Publications

Mark Shlomchik

Luo W, Hawse W, Conter L, Trivedi N, Weisel F, Wikenheiser D, Cattley RT, Shlomchik MJ. The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells. Nat Immunol. 2019 Jun;20(6):736-746. doi: 10.1038/s41590-019-0376-3. PubMed PMID: 31011187; PMCID: PMC6724213.
Shlomchik MJ, Luo W, Weisel F. Linking signaling and selection in the germinal center. Immunol Rev. 2019 Mar;288(1):49-63. doi: 10.1111/imr.12744. PubMed PMID: 30874353; PMCID: PMC6422174.
Shlomchik MJ, Weisel F. B cell primary immune responses. Immunol Rev. 2019 Mar;288(1):5-9. doi: 10.1111/imr.12756. PubMed PMID: 30874348.
Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Berghe TV, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M. To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death Differ. 2019 Mar;26(3):395-408. doi: 10.1038/s41418-018-0261-x. PubMed PMID: 30622307; PMCID: PMC6370810.
Tilstra JS, Avery L, Menk AV, Gordon RA, Smita S, Kane LP, Chikina M, Delgoffe GM, Shlomchik MJ. Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted. J Clin Invest. 2018 Nov 1;128(11):4884-4897. doi: 10.1172/JCI120859. PubMed PMID: 30130253; PMCID: PMC6205402.
Wallace CH, Wu BX, Salem M, Ansa-Addo EA, Metelli A, Sun S, Gilkeson G, Shlomchik MJ, Liu B, Li Z. B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex. JCI Insight. 2018 Apr 5;3(7): doi: 10.1172/jci.insight.99863. PubMed PMID: 29618665; PMCID: PMC5928869.
Raybuck AL, Cho SH, Li J, Rogers MC, Lee K, Williams CL, Shlomchik M, Thomas JW, Chen J, Williams JV, Boothby MR. B Cell-Intrinsic mTORC1 Promotes Germinal Center-Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity. J Immunol. 2018 Apr 15;200(8):2627-2639. doi: 10.4049/jimmunol.1701321. PubMed PMID: 29531165; PMCID: PMC5893413.
Luo W, Weisel F, Shlomchik MJ. B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells. Immunity. 2018 Feb 20;48(2):313-326.e5. doi: 10.1016/j.immuni.2018.01.008. PubMed PMID: 29396161; PMCID: PMC5821563.
Roberts AW, Lee BL, Deguine J, John S, Shlomchik MJ, Barton GM. Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells. Immunity. 2017 Nov 21;47(5):913-927.e6. doi: 10.1016/j.immuni.2017.10.006. PubMed PMID: 29150239; PMCID: PMC5728676.
Meng W, Zhang B, Schwartz GW, Rosenfeld AM, Ren D, Thome JJC, Carpenter DJ, Matsuoka N, Lerner H, Friedman AL, Granot T, Farber DL, Shlomchik MJ, Hershberg U, Luning Prak ET. An atlas of B-cell clonal distribution in the human body. Nat Biotechnol. 2017 Sep;35(9):879-884. doi: 10.1038/nbt.3942. PubMed PMID: 28829438; PMCID: PMC5679700.
Sweet RA, Nickerson KM, Cullen JL, Wang Y, Shlomchik MJ. B Cell-Extrinsic Myd88 and Fcer1g Negatively Regulate Autoreactive and Normal B Cell Immune Responses. J Immunol. 2017 Aug 1;199(3):885-893. doi: 10.4049/jimmunol.1600861. PubMed PMID: 28659358; PMCID: PMC5547912.
Shlomchik MJ. Do Memory B Cells Form Secondary Germinal Centers? Yes and No. Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1): doi: 10.1101/cshperspect.a029405. PubMed PMID: 28320754; PMCID: PMC5749155.
Giles JR, Neves AT, Marshak-Rothstein A, Shlomchik MJ. Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation. JCI Insight. 2017 Feb 23;2(4):e90870. doi: 10.1172/jci.insight.90870. PubMed PMID: 28239656; PMCID: PMC5313065.
Weisel F, Shlomchik M. Memory B Cells of Mice and Humans. Annu Rev Immunol. 2017 Apr 26;35255-284. doi: 10.1146/annurev-immunol-041015-055531. PubMed PMID: 28142324.
Ols ML, Cullen JL, Turqueti-Neves A, Giles J, Shlomchik MJ. Dendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand. Immunity. 2016 Nov 15;45(5):1052-1065. doi: 10.1016/j.immuni.2016.10.005. PubMed PMID: 27793595; PMCID: PMC5112117.
Cui A, Di Niro R, Vander Heiden JA, Briggs AW, Adams K, Gilbert T, O'Connor KC, Vigneault F, Shlomchik MJ, Kleinstein SH. A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data. J Immunol. 2016 Nov 1;197(9):3566-3574. doi: 10.4049/jimmunol.1502263. PubMed PMID: 27707999; PMCID: PMC5161250.
Zuccarino-Catania G, Shlomchik M. Adoptive Transfer of Memory B Cells. Bio Protoc. 2015 Aug 20;5(16): doi: 10.21769/bioprotoc.1563. PubMed PMID: 27453915; PMCID: PMC4957582.
Jash A, Wang Y, Weisel FJ, Scharer CD, Boss JM, Shlomchik MJ, Bhattacharya D. ZBTB32 Restricts the Duration of Memory B Cell Recall Responses. J Immunol. 2016 Aug 15;197(4):1159-68. doi: 10.4049/jimmunol.1600882. PubMed PMID: 27357154; PMCID: PMC4975986.
Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC. Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med. 2016 May 2;213(5):751-69. doi: 10.1084/jem.20150537. PubMed PMID: 27114609; PMCID: PMC4854724.
Weisel FJ, Zuccarino-Catania GV, Chikina M, Shlomchik MJ. A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells. Immunity. 2016 Jan 19;44(1):116-130. doi: 10.1016/j.immuni.2015.12.004. PubMed PMID: 26795247; PMCID: PMC4724390.
Xu RH, Wong EB, Rubio D, Roscoe F, Ma X, Nair S, Remakus S, Schwendener R, John S, Shlomchik M, Sigal LJ. Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection. Immunity. 2015 Dec 15;43(6):1148-59. doi: 10.1016/j.immuni.2015.11.015. PubMed PMID: 26682986; PMCID: PMC4684903.
Russell L, John S, Cullen J, Luo W, Shlomchik MJ, Garrett-Sinha LA. Requirement for Transcription Factor Ets1 in B Cell Tolerance to Self-Antigens. J Immunol. 2015 Oct 15;195(8):3574-83. doi: 10.4049/jimmunol.1500776. PubMed PMID: 26355157; PMCID: PMC4568556.
Wieland A, Shashidharamurthy R, Kamphorst AO, Han JH, Aubert RD, Choudhury BP, Stowell SR, Lee J, Punkosdy GA, Shlomchik MJ, Selvaraj P, Ahmed R. Antibody effector functions mediated by Fcγ-receptors are compromised during persistent viral infection. Immunity. 2015 Feb 17;42(2):367-378. doi: 10.1016/j.immuni.2015.01.009. PubMed PMID: 25680276; PMCID: PMC4339104.
Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E710-7. doi: 10.1073/pnas.1420217112. PubMed PMID: 25646421; PMCID: PMC4343138.

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