Publications

. Rational development of gemcitabine-based nanoplatform for targeting SERPINB9/Granzyme B axis to overcome chemo-immune-resistance. Nat Commun. 2025-05-05;16(1):4176. doi: 10.1038/s41467-025-59490-y. PubMed PMID: 40325025; PMCID: PMC12053578.

. Aged and BRCA mutated stromal cells drive epithelial cell transformation. Cancer Discov. 2025-03-14; doi: 10.1158/2159-8290.CD-24-0805. PubMed PMID: 40084985.

. The de-sulfinylation enzyme sulfiredoxin-1 attenuates hepatic stellate cell activation and liver fibrosis by modulating the PTPN12-NLRP3 axis. Hepatology. 2024-10-24; doi: 10.1097/HEP.0000000000001133. PubMed PMID: 39446334.

. Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose. Sci Transl Med. 2024-09-25;16(766):eadk8446. doi: 10.1126/scitranslmed.adk8446. PubMed PMID: 39321267.

. Rhodium(I)-Catalyzed Annulation of Bicyclo[1.1.0]butyl-Substituted Dihydroquinolines and Dihydropyridines. J Am Chem Soc. 2024-06-05; doi: 10.1021/jacs.4c04081. PubMed PMID: 38767459; PMCID: PMC11157536.

. Knocking down of Xkr8 enhances chemotherapy efficacy through modulating tumor immune microenvironment. J Control Release. 2024-06-01; doi: 10.1016/j.jconrel.2024.04.041. PubMed PMID: 38685385; PMCID: PMC11186464.

. Paclitaxel therapeutic drug monitoring - International association of therapeutic drug monitoring and clinical toxicology recommendations. Eur J Cancer. 2024-05-01;202114024. doi: 10.1016/j.ejca.2024.114024. PubMed PMID: 38513383; PMCID: PMC11053297.

. Impact of the 2021 CKD-EPI equation on anticancer pharmacotherapy in black and non-black cancer patients. Cancer Lett. 2024-04-01;216679. doi: 10.1016/j.canlet.2024.216679. PubMed PMID: 38307411; PMCID: PMC10939791.

. Knocking down of Xkr8 enhances chemotherapy efficacy through modulating tumor immune microenvironment. J Control Release. 2024-03-10; doi: 10.1016/j.jconrel.2024.03.011. PubMed PMID: 38471639.

. Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer. Oncogene. 2024-03-01; doi: 10.1038/s41388-024-02939-z. PubMed PMID: 38273024; PMCID: PMC11556418.

. Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis. Acta Pharm Sin B. 2024-03-01;14(3):1241-1256. doi: 10.1016/j.apsb.2023.12.006. PubMed PMID: 38487006; PMCID: PMC10935170.

. Project Confirm: Accelerated Drug Approvals for CML-Letter. Clin Cancer Res. 2024-01-05;30(1):235-236. doi: 10.1158/1078-0432.CCR-23-2630. PubMed PMID: 38178775; PMCID: PMC10783536.

. Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy. Nat Commun. 2024-01-04;15(1):255. doi: 10.1038/s41467-023-44572-6. PubMed PMID: 38177179; PMCID: PMC10766965.

. Cell Surface Labeling and Detection of Protein Tyrosine Kinase 7 via Covalent Aptamers. J Am Chem Soc. 2023-08-02;145(30):16458-16463. doi: 10.1021/jacs.3c02752. PubMed PMID: 37473438; PMCID: PMC10401710.

. Quality-of-life outcomes and risk prediction for patients randomized to nivolumab plus ipilimumab vs nivolumab on LungMAP-S1400I. J Natl Cancer Inst. 2023-04-11;115(4):437-446. doi: 10.1093/jnci/djad003. PubMed PMID: 36625510; PMCID: PMC10086628.

. Targeting Xkr8 via nanoparticle-mediated in situ co-delivery of siRNA and chemotherapy drugs for cancer immunochemotherapy. Nat Nanotechnol. 2023-02-01;18(2):193-204. doi: 10.1038/s41565-022-01266-2. PubMed PMID: 36424448; PMCID: PMC9974593.

. Engineering Small Molecule Switches of Protein Function in Zebrafish Embryos. J Am Chem Soc. 2023-02-01;145(4):2395-2403. doi: 10.1021/jacs.2c11366. PubMed PMID: 36662675.

. Chemically Acylated tRNAs are Functional in Zebrafish Embryos. J Am Chem Soc. 2023-02-01;145(4):2414-2420. doi: 10.1021/jacs.2c11452. PubMed PMID: 36669466; PMCID: PMC10155198.

. Improved antitumor activity against prostate cancer via synergistic targeting of Myc and GFAT-1. Theranostics. 2023-01-01;13(2):578-595. doi: 10.7150/thno.76614. PubMed PMID: 36632215; PMCID: PMC9830436.

. Endometriosis-Associated Mesenchymal Stem Cells Support Ovarian Clear Cell Carcinoma through Iron Regulation. Cancer Res. 2022-12-16;82(24):4680-4693. doi: 10.1158/0008-5472.CAN-22-1294. PubMed PMID: 36219681; PMCID: PMC9755968.

. All Optimal Dosing Roads Lead to Therapeutic Drug Monitoring-Why Take the Slow Lane. JAMA Oncol. 2022-12-01;8(12):1733-1735. doi: 10.1001/jamaoncol.2022.4452. PubMed PMID: 36264552; PMCID: PMC9772116.

. Optical Control of MicroRNA Function in Zebrafish Embryos. J Am Chem Soc. 2022-09-21;144(37):16819-16826. doi: 10.1021/jacs.2c04479. PubMed PMID: 36073798.

. Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure. Gastroenterology. 2022-04-01;162(4):1226-1241. doi: 10.1053/j.gastro.2021.12.260. PubMed PMID: 34954226; PMCID: PMC8934304.

. Engineering a folic acid-decorated ultrasmall gemcitabine nanocarrier for breast cancer therapy: Dual targeting of tumor cells and tumor-associated macrophages. Acta Pharm Sin B. 2022-03-01;12(3):1148-1162. doi: 10.1016/j.apsb.2021.09.024. PubMed PMID: 35530140; PMCID: PMC9072252.

. Targeting metabotropic glutamate receptor 4 for cancer immunotherapy. Sci Adv. 2021-12-10;7(50):eabj4226. doi: 10.1126/sciadv.abj4226. PubMed PMID: 34890233; PMCID: PMC8664261.

. Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction. J Am Chem Soc. 2021-11-10;143(44):18665-18671. doi: 10.1021/jacs.1c08723. PubMed PMID: 34705461; PMCID: PMC9014490.

. Scalable Birch reduction with lithium and ethylenediamine in tetrahydrofuran. Science. 2021-11-05;374(6568):741-746. doi: 10.1126/science.abk3099. PubMed PMID: 34735232.

. The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1. Sci Adv. 2021-09-03;7(36):eabg9241. doi: 10.1126/sciadv.abg9241. PubMed PMID: 34516906; PMCID: PMC8442864.

. Author response to Cunha et al. J Immunother Cancer. 2021-07-01;9(7): doi: 10.1136/jitc-2021-003299. PubMed PMID: 34315823; PMCID: PMC8317086.

. Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis. Gastroenterology. 2021-07-01;161(1):271-286.e11. doi: 10.1053/j.gastro.2021.03.048. PubMed PMID: 33819483; PMCID: PMC8238844.

. Targeted Protein Degradation through Fast Optogenetic Activation and Its Application to the Control of Cell Signaling. J Am Chem Soc. 2021-06-23;143(24):9222-9229. doi: 10.1021/jacs.1c04324. PubMed PMID: 34121391.

. Crizotinib in Patients With MET-Amplified NSCLC. J Thorac Oncol. 2021-06-01;16(6):1017-1029. doi: 10.1016/j.jtho.2021.02.010. PubMed PMID: 33676017.

. Radiomics analysis for predicting pembrolizumab response in patients with advanced rare cancers. J Immunother Cancer. 2021-04-01;9(4): doi: 10.1136/jitc-2020-001752. PubMed PMID: 33849924; PMCID: PMC8051405.

. A novel immunochemotherapy based on targeting of cyclooxygenase and induction of immunogenic cell death. Biomaterials. 2021-03-01;270120708. doi: 10.1016/j.biomaterials.2021.120708. PubMed PMID: 33578254; PMCID: PMC7910750.

. Tumor size-dependent abscopal effect of polydopamine-coated all-in-one nanoparticles for immunochemo-photothermal therapy of early- and late-stage metastatic cancer. Biomaterials. 2021-02-01;269120629. doi: 10.1016/j.biomaterials.2020.120629. PubMed PMID: 33387938; PMCID: PMC8466812.

. Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR). Acta Pharm Sin B. 2021-02-01;11(2):434-441. doi: 10.1016/j.apsb.2020.08.015. PubMed PMID: 33643822; PMCID: PMC7893119.

. ERINA Is an Estrogen-Responsive LncRNA That Drives Breast Cancer through the E2F1/RB1 Pathway. Cancer Res. 2020-10-15;80(20):4399-4413. doi: 10.1158/0008-5472.CAN-20-1031. PubMed PMID: 32826278; PMCID: PMC7572695.

. Immune Checkpoint Blockade in Oncogene-Driven Non-Small-Cell Lung Cancer. Drugs. 2020-06-01;80(9):883-892. doi: 10.1007/s40265-020-01320-0. PubMed PMID: 32436070; PMCID: PMC8579493.

. Optical Control of Small Molecule-Induced Protein Degradation. J Am Chem Soc. 2020-02-05;142(5):2193-2197. doi: 10.1021/jacs.9b12718. PubMed PMID: 31927988; PMCID: PMC7229639.

. Sensitizing Triple Negative Breast Cancer to Tamoxifen Chemotherapy via a Redox-Responsive Vorinostat-containing Polymeric Prodrug Nanocarrier. Theranostics. 2020-01-20;10(6):2463-2478. doi: 10.7150/thno.38973. PubMed PMID: 32194813; PMCID: PMC7052901.

. High Loading of Hydrophobic and Hydrophilic Agents via Small Immunostimulatory Carrier for Enhanced Tumor Penetration and Combinational Therapy. Theranostics. 2020-01-01;10(3):1136-1150. doi: 10.7150/thno.38287. PubMed PMID: 31938056; PMCID: PMC6956803.

. Editorial of Special Issue on Drug Metabolism and Disposition in Diseases. Acta Pharm Sin B. 2020-01-01;10(1):2. doi: 10.1016/j.apsb.2019.12.016. PubMed PMID: 31993303; PMCID: PMC6977160.

. Long-noncoding RNAs (lncRNAs) in drug metabolism and disposition, implications in cancer chemo-resistance. Acta Pharm Sin B. 2020-01-01;10(1):105-112. doi: 10.1016/j.apsb.2019.09.011. PubMed PMID: 31993309; PMCID: PMC6976993.

. Optical control of protein phosphatase function. Nat Commun. 2019-09-26;10(1):4384. doi: 10.1038/s41467-019-12260-z. PubMed PMID: 31558717; PMCID: PMC6763421.

. Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury. Hepatology. 2019-09-01;70(3):995-1010. doi: 10.1002/hep.30691. PubMed PMID: 31038762; PMCID: PMC6717545.

. Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice. Gastroenterology. 2019-09-01;157(3):793-806.e14. doi: 10.1053/j.gastro.2019.05.066. PubMed PMID: 31170413; PMCID: PMC6707837.

. Multicenter study demonstrates radiomic features derived from magnetic resonance perfusion images identify pseudoprogression in glioblastoma. Nat Commun. 2019-07-18;10(1):3170. doi: 10.1038/s41467-019-11007-0. PubMed PMID: 31320621; PMCID: PMC6639324.

. Creatine based polymer for codelivery of bioengineered MicroRNA and chemodrugs against breast cancer lung metastasis. Biomaterials. 2019-07-01;21025-40. doi: 10.1016/j.biomaterials.2019.04.025. PubMed PMID: 31054369; PMCID: PMC6538300.

. Predicting Outcome in Head and Neck Cancer: miRNAs with Potentially Big Effects. Clin Cancer Res. 2019-03-01;25(5):1441-1442. doi: 10.1158/1078-0432.CCR-18-3078. PubMed PMID: 30413524; PMCID: PMC6415532.

. Shared heritability and functional enrichment across six solid cancers. Nat Commun. 2019-01-25;10(1):431. doi: 10.1038/s41467-018-08054-4. PubMed PMID: 30683880; PMCID: PMC6347624.

. Metformin action through the microbiome and bile acids. Nat Med. 2018-12-01;24(12):1789-1790. doi: 10.1038/s41591-018-0273-6. PubMed PMID: 30523325.

. Novel glucosylceramide synthase inhibitor based prodrug copolymer micelles for delivery of anticancer agents. J Control Release. 2018-10-28;288212-226. doi: 10.1016/j.jconrel.2018.09.011. PubMed PMID: 30223045; PMCID: PMC6177216.

. Disease Response with the Addition of Platinum-Based Chemotherapy to Pembrolizumab after Progression on Pembrolizumab Monotherapy in PD-L1-Expressing Non-Small Cell Lung Cancer. J Thorac Oncol. 2018-08-01;13(8):e135-e136. doi: 10.1016/j.jtho.2018.02.031. PubMed PMID: 30049372.

. Small Molecule Release and Activation through DNA Computing. J Am Chem Soc. 2017-10-04;139(39):13909-13915. doi: 10.1021/jacs.7b07831. PubMed PMID: 28945369.

. Doxorubicin delivered by a redox-responsive dasatinib-containing polymeric prodrug carrier for combination therapy. J Control Release. 2017-07-28;25843-55. doi: 10.1016/j.jconrel.2017.05.006. PubMed PMID: 28501705; PMCID: PMC5525542.

. Genetic Code Expansion in Zebrafish Embryos and Its Application to Optical Control of Cell Signaling. J Am Chem Soc. 2017-07-12;139(27):9100-9103. doi: 10.1021/jacs.7b02145. PubMed PMID: 28657738; PMCID: PMC6022368.

. Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis. Hepatology. 2017-03-01;65(3):893-906. doi: 10.1002/hep.28924. PubMed PMID: 28102638; PMCID: PMC5319891.

. An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy. Nat Commun. 2016-11-07;713443. doi: 10.1038/ncomms13443. PubMed PMID: 27819653; PMCID: PMC5103075.

. Small-molecule control of protein function through Staudinger reduction. Nat Chem. 2016-11-01;8(11):1027-1034. doi: 10.1038/nchem.2573. PubMed PMID: 27768095; PMCID: PMC5119652.

. Reply to: "miR-122 expression is not regulated during activation of hepatic stellate cells". J Hepatol. 2016-10-01;65(4):868. doi: 10.1016/j.jhep.2016.06.020. PubMed PMID: 27388922.

. A brief history of the discovery of PXR and CAR as xenobiotic receptors. Acta Pharm Sin B. 2016-09-01;6(5):450-452. doi: 10.1016/j.apsb.2016.06.011. PubMed PMID: 27709013; PMCID: PMC5045536.

. Reply to V. Launay-Vacher, T. Shimokata et al, and C. Porta et al. J Clin Oncol. 2016-07-10;34(20):2430-1. doi: 10.1200/JCO.2016.67.2790. PubMed PMID: 27185845.

. Reply. Hepatology. 2016-04-01;63(4):1397-8. doi: 10.1002/hep.27957. PubMed PMID: 26109100; PMCID: PMC4691218.

. Click chemistry: Straining to react. Nat Chem. 2016-04-01;8(4):296-7. doi: 10.1038/nchem.2485. PubMed PMID: 27001724.

. A competitive and reversible deactivation approach to catalysis-based quantitative assays. Nat Commun. 2016-02-19;710691. doi: 10.1038/ncomms10691. PubMed PMID: 26891765; PMCID: PMC4762883.

. Effect of Renal Dysfunction on Toxicity in Three Decades of Cancer Therapy Evaluation Program-Sponsored Single-Agent Phase I Studies. J Clin Oncol. 2016-01-10;34(2):110-6. doi: 10.1200/JCO.2014.59.7302. PubMed PMID: 26392101; PMCID: PMC4980565.

. Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. J Hepatol. 2016-01-01;64(1):44-52. doi: 10.1016/j.jhep.2015.07.022. PubMed PMID: 26220752; PMCID: PMC4691383.

. Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury. J Hepatol. 2015-10-01;63(4):855-62. doi: 10.1016/j.jhep.2015.05.030. PubMed PMID: 26070408; PMCID: PMC4867094.

. Effective co-delivery of doxorubicin and dasatinib using a PEG-Fmoc nanocarrier for combination cancer chemotherapy. Biomaterials. 2015-10-01;67104-14. doi: 10.1016/j.biomaterials.2015.07.027. PubMed PMID: 26210177; PMCID: PMC4550547.

. Ovarian Cancer Survival and Chemotherapy Dosing, Body Mass Index, and Body Surface Area : Are We There Yet? JAMA Oncol. 2015-09-01;1(6):732-3. doi: 10.1001/jamaoncol.2015.1926. PubMed PMID: 26181495; PMCID: PMC4696392.

. The self-assembling camptothecin-tocopherol prodrug: An effective approach for formulating camptothecin. Biomaterials. 2015-09-01;62176-87. doi: 10.1016/j.biomaterials.2015.05.046. PubMed PMID: 26057133; PMCID: PMC4470812.

. Oestrogen sulfotransferase ablation sensitizes mice to sepsis. Nat Commun. 2015-08-10;67979. doi: 10.1038/ncomms8979. PubMed PMID: 26259151; PMCID: PMC4532951.

. Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21. Hepatology. 2015-06-01;61(6):1908-19. doi: 10.1002/hep.27719. PubMed PMID: 25614121; PMCID: PMC4441569.

. Optical Control of CRISPR/Cas9 Gene Editing. J Am Chem Soc. 2015-05-06;137(17):5642-5. doi: 10.1021/ja512664v. PubMed PMID: 25905628; PMCID: PMC4919123.

. Conditional control of alternative splicing through light-triggered splice-switching oligonucleotides. J Am Chem Soc. 2015-03-18;137(10):3656-62. doi: 10.1021/jacs.5b00580. PubMed PMID: 25734836; PMCID: PMC5545098.

. An improved D-α-tocopherol-based nanocarrier for targeted delivery of doxorubicin with reversal of multidrug resistance. J Control Release. 2014-12-28;196272-86. doi: 10.1016/j.jconrel.2014.10.016. PubMed PMID: 25456831; PMCID: PMC4267990.

. Genetically encoded optochemical probes for simultaneous fluorescence reporting and light activation of protein function with two-photon excitation. J Am Chem Soc. 2014-11-05;136(44):15551-8. doi: 10.1021/ja5055862. PubMed PMID: 25341086; PMCID: PMC4333581.

. A new family of iron-dependent halogenases acts on freestanding substrates. Nat Chem Biol. 2014-11-01;10(11):921-3. doi: 10.1038/nchembio.1625. PubMed PMID: 25218740.

. A PEG-Fmoc conjugate as a nanocarrier for paclitaxel. Biomaterials. 2014-08-01;35(25):7146-56. doi: 10.1016/j.biomaterials.2014.04.108. PubMed PMID: 24856103; PMCID: PMC4102141.