Publications

. Long-term outcomes by lobular versus ductal histology in four NSABP adjuvant breast cancer trials. J Natl Cancer Inst. 2025-01-01; doi: 10.1093/jnci/djae188. PubMed PMID: 39128018; PMCID: PMC11717417.

. Monoamine transporter ubiquitination and inward-open conformation synergistically maximize transporter endocytosis. Sci Adv. 2024-11-22;10(47):eadq9793. doi: 10.1126/sciadv.adq9793. PubMed PMID: 39576869; PMCID: PMC11584022.

. Paracrine Ovarian Cancer Cell-Derived CSF1 Signaling Regulates Macrophage Migration Dynamics in a 3D Microfluidic Model that Recapitulates in vivo Infiltration Patterns in Patient-Derived Xenografts. Adv Healthc Mater. 2024-11-01;e2401719. doi: 10.1002/adhm.202401719. PubMed PMID: 38807270; PMCID: PMC11560735.

. The dark side of human hepatocyte plasticity. Gastroenterology. 2024-10-01; doi: 10.1053/j.gastro.2024.06.011. PubMed PMID: 38936779; PMCID: PMC11980431.

. Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations. Proc Natl Acad Sci U S A. 2024-07-30;121(31):e2322068121. doi: 10.1073/pnas.2322068121. PubMed PMID: 39042692; PMCID: PMC11295029.

. International survey on invasive lobular breast cancer identifies priority research questions. NPJ Breast Cancer. 2024-07-20;10(1):61. doi: 10.1038/s41523-024-00661-3. PubMed PMID: 39033157; PMCID: PMC11271268.

. A Path to Persistence after EGFR Inhibition. Cancer Res. 2024-04-15;84(8):1188-1190. doi: 10.1158/0008-5472.CAN-24-0274. PubMed PMID: 38616658; PMCID: PMC11090642.

. Systematic investigation of chemo-immunotherapy synergism to shift anti-PD-1 resistance in cancer. Nat Commun. 2024-04-12;15(1):3178. doi: 10.1038/s41467-024-47433-y. PubMed PMID: 38609378; PMCID: PMC11015024.

. Learning human liver biology in humanized mice. Cell Res. 2024-01-01; doi: 10.1038/s41422-023-00877-1. PubMed PMID: 37730939; PMCID: PMC10770126.

. Wnt-β-catenin in hepatobiliary homeostasis, injury, and repair. Hepatology. 2023-12-01; doi: 10.1097/HEP.0000000000000495. PubMed PMID: 37246413; PMCID: PMC10687322.

. Beyond matrix stiffness: targeting force-induced cancer drug resistance. Trends Cancer. 2023-11-01; doi: 10.1016/j.trecan.2023.07.006. PubMed PMID: 37558577; PMCID: PMC10592424.

. Effects of socioeconomic status and race on survival and treatment in metastatic breast cancer. NPJ Breast Cancer. 2023-11-01;9(1):90. doi: 10.1038/s41523-023-00595-2. PubMed PMID: 37914742; PMCID: PMC10620133.

. Statins as a Secondary Preventive Agent for Metastatic Cancer. J Thorac Oncol. 2023-11-01;18(11):e125-e126. doi: 10.1016/j.jtho.2023.07.027. PubMed PMID: 37879767.

. Neural deficits in a mouse model of PACS1 syndrome are corrected with PACS1- or HDAC6-targeting therapy. Nat Commun. 2023-10-17;14(1):6547. doi: 10.1038/s41467-023-42176-8. PubMed PMID: 37848409; PMCID: PMC10582149.

. Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation. Cell Rep. 2023-08-29;42(8):112830. doi: 10.1016/j.celrep.2023.112830. PubMed PMID: 37481724; PMCID: PMC10591215.

. The EstroGene Database Reveals Diverse Temporal, Context-Dependent, and Bidirectional Estrogen Receptor Regulomes in Breast Cancer. Cancer Res. 2023-08-15;83(16):2656-2674. doi: 10.1158/0008-5472.CAN-23-0539. PubMed PMID: 37272757; PMCID: PMC10527051.

. Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy. Clin Cancer Res. 2023-05-15;29(10):1969-1983. doi: 10.1158/1078-0432.CCR-22-2254. PubMed PMID: 36795892; PMCID: PMC10192102.

. Hepatocyte β-catenin loss is compensated by Insulin-mTORC1 activation to promote liver regeneration. Hepatology. 2023-05-01;77(5):1593-1611. doi: 10.1002/hep.32680. PubMed PMID: 35862186; PMCID: PMC9859954.

. Reply. Hepatology. 2023-05-01;77(5):E86-E87. doi: 10.1002/hep.32694. PubMed PMID: 36054712.

. The Great Immune Escape: Understanding the Divergent Immune Response in Breast Cancer Subtypes. Cancer Discov. 2023-01-09;13(1):23-40. doi: 10.1158/2159-8290.CD-22-0475. PubMed PMID: 36620880; PMCID: PMC9833841.

. Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response. Sci Adv. 2022-12-09;8(49):eadd0005. doi: 10.1126/sciadv.add0005. PubMed PMID: 36475797; PMCID: PMC9728976.

. The Great Immune Escape: Understanding the Divergent Immune Response in Breast Cancer Subtypes. Cancer Discov. 2022-12-06;OF1-OF18. doi: 10.1158/2159-8290.CD-22-0475. PubMed PMID: 36473061.

. Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b. Cell Rep Med. 2022-10-18;3(10):100754. doi: 10.1016/j.xcrm.2022.100754. PubMed PMID: 36220068; PMCID: PMC9588996.

. A Druggable Rheostat for Ewing Sarcoma? Clin Cancer Res. 2022-10-14;28(20):4360-4362. doi: 10.1158/1078-0432.CCR-22-1794. PubMed PMID: 35921177; PMCID: PMC9588653.

. Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer. Nat Rev Cancer. 2022-06-01;22(6):323-339. doi: 10.1038/s41568-022-00454-5. PubMed PMID: 35264777; PMCID: PMC9149051.

. ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation. Nat Commun. 2022-04-19;13(1):2011. doi: 10.1038/s41467-022-29498-9. PubMed PMID: 35440136; PMCID: PMC9019037.

. Fatty acid nitroalkene reversal of established lung fibrosis. Redox Biol. 2022-04-01;50102226. doi: 10.1016/j.redox.2021.102226. PubMed PMID: 35150970; PMCID: PMC8844680.

. Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis. Cancer Res. 2022-04-01;82(7):1321-1339. doi: 10.1158/0008-5472.CAN-21-2576. PubMed PMID: 35078818; PMCID: PMC8983597.

. Characterization of systemic immunosuppression by IDH mutant glioma small extracellular vesicles. Neuro Oncol. 2022-02-01;24(2):197-209. doi: 10.1093/neuonc/noab153. PubMed PMID: 34254643; PMCID: PMC8804898.

. Coupling high-throughput mapping with proteomics analysis delineates cis-regulatory elements at high resolution. Nucleic Acids Res. 2022-01-11;50(1):e5. doi: 10.1093/nar/gkab890. PubMed PMID: 34634809; PMCID: PMC8754656.

. Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition. Sci Adv. 2021-11-12;7(46):eabi5790. doi: 10.1126/sciadv.abi5790. PubMed PMID: 34767446; PMCID: PMC8589308.

. Nuclear factor erythroid 2-related factor 2 and β-Catenin Coactivation in Hepatocellular Cancer: Biological and Therapeutic Implications. Hepatology. 2021-08-01;74(2):741-759. doi: 10.1002/hep.31730. PubMed PMID: 33529367; PMCID: PMC8326305.

. Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis. Annu Rev Biochem. 2021-06-20;90709-737. doi: 10.1146/annurev-biochem-081820-092427. PubMed PMID: 33606955; PMCID: PMC8608402.

. Integrative microphysiological tissue systems of cancer metastasis to the liver. Semin Cancer Biol. 2021-06-01;71157-169. doi: 10.1016/j.semcancer.2020.06.010. PubMed PMID: 32580025; PMCID: PMC7750290.

. Regulation and targeting of androgen receptor nuclear localization in castration-resistant prostate cancer. J Clin Invest. 2021-02-15;131(4): doi: 10.1172/JCI141335. PubMed PMID: 33332287; PMCID: PMC7880411.

. Syngeneic tobacco carcinogen-induced mouse lung adenocarcinoma model exhibits PD-L1 expression and high tumor mutational burden. JCI Insight. 2021-02-08;6(3): doi: 10.1172/jci.insight.145307. PubMed PMID: 33351788; PMCID: PMC7934870.

. LincRNA-immunity landscape analysis identifies EPIC1 as a regulator of tumor immune evasion and immunotherapy resistance. Sci Adv. 2021-02-01;7(7): doi: 10.1126/sciadv.abb3555. PubMed PMID: 33568470; PMCID: PMC7875530.

. Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors. Theranostics. 2021-01-20;11(8):3540-3551. doi: 10.7150/thno.51885. PubMed PMID: 33664846; PMCID: PMC7914353.

. Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells. Cancer Res. 2021-01-15;81(2):268-281. doi: 10.1158/0008-5472.CAN-20-0696. PubMed PMID: 33148662; PMCID: PMC7856056.

. Targeting KRAS-Mutant Non-Small-Cell Lung Cancer: One Mutation at a Time, With a Focus on KRAS G12C Mutations. J Clin Oncol. 2020-12-10;38(35):4208-4218. doi: 10.1200/JCO.20.00744. PubMed PMID: 33104438; PMCID: PMC7723684.

. A sequential methodology for the rapid identification and characterization of breast cancer-associated functional SNPs. Nat Commun. 2020-07-03;11(1):3340. doi: 10.1038/s41467-020-17159-8. PubMed PMID: 32620845; PMCID: PMC7334201.

. Copy Number Amplification of DNA Damage Repair Pathways Potentiates Therapeutic Resistance in Cancer. Theranostics. 2020-03-04;10(9):3939-3951. doi: 10.7150/thno.39341. PubMed PMID: 32226530; PMCID: PMC7086350.

. An evolving paradigm of cancer stem cell hierarchies: therapeutic implications. Theranostics. 2020-02-10;10(7):3083-3098. doi: 10.7150/thno.41647. PubMed PMID: 32194856; PMCID: PMC7053211.

. GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein. J Clin Invest. 2020-02-03;130(2):1036-1051. doi: 10.1172/JCI97040. PubMed PMID: 31961340; PMCID: PMC6994119.

. No Zones Left Behind: Democratic Hepatocytes Contribute to Liver Homeostasis and Repair. Cell Stem Cell. 2020-01-02;26(1):2-3. doi: 10.1016/j.stem.2019.12.002. PubMed PMID: 31951586.

. Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors. J Immunother Cancer. 2019-10-18;7(1):265. doi: 10.1186/s40425-019-0755-1. PubMed PMID: 31627744; PMCID: PMC6798422.

. No Role for Maintenance Bevacizumab for Up-Front Stage IIIc (R0) Ovarian Cancer. J Clin Oncol. 2019-10-10;37(29):2707-2708. doi: 10.1200/JCO.19.01650. PubMed PMID: 31449471.

. Chemical Strike against a Dominant-Inherited MUC1-Frameshifted Protein Associated with Progressive Kidney Disease. Trends Mol Med. 2019-10-01;25(10):821-823. doi: 10.1016/j.molmed.2019.08.011. PubMed PMID: 31521560; PMCID: PMC8405134.

. Ultrasound and Microbubble-targeted Delivery of a microRNA Inhibitor to the Heart Suppresses Cardiac Hypertrophy and Preserves Cardiac Function. Theranostics. 2019-09-21;9(23):7088-7098. doi: 10.7150/thno.34895. PubMed PMID: 31660088; PMCID: PMC6815962.

. Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer. Nat Commun. 2019-07-11;10(1):3055. doi: 10.1038/s41467-019-11044-9. PubMed PMID: 31296870; PMCID: PMC6624260.

. Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations. Cell Metab. 2019-05-07;29(5):1135-1150.e6. doi: 10.1016/j.cmet.2019.01.002. PubMed PMID: 30713111; PMCID: PMC6506359.

. Electrophilic nitro-oleic acid reverses obesity-induced hepatic steatosis. Redox Biol. 2019-04-01;22101132. doi: 10.1016/j.redox.2019.101132. PubMed PMID: 30769284; PMCID: PMC6375063.

. Hepatic Zonation Now on Hormones! Hepatology. 2019-03-01;69(3):1339-1342. doi: 10.1002/hep.30221. PubMed PMID: 30120897; PMCID: PMC6379153.

. Hepatocyte-Specific β-Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes. Hepatology. 2019-02-01;69(2):742-759. doi: 10.1002/hep.30270. PubMed PMID: 30215850; PMCID: PMC6351199.

. An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity. Mol Cell. 2018-12-20;72(6):985-998.e7. doi: 10.1016/j.molcel.2018.10.007. PubMed PMID: 30415949; PMCID: PMC6309500.

. Comprehensive Phenotypic Characterization of Human Invasive Lobular Carcinoma Cell Lines in 2D and 3D Cultures. Cancer Res. 2018-11-01;78(21):6209-6222. doi: 10.1158/0008-5472.CAN-18-1416. PubMed PMID: 30228172; PMCID: PMC6507416.

. Loss of E-cadherin Enhances IGF1-IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors. Clin Cancer Res. 2018-10-15;24(20):5165-5177. doi: 10.1158/1078-0432.CCR-18-0279. PubMed PMID: 29941485; PMCID: PMC6821389.

. Systematic identification of non-coding pharmacogenomic landscape in cancer. Nat Commun. 2018-08-09;9(1):3192. doi: 10.1038/s41467-018-05495-9. PubMed PMID: 30093685; PMCID: PMC6085336.

. Developmental Loci Harbor Clusters of Accelerated Regions That Evolved Independently in Ape Lineages. Mol Biol Evol. 2018-08-01;35(8):2034-2045. doi: 10.1093/molbev/msy109. PubMed PMID: 29897475; PMCID: PMC6063267.

. High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction. Nat Genet. 2018-08-01;50(8):1180-1188. doi: 10.1038/s41588-018-0159-z. PubMed PMID: 30013183; PMCID: PMC6072570.

. Novel Genetic Activation Screening in Liver Repopulation and Cancer: Now CRISPR Than Ever! Hepatology. 2018-08-01;68(2):408-411. doi: 10.1002/hep.30084. PubMed PMID: 29742805; PMCID: PMC6097894.

. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology. 2018-06-01;67(6):2320-2337. doi: 10.1002/hep.29585. PubMed PMID: 29023813; PMCID: PMC5893443.

. lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Cancer Cell. 2018-04-09;33(4):706-720.e9. doi: 10.1016/j.ccell.2018.03.006. PubMed PMID: 29622465; PMCID: PMC6143179.

. Preclinical Evidence for Combined Use of Aromatase Inhibitors and NSAIDs as Preventive Agents of Tobacco-Induced Lung Cancer. J Thorac Oncol. 2018-03-01;13(3):399-412. doi: 10.1016/j.jtho.2017.11.126. PubMed PMID: 29233790; PMCID: PMC5825271.

. The CARMA3-Bcl10-MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor-Positive Breast Cancer. Cancer Res. 2018-03-01;78(5):1225-1240. doi: 10.1158/0008-5472.CAN-17-1089. PubMed PMID: 29259013; PMCID: PMC6436094.

. Lipid metabolic reprogramming in hepatic ischemia-reperfusion injury. Nat Med. 2018-01-09;24(1):6-7. doi: 10.1038/nm.4468. PubMed PMID: 29315298.

. First-Line Osimertinib in Patients with Treatment-Naive Somatic or Germline EGFR T790M-Mutant Metastatic NSCLC. J Thorac Oncol. 2018-01-01;13(1):e3-e5. doi: 10.1016/j.jtho.2017.09.1963. PubMed PMID: 28989039.

. Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. Mol Cancer. 2017-11-14;16(1):172. doi: 10.1186/s12943-017-0740-6. PubMed PMID: 29137633; PMCID: PMC5686836.

. Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation. Cancer Res. 2017-11-01;77(21):5795-5807. doi: 10.1158/0008-5472.CAN-17-1325. PubMed PMID: 28883002; PMCID: PMC5668145.

. Mice lacking liver-specific β-catenin develop steatohepatitis and fibrosis after iron overload. J Hepatol. 2017-08-01;67(2):360-369. doi: 10.1016/j.jhep.2017.03.012. PubMed PMID: 28341391; PMCID: PMC5515705.

. Active Estrogen Receptor-alpha Signaling in Ovarian Cancer Models and Clinical Specimens. Clin Cancer Res. 2017-07-15;23(14):3802-3812. doi: 10.1158/1078-0432.CCR-16-1501. PubMed PMID: 28073843; PMCID: PMC5503796.

. Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases. JAMA Oncol. 2017-05-01;3(5):666-671. doi: 10.1001/jamaoncol.2016.5630. PubMed PMID: 27926948; PMCID: PMC5508875.

. Targeting β-catenin in hepatocellular cancers induced by coexpression of mutant β-catenin and K-Ras in mice. Hepatology. 2017-05-01;65(5):1581-1599. doi: 10.1002/hep.28975. PubMed PMID: 27981621; PMCID: PMC5397318.

. The next generation of immunotherapy: keeping lung cancer in check. J Hematol Oncol. 2017-04-24;10(1):87. doi: 10.1186/s13045-017-0456-5. PubMed PMID: 28434399; PMCID: PMC5402056.

. Non-coding single nucleotide variants affecting estrogen receptor binding and activity. Genome Med. 2016-12-13;8(1):128. doi: 10.1186/s13073-016-0382-0. PubMed PMID: 27964748; PMCID: PMC5154163.

. Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling. Hepatology. 2016-11-01;64(5):1725-1742. doi: 10.1002/hep.28755. PubMed PMID: 27482645; PMCID: PMC5074910.

. Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant β-catenin. Hepatology. 2016-11-01;64(5):1587-1605. doi: 10.1002/hep.28601. PubMed PMID: 27097116; PMCID: PMC5073058.

. Intratumor Heterogeneity Affects Gene Expression Profile Test Prognostic Risk Stratification in Early Breast Cancer. Clin Cancer Res. 2016-11-01;22(21):5362-5369. doi: 10.1158/1078-0432.CCR-15-2889. PubMed PMID: 27185370; PMCID: PMC5093028.

. IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression. Neuro Oncol. 2016-10-01;18(10):1402-12. doi: 10.1093/neuonc/now061. PubMed PMID: 27116977; PMCID: PMC5035522.

. Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients. Clin Cancer Res. 2016-03-01;22(5):1130-7. doi: 10.1158/1078-0432.CCR-15-1534. PubMed PMID: 26500237; PMCID: PMC4775406.

. Ultrasound Targeted Microbubble Destruction-Mediated Delivery of a Transcription Factor Decoy Inhibits STAT3 Signaling and Tumor Growth. Theranostics. 2015-10-16;5(12):1378-87. doi: 10.7150/thno.12822. PubMed PMID: 26681983; PMCID: PMC4672019.

. The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence. Nucleic Acids Res. 2015-09-18;43(16):8077-88. doi: 10.1093/nar/gkv748. PubMed PMID: 26206669; PMCID: PMC4652764.

. To B(MP-2) or Not To B(MP-2): Cytokines and Tumor Surgery—Response. Clin Cancer Res. 2015-09-01;21(17):4023. doi: 10.1158/1078-0432.CCR-15-0875. PubMed PMID: 26330507.

. "To B(MP-2) or Not To B(MP-2)" or "Much Ado About Nothing": Are Orthobiologics in Tumor Surgery Worth the Risks? Clin Cancer Res. 2015-07-01;21(13):2889-91. doi: 10.1158/1078-0432.CCR-14-3069. PubMed PMID: 25609065.

. β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis. Gastroenterology. 2015-06-01;148(7):1294-310. doi: 10.1053/j.gastro.2015.02.056. PubMed PMID: 25747274; PMCID: PMC4494085.

. Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model. J Hepatol. 2015-02-01;62(2):380-7. doi: 10.1016/j.jhep.2014.10.021. PubMed PMID: 25457204; PMCID: PMC4300253.

. Genomic instability causes HGF gene activation in colon cancer cells, promoting their resistance to necroptosis. Gastroenterology. 2015-01-01;148(1):181-191.e17. doi: 10.1053/j.gastro.2014.09.019. PubMed PMID: 25244939; PMCID: PMC4274190.

. Co-targeting c-Met and COX-2 leads to enhanced inhibition of lung tumorigenesis in a murine model with heightened airway HGF. J Thorac Oncol. 2014-09-01;9(9):1285-93. doi: 10.1097/JTO.0000000000000245. PubMed PMID: 25057941; PMCID: PMC4134355.

. Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice. Gastroenterology. 2014-09-01;147(3):690-701. doi: 10.1053/j.gastro.2014.05.004. PubMed PMID: 24837480; PMCID: PMC4143445.

. β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation! Hepatology. 2014-09-01;60(3):964-76. doi: 10.1002/hep.27082. PubMed PMID: 24700412; PMCID: PMC4139486.

. Tri-iodothyronine induces hepatocyte proliferation by protein kinase A-dependent β-catenin activation in rodents. Hepatology. 2014-06-01;59(6):2309-20. doi: 10.1002/hep.26775. PubMed PMID: 24122933; PMCID: PMC3979513.