Gary Thomas, PhD

Summary

We investigate signaling pathways that integrate membrane traffic with the regulation of homeostasis and the onset of disease, including cancer and autism, and we leverage these discoveries to develop targeted therapies. Our studies are grounded by our discovery of the PACS family of multi-functional sorting proteins. Currently, we are investigating how the PACS proteins regulate key deacetylases, including SIRT1 and HDAC6, to control signaling pathways impacting cancer cell death, obesity, and neurodevelopmental disorders.