. 2024;. PMCID: PMC11598642.. PubMed PMID: 39054343; PMCID: PMC11598642.
Peralta RM, Xie B, Lontos K, Nieves-Rosado H, Spahr K, Joshi S, Ford BR, Quann K, Frisch AT, Dean V, Philbin M, Cillo AR, Gingras S, Poholek AC, Kane LP, Rivadeneira DB, Delgoffe GM. Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism. Nat Immunol. 2024-12-01; doi: 10.1038/s41590-024-01999-3. nihFormattedCitation: Peralta RM, Xie B, Lontos K, Nieves-Rosado H, Spahr K, Joshi S, Ford BR, Quann K, Frisch AT, Dean V, Philbin M, Cillo AR, Gingras S, Poholek AC, Kane LP, Rivadeneira DB, Delgoffe GM. Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism. Nat Immunol. 2024;. PMCID: PMC11588660.. PubMed PMID: 39516648; PMCID: PMC11588660.
Adam K, Butler SC, Workman CJ, Vignali DAA. Advances in LAG3 cancer immunotherapeutics. Trends Cancer. 2024-11-26; doi: 10.1016/j.trecan.2024.10.009. nihFormattedCitation: Adam K, Butler SC, Workman CJ, Vignali DAA. Advances in LAG3 cancer immunotherapeutics. Trends Cancer. 2024;.. PubMed PMID: 39603977.
Davar D, Carneiro BA, Dy GK, Sheth S, Borad MJ, Harrington KJ, Patel SP, Galanis E, Samson A, Agrawal S, Chen Z, Fan C, Gong M, Burton J, Tu E, Durham N, Laubscher K, Arnaldez F, Zamarin D. Phase I study of a recombinant attenuated oncolytic virus, MEDI5395 (NDV-GM-CSF), administered systemically in combination with durvalumab in patients with advanced solid tumors. J Immunother Cancer. 2024-11-17;12(11): doi: 10.1136/jitc-2024-009336. nihFormattedCitation: Davar D, Carneiro BA, Dy GK, Sheth S, Borad MJ, Harrington KJ, Patel SP, Galanis E, Samson A, Agrawal S, Chen Z, Fan C, Gong M, Burton J, Tu E, Durham N, Laubscher K, Arnaldez F, Zamarin D. Phase I study of a recombinant attenuated oncolytic virus, MEDI5395 (NDV-GM-CSF), administered systemically in combination with durvalumab in patients with advanced solid tumors. J Immunother Cancer. 2024;12(11). PMCID: PMC11574399.. PubMed PMID: 39551600; PMCID: PMC11574399.
Karapetyan L, Li A, Vargas De Stefano D, Abushukair HM, Al-Bzour AN, Knight A, Layding C, Wang H, Xu J, Yao J, Song X, Joy M, Nguyen J, Moran-Segura C, Bruno S, Sander C, Messina J, Mule JJ, Storkus WJ, Kirkwood JM. Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas. J Immunother Cancer. 2024-11-12;12(11): doi: 10.1136/jitc-2024-009231. nihFormattedCitation: Karapetyan L, Li A, Vargas De Stefano D, Abushukair HM, Al-Bzour AN, Knight A, Layding C, Wang H, Xu J, Yao J, Song X, Joy M, Nguyen J, Moran-Segura C, Bruno S, Sander C, Messina J, Mule JJ, Storkus WJ, Kirkwood JM. Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas. J Immunother Cancer. 2024;12(11). PMCID: PMC11575263.. PubMed PMID: 39537211; PMCID: PMC11575263.
Davar D, Morrison RM, Dzutsev AK, Karunamurthy A, Chauvin JM, Amatore F, Deutsch JS, Das Neves RX, Rodrigues RR, McCulloch JA, Wang H, Hartman DJ, Badger JH, Fernandes MR, Bai Y, Sun J, Cole AM, Aggarwal P, Fang JR, Deitrick C, Bao R, Duvvuri U, Sridharan SS, Kim SW, A Choudry H, Holtzman MP, Pingpank JF, O'Toole JP, DeBlasio R, Jin Y, Ding Q, Gao W, Groetsch C, Pagliano O, Rose A, Urban C, Singh J, Divarkar P, Mauro D, Bobilev D, Wooldridge J, Krieg AM, Fury MG, Whiteaker JR, Zhao L, Paulovich AG, Najjar YG, Luke JJ, Kirkwood JM, Taube JM, Park HJ, Trinchieri G, Zarour HM. Neoadjuvant vidutolimod and nivolumab in high-risk resectable melanoma: A prospective phase II trial. Cancer Cell. 2024-11-11; doi: 10.1016/j.ccell.2024.10.007. nihFormattedCitation: Davar D, Morrison RM, Dzutsev AK, Karunamurthy A, Chauvin JM, Amatore F, Deutsch JS, Das Neves RX, Rodrigues RR, McCulloch JA, Wang H, Hartman DJ, Badger JH, Fernandes MR, Bai Y, Sun J, Cole AM, Aggarwal P, Fang JR, Deitrick C, Bao R, Duvvuri U, Sridharan SS, Kim SW, A Choudry H, Holtzman MP, Pingpank JF, O'Toole JP, DeBlasio R, Jin Y, Ding Q, Gao W, Groetsch C, Pagliano O, Rose A, Urban C, Singh J, Divarkar P, Mauro D, Bobilev D, Wooldridge J, Krieg AM, Fury MG, Whiteaker JR, Zhao L, Paulovich AG, Najjar YG, Luke JJ, Kirkwood JM, Taube JM, Park HJ, Trinchieri G, Zarour HM. Neoadjuvant vidutolimod and nivolumab in high-risk resectable melanoma: A prospective phase II trial. Cancer Cell. 2024;. PMCID: PMC11560503.. PubMed PMID: 39486411; PMCID: PMC11560503.
MacFawn IP, Magnon G, Gorecki G, Kunning S, Rashid R, Kaiza ME, Atiya H, Ruffin AT, Taylor S, Soong TR, Bao R, Coffman LG, Bruno TC. The activity of tertiary lymphoid structures in high grade serous ovarian cancer is governed by site, stroma, and cellular interactions. Cancer Cell. 2024-11-11; doi: 10.1016/j.ccell.2024.09.007. nihFormattedCitation: MacFawn IP, Magnon G, Gorecki G, Kunning S, Rashid R, Kaiza ME, Atiya H, Ruffin AT, Taylor S, Soong TR, Bao R, Coffman LG, Bruno TC. The activity of tertiary lymphoid structures in high grade serous ovarian cancer is governed by site, stroma, and cellular interactions. Cancer Cell. 2024;.. PubMed PMID: 39393357.
Hamze Sinno S, Imperatore JA, Bai S, Gomes-Jourdan N, Mafarachisi N, Coronnello C, Zhang L, Jašarević E, Osmanbeyoglu HU, Buckanovich RJ, Cascio S. Egfl6 promotes ovarian cancer progression by enhancing the immunosuppressive functions of tumor-associated myeloid cells. J Clin Invest. 2024-11-01; doi: 10.1172/JCI175147. nihFormattedCitation: Hamze Sinno S, Imperatore JA, Bai S, Gomes-Jourdan N, Mafarachisi N, Coronnello C, Zhang L, Jašarević E, Osmanbeyoglu HU, Buckanovich RJ, Cascio S. Egfl6 promotes ovarian cancer progression by enhancing the immunosuppressive functions of tumor-associated myeloid cells. J Clin Invest. 2024;. PMCID: PMC11527450.. PubMed PMID: 39312740; PMCID: PMC11527450.
Mowery YM, Luke JJ. NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance. Clin Cancer Res. 2024-09-13; doi: 10.1158/1078-0432.CCR-24-1363. nihFormattedCitation: Mowery YM, Luke JJ. NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance. Clin Cancer Res. 2024;. PMCID: PMC11398986.. PubMed PMID: 39007757; PMCID: PMC11398986.
Luke JJ, Hamid O, Fox BA, Ascierto PA, Osman I, Mule JJ, Romero PJ, Lotze MT. Jeffrey S Weber, MD, PhD (1952-2024): in memoriam to discovery, friendship and family. J Immunother Cancer. 2024-09-10;12(9): doi: 10.1136/jitc-2024-010464. nihFormattedCitation: Luke JJ, Hamid O, Fox BA, Ascierto PA, Osman I, Mule JJ, Romero PJ, Lotze MT. Jeffrey S Weber, MD, PhD (1952-2024): in memoriam to discovery, friendship and family. J Immunother Cancer. 2024;12(9).. PubMed PMID: 39260827.
Cillo AR, Kirkwood JM. Assessing clonal changes in T cells over time following immunotherapy is a breeze with Cyclone. Cancer Cell. 2024-09-09;42(9):1491-1493. doi: 10.1016/j.ccell.2024.08.014. nihFormattedCitation: Cillo AR, Kirkwood JM. Assessing clonal changes in T cells over time following immunotherapy is a breeze with Cyclone. Cancer Cell. 2024;42(9):1491-1493.. PubMed PMID: 39255774.
DePeaux K, Gunn WG, Rivadeneira DB, Delgoffe GM. Treatment with oncolytic vaccinia virus infects tumor-infiltrating regulatory and exhausted T cells. J Immunother Cancer. 2024-08-17;12(8): doi: 10.1136/jitc-2024-009062. nihFormattedCitation: DePeaux K, Gunn WG, Rivadeneira DB, Delgoffe GM. Treatment with oncolytic vaccinia virus infects tumor-infiltrating regulatory and exhausted T cells. J Immunother Cancer. 2024;12(8). PMCID: PMC11331848.. PubMed PMID: 39153823; PMCID: PMC11331848.
Cavalcante L, Chandana S, Lakhani N, Enstrom A, LeBlanc H, Schmalz J, Lengyel K, Schneider F, Thomas H, Chisamore MJ, Peng SL, Naumovski A, Davar D. Case report of fatal immune-mediated myocarditis following treatment with davoceticept (ALPN-202), a PD-L1-dependent CD28 costimulator and dual PD-L1/CTLA-4 checkpoint inhibitor, in combination with pembrolizumab. J Immunother Cancer. 2024-08-13;12(8): doi: 10.1136/jitc-2024-009475. nihFormattedCitation: Cavalcante L, Chandana S, Lakhani N, Enstrom A, LeBlanc H, Schmalz J, Lengyel K, Schneider F, Thomas H, Chisamore MJ, Peng SL, Naumovski A, Davar D. Case report of fatal immune-mediated myocarditis following treatment with davoceticept (ALPN-202), a PD-L1-dependent CD28 costimulator and dual PD-L1/CTLA-4 checkpoint inhibitor, in combination with pembrolizumab. J Immunother Cancer. 2024;12(8). PMCID: PMC11337706.. PubMed PMID: 39142718; PMCID: PMC11337706.
Cillo AR, Cardello C, Shan F, Karapetyan L, Kunning S, Sander C, Rush E, Karunamurthy A, Massa RC, Rohatgi A, Workman CJ, Kirkwood JM, Bruno TC, Vignali DAA. Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8(+) T cells to promote antitumor immunity. Cell. 2024-08-08;187(16):4373-4388.e15. doi: 10.1016/j.cell.2024.06.036. nihFormattedCitation: Cillo AR, Cardello C, Shan F, Karapetyan L, Kunning S, Sander C, Rush E, Karunamurthy A, Massa RC, Rohatgi A, Workman CJ, Kirkwood JM, Bruno TC, Vignali DAA. Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8(+) T cells to promote antitumor immunity. Cell. 2024;187(16):4373-4388.e15. PMCID: PMC11346583.. PubMed PMID: 39121849; PMCID: PMC11346583.
Andrews LP, Butler SC, Cui J, Cillo AR, Cardello C, Liu C, Brunazzi EA, Baessler A, Xie B, Kunning SR, Ngiow SF, Huang YJ, Manne S, Sharpe AH, Delgoffe GM, Wherry EJ, Kirkwood JM, Bruno TC, Workman CJ, Vignali DAA. LAG-3 and PD-1 synergize on CD8(+) T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity. Cell. 2024-08-08;187(16):4355-4372.e22. doi: 10.1016/j.cell.2024.07.016. nihFormattedCitation: Andrews LP, Butler SC, Cui J, Cillo AR, Cardello C, Liu C, Brunazzi EA, Baessler A, Xie B, Kunning SR, Ngiow SF, Huang YJ, Manne S, Sharpe AH, Delgoffe GM, Wherry EJ, Kirkwood JM, Bruno TC, Workman CJ, Vignali DAA. LAG-3 and PD-1 synergize on CD8(+) T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity. Cell. 2024;187(16):4355-4372.e22. PMCID: PMC11323044.. PubMed PMID: 39121848; PMCID: PMC11323044.
Davar D, Cavalcante L, Lakhani N, Moser J, Millward M, McKean M, Voskoboynik M, Sanborn RE, Grewal JS, Narayan A, Patnaik A, Gainor JF, Sznol M, Enstrom A, Blanchfield L, LeBlanc H, Thomas H, Chisamore MJ, Peng SL, Naumovski A. Phase I studies of davoceticept (ALPN-202), a PD-L1-dependent CD28 co-stimulator and dual PD-L1/CTLA-4 inhibitor, as monotherapy and in combination with pembrolizumab in advanced solid tumors (NEON-1 and NEON-2). J Immunother Cancer. 2024-08-03;12(8): doi: 10.1136/jitc-2024-009474. nihFormattedCitation: Davar D, Cavalcante L, Lakhani N, Moser J, Millward M, McKean M, Voskoboynik M, Sanborn RE, Grewal JS, Narayan A, Patnaik A, Gainor JF, Sznol M, Enstrom A, Blanchfield L, LeBlanc H, Thomas H, Chisamore MJ, Peng SL, Naumovski A. Phase I studies of davoceticept (ALPN-202), a PD-L1-dependent CD28 co-stimulator and dual PD-L1/CTLA-4 inhibitor, as monotherapy and in combination with pembrolizumab in advanced solid tumors (NEON-1 and NEON-2). J Immunother Cancer. 2024;12(8). PMCID: PMC11344531.. PubMed PMID: 39097413; PMCID: PMC11344531.
Lotze MT, Maeurer M, Quezada SA, Coukos G. Lung Cancer Adoptive Cell Therapy: Inspiring TIL ACT Comes Center Stage. Cancer Discov. 2024-08-02;14(8):1366-1368. doi: 10.1158/2159-8290.CD-24-0645. nihFormattedCitation: Lotze MT, Maeurer M, Quezada SA, Coukos G. Lung Cancer Adoptive Cell Therapy: Inspiring TIL ACT Comes Center Stage. Cancer Discov. 2024;14(8):1366-1368.. PubMed PMID: 39091204.
Lee AH, Randhawa SK, Meisel M. Dietary commensal wrestles iron from tumor microenvironment to activate antitumoral macrophages. Cancer Res. 2024-08-01; doi: 10.1158/0008-5472.CAN-24-1833. nihFormattedCitation: Lee AH, Randhawa SK, Meisel M. Dietary commensal wrestles iron from tumor microenvironment to activate antitumoral macrophages. Cancer Res. 2024;. PMCID: PMC11552448.. PubMed PMID: 38832925; PMCID: PMC11552448.
Ghosh CC, Cournoyer L, Liu Y, Ballarin A, Layman IB, LaPorte J, Morrissey M, Fraser K, Perati S, Cox BF, Yakirevich E, Treaba DO, Murtha TD, Guha P, Katz SC, Davar D. Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myeloid-derived suppressor cells and control of liver metastases. J Immunother Cancer. 2024-07-22;12(7): doi: 10.1136/jitc-2024-008837. nihFormattedCitation: Ghosh CC, Cournoyer L, Liu Y, Ballarin A, Layman IB, LaPorte J, Morrissey M, Fraser K, Perati S, Cox BF, Yakirevich E, Treaba DO, Murtha TD, Guha P, Katz SC, Davar D. Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myeloid-derived suppressor cells and control of liver metastases. J Immunother Cancer. 2024;12(7). PMCID: PMC11268044.. PubMed PMID: 39038918; PMCID: PMC11268044.
van der Burg SH, Lotze MT. Perspectives from the leadership of Journal for ImmunoTherapy of Cancer. J Immunother Cancer. 2024-06-19;12(6): doi: 10.1136/jitc-2024-009661. nihFormattedCitation: van der Burg SH, Lotze MT. Perspectives from the leadership of Journal for ImmunoTherapy of Cancer. J Immunother Cancer. 2024;12(6). PMCID: PMC11191768.. PubMed PMID: 38901880; PMCID: PMC11191768.
Shao L, Srivastava R, Delgoffe GM, Thorne SH, Sarkar SN. An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T cells and Promotes Tumor Clearance. Cancer Immunol Res. 2024-06-04; doi: 10.1158/2326-6066.CIR-23-0573. nihFormattedCitation: Shao L, Srivastava R, Delgoffe GM, Thorne SH, Sarkar SN. An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T cells and Promotes Tumor Clearance. Cancer Immunol Res. 2024;. PMCID: PMC11150089.. PubMed PMID: 38517470; PMCID: PMC11150089.
Maleki Vareki S, Davar D. Identification of dynamic microbiota signatures in patients with melanoma receiving ICIs: opportunities and challenges. Nat Rev Clin Oncol. 2024-06-01; doi: 10.1038/s41571-024-00882-2. nihFormattedCitation: Maleki Vareki S, Davar D. Identification of dynamic microbiota signatures in patients with melanoma receiving ICIs: opportunities and challenges. Nat Rev Clin Oncol. 2024;.. PubMed PMID: 38509333.
Butterfield LH, Najjar YG. Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations. Nat Rev Immunol. 2024-06-01; doi: 10.1038/s41577-023-00973-8. nihFormattedCitation: Butterfield LH, Najjar YG. Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations. Nat Rev Immunol. 2024;. PMCID: PMC11460566.. PubMed PMID: 38057451; PMCID: PMC11460566.
Baessler A, Vignali DAA. T Cell Exhaustion. Annu Rev Immunol. 2024-06-01; doi: 10.1146/annurev-immunol-090222-110914. nihFormattedCitation: Baessler A, Vignali DAA. T Cell Exhaustion. Annu Rev Immunol. 2024;.. PubMed PMID: 38166256.
Luke JJ, Ascierto PA, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Long GV. Pembrolizumab Versus Placebo as Adjuvant Therapy in Resected Stage IIB or IIC Melanoma: Final Analysis of Distant Metastasis-Free Survival in the Phase III KEYNOTE-716 Study. J Clin Oncol. 2024-05-10;JCO2302355. doi: 10.1200/JCO.23.02355. nihFormattedCitation: Luke JJ, Ascierto PA, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Long GV. Pembrolizumab Versus Placebo as Adjuvant Therapy in Resected Stage IIB or IIC Melanoma: Final Analysis of Distant Metastasis-Free Survival in the Phase III KEYNOTE-716 Study. J Clin Oncol. 2024;:JCO2302355. PMCID: PMC11095869.. PubMed PMID: 38452313; PMCID: PMC11095869.
Mangla A, Lee C, Mirsky MM, Wang M, Rothermel LD, Hoehn R, Bordeaux JS, Carrol BT, Theuner J, Li S, Fu P, Kirkwood JM. Neoadjuvant Dual Checkpoint Inhibitors vs Anti-PD1 Therapy in High-Risk Resectable Melanoma: A Pooled Analysis. JAMA Oncol. 2024-05-01; doi: 10.1001/jamaoncol.2023.7333. nihFormattedCitation: Mangla A, Lee C, Mirsky MM, Wang M, Rothermel LD, Hoehn R, Bordeaux JS, Carrol BT, Theuner J, Li S, Fu P, Kirkwood JM. Neoadjuvant Dual Checkpoint Inhibitors vs Anti-PD1 Therapy in High-Risk Resectable Melanoma: A Pooled Analysis. JAMA Oncol. 2024;. PMCID: PMC10979364.. PubMed PMID: 38546551; PMCID: PMC10979364.
Vignali PDA, Luke JJ. Unraveling the therapeutic benefit of sequenced chemo-immunotherapy. Clin Cancer Res. 2024-05-01; doi: 10.1158/1078-0432.CCR-23-3736. nihFormattedCitation: Vignali PDA, Luke JJ. Unraveling the therapeutic benefit of sequenced chemo-immunotherapy. Clin Cancer Res. 2024;. PMCID: PMC11062819.. PubMed PMID: 38372597; PMCID: PMC11062819.
Luke JJ, Davar D, Andtbacka RH, Bhardwaj N, Brody JD, Chesney J, Coffin R, de Baere T, de Gruijl TD, Fury M, Goldmacher G, Harrington KJ, Kaufman H, Kelly CM, Khilnani AD, Liu K, Loi S, Long GV, Melero I, Middleton M, Neyns B, Pinato DJ, Sheth RA, Solomon SB, Szapary P, Marabelle A. Society for Immunotherapy of Cancer (SITC) recommendations on intratumoral immunotherapy clinical trials (IICT): from premalignant to metastatic disease. J Immunother Cancer. 2024-04-18;12(4): doi: 10.1136/jitc-2023-008378. nihFormattedCitation: Luke JJ, Davar D, Andtbacka RH, Bhardwaj N, Brody JD, Chesney J, Coffin R, de Baere T, de Gruijl TD, Fury M, Goldmacher G, Harrington KJ, Kaufman H, Kelly CM, Khilnani AD, Liu K, Loi S, Long GV, Melero I, Middleton M, Neyns B, Pinato DJ, Sheth RA, Solomon SB, Szapary P, Marabelle A. Society for Immunotherapy of Cancer (SITC) recommendations on intratumoral immunotherapy clinical trials (IICT): from premalignant to metastatic disease. J Immunother Cancer. 2024;12(4). PMCID: PMC11029323.. PubMed PMID: 38641350; PMCID: PMC11029323.
Leonard-Murali S, Bhaskarla C, Yadav GS, Maurya SK, Galiveti CR, Tobin JA, Kann RJ, Ashwat E, Murphy PS, Chakka AB, Soman V, Cantalupo PG, Zhuo X, Vyas G, Kozak DL, Kelly LM, Smith E, Chandran UR, Hsu YS, Kammula US. Uveal melanoma immunogenomics predict immunotherapy resistance and susceptibility. Nat Commun. 2024-04-16;15(1):2863. doi: 10.1038/s41467-024-46906-4. nihFormattedCitation: Leonard-Murali S, Bhaskarla C, Yadav GS, Maurya SK, Galiveti CR, Tobin JA, Kann RJ, Ashwat E, Murphy PS, Chakka AB, Soman V, Cantalupo PG, Zhuo X, Vyas G, Kozak DL, Kelly LM, Smith E, Chandran UR, Hsu YS, Kammula US. Uveal melanoma immunogenomics predict immunotherapy resistance and susceptibility. Nat Commun. 2024;15(1):2863. PMCID: PMC11021475.. PubMed PMID: 38627362; PMCID: PMC11021475.
Sitc S, Lotze MT, Cottrell T, Bifulco C, Chow L, Cope L, Gnjatic S, Maecker HT, Yeong Poh Shen J. SITC Clinical Immuno-Oncology Network (SCION) commentary on measurement and interpretation of essential biomarkers in early clinical trials. J Immunother Cancer. 2024-03-21;12(3): doi: 10.1136/jitc-2023-008655. nihFormattedCitation: Sitc S, Lotze MT, Cottrell T, Bifulco C, Chow L, Cope L, Gnjatic S, Maecker HT, Yeong Poh Shen J. SITC Clinical Immuno-Oncology Network (SCION) commentary on measurement and interpretation of essential biomarkers in early clinical trials. J Immunother Cancer. 2024;12(3). PMCID: PMC10961490.. PubMed PMID: 38519056; PMCID: PMC10961490.
DePeaux K, Delgoffe GM. Integrating innate and adaptive immunity in oncolytic virus therapy. Trends Cancer. 2024-02-01; doi: 10.1016/j.trecan.2023.09.012. nihFormattedCitation: DePeaux K, Delgoffe GM. Integrating innate and adaptive immunity in oncolytic virus therapy. Trends Cancer. 2024;. PMCID: PMC10922271.. PubMed PMID: 37880008; PMCID: PMC10922271.
Wilfahrt D, Delgoffe GM. Metabolic waypoints during T cell differentiation. Nat Immunol. 2024-02-01; doi: 10.1038/s41590-023-01733-5. nihFormattedCitation: Wilfahrt D, Delgoffe GM. Metabolic waypoints during T cell differentiation. Nat Immunol. 2024;.. PubMed PMID: 38238609.
Casillo SM, Gatesman TA, Chilukuri A, Varadharajan S, Johnson BJ, David Premkumar DR, Jane EP, Plute TJ, Koncar RF, Stanton AJ, Biagi-Junior CAO, Barber CS, Halbert ME, Golbourn BJ, Halligan K, Cruz AF, Mansi NM, Cheney A, Mullett SJ, Land CV, Perez JL, Myers MI, Agrawal N, Michel JJ, Chang YF, Vaske OM, MichaelRaj A, Lieberman FS, Felker J, Shiva S, Bertrand KC, Amankulor N, Hadjipanayis CG, Abdullah KG, Zinn PO, Friedlander RM, Abel TJ, Nazarian J, Venneti S, Filbin MG, Gelhaus SL, Mack SC, Pollack IF, Agnihotri S. An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma. Cell Rep. 2024-01-23;43(1):113557. doi: 10.1016/j.celrep.2023.113557. nihFormattedCitation: Casillo SM, Gatesman TA, Chilukuri A, Varadharajan S, Johnson BJ, David Premkumar DR, Jane EP, Plute TJ, Koncar RF, Stanton AJ, Biagi-Junior CAO, Barber CS, Halbert ME, Golbourn BJ, Halligan K, Cruz AF, Mansi NM, Cheney A, Mullett SJ, Land CV, Perez JL, Myers MI, Agrawal N, Michel JJ, Chang YF, Vaske OM, MichaelRaj A, Lieberman FS, Felker J, Shiva S, Bertrand KC, Amankulor N, Hadjipanayis CG, Abdullah KG, Zinn PO, Friedlander RM, Abel TJ, Nazarian J, Venneti S, Filbin MG, Gelhaus SL, Mack SC, Pollack IF, Agnihotri S. An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma. Cell Rep. 2024;43(1):113557.. PubMed PMID: 38113141.
Silk AW, Davar D. Tumor-Associated Macrophages in Merkel Cell Carcinoma: Old Balances, New Checks. Clin Cancer Res. 2024-01-17;OF1-OF3. doi: 10.1158/1078-0432.CCR-23-3320. nihFormattedCitation: Silk AW, Davar D. Tumor-Associated Macrophages in Merkel Cell Carcinoma: Old Balances, New Checks. Clin Cancer Res. 2024;:OF1-OF3.. PubMed PMID: 38230965.
Jana JA, Overacre-Delgoffe AE. You are the tumor queen, microbiome fiend, IL-17. Immunity. 2024-01-09;57(1):11-13. doi: 10.1016/j.immuni.2023.12.011. nihFormattedCitation: Jana JA, Overacre-Delgoffe AE. You are the tumor queen, microbiome fiend, IL-17. Immunity. 2024;57(1):11-13.. PubMed PMID: 38198848.
Wu RC, Luke JJ. Uncovering the potential of CD40 agonism to enhance immune-checkpoint blockade. Clin Cancer Res. 2024-01-05; doi: 10.1158/1078-0432.CCR-23-2437. nihFormattedCitation: Wu RC, Luke JJ. Uncovering the potential of CD40 agonism to enhance immune-checkpoint blockade. Clin Cancer Res. 2024;. PMCID: PMC10842335.. PubMed PMID: 37870487; PMCID: PMC10842335.
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Betof Warner A, Luke JJ. CD4+ TIL to the rescue of anti-PD-1 failure by targeting MHC-II. Clin Cancer Res. 2023-10-02; doi: 10.1158/1078-0432.CCR-23-1333. nihFormattedCitation: Betof Warner A, Luke JJ. CD4+ TIL to the rescue of anti-PD-1 failure by targeting MHC-II. Clin Cancer Res. 2023;. PMCID: PMC10592266.. PubMed PMID: 37534980; PMCID: PMC10592266.
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Zhang X, Ferris L, Faries MB, Luke JJ. Debating Sentinel Lymph Node Biopsy for Melanoma in the Modern Adjuvant Era. J Clin Oncol. 2023-09-10;JCO2300255. doi: 10.1200/JCO.23.00255. nihFormattedCitation: Zhang X, Ferris L, Faries MB, Luke JJ. Debating Sentinel Lymph Node Biopsy for Melanoma in the Modern Adjuvant Era. J Clin Oncol. 2023;:JCO2300255. PMCID: PMC10852382.. PubMed PMID: 37410978; PMCID: PMC10852382.
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Aggarwal V, Workman CJ, Vignali DAA. LAG-3 as the third checkpoint inhibitor. Nat Immunol. 2023-09-01;24(9):1415-1422. doi: 10.1038/s41590-023-01569-z. nihFormattedCitation: Aggarwal V, Workman CJ, Vignali DAA. LAG-3 as the third checkpoint inhibitor. Nat Immunol. 2023;24(9):1415-1422. PMCID: PMC11144386.. PubMed PMID: 37488429; PMCID: PMC11144386.
Augustin RC, Luke JJ. PD-1 Monotherapy Reigns Supreme in Adjuvant Melanoma…But for How Long? Clin Cancer Res. 2023-09-01;29(17):3253-3255. doi: 10.1158/1078-0432.CCR-23-1194. nihFormattedCitation: Augustin RC, Luke JJ. PD-1 Monotherapy Reigns Supreme in Adjuvant Melanoma…But for How Long? Clin Cancer Res. 2023;29(17):3253-3255. PMCID: PMC10527539.. PubMed PMID: 37378689; PMCID: PMC10527539.
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Smithy JW, Luke JJ. CD16+ Macrophages: An Emerging Biomarker for Combined CTLA-4 and PD-1 Blockade. Clin Cancer Res. 2023-07-05;29(13):2345-2347. doi: 10.1158/1078-0432.CCR-23-0490. nihFormattedCitation: Smithy JW, Luke JJ. CD16+ Macrophages: An Emerging Biomarker for Combined CTLA-4 and PD-1 Blockade. Clin Cancer Res. 2023;29(13):2345-2347. PMCID: PMC10330271.. PubMed PMID: 37097465; PMCID: PMC10330271.
Luke JJ, Piha-Paul SA, Medina T, Verschraegen CF, Varterasian M, Brennan AM, Riese RJ, Sokolovska A, Strauss J, Hava DL, Janku F. Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies. Clin Cancer Res. 2023-07-05;29(13):2435-2444. doi: 10.1158/1078-0432.CCR-23-0118. nihFormattedCitation: Luke JJ, Piha-Paul SA, Medina T, Verschraegen CF, Varterasian M, Brennan AM, Riese RJ, Sokolovska A, Strauss J, Hava DL, Janku F. Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies. Clin Cancer Res. 2023;29(13):2435-2444. PMCID: PMC11225568.. PubMed PMID: 37227176; PMCID: PMC11225568.
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Korpics MC, Onderdonk BE, Dadey RE, Hara JH, Karapetyan L, Zha Y, Karrison TG, Olson AC, Fleming GF, Weichselbaum RR, Bao R, Chmura SJ, Luke JJ. Partial tumor irradiation plus pembrolizumab in treating large advanced solid tumor metastases. J Clin Invest. 2023-05-15;133(10): doi: 10.1172/JCI162260. nihFormattedCitation: Korpics MC, Onderdonk BE, Dadey RE, Hara JH, Karapetyan L, Zha Y, Karrison TG, Olson AC, Fleming GF, Weichselbaum RR, Bao R, Chmura SJ, Luke JJ. Partial tumor irradiation plus pembrolizumab in treating large advanced solid tumor metastases. J Clin Invest. 2023;133(10). PMCID: PMC10178837.. PubMed PMID: 37183819; PMCID: PMC10178837.
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Olson DJ, Luke JJ. Myeloid Maturity: ATRA to Enhance Anti-PD-1? Clin Cancer Res. 2023-04-03;29(7):1167-1169. doi: 10.1158/1078-0432.CCR-22-3652. nihFormattedCitation: Olson DJ, Luke JJ. Myeloid Maturity: ATRA to Enhance Anti-PD-1? Clin Cancer Res. 2023;29(7):1167-1169. PMCID: PMC10073251.. PubMed PMID: 36656164; PMCID: PMC10073251.
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Karapetyan L, Luke JJ. Interferon Biology and LAG-3 Shedding in PD-(L)1 plus LAG-3 Immunotherapy. Clin Cancer Res. 2023-03-01;29(5):835-837. doi: 10.1158/1078-0432.CCR-22-3312. nihFormattedCitation: Karapetyan L, Luke JJ. Interferon Biology and LAG-3 Shedding in PD-(L)1 plus LAG-3 Immunotherapy. Clin Cancer Res. 2023;29(5):835-837. PMCID: PMC9992241.. PubMed PMID: 36534010; PMCID: PMC9992241.
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