Publications

Carlos Camacho

Lin G, Weiss SC, Vergara S, Camacho C, Calero G. Transcription with a laser: Radiation-damage-free diffraction of RNA Polymerase II crystals. Methods. 2019 Apr 15;159-16023-28. doi: 10.1016/j.ymeth.2019.04.011. PubMed PMID: 31029767.
Pabon NA, Zhang Q, Cruz JA, Schipper DL, Camacho CJ, Lee REC. A network-centric approach to drugging TNF-induced NF-κB signaling. Nat Commun. 2019 Feb 26;10(1):860. doi: 10.1038/s41467-019-08802-0. PubMed PMID: 30808860; PMCID: PMC6391473.
Pabon NA, Xia Y, Estabrooks SK, Ye Z, Herbrand AK, Süß E, Biondi RM, Assimon VA, Gestwicki JE, Brodsky JL, Camacho CJ, Bar-Joseph Z. Predicting protein targets for drug-like compounds using transcriptomics. PLoS Comput Biol. 2018 Dec;14(12):e1006651. doi: 10.1371/journal.pcbi.1006651. PubMed PMID: 30532261; PMCID: PMC6300300.
Asan A, Skoko JJ, Woodcock CC, Wingert BM, Woodcock SR, Normolle D, Huang Y, Stark JM, Camacho CJ, Freeman BA, Neumann CA. Electrophilic fatty acids impair RAD51 function and potentiate the effects of DNA-damaging agents on growth of triple-negative breast cells. J Biol Chem. 2019 Jan 11;294(2):397-404. doi: 10.1074/jbc.AC118.005899. PubMed PMID: 30478172; PMCID: PMC6333886.
Pulugulla SH, Workman R, Rutter NW, Yang Z, Adamik J, Lupish B, Macar DA, El Abdouni S, Esposito EX, Galson DL, Camacho CJ, Madura JD, Auron PE. A combined computational and experimental approach reveals the structure of a C/EBPβ-Spi1 interaction required for IL1B gene transcription. J Biol Chem. 2018 Dec 28;293(52):19942-19956. doi: 10.1074/jbc.RA118.005627. PubMed PMID: 30355733; PMCID: PMC6311527.
Wingert BM, Camacho CJ. Improving small molecule virtual screening strategies for the next generation of therapeutics. Curr Opin Chem Biol. 2018 Jun;4487-92. doi: 10.1016/j.cbpa.2018.06.006. PubMed PMID: 29920436; PMCID: PMC6089075.
Koes DR, Dömling A, Camacho CJ. AnchorQuery: Rapid online virtual screening for small-molecule protein-protein interaction inhibitors. Protein Sci. 2018 Jan;27(1):229-232. doi: 10.1002/pro.3303. PubMed PMID: 28921842; PMCID: PMC5734307.
Wingert BM, Oerlemans R, Camacho CJ. Optimal affinity ranking for automated virtual screening validated in prospective D3R grand challenges. J Comput Aided Mol Des. 2018 Jan;32(1):287-297. doi: 10.1007/s10822-017-0065-y. PubMed PMID: 28918599; PMCID: PMC5771500.
Ye Z, Needham PG, Estabrooks SK, Whitaker SK, Garcia BL, Misra S, Brodsky JL, Camacho CJ. Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase. Sci Rep. 2017 May 11;7(1):1789. doi: 10.1038/s41598-017-01880-4. PubMed PMID: 28496195; PMCID: PMC5431976.
Pabon NA, Camacho CJ. Probing protein flexibility reveals a mechanism for selective promiscuity. Elife. 2017 Apr 22;6 doi: 10.7554/eLife.22889. PubMed PMID: 28432789; PMCID: PMC5446241.
Surmiak E, Neochoritis CG, Musielak B, Twarda-Clapa A, Kurpiewska K, Dubin G, Camacho C, Holak TA, Dömling A. Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction. Eur J Med Chem. 2017 Jan 27;126384-407. doi: 10.1016/j.ejmech.2016.11.029. PubMed PMID: 27907876.
Ye Z, Baumgartner MP, Wingert BM, Camacho CJ. Optimal strategies for virtual screening of induced-fit and flexible target in the 2015 D3R Grand Challenge. J Comput Aided Mol Des. 2016 Sep;30(9):695-706. doi: 10.1007/s10822-016-9941-0. PubMed PMID: 27573981; PMCID: PMC5079819.
Travers TS, Harlow L, Rosas IO, Gochuico BR, Mikuls TR, Bhattacharya SK, Camacho CJ, Ascherman DP. Extensive Citrullination Promotes Immunogenicity of HSP90 through Protein Unfolding and Exposure of Cryptic Epitopes. J Immunol. 2016 Sep 1;197(5):1926-36. doi: 10.4049/jimmunol.1600162. PubMed PMID: 27448590; PMCID: PMC5061338.
Hain E, Camacho CJ, Koes DR. Fragment oriented molecular shapes. J Mol Graph Model. 2016 May;66143-54. doi: 10.1016/j.jmgm.2016.03.017. PubMed PMID: 27085751; PMCID: PMC4862882.
Tejero J, Kapralov AA, Baumgartner MP, Sparacino-Watkins CE, Anthonymutu TS, Vlasova II, Camacho CJ, Gladwin MT, Bayir H, Kagan VE. Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences. Biochim Biophys Acta. 2016 May;1861(5):391-401. doi: 10.1016/j.bbalip.2016.02.022. PubMed PMID: 26928591; PMCID: PMC4821708.
Kroon E, Schulze JO, Süß E, Camacho CJ, Biondi RM, Dömling A. Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods. Angew Chem Int Ed Engl. 2015 Nov 16;54(47):13933-6. doi: 10.1002/anie.201506310. PubMed PMID: 26385475; PMCID: PMC4721676.
Abdelraheem EM, Camacho CJ, Dömling A. Focusing on shared subpockets - new developments in fragment-based drug discovery. Expert Opin Drug Discov. 2015;10(11):1179-87. doi: 10.1517/17460441.2015.1080684. PubMed PMID: 26296101; PMCID: PMC4933841.
Koes DR, Pabon NA, Deng X, Phillips MA, Camacho CJ. A Teach-Discover-Treat Application of ZincPharmer: An Online Interactive Pharmacophore Modeling and Virtual Screening Tool. PLoS One. 2015;10(8):e0134697. doi: 10.1371/journal.pone.0134697. PubMed PMID: 26258606; PMCID: PMC4530941.
Baumgartner MP, Camacho CJ. Choosing the Optimal Rigid Receptor for Docking and Scoring in the CSAR 2013/2014 Experiment. J Chem Inf Model. 2016 Jun 27;56(6):1004-12. doi: 10.1021/acs.jcim.5b00338. PubMed PMID: 26222931; PMCID: PMC4744803.
Grover P, Shi H, Baumgartner M, Camacho CJ, Smithgall TE. Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function. PLoS One. 2015;10(7):e0133590. doi: 10.1371/journal.pone.0133590. PubMed PMID: 26222440; PMCID: PMC4519180.
Koes DR, Camacho CJ. Indexing Volumetric Shapes with Matching and Packing. Knowl Inf Syst. 2015 Apr 1;43(1):157-180. doi: 10.1007/s10115-014-0729-z. PubMed PMID: 26085707; PMCID: PMC4465823.
Travers T, Shao H, Joughin BA, Lauffenburger DA, Wells A, Camacho CJ. Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function. Sci Signal. 2015 May 26;8(378):ra51. doi: 10.1126/scisignal.aaa1977. PubMed PMID: 26012634; PMCID: PMC4522051.
Rahaman MM, Reinders FG, Koes D, Nguyen AT, Mutchler SM, Sparacino-Watkins C, Alvarez RA, Miller MP, Cheng D, Chen BB, Jackson EK, Camacho CJ, Straub AC. Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability. J Biol Chem. 2015 Jul 3;290(27):16861-72. doi: 10.1074/jbc.M114.629964. PubMed PMID: 26001785; PMCID: PMC4505432.
Kwun HJ, Shuda M, Camacho CJ, Gamper AM, Thant M, Chang Y, Moore PS. Restricted protein phosphatase 2A targeting by Merkel cell polyomavirus small T antigen. J Virol. 2015 Apr;89(8):4191-200. doi: 10.1128/JVI.00157-15. PubMed PMID: 25631078; PMCID: PMC4442354.
Harlow L, Gochuico BR, Rosas IO, Doyle TJ, Osorio JC, Travers TS, Camacho CC, Oddis CV, Ascherman DP. Anti-citrullinated heat shock protein 90 antibodies identified in bronchoalveolar lavage fluid are a marker of lung-specific immune responses. Clin Immunol. 2014 Nov;155(1):60-70. doi: 10.1016/j.clim.2014.08.004. PubMed PMID: 25150019; PMCID: PMC4629481.
Koes DR, Camacho CJ. Shape-based virtual screening with volumetric aligned molecular shapes. J Comput Chem. 2014 Sep 30;35(25):1824-34. doi: 10.1002/jcc.23690. PubMed PMID: 25049193; PMCID: PMC4140985.

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