Velvet Journigan, PhD

Summary

Understanding the mechanism of cold temperature detection in humans on a molecular level, and small molecule drug discovery to treat chemotherapy-induced peripheral neuropathy (CIPN) cold hypersensitivity. CIPN sensory neuropathy to temperature and other environmental stimuli profoundly impacts survivorship, limiting the dose of chemotherapy tolerated and/or leads to discontinuation of treatment. Our lab combines biochemical techniques and synthetic medicinal chemistry to translate the sensory pharmacology of transient receptor potential (TRP) channels to novel pharmacological treatments for CIPN.