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Edward Prochownik

Edward Prochownik

Program: Cancer Biology

(412) 692-6795 procev@chp.edu Rangos Research Center, Room 5124
Children’s Hospital of Pittsburgh, 4401 Penn Ave.
Pittsburgh PA
Summary

 Dr. Prochownik is interested in cancers resulting from the de-regulated expression of the c-Myc oncoprotein. He is using animal models of pediatric and adult liver cancer (hepatoblastoma and hepatocellular carcinoma) to ascertain the molecular, biochemical and metabolic changes that accompany tumor progression, regression and recurrence. He is utilizing over-expression and knockout models to determine how genes that cooperate with or are affected by Myc such as ChREBP and pyruvate dehydrogenase specifically contribute to the metabolic and molecular landscapes of these tumors.

Research Interests and Keywords
  • c-Myc
  • molecular oncology
  • tumor suppressors
  • tumor metabolism
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