Radiation and Oxidative Damage
. OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts. Nat Commun. 2025-01-21;16(1):893. doi: 10.1038/s41467-024-55638-4. PubMed PMID: 39837827; PMCID: PMC11751180.
. Unlocking transcription-coupled DNA repair with the STK19 key. Mol Cell. 2024-12-19;84(24):4693-4695. doi: 10.1016/j.molcel.2024.11.027. PubMed PMID: 39706162.
. Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine. Nat Commun. 2024-10-25;15(1):9226. doi: 10.1038/s41467-024-53497-7. PubMed PMID: 39455577; PMCID: PMC11512004.
. Deregulated DNA ADP-ribosylation impairs telomere replication. Nat Struct Mol Biol. 2024-05-01; doi: 10.1038/s41594-024-01279-6. PubMed PMID: 38714889; PMCID: PMC11102865.
. Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer. Oncogene. 2024-03-01; doi: 10.1038/s41388-024-02939-z. PubMed PMID: 38273024; PMCID: PMC11556418.
. BG4 antibody can recognize telomeric G-quadruplexes harboring destabilizing base modifications and lesions. Nucleic Acids Res. 2024-02-28; doi: 10.1093/nar/gkad1209. PubMed PMID: 38153143; PMCID: PMC10939409.
. Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair. Cell Rep. 2024-01-23;43(1):113656. doi: 10.1016/j.celrep.2023.113656. PubMed PMID: 38194346; PMCID: PMC10851105.
. FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner. Clin Cancer Res. 2024-01-05;30(1):187-197. doi: 10.1158/1078-0432.CCR-23-0964. PubMed PMID: 37819945; PMCID: PMC10767302.
. Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity. Proc Natl Acad Sci U S A. 2023-07-25;120(30):e2308010120. doi: 10.1073/pnas.2308010120. PubMed PMID: 37459531; PMCID: PMC10372695.
. Spatial mapping of cellular senescence: emerging challenges and opportunities. Nat Aging. 2023-07-01;3(7):776-790. doi: 10.1038/s43587-023-00446-6. PubMed PMID: 37400722; PMCID: PMC10505496.
. Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators. Proc Natl Acad Sci U S A. 2023-06-20;120(25):e2218896120. doi: 10.1073/pnas.2218896120. PubMed PMID: 37327313; PMCID: PMC10288584.
. UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties. Nucleic Acids Res. 2023-06-09;51(10):4881-4898. doi: 10.1093/nar/gkad206. PubMed PMID: 36971122; PMCID: PMC10250209.
. Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE). Nucleic Acids Res. 2023-04-24;51(7):e39. doi: 10.1093/nar/gkad095. PubMed PMID: 36861323; PMCID: PMC10123111.
. Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats. Nat Commun. 2023-02-21;14(1):670. doi: 10.1038/s41467-023-36284-8. PubMed PMID: 36810851; PMCID: PMC9944903.
. Cooperative interaction between AAG and UV-DDB in the removal of modified bases. Nucleic Acids Res. 2022-12-09;50(22):12856-12871. doi: 10.1093/nar/gkac1145. PubMed PMID: 36511855; PMCID: PMC9825174.
. RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA. Mol Cell. 2022-11-03;82(21):4001-4017.e7. doi: 10.1016/j.molcel.2022.09.025. PubMed PMID: 36265488; PMCID: PMC9713952.
. Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening. Nat Struct Mol Biol. 2022-07-01;29(7):639-652. doi: 10.1038/s41594-022-00790-y. PubMed PMID: 35773409; PMCID: PMC9287163.
. Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death. Redox Biol. 2022-04-01;50102232. doi: 10.1016/j.redox.2022.102232. PubMed PMID: 35101798; PMCID: PMC8804265.
. p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade. Cancer Res. 2022-03-01;82(5):916-928. doi: 10.1158/0008-5472.CAN-21-2101. PubMed PMID: 34965932; PMCID: PMC9136619.
. Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins. Nat Commun. 2022-02-21;13(1):974. doi: 10.1038/s41467-022-28642-9. PubMed PMID: 35190564; PMCID: PMC8861037.
. Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60. Sci Adv. 2022-02-18;8(7):eabl6083. doi: 10.1126/sciadv.abl6083. PubMed PMID: 35171671; PMCID: PMC8849393.
. TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA. Nucleic Acids Res. 2021-12-16;49(22):13000-13018. doi: 10.1093/nar/gkab1142. PubMed PMID: 34883513; PMCID: PMC8682769.
. Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function. Nat Commun. 2021-11-03;12(1):6340. doi: 10.1038/s41467-021-26570-8. PubMed PMID: 34732714; PMCID: PMC8566594.
. Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover. Nucleic Acids Res. 2021-08-20;49(14):8177-8188. doi: 10.1093/nar/gkab591. PubMed PMID: 34232996; PMCID: PMC8373069.
. p53 dynamics vary between tissues and are linked with radiation sensitivity. Nat Commun. 2021-02-09;12(1):898. doi: 10.1038/s41467-021-21145-z. PubMed PMID: 33563973; PMCID: PMC7873198.
. Syngeneic tobacco carcinogen-induced mouse lung adenocarcinoma model exhibits PD-L1 expression and high tumor mutational burden. JCI Insight. 2021-02-08;6(3): doi: 10.1172/jci.insight.145307. PubMed PMID: 33351788; PMCID: PMC7934870.
. Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol. 2020-12-01;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. PubMed PMID: 33046907; PMCID: PMC7809635.
. The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage. Nucleic Acids Res. 2020-11-18;48(20):11227-11243. doi: 10.1093/nar/gkaa777. PubMed PMID: 33010169; PMCID: PMC7672477.
. Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs. Nat Commun. 2020-10-20;11(1):5288. doi: 10.1038/s41467-020-19115-y. PubMed PMID: 33082336; PMCID: PMC7576608.
. Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search. Nat Commun. 2020-03-13;11(1):1356. doi: 10.1038/s41467-020-15168-1. PubMed PMID: 32170071; PMCID: PMC7069974.
. Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends. Trends Cancer. 2020-03-01;6(3):247-260. doi: 10.1016/j.trecan.2019.12.009. PubMed PMID: 32101727; PMCID: PMC7199893.
. The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination. Nucleic Acids Res. 2019-11-04;47(19):10151-10165. doi: 10.1093/nar/gkz738. PubMed PMID: 31665741; PMCID: PMC6821187.
. RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Mol Cell. 2019-10-03;76(1):11-26.e7. doi: 10.1016/j.molcel.2019.06.043. PubMed PMID: 31400850; PMCID: PMC6778027.
. The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway. Nat Commun. 2019-08-05;10(1):3515. doi: 10.1038/s41467-019-11374-8. PubMed PMID: 31383866; PMCID: PMC6683157.
. Damage sensor role of UV-DDB during base excision repair. Nat Struct Mol Biol. 2019-08-01;26(8):695-703. doi: 10.1038/s41594-019-0261-7. PubMed PMID: 31332353; PMCID: PMC6684372.
. Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis. Mol Cell. 2019-07-11;75(1):117-130.e6. doi: 10.1016/j.molcel.2019.04.024. PubMed PMID: 31101499; PMCID: PMC6625854.
. Predicting Outcome in Head and Neck Cancer: miRNAs with Potentially Big Effects. Clin Cancer Res. 2019-03-01;25(5):1441-1442. doi: 10.1158/1078-0432.CCR-18-3078. PubMed PMID: 30413524; PMCID: PMC6415532.
. Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE. J Am Chem Soc. 2018-12-26;140(51):17835-17839. doi: 10.1021/jacs.8b09913. PubMed PMID: 30525572; PMCID: PMC6622169.
. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biol. 2018-09-01;18191-199. doi: 10.1016/j.redox.2018.06.005. PubMed PMID: 30031267; PMCID: PMC6076207.
. ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation. J Clin Invest. 2018-08-31;128(9):3926-3940. doi: 10.1172/JCI96519. PubMed PMID: 29952768; PMCID: PMC6118586.
. PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1. Nucleic Acids Res. 2017-12-15;45(22):12834-12847. doi: 10.1093/nar/gkx1047. PubMed PMID: 29121337; PMCID: PMC5728402.
. ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1. Nat Commun. 2017-11-09;8(1):1392. doi: 10.1038/s41467-017-01401-x. PubMed PMID: 29123096; PMCID: PMC5680267.
. Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors. Clin Cancer Res. 2017-01-15;23(2):600-609. doi: 10.1158/1078-0432.CCR-16-1113. PubMed PMID: 27407094; PMCID: PMC6560642.
. Telomere-associated aging disorders. Ageing Res Rev. 2017-01-01;3352-66. doi: 10.1016/j.arr.2016.05.009. PubMed PMID: 27215853; PMCID: PMC9926533.
. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017-01-01;13(1):81-90. doi: 10.1038/nchembio.2238. PubMed PMID: 27842066; PMCID: PMC5506843.
. Oxidative guanine base damage regulates human telomerase activity. Nat Struct Mol Biol. 2016-12-01;23(12):1092-1100. doi: 10.1038/nsmb.3319. PubMed PMID: 27820808; PMCID: PMC5140714.
. DNA repair: Clamping down on copy errors. Nature. 2016-11-24;539(7630):498-499. doi: 10.1038/nature20475. PubMed PMID: 27851733; PMCID: PMC5641404.
. Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process. Mol Cell. 2016-10-20;64(2):376-387. doi: 10.1016/j.molcel.2016.09.005. PubMed PMID: 27720644; PMCID: PMC5123691.
. The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products. Nucleic Acids Res. 2016-09-30;44(17):8199-215. doi: 10.1093/nar/gkw535. PubMed PMID: 27298254; PMCID: PMC5041462.
. New Thoughts about the Origin of Plexiform Lesions. Am J Respir Crit Care Med. 2016-03-01;193(5):484-5. doi: 10.1164/rccm.201510-1959ED. PubMed PMID: 26930432.
. A genetically targetable near-infrared photosensitizer. Nat Methods. 2016-03-01;13(3):263-8. doi: 10.1038/nmeth.3735. PubMed PMID: 26808669; PMCID: PMC4916159.
. Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts. Nat Commun. 2015-09-09;68214. doi: 10.1038/ncomms9214. PubMed PMID: 26351258; PMCID: PMC4566151.
. Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52. Nat Commun. 2015-07-28;67834. doi: 10.1038/ncomms8834. PubMed PMID: 26215801; PMCID: PMC4525180.
. Pulmonary Arterial Hypertension Is Associated with Oxidative Stress-induced Genome Instability. Am J Respir Crit Care Med. 2015-07-15;192(2):129-30. doi: 10.1164/rccm.201505-0904ED. PubMed PMID: 26177169; PMCID: PMC4532829.
. Polymerase η suppresses telomere defects induced by DNA damaging agents. Nucleic Acids Res. 2014-12-01;42(21):13096-109. doi: 10.1093/nar/gku1030. PubMed PMID: 25355508; PMCID: PMC4245935.
. Assembly of telomeric chromatin to create ALTernative endings. Trends Cell Biol. 2014-11-01;24(11):675-85. doi: 10.1016/j.tcb.2014.07.007. PubMed PMID: 25172551.
