Publications

. Celebrating 25 years of Molecular Therapy. Mol Ther. 2025-04-14; doi: 10.1016/j.ymthe.2025.03.059. PubMed PMID: 40233755.

. Next-Generation Replication-Defective HSV Vectors for Delivery of Large DNA Payloads. Mol Ther. 2025-04-02; doi: 10.1016/j.ymthe.2025.03.055. PubMed PMID: 40181547.

. Viral and Cellular Insulators Promote Sustained HSV Vector Mediated Transgene Expression in Brain. Mol Ther. 2025-04-02; doi: 10.1016/j.ymthe.2025.02.039. PubMed PMID: 40022446; PMCID: PMC11997511.

. High IgG titers against EBV glycoprotein 42 correlate with lower risk of nasopharyngeal carcinoma. J Clin Invest. 2025-02-17;135(4): doi: 10.1172/JCI189207. PubMed PMID: 39959976; PMCID: PMC11827836.

. A new era of Molecular Therapy: My vision for the future of the journal as the incoming Editor-in-Chief. Mol Ther. 2025-02-05; doi: 10.1016/j.ymthe.2024.12.056. PubMed PMID: 39805272; PMCID: PMC11852935.

. The Epstein-Barr virus nuclear antigen 1 variant associated with nasopharyngeal carcinoma defines the sequence criteria for serologic risk prediction. Clin Cancer Res. 2024-11-15; doi: 10.1158/1078-0432.CCR-24-1142. PubMed PMID: 39264275; PMCID: PMC11567791.

. The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation. Immunity. 2024-08-13; doi: 10.1016/j.immuni.2024.06.003. PubMed PMID: 38955184; PMCID: PMC11324410.

. An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T cells and Promotes Tumor Clearance. Cancer Immunol Res. 2024-06-04; doi: 10.1158/2326-6066.CIR-23-0573. PubMed PMID: 38517470; PMCID: PMC11150089.

. Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production. Immunity. 2024-03-12;57(3):446-461.e7. doi: 10.1016/j.immuni.2024.02.002. PubMed PMID: 38423012; PMCID: PMC10939734.

. Hepatitis B virus-related hepatocellular carcinoma exhibits distinct intratumoral microbiota and immune microenvironment signatures. J Med Virol. 2024-02-01;96(2):e29485. doi: 10.1002/jmv.29485. PubMed PMID: 38377167; PMCID: PMC10916714.

. Membrane-bound Merkel cell polyomavirus middle T protein constitutively activates PLCγ1 signaling through Src-family kinases. Proc Natl Acad Sci U S A. 2023-12-19;120(51):e2316467120. doi: 10.1073/pnas.2316467120. PubMed PMID: 38079542; PMCID: PMC10740393.

. METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle. Cell Death Dis. 2023-09-06;14(9):591. doi: 10.1038/s41419-023-06121-3. PubMed PMID: 37673880; PMCID: PMC10482891.

. Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity. Proc Natl Acad Sci U S A. 2023-07-25;120(30):e2308010120. doi: 10.1073/pnas.2308010120. PubMed PMID: 37459531; PMCID: PMC10372695.

. Long-acting antiretrovirals and HIV treatment adherence. Lancet HIV. 2023-05-01;10(5):e332-e342. doi: 10.1016/S2352-3018(23)00051-6. PubMed PMID: 37062293; PMCID: PMC10734401.

. Characterization of Viruses in Phase 3 and Phase 3b Trials (the Ring Study and the Dapivirine Ring Extended Access and Monitoring Trial) of the Dapivirine Vaginal Ring for Human Immunodeficiency Virus Type 1 Infection Risk Reduction. Clin Infect Dis. 2023-03-21;76(6):996-1002. doi: 10.1093/cid/ciac875. PubMed PMID: 36345569.

. Clinical Presentation, Treatment Response, and Virology Outcomes of Women Who Seroconverted in the Dapivirine Vaginal Ring Trials-The Ring Study and DREAM. Clin Infect Dis. 2023-02-08;76(3):389-397. doi: 10.1093/cid/ciac804. PubMed PMID: 36189636; PMCID: PMC10169386.

. Development and characterization of a new monoclonal antibody against SARS-CoV-2 NSP12 (RdRp). J Med Virol. 2023-01-01;95(1):e28246. doi: 10.1002/jmv.28246. PubMed PMID: 36271490; PMCID: PMC9874566.

. Serologic Profiling Using an Epstein-Barr Virus Mammalian Expression Library Identifies EBNA1 IgA as a Prediagnostic Marker for Nasopharyngeal Carcinoma. Clin Cancer Res. 2022-12-01;28(23):5221-5230. doi: 10.1158/1078-0432.CCR-22-1600. PubMed PMID: 36165913; PMCID: PMC9722633.

. Significance of Uncinate Duct Dilatation in IPMNs: A New High-risk Criterion? Ann Surg. 2022-06-01;275(6):e789-e795. doi: 10.1097/SLA.0000000000004307. PubMed PMID: 33201115.

. Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies. Clin Infect Dis. 2022-03-09;74(5):865-870. doi: 10.1093/cid/ciab541. PubMed PMID: 34117753; PMCID: PMC8906742.

. Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas. Sci Adv. 2021-10-15;7(42):eabi8795. doi: 10.1126/sciadv.abi8795. PubMed PMID: 34644108; PMCID: PMC8514100.

. The emerging plasticity of SARS-CoV-2. Science. 2021-03-26;371(6536):1306-1308. doi: 10.1126/science.abg4493. PubMed PMID: 33766871.

. RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation. Nat Commun. 2021-02-16;12(1):1055. doi: 10.1038/s41467-021-21206-3. PubMed PMID: 33594058; PMCID: PMC7887217.

. Proteomic approach to discover human cancer viruses from formalin-fixed tissues. JCI Insight. 2020-11-19;5(22): doi: 10.1172/jci.insight.143003. PubMed PMID: 33055416; PMCID: PMC7710300.

. HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus. J Clin Invest. 2020-11-02;130(11):5847-5857. doi: 10.1172/JCI138099. PubMed PMID: 33016926; PMCID: PMC7598056.

. Diverse Human Immunodeficiency Virus-1 Drug Resistance Profiles at Screening for ACTG A5288: A Study of People Experiencing Virologic Failure on Second-line Antiretroviral Therapy in Resource-limited Settings. Clin Infect Dis. 2020-10-23;71(7):e170-e177. doi: 10.1093/cid/ciz1116. PubMed PMID: 31724034; PMCID: PMC7583422.

. Better Biomarkers for Surgeons Treating Cancer. JAMA Surg. 2020-07-01;155(7):580. doi: 10.1001/jamasurg.2020.1134. PubMed PMID: 32520321.

. Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety. J Immunother Cancer. 2020-03-01;8(1): doi: 10.1136/jitc-2020-000710. PubMed PMID: 32209602; PMCID: PMC7103801.

. Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance. J Clin Invest. 2019-07-15;129(8):3339-3346. doi: 10.1172/JCI127413. PubMed PMID: 31305262; PMCID: PMC6668666.

. Kaposi sarcoma-associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesis. J Clin Invest. 2019-07-15;129(8):3310-3323. doi: 10.1172/JCI127166. PubMed PMID: 31305263; PMCID: PMC6668677.

. Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production. Immunity. 2019-01-15;50(1):51-63.e5. doi: 10.1016/j.immuni.2018.12.013. PubMed PMID: 30635239; PMCID: PMC6342484.

. Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics. J Immunother Cancer. 2019-01-09;7(1):6. doi: 10.1186/s40425-018-0495-7. PubMed PMID: 30626434; PMCID: PMC6325819.

. Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2. Nat Commun. 2018-11-08;9(1):4682. doi: 10.1038/s41467-018-06954-z. PubMed PMID: 30410056; PMCID: PMC6224581.

. Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade. Mol Ther. 2018-10-03;26(10):2476-2486. doi: 10.1016/j.ymthe.2018.07.013. PubMed PMID: 30064894; PMCID: PMC6171074.

. Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy. Nat Commun. 2017-03-27;814754. doi: 10.1038/ncomms14754. PubMed PMID: 28345650; PMCID: PMC5378974.

. Reply to P. de Boissieu et al. J Clin Oncol. 2016-10-01;34(28):3483. doi: 10.1200/JCO.2016.68.7764. PubMed PMID: 27458296.

. Phase 1 Study of Intravenous Oncolytic Poxvirus (vvDD) in Patients With Advanced Solid Cancers. Mol Ther. 2016-08-01;24(8):1492-501. doi: 10.1038/mt.2016.101. PubMed PMID: 27203445; PMCID: PMC5023393.

. Depressive Symptoms in Patients Scheduled for Hyperthermic Intraperitoneal Chemotherapy With Cytoreductive Surgery: Prospective Associations With Morbidity and Mortality. J Clin Oncol. 2016-04-10;34(11):1217-22. doi: 10.1200/JCO.2015.62.9683. PubMed PMID: 26903574; PMCID: PMC4872322.

. Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer. Cancer Res. 2015-08-15;75(16):3209-15. doi: 10.1158/0008-5472.CAN-14-3042. PubMed PMID: 26122841; PMCID: PMC4537823.

. First-in-man study of western reserve strain oncolytic vaccinia virus: safety, systemic spread, and antitumor activity. Mol Ther. 2015-01-01;23(1):202-14. doi: 10.1038/mt.2014.194. PubMed PMID: 25292189; PMCID: PMC4426804.

. Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. Immunity. 2014-06-19;40(6):936-48. doi: 10.1016/j.immuni.2014.05.007. PubMed PMID: 24931123; PMCID: PMC4101812.

. The conundrum of causality in tumor virology: the cases of KSHV and MCV. Semin Cancer Biol. 2014-06-01;264-12. doi: 10.1016/j.semcancer.2013.11.001. PubMed PMID: 24304907; PMCID: PMC4040341.