Publications

2017 WCRC Highlighted Publications

• Mathew A, Rajagopal PS, Villgran V, Sandhu GS, Jankowitz RC, Jacob M, Rosenzweig M, Oesterreich S, Brufsky A. Distinct Pattern of Metastases in Patients with Invasive Lobular Carcinoma of the Breast. Geburtshilfe Frauenheilkd. 2017 Jun;77(6):660-666. doi: 10.1055/s-0043-109374. Epub 2017 Jun 28. PMID: 28757653
• Jiang C, Ding Z, Joy M, Chakraborty S, Kim SH, Bottcher R, Condeelis J, Singh S, Roy P. A balanced level of profilin-1 promotes stemness and tumor-initiating potential of breast cancercells. Cell Cycle. 2017 Jul 12:0. doi: 10.1080/15384101.2017.1346759. [Epub ahead of print] PMID: 28699810
• Budiu RA, Vlad AM, Nazario L, Bathula C, Cooper KL, Edmed J, Thaker PH, Urban J, Kalinski P, Lee AV, Elishaev EL, Conrads TP, Flint MS. Restraint and Social Isolation Stressors Differentially Regulate Adaptive Immunity and Tumor Angiogenesis in a Breast Cancer Mouse Model. Cancer Clin Oncol. 2017 May;6(1):12-24. doi: 10.5539/cco.v6n1p12. Epub 2016 Nov 11. PMID:28603578
• Bahreini A, Li Z, Wang P, Levine KM, Tasdemir N, Cao L, Weir HM, Puhalla SL, Davidson NE, Stern AM, Chu D, Park BH, Lee AV, Oesterreich S. Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models. Breast Cancer Res. 2017 May 23;19(1):60. doi: 10.1186/s13058-017-0851-4. PMID:28535794
• Andersen CL, Sikora MJ, Boisen MM, Ma T, Christie A, Tseng G, Park YS, Luthra S, Chandran U, Haluska P, Mantia-Smaldone G, Odunsi K, McLean K, Lee AV, Elishaev E, Edwards RP, Oesterreich S. Active estrogen receptor-alpha signaling in ovarian cancer models and clinical specimens. Clin Cancer Res. 2017 Jan 10. pii: clincanres.1501.2016. doi: 10.1158/1078-0432.CCR-16-1501. [Epub ahead of print]
• Zhang M, Lee AV, Rosen JM. The Cellular Origin and Evolution of Breast Cancer. Cold Spring Harb Perspect Med. 2017 Jan 6. pii: a027128. doi: 10.1101/cshperspect.a027128. [Epub ahead of print] PMID:28062556

2016 WCRC Highlighted Publications

• Huang Y, Davidson NE. Targeting tumorigenicity of breast cancer stem-like cells using combination epigenetic therapy: something old and something new. J Thorac Dis. 2016 Nov;8(11):2971-2974. doi: 10.21037/jtd.2016.11.18. No abstract available. PMID:28066560
• Jankowitz RC, Oesterreich S, Lee AV, Davidson NE. New Strategies in Metastatic Hormone Receptor-Positive Breast Cancer: Searching for Biomarkers to Tailor Endocrine and Other Targeted Therapies. Clin Cancer Res. 2016 Dec 15. doi: 10.1158/1078-0432.CCR-16-0591. [Epub ahead of print] PMID: 27979914
• Bahreini A, Levine K, Santana-Santos L, Benos PV, Wang P, Andersen C, Oesterreich S, Lee AV. Non-coding single nucleotide variants affecting estrogen receptor binding and activity. Genome Med. 2016 Dec 13;8(1):128. PMID:27964748
• Priedigkeit N, Hartmaier RJ, Chen Y, Vareslija D, Basudan A, Watters RJ, Thomas R, Leone JP, Lucas PC, Bhargava R, Hamilton RL, Chmielecki J, Puhalla SL, Davidson NE, Oesterreich S, Brufsky AM, Young L, Lee AV. Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases. JAMA Oncol. 2016 Dec 7. doi: 10.1001/jamaoncol.2016.5630. [Epub ahead of print] PMID: 27926948
• Gyanchandani R, Lin Y, Lin HM, Cooper K, Normolle DP, Brufsky A, Fastuca M, Crosson W, Oesterreich S, Davidson NE, Bhargava R, Dabbs DJ, Lee AV. Intratumor Heterogeneity Affects Gene Expression Profile Test Prognostic Risk Stratification in Early Breast Cancer. Clin Cancer Res. 2016 Nov 1;22(21):5362-5369. PMID: 27185370
• Farabaugh SM, Chan BT, Cui X, Dearth RK, Lee AV. Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer. Cell Commun Signal. 2016 Oct 21;14(1):25. PMID:27765041
• Kim JA, Tan Y, Wang X, Cao X, Veeraraghavan J, Liang Y, Edwards DP, Huang S, Pan X, Li K, Schiff R, Wang XS. Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers. Nat Commun. 2016 Oct 3;7:12991. doi: 10.1038/ncomms12991. PMID:27694828
• Lee AV. The Endocrine Society Centennial: 40 Years of Aromatase Inhibitors as Targeted Therapy for Breast Cancer. Endocrinology. 2016 Oct;157(10):3697-3698. No abstract available. PMID: 27599035
• Sikora MJ, Jacobsen BM, Levine K, Chen J, Davidson NE, Lee AV, Alexander CM, Oesterreich S. WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines. Breast Cancer Res. 2016 Sep 20;18(1):92. doi: 10.1186/s13058-016-0748-7. PMID:27650553
• Soran A, Bhargava R, Johnson R, Ahrendt G, Bonaventura M, Diego E, McAuliffe PF, Serrano M, Menekse E, Sezgin E, McGuire KP. The impact of Oncotype DX® recurrence score of paraffin-embedded core biopsy tissues in predicting response to neoadjuvant chemotherapy in women with breast cancer. Breast Dis. 2016 Jul 28;36(2-3):65-71. doi: 10.3233/BD-150199. PMID: 27662272
• Gyanchandani R, Kota KJ, Jonnalagadda AR, Minteer T, Knapick BA, Oesterreich S, Brufsky AM, Lee AV, Puhalla SL Detection of ESR1 mutations in circulating cell-free DNA from patients with metastatic breast cancer treated with palbociclib and letrozole. Oncotarget. 2016 Aug 19. doi: 10.18632/oncotarget.11383. [Epub ahead of print] PMID: 27556863
• Sgroi DC, Brufsky A. Biomarkers for Early-Stage Breast Cancer: Clinical Utility for Extended Adjuvant Treatment Decisions. J Clin Oncol. 2016 Aug 22. pii: JCO672949. [Epub ahead of print] No abstract available. PMID: 27551134
• Brufsky AM, Davidson NE. Multi-parametric genomic assays for breast cancer: Time for the next generation? Clin Cancer Res. 2016 Aug 12. pii: clincanres.1513.2016. [Epub ahead of print] PMID: 27521446
• Kim JA, Anurag M, Veeraraghavan J, Schiff R, Li K, Wang X. Amplification of TLK2 Induces Genomic Instability via Impairing the G2/M Checkpoint. Mol Cancer Res. 2016 Aug 3. pii: molcanres.0161.2016. [Epub ahead of print] PMID: 27489360
• Sikora MJ, Johnson MD, Lee AV, Oesterreich S. Endocrine response phenotypes are altered by charcoal-stripped serum variability. Endocrinology. 2016 Jul 26:en20161297. [Epub ahead of print] PMID: 27459541
• Steiman J, Soran A, McAuliffe P, Diego E, Bonaventura M, Johnson R, Ahrendt G, McGuire K. Predictive value of axillary nodal imaging by magnetic resonance imaging based on breast cancersubtype after neoadjuvant chemotherapy. J Surg Res. 2016 Jul;204(1):237-41. doi: 10.1016/j.jss.2016.04.048. Epub 2016 Apr 27. PMID: 27451892
• Puhalla SL, Davidson NE. Breast cancer: The 21-gene recurrence score – biology remains at the forefront. Nat Rev Clin Oncol. 2016 Aug;13(8):470-2. doi: 10.1038/nrclinonc.2016.98. Epub 2016 Jun 14. No abstract available. PMID: 27296295
• Cao C, Vasilatos SN, Bhargava R, Fine JL, Oesterreich S, Davidson NE, Huang Y. Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression. Oncogene. 2016 May 23. doi: 10.1038/onc.2016.186. [Epub ahead of print] PMID: 27212032
• Gyanchandani R, Lin Y, Lin HM, Cooper KL, Normolle DP, Brufsky AM, Fastuca M, Crosson W, Oesterreich S, Davidson NE, Bhargava R, Dabbs DJ, Lee AV. Intra-tumor heterogeneity affects gene expression profile test prognostic risk stratification in earlybreast cancer. Clin Cancer Res. 2016 May 16. pii: clincanres.2889.2015. [Epub ahead of print] PMID: 27185370
• Delgado E, Boisen MM, Laskey R, Chen R, Song C, Sallit J, Yochum ZA, Andersen CL, Sikora MJ, Wagner J, Safe S, Elishaev E, Lee A, Edwards RP, Haluska P, Tseng G, Schurdak M, Oesterreich S. High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecol Oncol. 2016 May;141(2):348-56. doi: 10.1016/j.ygyno.2016.02.030. Epub 2016 Mar 11. PMID:26946093
• Davidson NE. Conquering Metastatic Breast Cancer. J Oncol Pract. 2016 Jan;12(1):11-2. doi: 10.1200/JOP.2015.009167.

2015 WCRC Highlighted Publications

• Zhang M, Rosen JM. Developmental Insights into Breast Cancer Intratumoral Heterogeneity. Trends Cancer. 2015 Dec 1;1(4):242-251. PMID: 26753176
• Wang P, Bahreini A, Gyanchandani R, Lucas PC, Hartmaier RJ, Watters RJ, Jonnalagadda AR, Trejo Bittar HE, Berg A, Hamilton RL, Kurland BF, Weiss KR, Mathew A, Leone JP, Davidson NE, Nikiforova MN, Brufsky AM, Ambros TF, Stern AM, Puhalla SL, Lee AV, Oesterreich S. Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients. Clin Cancer Res. 2016 Mar 1;22(5):1130-7. doi: 10.1158/1078-0432.CCR-15-1534. Epub 2015 Oct 23. PMID: 26500237
• Katz TA, Liao S, Palmieri VJ, Dearth RK, Pathiraja TN, Huo Z, Shaw P, Small S, Davidson NE, Peters DG, Tseng G, Oesterreich S, Lee AV. Targeted DNA methylation screen in the mouse mammary genome reveals a parity-induced hypermethylation of IGF1R which persists long after parturition. Cancer Prev Res (Phila). 2015 Aug 19. pii: canprevres.0178.2015. [Epub ahead of print] PMID: 26290394
• Brown DD, Dabbs DJ, Lee AV, McGuire KP, Ahrendt GM, Bhargava R, Davidson NE, Brufsky AM, Johnson RR, Oesterreich S, McAuliffe PF. Developing in vitro models of human ductal carcinoma in situ from primary tissue explants. Breast Cancer Res Treat. 2015 Aug 18. [Epub ahead of print] PMID: 26283301
• Boisen MM, Andersen CL, Sreekumar S, Stern AM, Oesterreich S. Treating gynecologic malignancies with selective estrogen receptor downregulators (SERDs): promise and challenges. Mol Cell Endocrinol. 2015 Aug 11. pii: S0303-7207(15)30038-1. doi: 10.1016/j.mce.2015.04.035. [Epub ahead of print] PMID: 26276546
• Casa AJ, Hochbaum D, Sreekumar S, Oesterreich S, Lee AV. The estrogen receptor alpha nuclear localization sequence is critical for fulvestrant-induced degradation of the receptor. Mol Cell Endocrinol. 2015 Aug 10. pii: S0303-7207(15)30047-2. doi: 10.1016/j.mce.2015.08.007. [Epub ahead of print] PMID: 26272024
• Mathew A, Davidson NE. Adjuvant endocrine therapy for premenopausal women with hormone-responsive breast cancer. Breast. 2015 Aug 6. pii: S0960-9776(15)00165-4. doi: 10.1016/j.breast.2015.07.027. [Epub ahead of print] PMID: 26255743
• Liao S, Hartmaier RJ, McGuire KP, Puhalla SL, Luthra S, Chandran UR, Ma T, Bhargava R, Modugno F, Davidson NE, Benz S, Lee AV, Tseng GC, Oesterreich S. The molecular landscape of premenopausal breast cancer. Breast Cancer Res. 2015 Aug 7;17:104. doi: 10.1186/s13058-015-0618-8. PMID: 26251034
• Brufsky A, Mathew A. Bisphosphonates, bone, and breast cancer recurrence. Lancet. 2015 Jul 23. pii: S0140-6736(15)61163-1. doi: 10.1016/S0140-6736(15)61163-1. [Epub ahead of print] No abstract available. PMID: 26211825
• Jiang C, Veon W, Li H, Hallows KR, Roy P. Epithelial morphological reversion drives Profilin-1-induced elevation of p27^kip1 in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation. Jiang C, Veon W, Li H, Hallows KR, Roy P. Cell Cycle. 2015 Jul 15:1-10. [Epub ahead of print] PMID: 26176334
• Nayak SR, Harrington E, Boone D, Hartmaier R, Chen J, Pathiraja TN, Cooper KL, Fine JL, Sanfilippo J, Davidson NE, Lee AV, Dabbs D, Oesterreich S. A Role for Histone H2B Variants in Endocrine-Resistant Breast Cancer. Horm Cancer. 2015 Jun 26. [Epub ahead of print] PMID: 26113056
• Jiang S, Katz TA, Garee JP, DeMayo FJ, Lee AV, Oesterreich S. Scaffold attachment factor B2 (SAFB2) null mice reveal non-redundant functions compared to its paralog SAFB1. Dis Model Mech. 2015 Jun 18. pii: dmm.019885. [Epub ahead of print] PMID: 26092125
• Sparano JA, Zhao F, Martino S, Ligibel JA, Perez EA, Saphner T, Wolff AC, Sledge GW Jr, Wood WC, Davidson NE. Long-Term Follow-Up of the E1199 Phase III Trial Evaluating the Role of Taxane and Schedule in Operable Breast Cancer. J Clin Oncol. 2015 Jul 20;33(21):2353-60. doi: 10.1200/JCO.2015.60.9271. Epub 2015 Jun 15. PMID: 26077235
• Logan GJ, Dabbs DJ, Lucas PC, Jankowitz RC, Brown DD, Clark BZ, Oesterreich S, McAuliffe PF. Molecular drivers of lobular carcinoma in situ. Breast Cancer Res. 2015 Jun 4;17:76. doi: 10.1186/s13058-015-0580-5. PMID: 26041550
• Farabaugh SM, Boone DN, Lee AV. Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation. Front Endocrinol (Lausanne). 2015 Apr 24;6:59. doi: 10.3389/fendo.2015.00059. eCollection 2015. Review.
• Reeder A, Attar M, Nazario L, Bathula C, Zhang A, Hochbaum D, Roy E, Cooper KL, Oesterreich S, Davidson NE, Neumann CA, Flint MS. Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage. Br J Cancer. 2015 Apr 28;112(9):1461-70. doi: 10.1038/bjc.2015.133. Epub 2015 Apr 16.
• Gau DM, Lesnock JL, Hood BL, Bhargava R, Sun M, Darcy K, Luthra S, Chandran U, Conrads TP, Edwards RP, Kelley JL, Krivak TC, Roy P. BRCA1 deficiency in ovarian cancer is associated with alteration in expression of several key regulators of cell motility – A proteomics study. Cell Cycle. 2015 Apr 30:0. [Epub ahead of print]
• Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage. Reeder A1, Attar M2, Nazario L1, Bathula C3, Zhang A1, Hochbaum D1, Roy E1, Cooper KL4, Oesterreich S2, Davidson NE5, Neumann CA2, Flint MS6. Br J Cancer. 2015 Apr 16. doi: 10.1038/bjc.2015.133. [Epub ahead of print]
• Mcf-7 cells-changing the course of breast cancer research and care for 45 years. Lee AV, Oesterreich S, Davidson NE. J Natl Cancer Inst. 2015 Mar 31;107(7). pii: djv073. doi: 10.1093/jnci/djv073. Print 2015 Jul. PMID: 25828948
• Intratumoral heterogeneity in a p53 null mouse model of human breast cancer. Mei Zhang, Anna Tsimelzon, Chi-Hsuan Chang, Cheng Fan, Andrew Wolff, Charles M. Perou, Susan G. Hilsenbeck and Jeffrey M. Rosen. Cancer Discovery Published OnlineFirst March 3, 2015; doi: 10.1158/2159-8290.CD-14-1101

2014 Publications

• Complement pathway is frequently altered in endometriosis and endometriosis-associated ovarian cancer. Suryawanshi S, Huang X, Elishaev E, Budiu RA, Zhang L, Kim S, Donnellan N, Mantia-Smaldone G, Ma T, Tseng G, Lee T, Mansuria S, Edwards RP, Vlad AM. Clin Cancer Res. 2014 Dec 1;20(23):6163-74. doi: 10.1158/1078-0432.CCR-14-1338. Epub 2014 Oct 7.
• A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Lu H, Clauser KR, Tam WL, Fröse J, Ye X, Eaton EN, Reinhardt F, Donnenberg VS, Bhargava R, Carr SA, Weinberg RA. Nat Cell Biol. 2014 Nov;16(11):1105-17. doi: 10.1038/ncb3041. Epub 2014 Sep 28
• Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells. Breast Cancer Res Treat. 2014 Jul;146(1):99-108. doi: 10.1007/s10549-014-3012-9. Epub 2014 Jun 13. Katz TA, Vasilatos SN, Harrington E, Oesterreich S, Davidson NE, Huang Y.
• Managing Postmenopausal Women with Hormone Receptor Positive Advanced Breast Cancer Who Progress on Endocrine Therapies with Inhibitors of the PI3K Pathway Adam M. Brufsky, Breast J. 2014 May 26. doi: 10.1111/tbj.12278. [Epub ahead of print]
• Wnt-Responsive Cancer Stem Cells Are Located Close to Distorted Blood Vessels and Not in Hypoxic Regions in a p53-Null Mouse Model of Human Breast Cancer. Tegy J. Vadakkan, John D. Landua, Wen Bu, Wei We, Fuhai Li, Stephen T.C. Wong, Mary E. Dickinson, Jeffrey M. Rosen, Michael T. Lewis and Mei Zhang Stem Cells Transl Med. 2014 May 5. [Epub ahead of print] PMID:24797826
• Epigenetic Reprogramming of HOXC10 in Endocrine-Resistant Breast Cancer. Pathiraja TN1, Nayak SR, Xi Y, Jiang S, Garee JP, Edwards DP, Lee AV, Chen J, Shea MJ, Santen RJ, Gannon F, Kangaspeska S, Jelinek J, Issa JP, Richer JK, Elias A, McIlroy M, Young LS, Davidson NE, Schiff R, Li W, Oesterreich S. Sci Transl Med. 2014 Mar 26;6(229):229ra41. doi: 10.1126/scitranslmed.3008326.
• Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response. Sikora MJ, Cooper KL, Bahreini A, Luthra S, Wang G, Chandran UR, Davidson NE, Dabbs DJ, Welm AL, Oesterreich S. Cancer Res. 2014 Jan 14. [Epub ahead of print]

2013 Publications

• Integrated proteomic and metabolic analysis of breast cancer progression. Shaw PG, Chaerkady R, Wang T, Vasilatos S, Huang Y, Van Houten B, Pandey A, Davidson NE. PLoS One. 2013 Sep 27;8(9):e76220. doi: 10.1371/journal.pone.0076220.
• An isoform of C/EBP beta, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration. Park BH, Kook S, Lee S, Jeong JH, Brufsky A, Lee BC. J Biol Chem. 2013 Aug 21.
• IL-18-primed helper NK cells collaborate with dendritic cells to promote recruitment of effector CD8+ T cells to the tumor microenvironment. Wong JL, Berk E, Edwards RP, Kalinski P. Cancer Res. 2013 Jun 12. [Epub ahead of print]
• Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis. Ding Z, Joy M, Bhargava R, Gunsaulus M, Lakshman N, Miron-Mendoza M, Petroll M, Condeelis J, Wells A, Roy P. Oncogene. 2013 May 20. doi: 10.1038/onc.2013.166. [Epub ahead of print] PMID:23686314
• Suryawanshi S, Vlad AM, Lin HM, Mantia-Smaldone G, Laskey R, Lee M, Lin Y, Donnellan N, Klein-Patel M, Lee T, Mansuria S, Elishaev E, Budiu R, Edwards RP, Huang X. Plasma MicroRNAs as Novel Biomarkers for Endometriosis and Endometriosis-Associated Ovarian Cancer. Clin Cancer Res. 2013 Mar 1;19(5):1213-1224. Epub 2013 Jan 29. PMID:23362326
• Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells. Vasilatos SN, Katz TA, Oesterreich S, Wan Y, Davidson NE, Huang Y. Carcinogenesis. 2013 Feb 18. PMID:23354309
• Turner-Ivey B, Manevich Y, Schulte J, Kistner-Griffin E, Jezierska-Drutel A, Liu Y, Neumann CA.: Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer. Oncogene. 2013 Jan 21. doi: 10.1038/onc.2012.624. [Epub ahead of print] PMID:23334324
• Comprehensive molecular portraits of human breast tumours. Cancer Genome Atlas Network. Nature. 2012 Oct 4;490(7418):61-70. doi: 10.1038/nature11412. Epub 2012 Sep 23.
• Immunobiology of human mucin 1 in a preclinical ovarian tumor model. Budiu RA, Elishaev E, Brozick J, Lee M, Edwards RP, Kalinski P, Vlad AM. Oncogene. 2012 Sep 10. doi: 10.1038/onc.2012.397. [Epub ahead of print]