Aging
. OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts. Nat Commun. 2025-01-21;16(1):893. doi: 10.1038/s41467-024-55638-4. PubMed PMID: 39837827; PMCID: PMC11751180.
. Unlocking transcription-coupled DNA repair with the STK19 key. Mol Cell. 2024-12-19;84(24):4693-4695. doi: 10.1016/j.molcel.2024.11.027. PubMed PMID: 39706162.
. Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine. Nat Commun. 2024-10-25;15(1):9226. doi: 10.1038/s41467-024-53497-7. PubMed PMID: 39455577; PMCID: PMC11512004.
. A persistent variant telomere sequence in a human pedigree. Nat Commun. 2024-06-01;15(1):4681. doi: 10.1038/s41467-024-49072-9. PubMed PMID: 38824190; PMCID: PMC11144197.
. Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer. Oncogene. 2024-03-01; doi: 10.1038/s41388-024-02939-z. PubMed PMID: 38273024; PMCID: PMC11556418.
. BG4 antibody can recognize telomeric G-quadruplexes harboring destabilizing base modifications and lesions. Nucleic Acids Res. 2024-02-28; doi: 10.1093/nar/gkad1209. PubMed PMID: 38153143; PMCID: PMC10939409.
. Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair. Cell Rep. 2024-01-23;43(1):113656. doi: 10.1016/j.celrep.2023.113656. PubMed PMID: 38194346; PMCID: PMC10851105.
. Intact mitochondrial function in the setting of telomere-induced senescence. Aging Cell. 2023-10-01;e13941. doi: 10.1111/acel.13941. PubMed PMID: 37688329; PMCID: PMC10577573.
. Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity. Proc Natl Acad Sci U S A. 2023-07-25;120(30):e2308010120. doi: 10.1073/pnas.2308010120. PubMed PMID: 37459531; PMCID: PMC10372695.
. Spatial mapping of cellular senescence: emerging challenges and opportunities. Nat Aging. 2023-07-01;3(7):776-790. doi: 10.1038/s43587-023-00446-6. PubMed PMID: 37400722; PMCID: PMC10505496.
. UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties. Nucleic Acids Res. 2023-06-09;51(10):4881-4898. doi: 10.1093/nar/gkad206. PubMed PMID: 36971122; PMCID: PMC10250209.
. Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE). Nucleic Acids Res. 2023-04-24;51(7):e39. doi: 10.1093/nar/gkad095. PubMed PMID: 36861323; PMCID: PMC10123111.
. Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats. Nat Commun. 2023-02-21;14(1):670. doi: 10.1038/s41467-023-36284-8. PubMed PMID: 36810851; PMCID: PMC9944903.
. Cooperative interaction between AAG and UV-DDB in the removal of modified bases. Nucleic Acids Res. 2022-12-09;50(22):12856-12871. doi: 10.1093/nar/gkac1145. PubMed PMID: 36511855; PMCID: PMC9825174.
. TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma. Science. 2022-11-11;378(6620):664-668. doi: 10.1126/science.abq0607. PubMed PMID: 36356143; PMCID: PMC10590476.
. Telomere-mediated lung disease. Physiol Rev. 2022-10-01;102(4):1703-1720. doi: 10.1152/physrev.00046.2021. PubMed PMID: 35532056; PMCID: PMC9306791.
. Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening. Nat Struct Mol Biol. 2022-07-01;29(7):639-652. doi: 10.1038/s41594-022-00790-y. PubMed PMID: 35773409; PMCID: PMC9287163.
. Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins. Nat Commun. 2022-02-21;13(1):974. doi: 10.1038/s41467-022-28642-9. PubMed PMID: 35190564; PMCID: PMC8861037.
. Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60. Sci Adv. 2022-02-18;8(7):eabl6083. doi: 10.1126/sciadv.abl6083. PubMed PMID: 35171671; PMCID: PMC8849393.
. TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA. Nucleic Acids Res. 2021-12-16;49(22):13000-13018. doi: 10.1093/nar/gkab1142. PubMed PMID: 34883513; PMCID: PMC8682769.
. Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover. Nucleic Acids Res. 2021-08-20;49(14):8177-8188. doi: 10.1093/nar/gkab591. PubMed PMID: 34232996; PMCID: PMC8373069.
. The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage. Nucleic Acids Res. 2020-11-18;48(20):11227-11243. doi: 10.1093/nar/gkaa777. PubMed PMID: 33010169; PMCID: PMC7672477.
. Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs. Nat Commun. 2020-10-20;11(1):5288. doi: 10.1038/s41467-020-19115-y. PubMed PMID: 33082336; PMCID: PMC7576608.
. Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search. Nat Commun. 2020-03-13;11(1):1356. doi: 10.1038/s41467-020-15168-1. PubMed PMID: 32170071; PMCID: PMC7069974.
. Damage sensor role of UV-DDB during base excision repair. Nat Struct Mol Biol. 2019-08-01;26(8):695-703. doi: 10.1038/s41594-019-0261-7. PubMed PMID: 31332353; PMCID: PMC6684372.
. Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis. Mol Cell. 2019-07-11;75(1):117-130.e6. doi: 10.1016/j.molcel.2019.04.024. PubMed PMID: 31101499; PMCID: PMC6625854.
. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biol. 2018-09-01;18191-199. doi: 10.1016/j.redox.2018.06.005. PubMed PMID: 30031267; PMCID: PMC6076207.
. PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1. Nucleic Acids Res. 2017-12-15;45(22):12834-12847. doi: 10.1093/nar/gkx1047. PubMed PMID: 29121337; PMCID: PMC5728402.
. Telomere-associated aging disorders. Ageing Res Rev. 2017-01-01;3352-66. doi: 10.1016/j.arr.2016.05.009. PubMed PMID: 27215853; PMCID: PMC9926533.
. Oxidative guanine base damage regulates human telomerase activity. Nat Struct Mol Biol. 2016-12-01;23(12):1092-1100. doi: 10.1038/nsmb.3319. PubMed PMID: 27820808; PMCID: PMC5140714.
. DNA repair: Clamping down on copy errors. Nature. 2016-11-24;539(7630):498-499. doi: 10.1038/nature20475. PubMed PMID: 27851733; PMCID: PMC5641404.
. Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process. Mol Cell. 2016-10-20;64(2):376-387. doi: 10.1016/j.molcel.2016.09.005. PubMed PMID: 27720644; PMCID: PMC5123691.
. Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts. Nat Commun. 2015-09-09;68214. doi: 10.1038/ncomms9214. PubMed PMID: 26351258; PMCID: PMC4566151.
. Pulmonary Arterial Hypertension Is Associated with Oxidative Stress-induced Genome Instability. Am J Respir Crit Care Med. 2015-07-15;192(2):129-30. doi: 10.1164/rccm.201505-0904ED. PubMed PMID: 26177169; PMCID: PMC4532829.
. Polymerase η suppresses telomere defects induced by DNA damaging agents. Nucleic Acids Res. 2014-12-01;42(21):13096-109. doi: 10.1093/nar/gku1030. PubMed PMID: 25355508; PMCID: PMC4245935.
