Publications

Investigating Mechanisms of Action of New and Exisiting Anticancer Agents

Zhou P, Huang G, Zhao Y, Zhong D, Xu Z, Zeng Y, Zhang Y, Li S, He F. MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells. Cell Signal. 2014 Jun;26(6):1347-54. doi: 10.1016/j.cellsig.2014.02.020. PubMed PMID: 24631531.
Zhang Y, Huang Y, Li S. Polymeric micelles: nanocarriers for cancer-targeted drug delivery. AAPS PharmSciTech. 2014 Aug;15(4):862-71. doi: 10.1208/s12249-014-0113-z. PubMed PMID: 24700296; PMCID: PMC4113619.
Cong D, Zhu W, Shi Y, Pointer KB, Clark PA, Shen H, Kuo JS, Hu S, Sun D. Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H⁺ extrusion, cell migration and survival. Carcinogenesis. 2014 Sep;35(9):2014-24. doi: 10.1093/carcin/bgu089. PubMed PMID: 24717311; PMCID: PMC4146414.
Jane EP, Premkumar DR, Morales A, Foster KA, Pollack IF. Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells. J Pharmacol Exp Ther. 2014 Jul;350(1):22-35. doi: 10.1124/jpet.114.212910. PubMed PMID: 24741074; PMCID: PMC4056270.
Lee JJ, Chu E. Sequencing of antiangiogenic agents in the treatment of metastatic colorectal cancer. Clin Colorectal Cancer. 2014 Sep;13(3):135-44. doi: 10.1016/j.clcc.2014.02.001. PubMed PMID: 24768040.
Solomon JD, Heitzer MD, Liu TT, Beumer JH, Parise RA, Normolle DP, Leach DA, Buchanan G, DeFranco DB. VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells. Mol Cancer Res. 2014 Aug;12(8):1166-80. doi: 10.1158/1541-7786.MCR-13-0395. PubMed PMID: 24825850; PMCID: PMC4134986.
DeCaprio JA, Duensing A. The DREAM complex in antitumor activity of imatinib mesylate in gastrointestinal stromal tumors. Curr Opin Oncol. 2014 Jul;26(4):415-21. doi: 10.1097/CCO.0000000000000090. PubMed PMID: 24840522; PMCID: PMC4236229.
Pillai VC, Parise RA, Christner SM, Rudek MA, Beumer JH, Venkataramanan R. Potential interactions between HIV drugs, ritonavir and efavirenz and anticancer drug, nilotinib--a study in primary cultures of human hepatocytes that is applicable to HIV patients with cancer. J Clin Pharmacol. 2014 Nov;54(11):1272-9. doi: 10.1002/jcph.333. PubMed PMID: 24846165.
Zhang P, Huang Y, Liu H, Marquez RT, Lu J, Zhao W, Zhang X, Gao X, Li J, Venkataramanan R, Xu L, Li S. A PEG-Fmoc conjugate as a nanocarrier for paclitaxel. Biomaterials. 2014 Aug;35(25):7146-56. doi: 10.1016/j.biomaterials.2014.04.108. PubMed PMID: 24856103; PMCID: PMC4102141.
Berhane H, Shinde A, Kalash R, Xu K, Epperly MW, Goff J, Franicola D, Zhang X, Dixon T, Shields D, Wang H, Wipf P, Li S, Gao X, Greenberger JS. Amelioration of radiation-induced oral cavity mucositis and distant bone marrow suppression in fanconi anemia Fancd2-/- (FVB/N) mice by intraoral GS-nitroxide JP4-039. Radiat Res. 2014 Jul;182(1):35-49. doi: 10.1667/RR13633.1. PubMed PMID: 24932534; PMCID: PMC4101533.
Parikh RA, Wang P, Beumer JH, Chu E, Appleman LJ. The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment. Onco Targets Ther. 2014;7969-83. doi: 10.2147/OTT.S40241. PubMed PMID: 24959084; PMCID: PMC4061161.
Landreneau RJ, Normolle DP, Christie NA, Awais O, Wizorek JJ, Abbas G, Pennathur A, Shende M, Weksler B, Luketich JD, Schuchert MJ. Recurrence and survival outcomes after anatomic segmentectomy versus lobectomy for clinical stage I non-small-cell lung cancer: a propensity-matched analysis. J Clin Oncol. 2014 Aug 10;32(23):2449-55. doi: 10.1200/JCO.2013.50.8762. PubMed PMID: 24982447; PMCID: PMC4121502.
Shinde A, Epperly MW, Cao S, Franicola D, Shields D, Wang H, Wipf P, Sprachman MM, Greenberger JS. Effects of the bifunctional sulfoxide MMS350, a radiation mitigator, on hematopoiesis in long-term bone marrow cultures and on radioresistance of marrow stromal cell lines. In Vivo. 2014 Jul-Aug;28(4):457-65. PubMed PMID: 24982210; PMCID: PMC6591577.
Epperly MW, Goff JP, Franicola D, Wang H, Wipf P, Li S, Greenberger JS. Esophageal radioprotection by swallowed JP4-039/F15 in thoracic-irradiated mice with transgenic lung tumors. In Vivo. 2014 Jul-Aug;28(4):435-40. PubMed PMID: 24982207; PMCID: PMC6436097.
Zhang X, Huang Y, Zhao W, Chen Y, Zhang P, Li J, Venkataramanan R, Li S. PEG-farnesyl thiosalicylic acid telodendrimer micelles as an improved formulation for targeted delivery of paclitaxel. Mol Pharm. 2014 Aug 4;11(8):2807-14. doi: 10.1021/mp500181x. PubMed PMID: 24987803; PMCID: PMC4123940.
Ou Z, Jiang M, Hu B, Huang Y, Xu M, Ren S, Li S, Liu S, Xie W, Huang M. Transcriptional regulation of human hydroxysteroid sulfotransferase SULT2A1 by LXRα. Drug Metab Dispos. 2014 Oct;42(10):1684-9. doi: 10.1124/dmd.114.058479. PubMed PMID: 25028566; PMCID: PMC4164974.
Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL. Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. PLoS One. 2014;9(7):e102678. doi: 10.1371/journal.pone.0102678. PubMed PMID: 25036749; PMCID: PMC4103836.
Hong CS, Muller L, Boyiadzis M, Whiteside TL. Isolation and characterization of CD34+ blast-derived exosomes in acute myeloid leukemia. PLoS One. 2014;9(8):e103310. doi: 10.1371/journal.pone.0103310. PubMed PMID: 25093329; PMCID: PMC4122364.
Zhang X, Liu K, Huang Y, Xu J, Li J, Ma X, Li S. Reduction-sensitive dual functional nanomicelles for improved delivery of paclitaxel. Bioconjug Chem. 2014 Sep 17;25(9):1689-96. doi: 10.1021/bc500292j. PubMed PMID: 25121577; PMCID: PMC4166038.
Beumer JH, Owzar K, Lewis LD, Jiang C, Holleran JL, Christner SM, Blum W, Devine S, Kolitz JE, Linker C, Vij R, Alyea EP, Larson RA, Ratain MJ, Egorin MJ. Effect of age on the pharmacokinetics of busulfan in patients undergoing hematopoietic cell transplantation; an alliance study (CALGB 10503, 19808, and 100103). Cancer Chemother Pharmacol. 2014 Nov;74(5):927-38. doi: 10.1007/s00280-014-2571-0. PubMed PMID: 25163570; PMCID: PMC4210372.
Christner SM, Parise RA, Levine ED, Rizvi NA, Gounder MM, Beumer JH. Quantitative method for the determination of iso-fludelone (KOS-1803) in human plasma by LC-MS/MS. J Pharm Biomed Anal. 2014 Nov;100199-204. doi: 10.1016/j.jpba.2014.08.007. PubMed PMID: 25168219; PMCID: PMC4179924.
Shinde A, Epperly MW, Cao S, Holt D, Goff J, Shields D, Franicola D, Wipf P, Wang H, Greenberger JS. Improved hematopoiesis in GS-nitroxide (JP4-039)-treated mouse long-term bone marrow cultures and radioresistance of derived bone marrow stromal cell lines. In Vivo. 2014 Sep-Oct;28(5):699-708. PubMed PMID: 25189880; PMCID: PMC6477534.
Zhang Y, Huang Y, Zhao W, Lu J, Zhang P, Zhang X, Li J, Gao X, Venkataramanan R, Li S. Fmoc-conjugated PEG-vitamin E2 micelles for tumor-targeted delivery of paclitaxel: enhanced drug-carrier interaction and loading capacity. AAPS J. 2014 Nov;16(6):1282-91. doi: 10.1208/s12248-014-9651-2. PubMed PMID: 25193267; PMCID: PMC4389742.
Monaco EA 3rd, Bhatnagar JP, Xu Y, Arai Y, Niranjan A, Huq MS, Lunsford LD. Evaluation of tumor progression and detection of new tumors during repeat Gamma Knife® stereotactic radiosurgery utilizing the co-registration tool in Leksell Gamma Plan®: technical note. Stereotact Funct Neurosurg. 2014;92(5):300-5. doi: 10.1159/000365227. PubMed PMID: 25247389.
Lu J, Zhao W, Huang Y, Liu H, Marquez R, Gibbs RB, Li J, Venkataramanan R, Xu L, Li S, Li S. Targeted delivery of Doxorubicin by folic acid-decorated dual functional nanocarrier. Mol Pharm. 2014 Nov 3;11(11):4164-78. doi: 10.1021/mp500389v. PubMed PMID: 25265550; PMCID: PMC4224520.
LaPorte MG, da Paz Lima DJ, Zhang F, Sen M, Grandis JR, Camarco D, Hua Y, Johnston PA, Lazo JS, Resnick LO, Wipf P, Huryn DM. 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5081-5. doi: 10.1016/j.bmcl.2014.09.001. PubMed PMID: 25288188; PMCID: PMC4250329.
Zhang X, Huang Y, Zhao W, Liu H, Marquez R, Lu J, Zhang P, Zhang Y, Li J, Gao X, Venkataramanan R, Xu L, Li S. Targeted delivery of anticancer agents via a dual function nanocarrier with an interfacial drug-interactive motif. Biomacromolecules. 2014 Nov 10;15(11):4326-35. doi: 10.1021/bm501339j. PubMed PMID: 25325795; PMCID: PMC4229023.
Ireland AW, Gobillot TA, Gupta T, Seguin SP, Liang M, Resnick L, Goldberg MT, Manos-Turvey A, Pipas JM, Wipf P, Brodsky JL. Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target. Bioorg Med Chem. 2014 Nov 15;22(22):6490-6502. doi: 10.1016/j.bmc.2014.09.019. PubMed PMID: 25440730; PMCID: PMC4293281.
Lu J, Zhao W, Liu H, Marquez R, Huang Y, Zhang Y, Li J, Xie W, Venkataramanan R, Xu L, Li S. An improved D-α-tocopherol-based nanocarrier for targeted delivery of doxorubicin with reversal of multidrug resistance. J Control Release. 2014 Dec 28;196272-86. doi: 10.1016/j.jconrel.2014.10.016. PubMed PMID: 25456831; PMCID: PMC4267990.
Stoyanovsky DA, Jiang J, Murphy MP, Epperly M, Zhang X, Li S, Greenberger J, Kagan V, Bayır H. Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator. ACS Med Chem Lett. 2014 Dec 11;5(12):1304-1307. doi: 10.1021/ml5003635. PubMed PMID: 25530831; PMCID: PMC4266336.
Warita K, Warita T, Beckwitt CH, Schurdak ME, Vazquez A, Wells A, Oltvai ZN. Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. Sci Rep. 2014 Dec 23;47593. doi: 10.1038/srep07593. PubMed PMID: 25534349; PMCID: PMC4274516.
Beumer JH, Kozo D, Harney RL, Baldasano CN, Jarrah J, Christner SM, Parise R, Baburina I, Courtney JB, Salamone SJ. An Automated Homogeneous Immunoassay for Quantitating Imatinib Concentrations in Plasma. Ther Drug Monit. 2015 Aug;37(4):486-92. doi: 10.1097/FTD.0000000000000178. PubMed PMID: 25551407; PMCID: PMC4486633.
Qian W, Salamoun J, Wang J, Roginskaya V, Van Houten B, Wipf P. The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak. Bioorg Med Chem Lett. 2015 Feb 15;25(4):856-63. doi: 10.1016/j.bmcl.2014.12.072. PubMed PMID: 25582599; PMCID: PMC4318771.
Chang HB, Gao X, Nepomuceno R, Hu S, Sun D. Na(+)/H(+) exchanger in the regulation of platelet activation and paradoxical effects of cariporide. Exp Neurol. 2015 Oct;27211-6. doi: 10.1016/j.expneurol.2014.12.023. PubMed PMID: 25595121; PMCID: PMC4500746.
Cong D, Zhu W, Kuo JS, Hu S, Sun D. Ion transporters in brain tumors. Curr Med Chem. 2015;22(10):1171-81. doi: 10.2174/0929867322666150114151946. PubMed PMID: 25620102; PMCID: PMC4363268.
Crum TS, Gleixner AM, Posimo JM, Mason DM, Broeren MT, Heinemann SD, Wipf P, Brodsky JL, Leak RK. Heat shock protein responses to aging and proteotoxicity in the olfactory bulb. J Neurochem. 2015 Jun;133(6):780-794. doi: 10.1111/jnc.13041. PubMed PMID: 25640060; PMCID: PMC4464935.
Boyiadzis M, Whiteside TL. Information transfer by exosomes: A new frontier in hematologic malignancies. Blood Rev. 2015 Sep;29(5):281-90. doi: 10.1016/j.blre.2015.01.004. PubMed PMID: 25686749.
Fenton M, Whiteside TL, Ferrone S, Boyiadzis M. Chondroitin sulfate proteoglycan-4 (CSPG4)-specific monoclonal antibody 225.28 in detection of acute myeloid leukemia blasts. Oncol Res. 2015;22(2):117-21. doi: 10.3727/096504014X14174484758503. PubMed PMID: 25706398.
Ross K, Gillespie-Twardy AL, Agha M, Raptis A, Hou JZ, Farah R, Redner RL, Im A, Duggal S, Ding F, Lin Y, Boyiadzis M. Intensive chemotherapy in patients aged 70 years or older newly diagnosed with acute myeloid leukemia. Oncol Res. 2015;22(2):85-92. doi: 10.3727/096504014X14146137738547. PubMed PMID: 25706395.
George Rosenker KM, Paquette WD, Johnston PA, Sharlow ER, Vogt A, Bakan A, Lazo JS, Wipf P. Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B. Bioorg Med Chem. 2015 Jun 15;23(12):2810-8. doi: 10.1016/j.bmc.2015.01.043. PubMed PMID: 25703307.
Mousavi SH, Kano H, Faraji AH, Gande A, Flickinger JC, Niranjan A, Monaco E 3rd, Lunsford LD. Hearing preservation up to 3 years after gamma knife radiosurgery for Gardner-Robertson class I patients with vestibular Schwannomas. Neurosurgery. 2015 May;76(5):584-90; discussion 590-1. doi: 10.1227/NEU.0000000000000674. PubMed PMID: 25706519.
Cheng Q, Inaba Y, Lu P, Xu M, He J, Zhao Y, Guo GL, Kuruba R, de la Vega R, Evans RW, Li S, Xie W. Chronic activation of FXR in transgenic mice caused perinatal toxicity and sensitized mice to cholesterol toxicity. Mol Endocrinol. 2015 Apr;29(4):571-82. doi: 10.1210/me.2014-1337. PubMed PMID: 25719402; PMCID: PMC4399273.
Duensing A. Targeting ETV1 in gastrointestinal stromal tumors: tripping the circuit breaker in GIST? Cancer Discov. 2015 Mar;5(3):231-3. doi: 10.1158/2159-8290.CD-15-0116. PubMed PMID: 25749973.
Tandon M, Salamoun JM, Carder EJ, Farber E, Xu S, Deng F, Tang H, Wipf P, Wang QJ. SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest. PLoS One. 2015;10(3):e0119346. doi: 10.1371/journal.pone.0119346. PubMed PMID: 25747583; PMCID: PMC4352033.
Lassman AB, Pugh SL, Gilbert MR, Aldape KD, Geinoz S, Beumer JH, Christner SM, Komaki R, DeAngelis LM, Gaur R, Youssef E, Wagner H, Won M, Mehta MP. Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627). Neuro Oncol. 2015 Jul;17(7):992-8. doi: 10.1093/neuonc/nov011. PubMed PMID: 25758746; PMCID: PMC5762006.
Walczak MA, Krainz T, Wipf P. Ring-strain-enabled reaction discovery: new heterocycles from bicyclo[1.1.0]butanes. Acc Chem Res. 2015 Apr 21;48(4):1149-58. doi: 10.1021/ar500437h. PubMed PMID: 25775119.
Posimo JM, Weilnau JN, Gleixner AM, Broeren MT, Weiland NL, Brodsky JL, Wipf P, Leak RK. Heat shock protein defenses in the neocortex and allocortex of the telencephalon. Neurobiol Aging. 2015 May;36(5):1924-37. doi: 10.1016/j.neurobiolaging.2015.02.011. PubMed PMID: 25771395; PMCID: PMC4417007.
Soni A, Djokic M, Hou JZ, Redner RL, Boyiadzis M. Outcomes of acute myeloid leukemia with t(15;17) not associated with acute promyelocytic leukemia. Leuk Lymphoma. 2015;56(11):3236-9. doi: 10.3109/10428194.2015.1036262. PubMed PMID: 25860246.
Boone BA, Bahary N, Zureikat AH, Moser AJ, Normolle DP, Wu WC, Singhi AD, Bao P, Bartlett DL, Liotta LA, Espina V, Loughran P, Lotze MT, Zeh HJ 3rd. Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma. Ann Surg Oncol. 2015 Dec;22(13):4402-10. doi: 10.1245/s10434-015-4566-4. PubMed PMID: 25905586; PMCID: PMC4663459.
Wissel G, Kudryavtsev P, Ghemtio L, Tammela P, Wipf P, Yliperttula M, Finel M, Urtti A, Kidron H, Xhaard H. Exploring the structure-activity relationships of ABCC2 modulators using a screening approach. Bioorg Med Chem. 2015 Jul 1;23(13):3513-25. doi: 10.1016/j.bmc.2015.04.029. PubMed PMID: 25935289; PMCID: PMC4461526.
Senutovitch N, Vernetti L, Boltz R, DeBiasio R, Gough A, Taylor DL. Fluorescent protein biosensors applied to microphysiological systems. Exp Biol Med (Maywood). 2015 Jun;240(6):795-808. doi: 10.1177/1535370215584934. PubMed PMID: 25990438; PMCID: PMC4464952.
Sehgal A, Whiteside TL, Boyiadzis M. Programmed death-1 checkpoint blockade in acute myeloid leukemia. Expert Opin Biol Ther. 2015;15(8):1191-203. doi: 10.1517/14712598.2015.1051028. PubMed PMID: 26036819; PMCID: PMC4778424.
Foster KA, Jane EP, Premkumar DR, Morales A, Pollack IF. NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5. Int J Oncol. 2015 Aug;47(2):506-16. doi: 10.3892/ijo.2015.3035. PubMed PMID: 26044191; PMCID: PMC4501659.
Christner SM, Clausen DM, Beumer JH, Parise RA, Guo J, Huang Y, Dömling AS, Eiseman JL. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of pyrazole-based small molecule inhibitors of Mdm2/4-p53 interaction. Cancer Chemother Pharmacol. 2015 Aug;76(2):287-99. doi: 10.1007/s00280-015-2791-y. PubMed PMID: 26050209; PMCID: PMC5033042.
Lu J, Liu C, Wang P, Ghazwani M, Xu J, Huang Y, Ma X, Zhang P, Li S. The self-assembling camptothecin-tocopherol prodrug: An effective approach for formulating camptothecin. Biomaterials. 2015 Sep;62176-87. doi: 10.1016/j.biomaterials.2015.05.046. PubMed PMID: 26057133; PMCID: PMC4470812.
Soni A, Chu E. Cost-Effectiveness of Adjuvant Chemotherapy in the Treatment of Early-Stage Colon Cancer. Clin Colorectal Cancer. 2015 Dec;14(4):219-26. doi: 10.1016/j.clcc.2015.05.002. PubMed PMID: 26072443.
Bakkenist CJ, Czambel RK, Hershberger PA, Tawbi H, Beumer JH, Schmitz JC. A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells. Oncoscience. 2015;2(5):542-54. doi: 10.18632/oncoscience.162. PubMed PMID: 26097887; PMCID: PMC4468340.
Chiba T, Skrypnyk NI, Skvarca LB, Penchev R, Zhang KX, Rochon ER, Fall JL, Paueksakon P, Yang H, Alford CE, Roman BL, Zhang MZ, Harris R, Hukriede NA, de Caestecker MP. Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after AKI. J Am Soc Nephrol. 2016 Feb;27(2):495-508. doi: 10.1681/ASN.2014111108. PubMed PMID: 26109319; PMCID: PMC4731115.
Boyiadzis M, Whiteside TL, Pavletic SZ. Immunotherapy for acute leukemia. Aging (Albany NY). 2015 Jun;7(6):354-5. doi: 10.18632/aging.100768. PubMed PMID: 26143183; PMCID: PMC4505159.
Kahle KT, Khanna AR, Alper SL, Adragna NC, Lauf PK, Sun D, Delpire E. K-Cl cotransporters, cell volume homeostasis, and neurological disease. Trends Mol Med. 2015 Aug;21(8):513-23. doi: 10.1016/j.molmed.2015.05.008. PubMed PMID: 26142773; PMCID: PMC4834970.
Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P. Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4828-4833. doi: 10.1016/j.bmcl.2015.06.073. PubMed PMID: 26159482; PMCID: PMC4607627.
Ivy SP, Beumer JH. Ovarian Cancer Survival and Chemotherapy Dosing, Body Mass Index, and Body Surface Area : Are We There Yet? JAMA Oncol. 2015 Sep;1(6):732-3. doi: 10.1001/jamaoncol.2015.1926. PubMed PMID: 26181495; PMCID: PMC4696392.
Parise RA, Eiseman JL, Clausen DM, Kicielinski KP, Hershberger PA, Egorin MJ, Beumer JH. Characterization of the metabolism of benzaldehyde dimethane sulfonate (NSC 281612, DMS612). Cancer Chemother Pharmacol. 2015 Sep;76(3):537-46. doi: 10.1007/s00280-015-2828-2. PubMed PMID: 26193988; PMCID: PMC4545378.
Pardee AD, Yano H, Weinstein AM, Ponce AA, Ethridge AD, Normolle DP, Vujanovic L, Mizejewski GJ, Watkins SC, Butterfield LH. Route of antigen delivery impacts the immunostimulatory activity of dendritic cell-based vaccines for hepatocellular carcinoma. J Immunother Cancer. 2015;332. doi: 10.1186/s40425-015-0077-x. PubMed PMID: 26199728; PMCID: PMC4509479.
Zhang P, Li J, Ghazwani M, Zhao W, Huang Y, Zhang X, Venkataramanan R, Li S. Effective co-delivery of doxorubicin and dasatinib using a PEG-Fmoc nanocarrier for combination cancer chemotherapy. Biomaterials. 2015 Oct;67104-14. doi: 10.1016/j.biomaterials.2015.07.027. PubMed PMID: 26210177; PMCID: PMC4550547.
Jiang M, Klein M, Zanger UM, Mohammad MK, Cave MC, Gaikwad NW, Dias NJ, Selcer KW, Guo Y, He J, Zhang X, Shen Q, Qin W, Li J, Li S, Xie W. Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. J Hepatol. 2016 Jan;64(1):44-52. doi: 10.1016/j.jhep.2015.07.022. PubMed PMID: 26220752; PMCID: PMC4691383.
Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle T Jr, Lu P, Brodsky JL, Hackam DJ. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100. doi: 10.1016/j.tetlet.2014.11.048. PubMed PMID: 26236050; PMCID: PMC4518473.
Lee DH, Zhang Y, Kassam AB, Park MJ, Gardner P, Prevedello D, Henry S, Horbinski C, Beumer JH, Tawbi H, Williams BJ, Shaffrey ME, Egorin MJ, Abounader R, Park DM. Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma. PLoS One. 2015;10(8):e0134426. doi: 10.1371/journal.pone.0134426. PubMed PMID: 26247786; PMCID: PMC4527706.
Takata K, Tomida J, Reh S, Swanhart LM, Takata M, Hukriede NA, Wood RD. Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ν (POLN). J Biol Chem. 2015 Oct 2;290(40):24278-93. doi: 10.1074/jbc.M115.677419. PubMed PMID: 26269593; PMCID: PMC4591814.
Teramachi J, Silbermann R, Yang P, Zhao W, Mohammad KS, Guo J, Anderson JL, Zhou D, Feng R, Myint KZ, Maertz N, Beumer JH, Eiseman JL, Windle JJ, Xie XQ, Roodman GD, Kurihara N. Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo. Leukemia. 2016 Feb;30(2):390-8. doi: 10.1038/leu.2015.229. PubMed PMID: 26286116; PMCID: PMC4740189.
Wonderlich ER, Wu WC, Normolle DP, Barratt-Boyes SM. Macrophages and Myeloid Dendritic Cells Lose T Cell-Stimulating Function in Simian Immunodeficiency Virus Infection Associated with Diminished IL-12 and IFN-α Production. J Immunol. 2015 Oct 1;195(7):3284-92. doi: 10.4049/jimmunol.1500683. PubMed PMID: 26297760; PMCID: PMC4575859.
Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, Wilson GM, Resnick LO, LaPorte MG, Wipf P, Huryn DM, Grandis JR. HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines. Assay Drug Dev Technol. 2015 Sep;13(7):356-76. doi: 10.1089/adt.2015.663. PubMed PMID: 26317883; PMCID: PMC4556090.
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Beumer JH, Ding F, Tawbi H, Lin Y, Viluh D, Chatterjee I, Rinker M, Chow SL, Ivy SP. Effect of Renal Dysfunction on Toxicity in Three Decades of Cancer Therapy Evaluation Program-Sponsored Single-Agent Phase I Studies. J Clin Oncol. 2016 Jan 10;34(2):110-6. doi: 10.1200/JCO.2014.59.7302. PubMed PMID: 26392101; PMCID: PMC4980565.
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Eads JR, Beumer JH, Negrea L, Holleran JL, Strychor S, Meropol NJ. A pharmacokinetic analysis of cisplatin and 5-fluorouracil in a patient with esophageal cancer on peritoneal dialysis. Cancer Chemother Pharmacol. 2016 Feb;77(2):333-8. doi: 10.1007/s00280-015-2939-9. PubMed PMID: 26687170; PMCID: PMC5090976.
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Kim MM, Camelo-Piragua S, Schipper M, Tao Y, Normolle D, Junck L, Mammoser A, Betz BL, Cao Y, Kim CJ, Heth J, Sagher O, Lawrence TS, Tsien CI. Gemcitabine Plus Radiation Therapy for High-Grade Glioma: Long-Term Results of a Phase 1 Dose-Escalation Study. Int J Radiat Oncol Biol Phys. 2016 Feb 1;94(2):305-11. doi: 10.1016/j.ijrobp.2015.10.032. PubMed PMID: 26853339; PMCID: PMC4746478.
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Shilkrut M, Sapir E, Hanasoge S, Schipper MJ, Normolle DP, Ben-Josef E, Ensminger W, Lawrence TS, Feng M. Phase I Trial of Dose-escalated Whole Liver Irradiation With Hepatic Arterial Fluorodeoxyuridine/Leucovorin and Streptozotocin Followed by Fluorodeoxyuridine/Leucovorin and Chemoembolization for Patients With Neuroendocrine Hepatic Metastases. Am J Clin Oncol. 2018 Apr;41(4):326-331. doi: 10.1097/COC.0000000000000276. PubMed PMID: 26886946; PMCID: PMC4985493.
Polyzos A, Holt A, Brown C, Cosme C, Wipf P, Gomez-Marin A, Castro MR, Ayala-Peña S, McMurray CT. Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes. Hum Mol Genet. 2016 May 1;25(9):1792-802. doi: 10.1093/hmg/ddw051. PubMed PMID: 26908614; PMCID: PMC4986333.
Roth CG, Gillespie-Twardy A, Marks S, Agha M, Raptis A, Hou JZ, Farah R, Lin Y, Qian Y, Pantanowitz L, Boyiadzis M. Flow Cytometric Evaluation of Double/Triple Hit Lymphoma. Oncol Res. 2016;23(3):137-46. doi: 10.3727/096504015X14500972666761. PubMed PMID: 26931436.
Delgado E, Boisen MM, Laskey R, Chen R, Song C, Sallit J, Yochum ZA, Andersen CL, Sikora MJ, Wagner J, Safe S, Elishaev E, Lee A, Edwards RP, Haluska P, Tseng G, Schurdak M, Oesterreich S. High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecol Oncol. 2016 May;141(2):348-356. doi: 10.1016/j.ygyno.2016.02.030. PubMed PMID: 26946093; PMCID: PMC5154956.
Stern AM, Schurdak ME, Bahar I, Berg JM, Taylor DL. A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine. J Biomol Screen. 2016 Jul;21(6):521-34. doi: 10.1177/1087057116635818. PubMed PMID: 26962875; PMCID: PMC4917453.
Akpinar B, Mousavi SH, McDowell MM, Niranjan A, Faraji AH, Flickinger JC, Lunsford LD. Early Radiosurgery Improves Hearing Preservation in Vestibular Schwannoma Patients With Normal Hearing at the Time of Diagnosis. Int J Radiat Oncol Biol Phys. 2016 Jun 1;95(2):729-34. doi: 10.1016/j.ijrobp.2016.01.019. PubMed PMID: 26975929.
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Pollack IF, Jakacki RI, Butterfield LH, Hamilton RL, Panigrahy A, Normolle DP, Connelly AK, Dibridge S, Mason G, Whiteside TL, Okada H. Immune responses and outcome after vaccination with glioma-associated antigen peptides and poly-ICLC in a pilot study for pediatric recurrent low-grade gliomas. Neuro Oncol. 2016 Aug;18(8):1157-68. doi: 10.1093/neuonc/now026. PubMed PMID: 26984745; PMCID: PMC4933485.
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Im A, Raptis A, Hou JZ, Tompkins C, Winfield M, Guay M, Boyiadzis M, Agha M. Hypomethylating Agents for Relapse after Allogeneic Hematopoietic Cell Transplantation in Myeloid Malignancies: A Case Series and Review of the Literature. Acta Haematol. 2016;135(4):232-7. doi: 10.1159/000444118. PubMed PMID: 27007668.
Kumar M, Reed N, Liu R, Aizenman E, Wipf P, Tzounopoulos T. Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. Mol Pharmacol. 2016 Jun;89(6):667-77. doi: 10.1124/mol.115.103200. PubMed PMID: 27005699.
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Hong CS, Funk S, Muller L, Boyiadzis M, Whiteside TL. Isolation of biologically active and morphologically intact exosomes from plasma of patients with cancer. J Extracell Vesicles. 2016;529289. doi: 10.3402/jev.v5.29289. PubMed PMID: 27018366; PMCID: PMC4808740.
Boyiadzis M, Whiteside TL. Plasma-derived exosomes in acute myeloid leukemia for detection of minimal residual disease: are we ready? Expert Rev Mol Diagn. 2016 Jun;16(6):623-9. doi: 10.1080/14737159.2016.1174578. PubMed PMID: 27043038; PMCID: PMC5400097.
Kummar S, Chen A, Gutierrez M, Pfister TD, Wang L, Redon C, Bonner WM, Yutzy W, Zhang Y, Kinders RJ, Ji J, Allen D, Covey JM, Eiseman JL, Holleran JL, Beumer JH, Rubinstein L, Collins J, Tomaszewski J, Parchment R, Pommier Y, Doroshow JH. Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2016 Jul;78(1):73-81. doi: 10.1007/s00280-016-2998-6. PubMed PMID: 27169793; PMCID: PMC5199138.
Johnston PA, Nguyen MM, Dar JA, Ai J, Wang Y, Masoodi KZ, Shun T, Shinde S, Camarco DP, Hua Y, Huryn DM, Wilson GM, Lazo JS, Nelson JB, Wipf P, Wang Z. Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells. Assay Drug Dev Technol. 2016 May;14(4):226-39. doi: 10.1089/adt.2016.716. PubMed PMID: 27187604; PMCID: PMC4876501.
Gearhart TL, Montelaro RC, Schurdak ME, Pilcher CD, Rinaldo CR, Kodadek T, Park Y, Islam K, Yurko R, Marques ET Jr, Burke DS. Selection of a potential diagnostic biomarker for HIV infection from a random library of non-biological synthetic peptoid oligomers. J Immunol Methods. 2016 Aug;43585-9. doi: 10.1016/j.jim.2016.05.001. PubMed PMID: 27182050; PMCID: PMC4947968.
Lee JJ, Beumer JH, Chu E. Therapeutic drug monitoring of 5-fluorouracil. Cancer Chemother Pharmacol. 2016 Sep;78(3):447-64. doi: 10.1007/s00280-016-3054-2. PubMed PMID: 27217046; PMCID: PMC5204259.
McCabe SR, Wipf P. Total synthesis, biosynthesis and biological profiles of clavine alkaloids. Org Biomol Chem. 2016 Jul 7;14(25):5894-913. doi: 10.1039/c6ob00878j. PubMed PMID: 27215547; PMCID: PMC4917493.
Gough A, Vernetti L, Bergenthal L, Shun TY, Taylor DL. The Microphysiology Systems Database for Analyzing and Modeling Compound Interactions with Human and Animal Organ Models. Appl In Vitro Toxicol. 2016 Jun 1;2(2):103-117. doi: 10.1089/aivt.2016.0011. PubMed PMID: 28781990; PMCID: PMC5119471.
Zhu W, Carney KE, Pigott VM, Falgoust LM, Clark PA, Kuo JS, Sun D. Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1. Carcinogenesis. 2016 Sep;37(9):839-851. doi: 10.1093/carcin/bgw068. PubMed PMID: 27287871; PMCID: PMC5008247.
Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, Chen X, Hofer L, Macher-Goeppinger S, Tolstov Y, Korzeniewski N, Duensing A, Grüllich C, Jäger D, Perner S, Schönberg G, Nyarangi-Dix J, Isaac S, Hatiboglu G, Teber D, Hadaschik B, Pahernik S, Roth W, Eils R, Schlesner M, Sültmann H, Hohenfellner M, Grabe N, Duensing S. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun. 2016 Jun 13;7ncomms11845. doi: 10.1038/ncomms11845. PubMed PMID: 27291893; PMCID: PMC4910022.
Salamoun JM, McQueeney KE, Patil K, Geib SJ, Sharlow ER, Lazo JS, Wipf P. Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor. Org Biomol Chem. 2016 Jul 6;14(27):6398-402. doi: 10.1039/c6ob00946h. PubMed PMID: 27291491; PMCID: PMC4935606.
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Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE. Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane. Cancer Prev Res (Phila). 2016 Jul;9(7):547-57. doi: 10.1158/1940-6207.CAPR-15-0290. PubMed PMID: 27339168; PMCID: PMC4930727.
Erdem C, Nagle AM, Casa AJ, Litzenburger BC, Wang YF, Taylor DL, Lee AV, Lezon TR. Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways. Mol Cell Proteomics. 2016 Sep;15(9):3045-57. doi: 10.1074/mcp.M115.057729. PubMed PMID: 27364358; PMCID: PMC5013316.
LaPorte MG, Wang Z, Colombo R, Garzan A, Peshkov VA, Liang M, Johnston PA, Schurdak ME, Sen M, Camarco DP, Hua Y, Pollock NI, Lazo JS, Grandis JR, Wipf P, Huryn DM. Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3581-5. doi: 10.1016/j.bmcl.2016.06.017. PubMed PMID: 27381083; PMCID: PMC4964800.
Clark AM, Ma B, Taylor DL, Griffith L, Wells A. Liver metastases: Microenvironments and ex-vivo models. Exp Biol Med (Maywood). 2016 Sep;241(15):1639-52. doi: 10.1177/1535370216658144. PubMed PMID: 27390264; PMCID: PMC4999624.
Naylor RW, Skvarca LB, Thisse C, Thisse B, Hukriede NA, Davidson AJ. BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. Nat Commun. 2016 Jul 13;712197. doi: 10.1038/ncomms12197. PubMed PMID: 27406002; PMCID: PMC4947171.
Sun J, Chen Y, Li K, Huang Y, Fu X, Zhang X, Zhao W, Wei Y, Xu L, Zhang P, Venkataramanan R, Li S. A prodrug micellar carrier assembled from polymers with pendant farnesyl thiosalicylic acid moieties for improved delivery of paclitaxel. Acta Biomater. 2016 Oct 1;43282-291. doi: 10.1016/j.actbio.2016.07.014. PubMed PMID: 27422196; PMCID: PMC5012958.
Hartsock B, Lim MJ, Roth CG, Raptis N, Weber D, Sehgal A, Boyiadzis M, Raptis A, Hou JZ, Im A, Dorritie K, Marks S, Agha M, Lim SH. ICU intervention during induction chemotherapy for adult patients with newly diagnosed acute myeloid leukemia. Leuk Res. 2016 Sep;4816-9. doi: 10.1016/j.leukres.2016.07.001. PubMed PMID: 27442892.
Niranjan A, Barnett S, Anand V, Agazzi S. Multimodality Management of Trigeminal Schwannomas. J Neurol Surg B Skull Base. 2016 Aug;77(4):371-8. doi: 10.1055/s-0036-1581138. PubMed PMID: 27441164; PMCID: PMC4949062.
Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9015-20. doi: 10.1073/pnas.1603883113. PubMed PMID: 27450084; PMCID: PMC4987817.
Holleran JL, Eiseman JL, Parise RA, Kummar S, Beumer JH. LC-MS/MS assay for the quantitation of FdCyd and its metabolites FdUrd and FU in human plasma. J Pharm Biomed Anal. 2016 Sep 10;129359-366. doi: 10.1016/j.jpba.2016.07.027. PubMed PMID: 27454087; PMCID: PMC5003709.
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Mousavi SH, Akpinar B, Niranjan A, Agarwal V, Cohen J, Flickinger JC, Kondziolka D, Lunsford LD. The clinical significance of persistent trigeminal nerve contrast enhancement in patients who undergo repeat radiosurgery. J Neurosurg. 2017 Jul;127(1):219-225. doi: 10.3171/2016.5.JNS16111. PubMed PMID: 27471888.
Parikh RA, Appleman LJ, Beumer JH, Matczak E, Chu E. Tyrosine Kinase and Mammalian Target of Rapamycin Inhibitors in the Treatment of Advanced Renal Cell Carcinoma: Practical Clinical Implications of Pharmacologic Features. Clin Genitourin Cancer. 2017 Feb;15(1):7-22. doi: 10.1016/j.clgc.2016.05.011. PubMed PMID: 27473523.
Gojo I, Beumer JH, Pratz KW, McDevitt MA, Baer MR, Blackford AL, Smith BD, Gore SD, Carraway HE, Showel MM, Levis MJ, Dezern AE, Gladstone DE, Ji JJ, Wang L, Kinders RJ, Pouquet M, Ali-Walbi I, Rudek MA, Poh W, Herman JG, Karnitz LM, Kaufmann SH, Chen A, Karp JE. A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):697-706. doi: 10.1158/1078-0432.CCR-16-0984. PubMed PMID: 27503200; PMCID: PMC5290001.
Milligan JA, Busacca CA, Senanayake CH, Wipf P. Hydrophosphination of Bicyclo[1.1.0]butane-1-carbonitriles. Org Lett. 2016 Sep 2;18(17):4300-3. doi: 10.1021/acs.orglett.6b02051. PubMed PMID: 27518583.
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Salamoun JM, Wipf P. Allosteric Modulation of Phosphatase Activity May Redefine Therapeutic Value. J Med Chem. 2016 Sep 8;59(17):7771-2. doi: 10.1021/acs.jmedchem.6b01210. PubMed PMID: 27539118.
Johnson JK, Skoda EM, Zhou J, Parrinello E, Wang D, O'Malley K, Eyer BR, Kazancioglu M, Eisermann K, Johnston PA, Nelson JB, Wang Z, Wipf P. Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer. ACS Med Chem Lett. 2016 Aug 11;7(8):785-90. doi: 10.1021/acsmedchemlett.6b00186. PubMed PMID: 27563404; PMCID: PMC4983742.
Yin Y, Sun G, Li E, Kiselyov K, Sun D. ER stress and impaired autophagy flux in neuronal degeneration and brain injury. Ageing Res Rev. 2017 Mar;343-14. doi: 10.1016/j.arr.2016.08.008. PubMed PMID: 27594375; PMCID: PMC5250579.
Pollack IF, Jakacki RI, Butterfield LH, Hamilton RL, Panigrahy A, Normolle DP, Connelly AK, Dibridge S, Mason G, Whiteside TL, Okada H. Antigen-specific immunoreactivity and clinical outcome following vaccination with glioma-associated antigen peptides in children with recurrent high-grade gliomas: results of a pilot study. J Neurooncol. 2016 Dec;130(3):517-527. doi: 10.1007/s11060-016-2245-3. PubMed PMID: 27624914; PMCID: PMC5363717.
Manos-Turvey A, Al-Ashtal HA, Needham PG, Hartline CB, Prichard MN, Wipf P, Brodsky JL. Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5087-5091. doi: 10.1016/j.bmcl.2016.08.080. PubMed PMID: 27624078; PMCID: PMC5050167.
Albrecht TA, Boyiadzis M, Elswick RK Jr, Starkweather A, Rosenzweig M. Symptom Management and Psychosocial Needs of Adults With Acute Myeloid Leukemia During Induction Treatment: A Pilot Study. Cancer Nurs. 2017 Nov/Dec;40(6):E31-E38. doi: 10.1097/NCC.0000000000000428. PubMed PMID: 27631113; PMCID: PMC5350068.
Ferry-Galow KV, Ji J, Kinders RJ, Zhang Y, Czambel RK, Schmitz JC, Herzog J, Evrard YA, Parchment RE. Pharmacodynamic analyses in a multi-laboratory network: lessons from the poly(ADP-ribose) assay. Semin Oncol. 2016 Aug;43(4):492-500. doi: 10.1053/j.seminoncol.2016.06.007. PubMed PMID: 27663481.
Krainz T, Gaschler MM, Lim C, Sacher JR, Stockwell BR, Wipf P. A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis. ACS Cent Sci. 2016 Sep 28;2(9):653-659. doi: 10.1021/acscentsci.6b00199. PubMed PMID: 27725964; PMCID: PMC5043442.
Villgran V, Agha M, Raptis A, Hou JZ, Farah R, Lim SH, Redner RL, Im A, Sehgal A, Dorritie KA, Kiss JE, Normolle D, Boyiadzis M. Leukapheresis in patients newly diagnosed with acute myeloid leukemia. Transfus Apher Sci. 2016 Oct;55(2):216-220. doi: 10.1016/j.transci.2016.07.001. PubMed PMID: 27470709.
Van Der Kraak L, Goel G, Ramanan K, Kaltenmeier C, Zhang L, Normolle DP, Freeman GJ, Tang D, Nason KS, Davison JM, Luketich JD, Dhupar R, Lotze MT. 5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers. J Immunother Cancer. 2016;465. doi: 10.1186/s40425-016-0163-8. PubMed PMID: 27777774; PMCID: PMC5067917.
Kiesel BF, Parise RA, Guo J, Huryn DM, Johnston PA, Colombo R, Sen M, Grandis JR, Beumer JH, Eiseman JL. Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation. Cancer Chemother Pharmacol. 2016 Dec;78(6):1225-1235. doi: 10.1007/s00280-016-3181-9. PubMed PMID: 27778071; PMCID: PMC5115981.
Brand RM, Epperly MW, Stottlemyer JM, Skoda EM, Gao X, Li S, Huq S, Wipf P, Kagan VE, Greenberger JS, Falo LD Jr. A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage. J Invest Dermatol. 2017 Mar;137(3):576-586. doi: 10.1016/j.jid.2016.09.033. PubMed PMID: 27794421; PMCID: PMC5466072.
Wei Y, Tang C, Sant V, Li S, Poloyac SM, Xie W. A Molecular Aspect in the Regulation of Drug Metabolism: Does PXR-Induced Enzyme Expression Always Lead to Functional Changes in Drug Metabolism? Curr Pharmacol Rep. 2016 Aug;2(4):187-192. doi: 10.1007/s40495-016-0062-1. PubMed PMID: 27795941; PMCID: PMC5082989.
Gyanchandani R, Lin Y, Lin HM, Cooper K, Normolle DP, Brufsky A, Fastuca M, Crosson W, Oesterreich S, Davidson NE, Bhargava R, Dabbs DJ, Lee AV. Intratumor Heterogeneity Affects Gene Expression Profile Test Prognostic Risk Stratification in Early Breast Cancer. Clin Cancer Res. 2016 Nov 1;22(21):5362-5369. doi: 10.1158/1078-0432.CCR-15-2889. PubMed PMID: 27185370; PMCID: PMC5093028.
Jane EP, Premkumar DR, Sutera PA, Cavaleri JM, Pollack IF. Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl-xL silenced glioma cell lines. Mol Carcinog. 2017 Apr;56(4):1251-1265. doi: 10.1002/mc.22587. PubMed PMID: 27805285; PMCID: PMC6844150.
Colombo R, Wang Z, Han J, Balachandran R, Daghestani HN, Camarco DP, Vogt A, Day BW, Mendel D, Wipf P. Total Synthesis and Biological Evaluation of Tubulysin Analogues. J Org Chem. 2016 Nov 4;81(21):10302-10320. doi: 10.1021/acs.joc.6b01314. PubMed PMID: 27447195.
Chen Y, Xia R, Huang Y, Zhao W, Li J, Zhang X, Wang P, Venkataramanan R, Fan J, Xie W, Ma X, Lu B, Li S. An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy. Nat Commun. 2016 Nov 7;713443. doi: 10.1038/ncomms13443. PubMed PMID: 27819653; PMCID: PMC5103075.
Dittrich C, Kosty M, Jezdic S, Pyle D, Berardi R, Bergh J, El-Saghir N, Lotz JP, Österlund P, Pavlidis N, Purkalne G, Awada A, Banerjee S, Bhatia S, Bogaerts J, Buckner J, Cardoso F, Casali P, Chu E, Close JL, Coiffier B, Connolly R, Coupland S, De Petris L, De Santis M, de Vries EG, Dizon DS, Duff J, Duska LR, Eniu A, Ernstoff M, Felip E, Fey MF, Gilbert J, Girard N, Glaudemans AW, Gopalan PK, Grothey A, Hahn SM, Hanna D, Herold C, Herrstedt J, Homicsko K, Jones DV Jr, Jost L, Keilholz U, Khan S, Kiss A, Köhne CH, Kunstfeld R, Lenz HJ, Lichtman S, Licitra L, Lion T, Litière S, Liu L, Loehrer PJ, Markham MJ, Markman B, Mayerhoefer M, Meran JG, Michielin O, Moser EC, Mountzios G, Moynihan T, Nielsen T, Ohe Y, Öberg K, Palumbo A, Peccatori FA, Pfeilstöcker M, Raut C, Remick SC, Robson M, Rutkowski P, Salgado R, Schapira L, Schernhammer E, Schlumberger M, Schmoll HJ, Schnipper L, Sessa C, Shapiro CL, Steele J, Sternberg CN, Stiefel F, Strasser F, Stupp R, Sullivan R, Tabernero J, Travado L, Verheij M, Voest E, Vokes E, Von Roenn J, Weber JS, Wildiers H, Yarden Y. ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016. ESMO Open. 2016;1(5):e000097. doi: 10.1136/esmoopen-2016-000097. PubMed PMID: 27843641; PMCID: PMC5070299.
Vernetti LA, Vogt A, Gough A, Taylor DL. Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy. Clin Liver Dis. 2017 Feb;21(1):197-214. doi: 10.1016/j.cld.2016.08.013. PubMed PMID: 27842772; PMCID: PMC6325638.
Huang J, Woods P, Normolle D, Goff JP, Benos PV, Stehle CJ, Steinman RA. Downregulation of estrogen receptor and modulation of growth of breast cancer cell lines mediated by paracrine stromal cell signals. Breast Cancer Res Treat. 2017 Jan;161(2):229-243. doi: 10.1007/s10549-016-4052-0. PubMed PMID: 27853906; PMCID: PMC5556382.
McCabe SR, Wipf P. Eight-Step Enantioselective Total Synthesis of (-)-Cycloclavine. Angew Chem Int Ed Engl. 2017 Jan 2;56(1):324-327. doi: 10.1002/anie.201608820. PubMed PMID: 27860203; PMCID: PMC5195887.
Kunos CA, Chu E, Beumer JH, Sznol M, Ivy SP. Phase I trial of daily triapine in combination with cisplatin chemotherapy for advanced-stage malignancies. Cancer Chemother Pharmacol. 2017 Jan;79(1):201-207. doi: 10.1007/s00280-016-3200-x. PubMed PMID: 27878356; PMCID: PMC5226891.
Kiesel BF, Parise RA, Wong A, Keyvanjah K, Jacobs S, Beumer JH. LC-MS/MS assay for the quantitation of the tyrosine kinase inhibitor neratinib in human plasma. J Pharm Biomed Anal. 2017 Feb 5;134130-136. doi: 10.1016/j.jpba.2016.11.035. PubMed PMID: 27907855; PMCID: PMC5183482.
Rausch JL, Boichuk S, Ali AA, Patil SS, Liu L, Lee DM, Brown MF, Makielski KR, Liu Y, Taguchi T, Kuan SF, Duensing A. Opposing roles of KIT and ABL1 in the therapeutic response of gastrointestinal stromal tumor (GIST) cells to imatinib mesylate. Oncotarget. 2017 Jan 17;8(3):4471-4483. doi: 10.18632/oncotarget.13882. PubMed PMID: 27965460; PMCID: PMC5354847.
Spagnolo DM, Gyanchandani R, Al-Kofahi Y, Stern AM, Lezon TR, Gough A, Meyer DE, Ginty F, Sarachan B, Fine J, Lee AV, Taylor DL, Chennubhotla SC. Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers. J Pathol Inform. 2016;747. doi: 10.4103/2153-3539.194839. PubMed PMID: 27994939; PMCID: PMC5139455.
Boyiadzis M, Bishop MR, Abonour R, Anderson KC, Ansell SM, Avigan D, Barbarotta L, Barrett AJ, Van Besien K, Bergsagel PL, Borrello I, Brody J, Brufsky J, Cairo M, Chari A, Cohen A, Cortes J, Forman SJ, Friedberg JW, Fuchs EJ, Gore SD, Jagannath S, Kahl BS, Kline J, Kochenderfer JN, Kwak LW, Levy R, de Lima M, Litzow MR, Mahindra A, Miller J, Munshi NC, Orlowski RZ, Pagel JM, Porter DL, Russell SJ, Schwartz K, Shipp MA, Siegel D, Stone RM, Tallman MS, Timmerman JM, Van Rhee F, Waller EK, Welsh A, Werner M, Wiernik PH, Dhodapkar MV. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia. J Immunother Cancer. 2016;490. doi: 10.1186/s40425-016-0188-z. PubMed PMID: 28018601; PMCID: PMC5168808.
Xu J, Zhang X, Chen Y, Huang Y, Wang P, Wei Y, Ma X, Li S. Improved Micellar Formulation for Enhanced Delivery for Paclitaxel. Mol Pharm. 2017 Jan 3;14(1):31-41. doi: 10.1021/acs.molpharmaceut.6b00581. PubMed PMID: 28043124.
Monserrate A, Zussman B, Ozpinar A, Niranjan A, Flickinger JC, Gerszten PC. Stereotactic radiosurgery for intradural spine tumors using cone-beam CT image guidance. Neurosurg Focus. 2017 Jan;42(1):E11. doi: 10.3171/2016.9.FOCUS16356. PubMed PMID: 28041317.
Samanta SK, Sehrawat A, Kim SH, Hahm ER, Shuai Y, Roy R, Pore SK, Singh KB, Christner SM, Beumer JH, Davidson NE, Singh SV. Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A. J Natl Cancer Inst. 2017 Jun;109(6): doi: 10.1093/jnci/djw293. PubMed PMID: 28040797; PMCID: PMC5928779.
Epperly MW, Sacher JR, Krainz T, Zhang X, Wipf P, Liang M, Fisher R, Li S, Wang H, Greenberger JS. Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators. In Vivo. 2017 Jan 2;31(1):39-43. doi: 10.21873/invivo.11022. PubMed PMID: 28064218; PMCID: PMC5267945.
von Gruenigen VE, Huang HQ, Beumer JH, Lankes HA, Tew W, Herzog T, Hurria A, Mannel RS, Rizack T, Landrum LM, Rose PG, Salani R, Bradley WH, Rutherford TJ, Higgins RV, Secord AA, Fleming G. Chemotherapy completion in elderly women with ovarian, primary peritoneal or fallopian tube cancer - An NRG oncology/Gynecologic Oncology Group study. Gynecol Oncol. 2017 Mar;144(3):459-467. doi: 10.1016/j.ygyno.2016.11.033. PubMed PMID: 28089376; PMCID: PMC5570471.
Niu Y, Xu M, Slagle BL, Huang H, Li S, Guo GL, Shi G, Qin W, Xie W. Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis. Hepatology. 2017 Mar;65(3):893-906. doi: 10.1002/hep.28924. PubMed PMID: 28102638; PMCID: PMC5319891.
Vendetti FP, Leibowitz BJ, Barnes J, Schamus S, Kiesel BF, Abberbock S, Conrads T, Clump DA, Cadogan E, O'Connor MJ, Yu J, Beumer JH, Bakkenist CJ. Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation. Sci Rep. 2017 Feb 1;741892. doi: 10.1038/srep41892. PubMed PMID: 28145510; PMCID: PMC5286430.
Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep. 2017 Feb 8;742296. doi: 10.1038/srep42296. PubMed PMID: 28176881; PMCID: PMC5296733.
Posluszny DM, Bovbjerg DH, Agha ME, Hou JZ, Raptis A, Boyiadzis MM, Dunbar-Jacob J, Schulz R, Dew MA. Patient and family caregiver dyadic adherence to the allogeneic hematopoietic cell transplantation medical regimen. Psychooncology. 2018 Jan;27(1):354-358. doi: 10.1002/pon.4393. PubMed PMID: 28181721; PMCID: PMC5750136.
Wissel G, Deng F, Kudryavtsev P, Ghemtio L, Wipf P, Xhaard H, Kidron H. A structure-activity relationship study of ABCC2 inhibitors. Eur J Pharm Sci. 2017 May 30;10360-69. doi: 10.1016/j.ejps.2017.02.005. PubMed PMID: 28185990; PMCID: PMC5429213.
Kiesel BF, Shogan JC, Rachid M, Parise RA, Vendetti FP, Bakkenist CJ, Beumer JH. LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma. J Pharm Biomed Anal. 2017 May 10;138158-165. doi: 10.1016/j.jpba.2017.01.055. PubMed PMID: 28213176; PMCID: PMC5357441.
Kim KP, Parise RA, Holleran JL, Lewis LD, Appleman L, van Erp N, Morris MJ, Beumer JH. Simultaneous quantitation of abiraterone, enzalutamide, N-desmethyl enzalutamide, and bicalutamide in human plasma by LC-MS/MS. J Pharm Biomed Anal. 2017 May 10;138197-205. doi: 10.1016/j.jpba.2017.02.018. PubMed PMID: 28219796; PMCID: PMC5357460.
Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla C, Schurdak ME, Haney SA, Taylor DL. Biologically Relevant Heterogeneity: Metrics and Practical Insights. SLAS Discov. 2017 Mar;22(3):213-237. doi: 10.1177/2472555216682725. PubMed PMID: 28231035; PMCID: PMC5464733.
Lee JJ, Chu E. Adherence, Dosing, and Managing Toxicities With Trifluridine/Tipiracil (TAS-102). Clin Colorectal Cancer. 2017 Jun;16(2):85-92. doi: 10.1016/j.clcc.2017.01.003. PubMed PMID: 28242161; PMCID: PMC5743195.
Zhang Y, Hu K, Beumer JH, Bakkenist CJ, D'Argenio DZ. RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology. DNA Repair (Amst). 2017 Apr;5224-30. doi: 10.1016/j.dnarep.2017.02.004. PubMed PMID: 28254357; PMCID: PMC5396547.
Poneros JM, Faye AS, Barr Fritcher EG, Sen A, Anandasabapathy S, Bresalier RS, Marcon N, Turgeon DK, Appelman H, Normolle D, Morrison LE, Brenner DE, Halling KC. A Multicenter Study of a Fluorescence In Situ Hybridization Probe Set for Diagnosing High-Grade Dysplasia and Adenocarcinoma in Barrett's Esophagus. Dig Dis Sci. 2017 May;62(5):1216-1222. doi: 10.1007/s10620-017-4517-y. PubMed PMID: 28265829; PMCID: PMC6052443.
Rader JS, Sill MW, Beumer JH, Lankes HA, Benbrook DM, Garcia F, Trimble C, Tate Thigpen J, Lieberman R, Zuna RE, Leath CA 3rd, Spirtos NM, Byron J, Thaker PH, Lele S, Alberts D. A stratified randomized double-blind phase II trial of celecoxib for treating patients with cervical intraepithelial neoplasia: The potential predictive value of VEGF serum levels: An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol. 2017 May;145(2):291-297. doi: 10.1016/j.ygyno.2017.02.040. PubMed PMID: 28285845; PMCID: PMC5794341.
Soumerai JD, Zelenetz AD, Moskowitz CH, Palomba ML, Hamlin PA Jr, Noy A, Straus DJ, Moskowitz AJ, Younes A, Matasar MJ, Horwitz SM, Portlock CS, Konner JA, Gounder MM, Hyman DM, Voss MH, Fury MG, Gajria D, Carvajal RD, Ho AL, Beumer JH, Kiesel B, Zhang Z, Chen A, Little RF, Jarjies C, Dang TO, France F, Mishra N, Gerecitano JF. The PARP Inhibitor Veliparib Can Be Safely Added to Bendamustine and Rituximab and Has Preliminary Evidence of Activity in B-Cell Lymphoma. Clin Cancer Res. 2017 Aug 1;23(15):4119-4126. doi: 10.1158/1078-0432.CCR-16-3068. PubMed PMID: 28314788; PMCID: PMC5541854.
D'Aiuto L, Williamson K, Dimitrion P, McNulty J, Brown CE, Dokuburra CB, Nielsen AJ, Lin WJ, Piazza P, Schurdak ME, Wood J, Yolken RH, Kinchington PR, Bloom DC, Nimgaonkar VL. Comparison of three cell-based drug screening platforms for HSV-1 infection. Antiviral Res. 2017 Jun;142136-140. doi: 10.1016/j.antiviral.2017.03.016. PubMed PMID: 28342892; PMCID: PMC5525147.
Jandial DA, Brady WE, Howell SB, Lankes HA, Schilder RJ, Beumer JH, Christner SM, Strychor S, Powell MA, Hagemann AR, Moore KN, Walker JL, DiSilvestro PA, Duska LR, Fracasso PM, Dizon DS. A phase I pharmacokinetic study of intraperitoneal bortezomib and carboplatin in patients with persistent or recurrent ovarian cancer: An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol. 2017 May;145(2):236-242. doi: 10.1016/j.ygyno.2017.03.013. PubMed PMID: 28341300; PMCID: PMC5706109.
Epperly MW, Rhieu BH, Franicola D, Dixon T, Cao S, Zhang X, Shields D, Wang H, Wipf P, Greenberger JS. Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350. In Vivo. 2017 Mar-Apr;31(2):159-168. doi: 10.21873/invivo.11040. PubMed PMID: 28358695; PMCID: PMC5411740.
Somlo G, Frankel PH, Arun BK, Ma CX, Garcia AA, Cigler T, Cream LV, Harvey HA, Sparano JA, Nanda R, Chew HK, Moynihan TJ, Vahdat LT, Goetz MP, Beumer JH, Hurria A, Mortimer J, Piekarz R, Sand S, Herzog J, Van Tongeren LR, Ferry-Galow KV, Chen AP, Ruel C, Newman EM, Gandara DR, Weitzel JN. Efficacy of the PARP Inhibitor Veliparib with Carboplatin or as a Single Agent in Patients with Germline BRCA1- or BRCA2-Associated Metastatic Breast Cancer: California Cancer Consortium Trial NCT01149083. Clin Cancer Res. 2017 Aug 1;23(15):4066-4076. doi: 10.1158/1078-0432.CCR-16-2714. PubMed PMID: 28356425; PMCID: PMC5540749.
Bowden G, Cavaleri J, Monaco E III, Niranjan A, Flickinger J, Lunsford LD. Cystic Vestibular Schwannomas Respond Best to Radiosurgery. Neurosurgery. 2017 Sep 1;81(3):490-497. doi: 10.1093/neuros/nyx027. PubMed PMID: 28368501.
Benoist GE, van der Meulen E, Lubberman FJE, Gerritsen WR, Smilde TJ, Schalken JA, Beumer JH, Burger DM, van Erp NP. Analytical challenges in quantifying abiraterone with LC-MS/MS in human plasma. Biomed Chromatogr. 2017 Nov;31(11): doi: 10.1002/bmc.3986. PubMed PMID: 28370076; PMCID: PMC6114173.
Niu J, Scheuerell C, Mehrotra S, Karan S, Puhalla S, Kiesel BF, Ji J, Chu E, Gopalakrishnan M, Ivaturi V, Gobburu J, Beumer JH. Parent-Metabolite Pharmacokinetic Modeling and Pharmacodynamics of Veliparib (ABT-888), a PARP Inhibitor, in Patients With BRCA 1/2-Mutated Cancer or PARP-Sensitive Tumor Types. J Clin Pharmacol. 2017 Aug;57(8):977-987. doi: 10.1002/jcph.892. PubMed PMID: 28387939; PMCID: PMC5503785.
Lee JJ, Chu E. Adjuvant Chemotherapy for Stage II Colon Cancer: The Debate Goes On. J Oncol Pract. 2017 Apr;13(4):245-246. doi: 10.1200/JOP.2017.022178. PubMed PMID: 28399385; PMCID: PMC5455155.
Kunos CA, Chu E, Makower D, Kaubisch A, Sznol M, Ivy SP. Phase I Trial of Triapine-Cisplatin-Paclitaxel Chemotherapy for Advanced Stage or Metastatic Solid Tumor Cancers. Front Oncol. 2017;762. doi: 10.3389/fonc.2017.00062. PubMed PMID: 28421163; PMCID: PMC5378786.
Kozo D, Ross MW, Jarrah J, Barrett M, Harney RL, Courtney JB, Baburina I, Holleran JL, Beumer JH, Peters GJ, Honeywell RJ, Salamone SJ. Rapid Homogeneous Immunoassay to Quantify Gemcitabine in Plasma for Therapeutic Drug Monitoring. Ther Drug Monit. 2017 Jun;39(3):235-242. doi: 10.1097/FTD.0000000000000402. PubMed PMID: 28490046; PMCID: PMC5460533.
Sun J, Liu Y, Chen Y, Zhao W, Zhai Q, Rathod S, Huang Y, Tang S, Kwon YT, Fernandez C, Venkataramanan R, Li S. Doxorubicin delivered by a redox-responsive dasatinib-containing polymeric prodrug carrier for combination therapy. J Control Release. 2017 Jul 28;25843-55. doi: 10.1016/j.jconrel.2017.05.006. PubMed PMID: 28501705; PMCID: PMC5525542.
Sun JJ, Chen YC, Huang YX, Zhao WC, Liu YH, Venkataramanan R, Lu BF, Li S. Programmable co-delivery of the immune checkpoint inhibitor NLG919 and chemotherapeutic doxorubicin via a redox-responsive immunostimulatory polymeric prodrug carrier. Acta Pharmacol Sin. 2017 Jun;38(6):823-834. doi: 10.1038/aps.2017.44. PubMed PMID: 28504251; PMCID: PMC5520195.
Overacre-Delgoffe AE, Chikina M, Dadey RE, Yano H, Brunazzi EA, Shayan G, Horne W, Moskovitz JM, Kolls JK, Sander C, Shuai Y, Normolle DP, Kirkwood JM, Ferris RL, Delgoffe GM, Bruno TC, Workman CJ, Vignali DAA. Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity. Cell. 2017 Jun 1;169(6):1130-1141.e11. doi: 10.1016/j.cell.2017.05.005. PubMed PMID: 28552348; PMCID: PMC5509332.
Atreya CE, Yaeger R, Chu E. Systemic Therapy for Metastatic Colorectal Cancer: From Current Standards to Future Molecular Targeted Approaches. Am Soc Clin Oncol Educ Book. 2017;37246-256. doi: 10.1200/EDBK_175679. PubMed PMID: 28561718.
Liu K, Zhu J, Huang Y, Li C, Lu J, Sachar M, Li S, Ma X. Metabolism of KO143, an ABCG2 inhibitor. Drug Metab Pharmacokinet. 2017 Aug;32(4):193-200. doi: 10.1016/j.dmpk.2017.02.003. PubMed PMID: 28619281.
Masoodi KZ, Xu Y, Dar JA, Eisermann K, Pascal LE, Parrinello E, Ai J, Johnston PA, Nelson JB, Wipf P, Wang Z. Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-based Small Molecules. Mol Cancer Ther. 2017 Oct;16(10):2120-2129. doi: 10.1158/1535-7163.MCT-17-0176. PubMed PMID: 28655783; PMCID: PMC5628124.
Lim MJ, Agha A, Im A, Raptis A, Hou JZ, Boyiadzis M, Sehgal AR, Redner RL, Dorritie K, Marks SS, Agha ME, Lim SH. Intensive induction chemotherapy vs hypomethylating agent-based regimen in patients aged ≥70 years with newly diagnosed acute myeloid leukemia. Hematol Oncol. 2018 Apr;36(2):495-497. doi: 10.1002/hon.2456. PubMed PMID: 28664979.
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Boyiadzis M, Agha M, Redner RL, Sehgal A, Im A, Hou JZ, Farah R, Dorritie KA, Raptis A, Lim SH, Wang H, Lapteva N, Mei Z, Butterfield LH, Rooney CM, Whiteside TL. Phase 1 clinical trial of adoptive immunotherapy using "off-the-shelf" activated natural killer cells in patients with refractory and relapsed acute myeloid leukemia. Cytotherapy. 2017 Oct;19(10):1225-1232. doi: 10.1016/j.jcyt.2017.07.008. PubMed PMID: 28864289.
Matsumoto J, Kiesel BF, Parise RA, Guo J, Taylor S, Huang M, Eiseman JL, Ivy SP, Kunos C, Chu E, Beumer JH. LC-MS/MS assay for the quantitation of the ribonucleotide reductase inhibitor triapine in human plasma. J Pharm Biomed Anal. 2017 Nov 30;146154-160. doi: 10.1016/j.jpba.2017.08.036. PubMed PMID: 28881312; PMCID: PMC5636190.
Kiesel BF, Scemama J, Parise RA, Villaruz L, Iffland A, Doyle A, Ivy P, Chu E, Bakkenist CJ, Beumer JH. LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma. J Pharm Biomed Anal. 2017 Nov 30;146244-250. doi: 10.1016/j.jpba.2017.08.037. PubMed PMID: 28888173; PMCID: PMC5632222.
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Eiseman JL, Sciullo M, Wang H, Beumer JH, Horn CC. Estimation of body surface area in the musk shrew ( Suncus murinus): a small animal for testing chemotherapy-induced emesis. Lab Anim. 2017 Oct;51(5):534-537. doi: 10.1177/0023677217695851. PubMed PMID: 28948895; PMCID: PMC5654602.
Luu T, Kim KP, Blanchard S, Anyang B, Hurria A, Yang L, Beumer JH, Somlo G, Yen Y. Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer. Breast Cancer Res Treat. 2018 Jan;167(2):469-478. doi: 10.1007/s10549-017-4516-x. PubMed PMID: 28956187.
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Djuric Z, Turgeon DK, Sen A, Ren J, Herman K, Ramaswamy D, Zhao L, Ruffin MT 4th, Normolle DP, Smith WL, Brenner DE. The Anti-inflammatory Effect of Personalized Omega-3 Fatty Acid Dosing for Reducing Prostaglandin E2 in the Colonic Mucosa Is Attenuated in Obesity. Cancer Prev Res (Phila). 2017 Dec;10(12):729-737. doi: 10.1158/1940-6207.CAPR-17-0091. PubMed PMID: 29133307; PMCID: PMC5767924.
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Beumer JH, Inker LA, Levey AS. Improving Carboplatin Dosing Based on Estimated GFR. Am J Kidney Dis. 2018 Feb;71(2):163-165. doi: 10.1053/j.ajkd.2017.10.005. PubMed PMID: 29217306; PMCID: PMC6317965.
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Beckwitt CH, Clark AM, Wheeler S, Taylor DL, Stolz DB, Griffith L, Wells A. Liver 'organ on a chip'. Exp Cell Res. 2018 Feb 1;363(1):15-25. doi: 10.1016/j.yexcr.2017.12.023. PubMed PMID: 29291400; PMCID: PMC5944300.
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Liang S, Johansson E, Barila G, Altschuler DL, Fagman H, Nilsson M. A branching morphogenesis program governs embryonic growth of the thyroid gland. Development. 2018 Jan 25;145(2): doi: 10.1242/dev.146829. PubMed PMID: 29361553; PMCID: PMC5825846.
Guan X, Hasan MN, Maniar S, Jia W, Sun D. Reactive Astrocytes in Glioblastoma Multiforme. Mol Neurobiol. 2018 Aug;55(8):6927-6938. doi: 10.1007/s12035-018-0880-8. PubMed PMID: 29363044.
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Govindaraju K, Ingels A, Hasan MN, Sun D, Mathieu V, Masi M, Evidente A, Kornienko A. Synthetic analogues of the montanine-type alkaloids with activity against apoptosis-resistant cancer cells. Bioorg Med Chem Lett. 2018 Feb 15;28(4):589-593. doi: 10.1016/j.bmcl.2018.01.041. PubMed PMID: 29409754; PMCID: PMC5831727.
Benoist GE, van der Meulen E, van Oort IM, Beumer JH, Somford DM, Schalken JA, Burger DM, van Erp NP. Development and Validation of a Bioanalytical Method to Quantitate Enzalutamide and its Active Metabolite N-Desmethylenzalutamide in Human Plasma: Application to Clinical Management of Patients With Metastatic Castration-Resistant Prostate Cancer. Ther Drug Monit. 2018 Apr;40(2):222-229. doi: 10.1097/FTD.0000000000000484. PubMed PMID: 29419723; PMCID: PMC6085835.
Lee DM, Duensing A. What's the FOX Got to Do with the KITten? Regulating the Lineage-Specific Transcriptional Landscape in GIST. Cancer Discov. 2018 Feb;8(2):146-149. doi: 10.1158/2159-8290.CD-17-1370. PubMed PMID: 29431674.
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Leibowitz BJ, Yang L, Wei L, Buchanan ME, Rachid M, Parise RA, Beumer JH, Eiseman JL, Schoen RE, Zhang L, Yu J. Targeting p53-dependent stem cell loss for intestinal chemoprotection. Sci Transl Med. 2018 Feb 7;10(427): doi: 10.1126/scitranslmed.aam7610. PubMed PMID: 29437148; PMCID: PMC5827930.
Liu H, Liu H, Zhou Z, Parise RA, Chu E, Schmitz JC. Herbal formula Huang Qin Ge Gen Tang enhances 5-fluorouracil antitumor activity through modulation of the E2F1/TS pathway. Cell Commun Signal. 2018 Feb 20;16(1):7. doi: 10.1186/s12964-018-0218-1. PubMed PMID: 29458395; PMCID: PMC5819251.
Ma J, Salamoun J, Wipf P, Edwards R, Van Houten B, Qian W. Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential. Oncotarget. 2018 Jan 19;9(5):6042-6054. doi: 10.18632/oncotarget.23679. PubMed PMID: 29464053; PMCID: PMC5814193.
Gough A, Shun TY, Taylor DL, Schurdak M. Integrating Analysis of Cellular Heterogeneity in High-Content Dose-Response Studies. Methods Mol Biol. 2018;174525-46. doi: 10.1007/978-1-4939-7680-5_2. PubMed PMID: 29476461.
McQueeney KE, Salamoun JM, Burnett JC, Barabutis N, Pekic P, Lewandowski SL, Llaneza DC, Cornelison R, Bai Y, Zhang ZY, Catravas JD, Landen CN, Wipf P, Lazo JS, Sharlow ER. Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor. Oncotarget. 2018 Feb 2;9(9):8223-8240. doi: 10.18632/oncotarget.23787. PubMed PMID: 29492190; PMCID: PMC5823565.
Keating SM, Taylor DL, Plant AL, Litwack ED, Kuhn P, Greenspan EJ, Hartshorn CM, Sigman CC, Kelloff GJ, Chang DD, Friberg G, Lee JSH, Kuida K. Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation. Clin Transl Sci. 2018 May;11(3):267-276. doi: 10.1111/cts.12536. PubMed PMID: 29498218; PMCID: PMC5944591.
Singh KB, Hahm ER, Rigatti LH, Normolle DP, Yuan JM, Singh SV. Inhibition of Glycolysis in Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate. Cancer Prev Res (Phila). 2018 Jun;11(6):337-346. doi: 10.1158/1940-6207.CAPR-17-0389. PubMed PMID: 29545400; PMCID: PMC5984685.
Willis J, Epperly MW, Fisher R, Zhang X, Shields D, Hou W, Wang H, Li S, Wipf P, Parmar K, Guinan E, Steinman J, Greenberger JS. Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca-/- and Fancg-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039). Radiat Res. 2018 Jun;189(6):560-578. doi: 10.1667/RR14878.1. PubMed PMID: 29584588; PMCID: PMC5973476.
Redner RL, Beumer JH, Kropf P, Agha M, Boyiadzis M, Dorritie K, Farah R, Hou JZ, Im A, Lim SH, Raptis A, Sehgal A, Christner SM, Normolle D, Johnson DE. A phase-1 study of dasatinib plus all-trans retinoic acid in acute myeloid leukemia. Leuk Lymphoma. 2018 Nov;59(11):2595-2601. doi: 10.1080/10428194.2018.1443330. PubMed PMID: 29616864; PMCID: PMC6201295.
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Dorchak JA, Maria S, Guarinoni JL, Duensing A, Somiari S, Cavanaugh J, Deyarmin B, Hu H, Iida J, Shriver CD, Witt-Enderby PA. The Impact of Hormonal Contraceptives on Breast Cancer Pathology. Horm Cancer. 2018 Aug;9(4):240-253. doi: 10.1007/s12672-018-0332-y. PubMed PMID: 29687205; PMCID: PMC6742516.
Tahata S, Singh SV, Lin Y, Hahm ER, Beumer JH, Christner SM, Rao UN, Sander C, Tarhini AA, Tawbi H, Ferris LK, Wilson M, Rose A, Dietz CM, Hughes E, Fahey JW, Leachman SA, Cassidy PB, Butterfield LH, Zarour HM, Kirkwood JM. Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi. Cancer Prev Res (Phila). 2018 Jul;11(7):429-438. doi: 10.1158/1940-6207.CAPR-17-0268. PubMed PMID: 29691233; PMCID: PMC6030491.
Faramand A, Kano H, Niranjan A, Johnson SA, Hassib M, Park KJ, Arai Y, Flickinger JC, Lunsford LD. Cranial nerve outcomes after primary stereotactic radiosurgery for symptomatic skull base meningiomas. J Neurooncol. 2018 Sep;139(2):341-348. doi: 10.1007/s11060-018-2866-9. PubMed PMID: 29691775.
Schurdak ME, Pei F, Lezon TR, Carlisle D, Friedlander R, Taylor DL, Stern AM. A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes. Methods Mol Biol. 2018;1787207-222. doi: 10.1007/978-1-4939-7847-2_16. PubMed PMID: 29736721.
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