Publications

Greg Delgoffe, PhD

Liu C, Chikina M, Deshpande R, Menk AV, Wang T, Tabib T, Brunazzi EA, Vignali KM, Sun M, Stolz DB, Lafyatis RA, Chen W, Delgoffe GM, Workman CJ, Wendell SG, Vignali DAA. Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ. Immunity. 2019 Aug 20;51(2):381-397.e6. doi: 10.1016/j.immuni.2019.06.017. PubMed PMID: 31350177; PMCID: PMC6703933.
Shao L, Hou W, Scharping NE, Vendetti FP, Srivastava R, Roy CN, Menk AV, Wang Y, Chauvin JM, Karukonda P, Thorne SH, Hornung V, Zarour HM, Bakkenist CJ, Delgoffe GM, Sarkar SN. IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell. Cancer Immunol Res. 2019 Aug;7(8):1258-1266. doi: 10.1158/2326-6066.CIR-18-0711. PubMed PMID: 31239318; PMCID: PMC6677597.
Piccirillo AR, Hyzny EJ, Beppu LY, Menk AV, Wallace CT, Hawse WF, Buechel HM, Wong BH, Foo JC, Cazenave-Gassiot A, Wenk MR, Delgoffe GM, Watkins SC, Silver DL, D'Cruz LM. The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8+ Memory T Cell Maintenance and Secondary Response to Infection. J Immunol. 2019 Jul 1;203(1):117-126. doi: 10.4049/jimmunol.1801585. PubMed PMID: 31127034; PMCID: PMC6581627.
Santos PM, Menk AV, Shi J, Tsung A, Delgoffe GM, Butterfield LH. Tumor-Derived α-Fetoprotein Suppresses Fatty Acid Metabolism and Oxidative Phosphorylation in Dendritic Cells. Cancer Immunol Res. 2019 Jun;7(6):1001-1012. doi: 10.1158/2326-6066.CIR-18-0513. PubMed PMID: 30988028.
Majumder S, Amatya N, Revu S, Jawale CV, Wu D, Rittenhouse N, Menk A, Kupul S, Du F, Raphael I, Bhattacharjee A, Siebenlist U, Hand TW, Delgoffe GM, Poholek AC, Gaffen SL, Biswas PS, McGeachy MJ. IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival. Nat Immunol. 2019 May;20(5):534-545. doi: 10.1038/s41590-019-0367-4. PubMed PMID: 30962593; PMCID: PMC6519710.
Previte DM, Martins CP, O'Connor EC, Marre ML, Coudriet GM, Beck NW, Menk AV, Wright RH, Tse HM, Delgoffe GM, Piganelli JD. Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells. Cell Rep. 2019 Apr 2;27(1):129-141.e4. doi: 10.1016/j.celrep.2019.03.004. PubMed PMID: 30943396.
Najjar YG, Menk AV, Sander C, Rao U, Karunamurthy A, Bhatia R, Zhai S, Kirkwood JM, Delgoffe GM. Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma. JCI Insight. 2019 Mar 7;4(5): doi: 10.1172/jci.insight.124989. PubMed PMID: 30721155; PMCID: PMC6483505.
Tilstra JS, Avery L, Menk AV, Gordon RA, Smita S, Kane LP, Chikina M, Delgoffe GM, Shlomchik MJ. Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted. J Clin Invest. 2018 Nov 1;128(11):4884-4897. doi: 10.1172/JCI120859. PubMed PMID: 30130253; PMCID: PMC6205402.
Vendetti FP, Karukonda P, Clump DA, Teo T, Lalonde R, Nugent K, Ballew M, Kiesel BF, Beumer JH, Sarkar SN, Conrads TP, O'Connor MJ, Ferris RL, Tran PT, Delgoffe GM, Bakkenist CJ. ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation. J Clin Invest. 2018 Aug 31;128(9):3926-3940. doi: 10.1172/JCI96519. PubMed PMID: 29952768; PMCID: PMC6118586.
Revu S, Wu J, Henkel M, Rittenhouse N, Menk A, Delgoffe GM, Poholek AC, McGeachy MJ. IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation. Cell Rep. 2018 Mar 6;22(10):2642-2653. doi: 10.1016/j.celrep.2018.02.044. PubMed PMID: 29514093; PMCID: PMC5884137.
Menk AV, Scharping NE, Rivadeneira DB, Calderon MJ, Watson MJ, Dunstane D, Watkins SC, Delgoffe GM. 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses. J Exp Med. 2018 Apr 2;215(4):1091-1100. doi: 10.1084/jem.20171068. PubMed PMID: 29511066; PMCID: PMC5881463.
Menk AV, Scharping NE, Moreci RS, Zeng X, Guy C, Salvatore S, Bae H, Xie J, Young HA, Wendell SG, Delgoffe GM. Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions. Cell Rep. 2018 Feb 6;22(6):1509-1521. doi: 10.1016/j.celrep.2018.01.040. PubMed PMID: 29425506; PMCID: PMC5973810.
Rivadeneira DB, Delgoffe GM. Antitumor T-cell Reconditioning: Improving Metabolic Fitness for Optimal Cancer Immunotherapy. Clin Cancer Res. 2018 Jun 1;24(11):2473-2481. doi: 10.1158/1078-0432.CCR-17-0894. PubMed PMID: 29386217; PMCID: PMC5984673.
Overacre-Delgoffe AE, Chikina M, Dadey RE, Yano H, Brunazzi EA, Shayan G, Horne W, Moskovitz JM, Kolls JK, Sander C, Shuai Y, Normolle DP, Kirkwood JM, Ferris RL, Delgoffe GM, Bruno TC, Workman CJ, Vignali DAA. Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity. Cell. 2017 Jun 1;169(6):1130-1141.e11. doi: 10.1016/j.cell.2017.05.005. PubMed PMID: 28552348; PMCID: PMC5509332.
Downs-Canner S, Berkey S, Delgoffe GM, Edwards RP, Curiel T, Odunsi K, Bartlett DL, Obermajer N. Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells. Nat Commun. 2017 Mar 14;814649. doi: 10.1038/ncomms14649. PubMed PMID: 28290453; PMCID: PMC5355894.
Phong B, Avery L, Menk AV, Delgoffe GM, Kane LP. Cutting Edge: Murine Mast Cells Rapidly Modulate Metabolic Pathways Essential for Distinct Effector Functions. J Immunol. 2017 Jan 15;198(2):640-644. doi: 10.4049/jimmunol.1601150. PubMed PMID: 27974455; PMCID: PMC5225044.
Scharping NE, Menk AV, Whetstone RD, Zeng X, Delgoffe GM. Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia. Cancer Immunol Res. 2017 Jan;5(1):9-16. doi: 10.1158/2326-6066.CIR-16-0103. PubMed PMID: 27941003; PMCID: PMC5340074.
Scharping NE, Delgoffe GM. Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity. Vaccines (Basel). 2016 Dec 6;4(4): doi: 10.3390/vaccines4040046. PubMed PMID: 27929420; PMCID: PMC5192366.
Delgoffe GM. Filling the Tank: Keeping Antitumor T Cells Metabolically Fit for the Long Haul. Cancer Immunol Res. 2016 Dec;4(12):1001-1006. doi: 10.1158/2326-6066.CIR-16-0244. PubMed PMID: 27908931; PMCID: PMC5408882.
Delgoffe GM. VHL Brings Warburg into the Memory Spotlight. Immunity. 2016 Nov 15;45(5):953-955. doi: 10.1016/j.immuni.2016.11.001. PubMed PMID: 27851921.
Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. Immunity. 2016 Aug 16;45(2):374-88. doi: 10.1016/j.immuni.2016.07.009. PubMed PMID: 27496732; PMCID: PMC5207350.
Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, Stelekati E, McLane LM, Paley MA, Delgoffe GM, Wherry EJ. Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. Immunity. 2016 Aug 16;45(2):358-73. doi: 10.1016/j.immuni.2016.07.008. PubMed PMID: 27496729; PMCID: PMC4988919.
Delgoffe GM. Tumor and T-cell metabolism: new insights into melanoma therapy. Clin Adv Hematol Oncol. 2016 Apr;14(4):232-4. PubMed PMID: 27166604.
Delgoffe GM. PP2A's restraint of mTOR is critical for T(reg) cell activity. Nat Immunol. 2016 May;17(5):478-9. doi: 10.1038/ni.3442. PubMed PMID: 27092798.
Pollizzi KN, Sun IH, Patel CH, Lo YC, Oh MH, Waickman AT, Tam AJ, Blosser RL, Wen J, Delgoffe GM, Powell JD. Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation. Nat Immunol. 2016 Jun;17(6):704-11. doi: 10.1038/ni.3438. PubMed PMID: 27064374; PMCID: PMC4873361.
Turnis ME, Sawant DV, Szymczak-Workman AL, Andrews LP, Delgoffe GM, Yano H, Beres AJ, Vogel P, Workman CJ, Vignali DA. Interleukin-35 Limits Anti-Tumor Immunity. Immunity. 2016 Feb 16;44(2):316-29. doi: 10.1016/j.immuni.2016.01.013. PubMed PMID: 26872697; PMCID: PMC4758699.
Delgoffe GM, Powell JD. Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion. Mol Immunol. 2015 Dec;68(2 Pt C):492-6. doi: 10.1016/j.molimm.2015.07.026. PubMed PMID: 26256793; PMCID: PMC4837657.
Delgoffe GM, Powell JD. Sugar, fat, and protein: new insights into what T cells crave. Curr Opin Immunol. 2015 Apr;3349-54. doi: 10.1016/j.coi.2015.01.015. PubMed PMID: 25665466; PMCID: PMC4397153.

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