Publications

Russell KL, Gorgulho CM, Allen A, Vakaki M, Wang Y, Facciabene A, Lee D, Roy P, Buchser WJ, Appleman LJ, Maranchie J, Storkus WJ, Lotze MT. Inhibiting Autophagy in Renal Cell Cancer and the Associated Tumor Endothelium. Cancer J. 2019 May/Jun;25(3):165-177. doi: 10.1097/PPO.0000000000000374. PubMed PMID: 31135523.
Gau D, Veon W, Shroff SG, Roy P. The VASP-profilin1 (Pfn1) interaction is critical for efficient cell migration and is regulated by cell-substrate adhesion in a PKA-dependent manner. J Biol Chem. 2019 Apr 26;294(17):6972-6985. doi: 10.1074/jbc.RA118.005255. PubMed PMID: 30814249; PMCID: PMC6497960.
Chakraborty S, Jiang C, Gau D, Oddo M, Ding Z, Vollmer L, Joy M, Schiemann W, Stolz DB, Vogt A, Ghosh S, Roy P. Profilin-1 deficiency leads to SMAD3 upregulation and impaired 3D outgrowth of breast cancer cells. Br J Cancer. 2018 Oct;119(9):1106-1117. doi: 10.1038/s41416-018-0284-6. PubMed PMID: 30318519; PMCID: PMC6219497.
Gau D, Roy P. SRF'ing and SAP'ing - the role of MRTF proteins in cell migration. J Cell Sci. 2018 Oct 11;131(19): doi: 10.1242/jcs.218222. PubMed PMID: 30309957.
Gau D, Lewis T, McDermott L, Wipf P, Koes D, Roy P. Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1-actin interaction. J Biol Chem. 2018 Feb 16;293(7):2606-2616. doi: 10.1074/jbc.M117.809137. PubMed PMID: 29282288; PMCID: PMC5818201.
Jiang C, Ding Z, Joy M, Chakraborty S, Kim SH, Bottcher R, Condeelis J, Singh S, Roy P. A balanced level of profilin-1 promotes stemness and tumor-initiating potential of breast cancer cells. Cell Cycle. 2017;16(24):2366-2373. doi: 10.1080/15384101.2017.1346759. PubMed PMID: 28699810; PMCID: PMC5788419.
Gau D, Veon W, Capasso TL, Bottcher R, Shroff S, Roman BL, Roy P. Pharmacological intervention of MKL/SRF signaling by CCG-1423 impedes endothelial cell migration and angiogenesis. Angiogenesis. 2017 Nov;20(4):663-672. doi: 10.1007/s10456-017-9560-y. PubMed PMID: 28638990; PMCID: PMC5985144.
Joy M, Gau D, Castellucci N, Prywes R, Roy P. The myocardin-related transcription factor MKL co-regulates the cellular levels of two profilin isoforms. J Biol Chem. 2017 Jul 14;292(28):11777-11791. doi: 10.1074/jbc.M117.781104. PubMed PMID: 28546428; PMCID: PMC5512072.
Ding Z, Joy M, Kameneva MV, Roy P. Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells. Breast Cancer (Dove Med Press). 2017;961-65. doi: 10.2147/BCTT.S128777. PubMed PMID: 28280386; PMCID: PMC5340241.
Gau D, Veon W, Zeng X, Yates N, Shroff SG, Koes DR, Roy P. Threonine 89 Is an Important Residue of Profilin-1 That Is Phosphorylatable by Protein Kinase A. PLoS One. 2016;11(5):e0156313. doi: 10.1371/journal.pone.0156313. PubMed PMID: 27228149; PMCID: PMC4882052.
Jiang C, Veon W, Li H, Hallows KR, Roy P. Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation. Cell Cycle. 2015;14(18):2914-23. doi: 10.1080/15384101.2015.1069929. PubMed PMID: 26176334; PMCID: PMC4825560.
Gau DM, Lesnock JL, Hood BL, Bhargava R, Sun M, Darcy K, Luthra S, Chandran U, Conrads TP, Edwards RP, Kelley JL, Krivak TC, Roy P. BRCA1 deficiency in ovarian cancer is associated with alteration in expression of several key regulators of cell motility - A proteomics study. Cell Cycle. 2015;14(12):1884-92. doi: 10.1080/15384101.2015.1036203. PubMed PMID: 25927284; PMCID: PMC4614952.

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