Journal Club

The focus of the Journal Club is to discuss the most exciting findings in women’s cancer research, report on related topics, and to stimulate interactions between basic, translational, and clinical researchers. The general theme will be translational research, discussing papers that give biological and mechanistic insight into clinical observations, with the goal of stimulating new thoughts on research programs in the WCRC.

Journal Club will return in the fall, please check back for dates.

Format: will be a 'round table discussion' with no slides...'presenters' will be more like discussion leaders giving a summary of the paper, explaining key points, and bringing prepared discussion points/questions to stimulate groups discussion.

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Breast Cancer Translational Research Working Group

The purpose of the Breast Cancer Translational Research Group is to bring together our multidisciplinary group of researchers to increase collaboration and streamline research efficiency and productivity. The meeting is the first and third Wednesday of each month, and it is open to all members of the Women's Cancer Research Center and the Magee Women's Breast Center, as well as trainees within these groups. It is a great forum to improve communication between basic scientists and clinicians to maximize study potential - both by understanding the clinical underpinnings of our bench work and to incorporate basic science correlates into our clinical studies. Here we identify research obstacles, troubleshoot problems, get feedback about new ideas and concepts, practice research short talks prior to presentation at national meetings and share successes. Our goal is to increase our initiation of, accrual to and completion of our home-grown clinical trials.

The following poster templates are for the Breast Cancer Translational Research Working Group poster presentation.

External Work-in-progress (WIP)

The goal of WIP is to provide a forum for investigators (trainees, students, fellows, junior faculty) to discuss their research in a multi-disciplinary setting.

Time: The first Thursday of every month, 10:30-11:30 am
Place: MWRI-1st Floor Conference Room

2017 Work-in-progress

Past Speakers / Affliliation Date of Seminar
Jorge Reis-Filho, MD, PhD, Physician-sicentist, Memorial Sloan Kettering Cancer Center - Genetic analysis of rare forms of triple-negative breast cancer: more than tumor philately 1/5/2017
Faina Linkov, Associate Professor, University of Pittsburgh School of Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, Magee-Womens Research Institute - Novel and existing research directions in the field of endometrial cancer 2/2/2017
Dr. Xin Huang, Assistant Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, Division of Gynecological Oncology, University of Pittsburgh - Non-coding RNA regulation of the hypoxic pathway 3/2/2017
Aleks Rajkovic, MD, PhD, Professor and Marcus Allen Hogge Chair in Reproductive Sciences, Director of Reproductive Genetics, Department of Obstetrics, Gynecology and Reproductive Sciences - Genetic Underpinnings of Leiomyoma 4/6/2017
Malcolm Ross and Erin Harnett, Gynecologic Oncology Fellow, University of Pittsburgh 6/8/2017

2016 Work-in-progress Archive

Past Speakers / Affliliation Date of Seminar
Da Yang, PhD, Physician-sicentist, Memorial Sloan Kettering Cancer Center 12/1/2016
Yang Liu, PhD, Assistant Professor of Pharmaceutical Sciences, University of Pittsburgh Cancer Instittute 11/3/2016
Lewis Chodosh, MD, PhD, Professor and Chair Associate Director for Basic Science, Abramson Cancer Center Director, Cancer Genetics, Abramson Family Cancer Research Institute 10/6/2016
Fellows (Shannon Grabosch, MD and Casey Hay, MD) 6/2/2016
Richard Steinman, MD PhD, New approaches to the microenvironment in breast cancer cellular dormancy and metastasis 5/5/2016
Karen Lu, MD, Phd, Chair, Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 4/7/2016
Madhavi Kumari Ganapathiraju, PhD, Assistant Professor, Department of Biomedical Informatics, University of Pittsburgh 3/3/2016
Xinghua Lu, PhD, Associate Professor, Department of Biomedical Informatics, University of Pittsburgh 2/4/2016
Binfeng Lu, PhD, Associate Professor, Department of Immunology, University of Pittsburgh 1/7/2016

2015 Work-in-progress Archive

Past Speakers / Affliliation Date of Seminar
Fellows (Shannon Grabosch and Casey Hay) 12/3/2015
Ann Ramsdell, PhD, Associate Professor, Department of Cell Biology and Anatomy, University of South Carolina School of Medicine 11/5/2015
Susan Domchek, MD, Basser Professor in Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania 10/1/2015
Shilpa Sant, PhD, Assistant Professor, School of Pharmacy, Department of Pharmaceutical Sciences, Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh 9/3/2015
Summer Break 8/6/2015
Summer Break 7/2/2015
Fellows 6/4/2015
Fariba Behbod, PhD, Associate Professor, Department of Pathology and Laboratory, University of Kansas School of Medicine, 3901 Rainbow Blvd. WHE 1005B 5/7/2015
Analisa Difeo, PhD, Assistant Professor, General Medical Sciences (Oncology), Norma C. and Albert I. Geller Designated Professor of Ovarian Cancer Research, Case Comprehensive Cancer Center, Case Western Reserve University 4/2/2015
Jianhua Xing, PhD, Visiting Associate Professor, Department of Computational & Systems Biology, School of Medicine, University of Pittsburgh 3/12/2015
Yang Liu, PhD, Associate Professor, Department of Medicine, Department of Bioengineering, University of Pittsburgh 3/5/2015
Kandace McGuire, MD, Assistant Professor of Surgery, University of Pittsburgh 2/12/2015

2014 Work-in-progress Archive

Past Speakers / Affliliation Date of Seminar
Dr. Adam Brufsky
Professor of Medicine Associate Chief, Division of Hematology/Oncology Co-Director, Comprehensive Breast Cancer Center Associate Director, Clinical Investigation
Fellows (Ob/Gyn) 11/6/14
Shandong Wu
Research Assistant Professor, Imaging Research Center Radiology, School of Medicine, University of Pittsburgh
Joanna Burdette
Associate Professor,Department of Medicinal Chemistry and Pharmacognosy and the Center of Pharmaceutical Biotechnology, University of Illinois at Chicago
Topic: "The impact of ovulation on fallopian tube epithelial cells and high-grade serous cancer"
Hansen & Berger
Fellows (Ob/Gyn)
Song Li, PhD
Professor, Department of Pharmaceutical Sciences, University of Pittsburgh
Sohrab Shah, PhD
Assistant Professor, Depts of Pathology and Computer Science, University of British Columbia
Charles N. Landen, Jr., MD, MS
Dept. of Obstetrics & Gynecology, Division of Gynecologic Oncology University of Alabama at Birmingham, AL
Topic: "Development of the patident-derived xenograft model to identifymediators of chemotherapy resistance in ovarian cancer"
McAllister-Lucas, Linda, MD, PhD
Chief, Division of Pediatric Hematology/Oncology, Assoc. Prof, Dept of Pediatrics Univ. of Pgh. School of Medicine

Lucas, Peter, MD, PhD
Associate Professor, Dept. of Pathology, Univ. of Pgh. School of Medicine
Topic: "Aberrant GPCR signaling in breast cancer pathogenesis"

Mai, Phuong, MD, MS
Genetice Candidate, Staff Physician, National Cancer Institute, Rockville, Maryland
Topic: "Hereditary Cancer Risk Management - Strategies and Challenges"
Lee, Byeong-Chel, PhD
UPCI - Assistant Professor of Medicine
Topic: "Heregulin-C/EBP beta CXCR4 axis in breast cancer progression and Metastasis"

2013 Work-in-progress Archive

Past Speakers / Affliliation Date of Seminar
Margaret Quinn Rosenzweig, PhD, FNP-BC, AOCNP
Assoc. Professor of Oncology Focus, Acute Care Nurse Practitioner Program, Univ. of Pittsburgh School of Nursing
Topic: "A longitudinal Analysis of Women with Metastatic Breast Cancer: Past, Present & Future"
Andrew Stern, PhD
Director of Novel Therapeutics, Univesity of Pittsburgh Drug Discovery Institute
Topic: "Identifying cancer cell dependencies and targeting them with repurposed drugs"
John Bartlett
Professor, Program Director, Transformative Pathology, Ontario Institute for Cancer Research (OICR)
Topic: "Predicting anthracycline response in breast cancer - have we finally arrived"
Anna Lokshin, PhD
Prof. of Medicine, Pathology & OB/Gyn/RS, Director Luminex Core Facility, Hillman Cancer Center
Topic: "Urine biomarkers in cancer"
David Boone, PhD
Postdoc in Adrian Lee's Lab
Topic: "SNHG7 is an IGF1 regulated lincRNA necessary for full proliferation of MCF7 breast cancer epithelial cells"
Rachel Schiff, PhD
Assoc. Prof., Dept of Medicine-Hematology/Oncology, Smith Breast Center, Baylor College of Medicine, Houston, TX
Topic: "Breast Cancer HER2-targeted therapy and mechanisms of resistance"
Jessica Berger, MD
Gyn/Onc Fellow/Dr.Kyle Orwig's Lab
Topic: "Preventing chemotherapy-induced dysfunction in an early stafe ovarian cancer model"
Karyn Hansen, MD
Gyn/Onc Fellow/Dr. Ben Van Houten's Lab
Topic: "Ovarian cancer cells demonstrate metabolic flexibility by utilizing fatty acid beta oxidation"
H. Michael Gach
Assoc. Prof. of Radiology & Bioengineering, Hillman/University of Pitt.
Topic: "MRI & PET/MRI in translational Research of How I Learned to Love Ovarian Cancer"
Tiffany Katz, PhD
Postdoc/Research Associate, Hillman
Topic: "Histone Lysine Specific Demethylase 2 (LSD2)"
Andrea Jeanne Berman, PhD
Asst Prof/Dept. of Biological Sciences, Univ. of Pgh.
Topic: "La-related Protein 1: a new player in ovarian cancer"
Jesus Gonzalez Bosquet, PhD
Gyn/Oncology Dept. at Moffitt Cancer & Research Institute
Topic: "Analysis of Ovarian Cancer Chemo-response using publcly available high-throughput data"
Sanaz Memarzadeh, MD, PhD
Assist. Prof., Dept. of Obstetrics & Gyn, The David Geffen School of Medicine at UCLA
Topic: "Signaling through the progesterone receptor in the tumor microenvironment is a key regulator of resonse to hormonal therapy"
Xinghua Lu, MD, PhD
Associate Professor, Dept. of Biomedical informatics, Univ. of Pgh.
Topic: "Identify Informative Modular Features for Predicting Cancer Clinical Outcomes"
Lesley Butler, PhD
Assoc. Prof. Univ. of Pgh.. Cancer Institute, UPMC Cancer Pavilion
Topic: "Urinary biomarkers of angiogenesis and breast cancer risk
Jeff Lin, MD
Gyn/Onc fellow in Huang's Lab
Topic: "Distinct Expression of MicroRNA in Ovarian Cancer Ascites"
Sarah Taylor, MD
Gyn/Onc Fellow in Lee's Lab
Topic: "IGF-1 Pathway as a potential Therapeutic target in Epithelial Ovarian Cancer"
Adrian Lee, PHD
Prof., Dept. of Pharmacology & Chem. Biology, Dir. Women's Cancer Institute
Topic: "Intra-tumor heterogeneity & personalized medicine: Studies ongoing at the WCRC"
Amir Bahreini, BSC
Graduate Student in Dr. Oesterreich's Lab
Topic: "The Identification of DNA Sequence Variants in Estrogen Receptor Binding Sites in Greast Cancer"
Jorge Rios, Fellow
Div. of Hematology-Oncology, University of Pgh. Institute (Lee's Lab)
Topic: "Bone metastasis in breast cancer: Association between clinical outcomes and molecular characteristics of the primary tumors and their metastasis"
Terence McGuire, PhD
Candidate for Non-Tenured Researcher
Topic: "Tumor-Derived Endothelium: In Vivo Evolution and In Vitro Recapitulation"
Xin Huang, PhD
Research Asst. Professor, Department of Pharmacology & Chemical Biology, The Hillman Cancer Center
Topic: "Targeting histone lysine demethylases in breast cancer therapy"
Linwah Yip, MD
Assistant Professor of Surgery, Division of Endocrine Surgery
Topic: "Molecular Markers in Thyroid Cancer"
Mei Zhang, PhD
Asst. Prof, Department of Developmental Biology
Topic: "Breast Cancer stem cells and their progeny"
Otto Metzge, MD
Research Fellow in Medicine, Breast Oncology Center, Dana Farber Cancer Institute, Boston
Topic: "New frontiers in the treatment of Invasive Lobular Carcinoma"
Li Lan, MD, PhD
Asst. Prof, Dept of Microbiology & Molecular Genetics, Univ. of Pgh., Hillman Cancer Center
Topic: "DNS repair and chromatin remodeling and their relationship to genome instability: in situ analysis of DNA damage responses"
Vera Donnenberg, PhD, FCP
Associate Prof. of Cardiothoracic Surgery & Pharmaceutical Sciences, Hillman Cancer Center
Topic: "Breast Cancer Stem Cells: a decade later"
Steffi Oesterreich, PhD
Prof, Dept. of Pharmacology & Chemical Biology, Co-Leader Molecular & Cellular cancer Biology Program, Univ. of Pgh., Cancer Institute & Dir. Of Education at the Women's Cancer Research Center
Topic: MWRI Methylation-age BRCA
Xin Huang, PhD
Asst. Prof., Gyn/Onc.
Magee Women's Research Institute
Topic: "MicroRNA expression profiling in endometriosis and endometriosis-associated ovarian cancer"
Anda Vlad, MD, PhD
Asst Prof. Dept. of Obstetrics, Gyn & Repro Sciences, Univ. of Pgh, School of Medicine, Magee
Topic: Immune dysregulatio in endometriosis and ovarian cancer
Chandra Batula, PhD
Dr. Lee's Lab
Topic: "Targeting IGF-IR as a Therapeutic approach for triple negative breast cancer"
Faina Linkov, PhD, MPH
Asst. Prof, Research Division
Topci: "Decision support systems for obese gynecologic onc patients: Funding opportunities through PCORI"
Per Basse, MD, PhD, DMSci
Assoc. Prof. of Immunology, UPCI at the Hillman Cancer Center
Topic: "Immunology of Breast Cancer Brain Metastases"

2012 Work-in-progress Archive

Past Speakers Affiliation Seminar Date of Seminar
Orla Conneely Baylor College of Medicine, Houston TX   11/6/2012
Suzanne Conzen University of Chicago   11/14/2012
Jennifer K. Richer, Ph.D. Associate Professor, Department of Pathology,
University of Colorado Anschutz Medical Campus
The Androgen Receptor in Breast Cancer - Novel Insights 10/4/2012
Bryan Welm Huntsman Cancer Institute, Salt Lake City Utah WCRC WIP 5/22/2012
Alana Welm Huntsman Cancer Institute, Salt Lake City Utah UPCI - Basic & Translational 5/22/2012
Carola Neumann, MD Medical University of South Carolina PCB 5/1/2012

2011 Work-in-progress Archive

Past Speakers Affiliation Seminar Date of Seminar
David Huntsman British Columbia Cancer Agency, Vancouver, BC, Canada WCRC WIP 10/26/2011
Aleks Milosevich Baylor College of Medicine, Houston TX WCRC special seminar 10/25/2011
Mitch Dowsett Royal Marsden, London, UK WCRC special seminar 10/24/2011
Powel Brown The University of Texas, MD Anderson Cancer Center UPCI - Basic & Translational 9/13/2011
Paul Haluska, MD, PhD Mayo Clinic, Rochester MN WCRC WIP 9/8/2011
Kenneth Nephew Simon Cancer Center, Indiana University UPCI - Basic & Translational 5/31/2011
Matthew Ellis, PhD Washington University, St. Louis, MO 1st Annual WCRC Retreat 5/6/2011
Carol Lange, PhD Masonic Cancer Center, University of Minnesota WCRC WIP 4/26/2011