Yuan Chang

Summary

The Chang-Moore Laboratory at the Hillman Cancer Center, led by Patrick Moore and Yuan Chang, has focused on human tumor viruses. We identified Kaposi sarcoma-associated herpesvirus (KSHV/HHV8) and established its link to Kaposi sarcoma, a common AIDS-related cancer in the U.S. and parts of Africa. We sequenced the KSHV genome, developed serologic assays, assessed its prevalence, and characterized key viral oncoproteins. 
Recently, we discovered Merkel cell polyomavirus (MCV), and established its causal role in ~80% of MCC.  We characterized the early T antigen oncoproteins (large T and small T), and identified several novel cellular interactors for T antigens that open new avenues of investigating critical oncogenic signaling pathways. 

Our group has focused on many aspects of cancer etiology as modeled through oncogenic tumor viruses; as well as investigations of the epidemiology and basic biology of these viruses. Our ongoing research explores virus-host interactions, particularly in pro-proliferative and innate immune signaling pathways. Characteristics of our laboratory include the ability to work collaboratively with colleagues, to incorporate innovative technologies, and to develop a rigorous training/research environment.