Publications

Alan Wells

Jiang X, Wells A, Brufsky A, Neapolitan R. A clinical decision support system learned from data to personalize treatment recommendations towards preventing breast cancer metastasis. PLoS One. 2019;14(3):e0213292. doi: 10.1371/journal.pone.0213292. PubMed PMID: 30849111; PMCID: PMC6407919.
Wells A, Clark A, Bradshaw A, Ma B, Edington H. The great escape: How metastases of melanoma, and other carcinomas, avoid elimination. Exp Biol Med (Maywood). 2018 Dec;243(17-18):1245-1255. doi: 10.1177/1535370218820287. PubMed PMID: 30764707; PMCID: PMC6348591.
Beckwitt CH, Brufsky A, Oltvai ZN, Wells A. Statin drugs to reduce breast cancer recurrence and mortality. Breast Cancer Res. 2018 Nov 20;20(1):144. doi: 10.1186/s13058-018-1066-z. PubMed PMID: 30458856; PMCID: PMC6247616.
Beckwitt CH, Clark AM, Ma B, Whaley D, Oltvai ZN, Wells A. Statins attenuate outgrowth of breast cancer metastases. Br J Cancer. 2018 Oct;119(9):1094-1105. doi: 10.1038/s41416-018-0267-7. PubMed PMID: 30401978.
Bradshaw A, Sylakowski K, Wells A. The Pro-reparative Engine: Stem Cells Aid Healing by Dampening Inflammation. Curr Pathobiol Rep. 2018 Jun;6(2):109-115. doi: 10.1007/s40139-018-0167-9. PubMed PMID: 30271682; PMCID: PMC6157924.
Wells A, Wiley HS. A systems perspective of heterocellular signaling. Essays Biochem. 2018 Oct 26;62(4):607-617. doi: 10.1042/EBC20180015. PubMed PMID: 30139877; PMCID: PMC6309864.
Ishikawa T, Hosaka YZ, Beckwitt C, Wells A, Oltvai ZN, Warita K. Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics. Oncotarget. 2018 Jun 29;9(50):29304-29315. doi: 10.18632/oncotarget.25448. PubMed PMID: 30034619; PMCID: PMC6047681.
Zeng Z, Jiang X, Li X, Wells A, Luo Y, Neapolitan R. Conjugated equine estrogen and medroxyprogesterone acetate are associated with decreased risk of breast cancer relative to bioidentical hormone therapy and controls. PLoS One. 2018;13(5):e0197064. doi: 10.1371/journal.pone.0197064. PubMed PMID: 29768475; PMCID: PMC5955567.
Beckwitt CH, Shiraha K, Wells A. Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling. PLoS One. 2018;13(5):e0197422. doi: 10.1371/journal.pone.0197422. PubMed PMID: 29763460; PMCID: PMC5953490.
Clark AM, Kumar MP, Wheeler SE, Young CL, Venkataramanan R, Stolz DB, Griffith LG, Lauffenburger DA, Wells A. A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures. Mol Cell Proteomics. 2018 Apr;17(4):619-630. doi: 10.1074/mcp.RA117.000370. PubMed PMID: 29353230; PMCID: PMC5880110.
Beckwitt CH, Clark AM, Wheeler S, Taylor DL, Stolz DB, Griffith L, Wells A. Liver 'organ on a chip'. Exp Cell Res. 2018 Feb 1;363(1):15-25. doi: 10.1016/j.yexcr.2017.12.023. PubMed PMID: 29291400; PMCID: PMC5944300.
Shao H, Wang A, Lauffenburger D, Wells A. Tyro3-mediated phosphorylation of ACTN4 at tyrosines is FAK-dependent and decreases susceptibility to cleavage by m-Calpain. Int J Biochem Cell Biol. 2018 Feb;9573-84. doi: 10.1016/j.biocel.2017.12.014. PubMed PMID: 29274473; PMCID: PMC5803314.
Khazali AS, Clark AM, Wells A. Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy. Br J Cancer. 2018 Feb 20;118(4):566-576. doi: 10.1038/bjc.2017.414. PubMed PMID: 29169181; PMCID: PMC5830588.
Raghu VK, Beckwitt CH, Warita K, Wells A, Benos PV, Oltvai ZN. Biomarker identification for statin sensitivity of cancer cell lines. Biochem Biophys Res Commun. 2018 Jan 1;495(1):659-665. doi: 10.1016/j.bbrc.2017.11.065. PubMed PMID: 29146185; PMCID: PMC5827944.
Dioufa N, Clark AM, Ma B, Beckwitt CH, Wells A. Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. Mol Cancer. 2017 Nov 14;16(1):172. doi: 10.1186/s12943-017-0740-6. PubMed PMID: 29137633; PMCID: PMC5686836.
Kader M, Alaoui-El-Azher M, Vorhauer J, Kode BB, Wells JZ, Stolz D, Michalopoulos G, Wells A, Scott M, Ismail N. MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. PLoS Pathog. 2017 Oct;13(10):e1006644. doi: 10.1371/journal.ppat.1006644. PubMed PMID: 29049365; PMCID: PMC5663626.
Yates CC, Rodrigues M, Nuschke A, Johnson ZI, Whaley D, Stolz D, Newsome J, Wells A. Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring. Stem Cell Res Ther. 2017 Sep 5;8(1):193. doi: 10.1186/s13287-017-0644-9. PubMed PMID: 28874184; PMCID: PMC5585998.
Shao H, Lauffenburger D, Wells A. Tyro3 carboxyl terminal region confers stability and contains the autophosphorylation sites. Biochem Biophys Res Commun. 2017 Aug 26;490(3):1074-1079. doi: 10.1016/j.bbrc.2017.06.168. PubMed PMID: 28668391; PMCID: PMC5553559.
Huen AC, Marathi A, Nam PK, Wells A. CXCL11 Expression by Keratinocytes Occurs Transiently Between Reaching Confluence and Cellular Compaction. Adv Wound Care (New Rochelle). 2016 Dec 1;5(12):517-526. doi: 10.1089/wound.2015.0680. PubMed PMID: 28078185; PMCID: PMC5165675.
Nuschke A, Rodrigues M, Wells AW, Sylakowski K, Wells A. Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation. Stem Cell Res Ther. 2016 Dec 1;7(1):179. doi: 10.1186/s13287-016-0436-7. PubMed PMID: 27906055; PMCID: PMC5134064.
González Á, García de Durango C, Alonso V, Bravo B, Rodríguez de Gortázar A, Wells A, Forteza J, Vidal-Vanaclocha F. Distinct Osteomimetic Response of Androgen-Dependent and Independent Human Prostate Cancer Cells to Mechanical Action of Fluid Flow: Prometastatic Implications. Prostate. 2017 Feb;77(3):321-333. doi: 10.1002/pros.23270. PubMed PMID: 27813116.
Ma B, Wheeler SE, Clark AM, Whaley DL, Yang M, Wells A. Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling. Hepatology. 2016 Nov;64(5):1725-1742. doi: 10.1002/hep.28755. PubMed PMID: 27482645; PMCID: PMC5074910.
Nuschke A, Rodrigues M, Rivera J, Yates C, Whaley D, Stolz D, Griffith L, Wells A. Epidermal Growth Factor Tethered to β-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. Stem Cells Transl Med. 2016 Nov;5(11):1580-1586. doi: 10.5966/sctm.2015-0326. PubMed PMID: 27400798; PMCID: PMC5070502.
Clark AM, Ma B, Taylor DL, Griffith L, Wells A. Liver metastases: Microenvironments and ex-vivo models. Exp Biol Med (Maywood). 2016 Sep;241(15):1639-52. doi: 10.1177/1535370216658144. PubMed PMID: 27390264; PMCID: PMC4999624.
Yang M, Ma B, Shao H, Clark AM, Wells A. Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. BMC Cancer. 2016 Jul 7;16419. doi: 10.1186/s12885-016-2411-1. PubMed PMID: 27387344; PMCID: PMC4936312.
Bodnar RJ, Satish L, Yates CC, Wells A. Pericytes: A newly recognized player in wound healing. Wound Repair Regen. 2016 Mar;24(2):204-14. doi: 10.1111/wrr.12415. PubMed PMID: 26969517; PMCID: PMC5036393.
Richard S, Wells A, Connor J, Price F. Use of ChemoFx® for Identification of Effective Treatments in Epithelial Ovarian Cancer. PLoS Curr. 2015 Jul 13;7 doi: 10.1371/currents.eogt.8b0b6fffc7b999b34bc4c8152edbf237. PubMed PMID: 26213638; PMCID: PMC4506277.
Bodnar RJ, Wells A. Differential regulation of pericyte function by the CXC receptor 3. Wound Repair Regen. 2015 Nov-Dec;23(6):785-96. doi: 10.1111/wrr.12346. PubMed PMID: 26207932; PMCID: PMC4662923.
Travers T, Shao H, Joughin BA, Lauffenburger DA, Wells A, Camacho CJ. Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function. Sci Signal. 2015 May 26;8(378):ra51. doi: 10.1126/scisignal.aaa1977. PubMed PMID: 26012634; PMCID: PMC4522051.
Ma B, Khazali A, Wells A. CXCR3 in carcinoma progression. Histol Histopathol. 2015 Jul;30(7):781-92. doi: 10.14670/HH-11-594. PubMed PMID: 25663474; PMCID: PMC4571436.
Furukawa M, Wheeler S, Clark AM, Wells A. Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells. PLoS One. 2015;10(1):e0118060. doi: 10.1371/journal.pone.0118060. PubMed PMID: 25635394; PMCID: PMC4311980.

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