This seminar series is open to the public, including all interested University of Pittsburgh and Carnegie Mellon University faculty, students, and staff. Arthur S. Levine, MD, Pitt’s senior vice chancellor for the health sciences and John and Gertrude Petersen Dean of Medicine, will introduce Young and lead the discussion following the lecture.
As a computational and systems biologist, Dr. Regev studies how gene regulation rewires when cells adapt to their environments, when they differentiate, and when species evolve. She and her lab members develop experimental and computational approaches to systematically decipher the mechanisms behind the transcriptional regulatory circuits in organisms ranging from yeast to humans. Dr. Regev investigates how these transcriptional circuits change on a variety of timescales: for example, when cells respond to changing growth conditions (within hours), when cells differentiate (within hours to days), and when species evolve (across millions of years). These studies have yielded detailed reconstructions and highlight key principles that govern the emergence of novel functions in gene regulation. Major research topics in the Regev lab include reconstructing the regulatory circuitry of mammalian cells, circuits controlling cell differentiation, the evolution of gene regulation, and understanding how specific genetic alterations in cancer-causing genes translate into the large-scale transcriptional changes that occur in tumor cells.
At Tel Aviv University, Dr. Regev studied biology, computer science, and mathematics, earning her MS in an interdisciplinary program and, later, her computational biology PhD. Dr. Regev, who is also a Howard Hughes Medical Institute investigator, is the recipient of numerous honors and awards, including the Memorial Sloan Kettering Paul Marks Prize for Cancer Research, an NIH Director’s Pioneer Award, and the Overton Prize from the International Society for Computational Biology. She was elected to the National Academy of Sciences in 2019.