Of the many viruses that infect humans, only seven have been shown to cause cancer to date. Two of these known cancer-causing viruses, Kaposi’s sarcoma herpesvirus (KSHV) and Merkel cell polyomavirus (MCV), were discovered by Patrick Moore, MD, MPH, and Yuan Chang, MD of the UPCI Cancer Virology Program. The Chang-Moore team developed a new technology for identifying human cancer viruses, called digital transcriptome subtraction, or DTS. Through the discovery of novel cancer viruses, and detailed investigation into their biology and mechanisms of action, the research team aims to develop effective targeted therapies for patients with virus-related cancers.
Watch Drs. Moore and Chang discuss their important work.
Video courtesy of the Carnegie Science Awards