Publications

Carolyn Coyne

Good C, Wells AI, Coyne CB. Type III interferon signaling restricts enterovirus 71 infection of goblet cells. Sci Adv. 2019 Mar;5(3):eaau4255. doi: 10.1126/sciadv.aau4255. PubMed PMID: 30854425; PMCID: PMC6402847.
Morosky S, Wells AI, Lemon K, Evans AS, Schamus S, Bakkenist CJ, Coyne CB. The neonatal Fc receptor is a pan-echovirus receptor. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3758-3763. doi: 10.1073/pnas.1817341116. PubMed PMID: 30808762; PMCID: PMC6397586.
Evans AS, Coyne CB. RIPK3: Beyond Necroptosis. Immunity. 2019 Jan 15;50(1):1-3. doi: 10.1016/j.immuni.2018.12.031. PubMed PMID: 30650369.
Ander SE, Diamond MS, Coyne CB. Immune responses at the maternal-fetal interface. Sci Immunol. 2019 Jan 11;4(31): doi: 10.1126/sciimmunol.aat6114. PubMed PMID: 30635356; PMCID: PMC6744611.
Freeman MC, Coyne CB, Green M, Williams JV, Silva LA. Emerging arboviruses and implications for pediatric transplantation: A review. Pediatr Transplant. 2019 Feb;23(1):e13303. doi: 10.1111/petr.13303. PubMed PMID: 30338634.
Wells AI, Coyne CB. Type III Interferons in Antiviral Defenses at Barrier Surfaces. Trends Immunol. 2018 Oct;39(10):848-858. doi: 10.1016/j.it.2018.08.008. PubMed PMID: 30219309; PMCID: PMC6179363.
Barrila J, Crabbé A, Yang J, Franco K, Nydam SD, Forsyth RJ, Davis RR, Gangaraju S, Ott CM, Coyne CB, Bissell MJ, Nickerson CA. Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age. Infect Immun. 2018 Nov;86(11): doi: 10.1128/IAI.00282-18. PubMed PMID: 30181350; PMCID: PMC6204695.
Lanik WE, Mara MA, Mihi B, Coyne CB, Good M. Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract. Viruses. 2018 Mar 10;10(3): doi: 10.3390/v10030124. PubMed PMID: 29534451; PMCID: PMC5869517.
Delorme-Axford E, Abernathy E, Lennemann NJ, Bernard A, Ariosa A, Coyne CB, Kirkegaard K, Klionsky DJ. The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy. Autophagy. 2018;14(5):898-912. doi: 10.1080/15548627.2018.1441648. PubMed PMID: 29465287; PMCID: PMC6070002.
Platt DJ, Smith AM, Arora N, Diamond MS, Coyne CB, Miner JJ. Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice. Sci Transl Med. 2018 Jan 31;10(426): doi: 10.1126/scitranslmed.aao7090. PubMed PMID: 29386359; PMCID: PMC6136894.
Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Sci Immunol. 2018 Jan 5;3(19): doi: 10.1126/sciimmunol.aao1680. PubMed PMID: 29305462; PMCID: PMC6049088.
Bayer A, Lennemann NJ, Ouyang Y, Sadovsky E, Sheridan MA, Roberts RM, Coyne CB, Sadovsky Y. Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling. Placenta. 2018 Jan;6133-38. doi: 10.1016/j.placenta.2017.11.004. PubMed PMID: 29277269; PMCID: PMC5745809.
Corry J, Arora N, Good CA, Sadovsky Y, Coyne CB. Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface. Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9433-9438. doi: 10.1073/pnas.1707513114. PubMed PMID: 28784796; PMCID: PMC5584447.
Bramley JC, Drummond CG, Lennemann NJ, Good CA, Kim KS, Coyne CB. A Three-Dimensional Cell Culture System To Model RNA Virus Infections at the Blood-Brain Barrier. mSphere. 2017 May-Jun;2(3): doi: 10.1128/mSphere.00206-17. PubMed PMID: 28656176; PMCID: PMC5480033.
Chang G, Mouillet JF, Mishima T, Chu T, Sadovsky E, Coyne CB, Parks WT, Surti U, Sadovsky Y. Expression and trafficking of placental microRNAs at the feto-maternal interface. FASEB J. 2017 Jul;31(7):2760-2770. doi: 10.1096/fj.201601146R. PubMed PMID: 28289056; PMCID: PMC5471515.
Drummond CG, Bolock AM, Ma C, Luke CJ, Good M, Coyne CB. Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1672-1677. doi: 10.1073/pnas.1617363114. PubMed PMID: 28137842; PMCID: PMC5320971.
Rausch K, Hackett BA, Weinbren NL, Reeder SM, Sadovsky Y, Hunter CA, Schultz DC, Coyne CB, Cherry S. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815. doi: 10.1016/j.celrep.2016.12.068. PubMed PMID: 28099856; PMCID: PMC5270376.
Ouyang Y, Bayer A, Chu T, Tyurin VA, Kagan VE, Morelli AE, Coyne CB, Sadovsky Y. Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity. Placenta. 2016 Nov;4786-95. doi: 10.1016/j.placenta.2016.09.008. PubMed PMID: 27780544; PMCID: PMC5123854.
Coyne CB, Lazear HM. Zika virus - reigniting the TORCH. Nat Rev Microbiol. 2016 Nov;14(11):707-715. doi: 10.1038/nrmicro.2016.125. PubMed PMID: 27573577.
Olagnier D, Muscolini M, Coyne CB, Diamond MS, Hiscott J. Mechanisms of Zika Virus Infection and Neuropathogenesis. DNA Cell Biol. 2016 Aug;35(8):367-72. doi: 10.1089/dna.2016.3404. PubMed PMID: 27348136; PMCID: PMC4971419.
Drummond CG, Nickerson CA, Coyne CB. A Three-Dimensional Cell Culture Model To Study Enterovirus Infection of Polarized Intestinal Epithelial Cells. mSphere. 2016 Jan-Feb;1(1): doi: 10.1128/mSphere.00030-15. PubMed PMID: 27303677; PMCID: PMC4863623.
Bayer A, Lennemann NJ, Ouyang Y, Bramley JC, Morosky S, Marques ET Jr, Cherry S, Sadovsky Y, Coyne CB. Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. Cell Host Microbe. 2016 May 11;19(5):705-12. doi: 10.1016/j.chom.2016.03.008. PubMed PMID: 27066743; PMCID: PMC4866896.
Cuevas RA, Ghosh A, Wallerath C, Hornung V, Coyne CB, Sarkar SN. MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction. J Immunol. 2016 May 1;196(9):3877-86. doi: 10.4049/jimmunol.1501359. PubMed PMID: 27016603; PMCID: PMC4868630.
McCormick KD, Ghosh A, Trivedi S, Wang L, Coyne CB, Ferris RL, Sarkar SN. Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma. Carcinogenesis. 2016 May;37(5):522-9. doi: 10.1093/carcin/bgw032. PubMed PMID: 26992898; PMCID: PMC6086476.
Morosky S, Lennemann NJ, Coyne CB. BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication. J Virol. 2016 May 15;90(10):5098-107. doi: 10.1128/JVI.00170-16. PubMed PMID: 26962226; PMCID: PMC4859712.
Harris KG, Coyne CB. Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases. PLoS One. 2015;10(10):e0141383. doi: 10.1371/journal.pone.0141383. PubMed PMID: 26509685; PMCID: PMC4624986.
Shu Q, Lennemann NJ, Sarkar SN, Sadovsky Y, Coyne CB. ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry. PLoS Pathog. 2015 Sep;11(9):e1005150. doi: 10.1371/journal.ppat.1005150. PubMed PMID: 26372645; PMCID: PMC4570769.
Harris KG, Morosky SA, Drummond CG, Patel M, Kim C, Stolz DB, Bergelson JM, Cherry S, Coyne CB. RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells. Cell Host Microbe. 2015 Aug 12;18(2):221-32. doi: 10.1016/j.chom.2015.07.007. PubMed PMID: 26269957; PMCID: PMC4562276.
Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Grewal R, Ninomiya J, Coyne CB, Jackson WT. Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes. J Biol Chem. 2015 May 22;290(21):13028-38. doi: 10.1074/jbc.M114.630558. PubMed PMID: 25869133; PMCID: PMC4505557.
Lennemann NJ, Coyne CB. Catch me if you can: the link between autophagy and viruses. PLoS Pathog. 2015 Mar;11(3):e1004685. doi: 10.1371/journal.ppat.1004685. PubMed PMID: 25811485; PMCID: PMC4374752.
Delorme-Axford E, Morosky S, Bomberger J, Stolz DB, Jackson WT, Coyne CB. BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation machinery. mBio. 2014 Dec 9;5(6):e02147. doi: 10.1128/mBio.02147-14. PubMed PMID: 25491355; PMCID: PMC4324245.
Zhu J, Zhang Y, Ghosh A, Cuevas RA, Forero A, Dhar J, Ibsen MS, Schmid-Burgk JL, Schmidt T, Ganapathiraju MK, Fujita T, Hartmann R, Barik S, Hornung V, Coyne CB, Sarkar SN. Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. Immunity. 2014 Jun 19;40(6):936-48. doi: 10.1016/j.immuni.2014.05.007. PubMed PMID: 24931123; PMCID: PMC4101812.

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